ATE402189T1 - Verbindungen und methoden zur wt1-spezifischen immuntherapie - Google Patents
Verbindungen und methoden zur wt1-spezifischen immuntherapieInfo
- Publication number
- ATE402189T1 ATE402189T1 AT01977493T AT01977493T ATE402189T1 AT E402189 T1 ATE402189 T1 AT E402189T1 AT 01977493 T AT01977493 T AT 01977493T AT 01977493 T AT01977493 T AT 01977493T AT E402189 T1 ATE402189 T1 AT E402189T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- polypeptide
- compounds
- specific immunotherapy
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464452—Transcription factors, e.g. SOX or c-MYC
- A61K39/464453—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/684,361 US7115272B1 (en) | 1998-09-30 | 2000-10-06 | Compositions and methods for WT1 specific immunotherapy |
US09/685,830 US7329410B1 (en) | 1998-09-30 | 2000-10-09 | Compositions and method for WT1 specific immunotherapy |
US09/785,019 US7144581B2 (en) | 2000-10-09 | 2001-02-15 | Compositions and methods for WT1 specific immunotherapy |
US09/938,864 US20030072767A1 (en) | 1998-09-30 | 2001-08-24 | Compositions and methods for WT1 specific immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE402189T1 true ATE402189T1 (de) | 2008-08-15 |
Family
ID=27505400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01977493T ATE402189T1 (de) | 2000-10-06 | 2001-10-03 | Verbindungen und methoden zur wt1-spezifischen immuntherapie |
Country Status (13)
Country | Link |
---|---|
US (1) | US20030072767A1 (de) |
EP (1) | EP1328287B1 (de) |
JP (2) | JP4130359B2 (de) |
KR (1) | KR100858231B1 (de) |
CN (1) | CN100545174C (de) |
AT (1) | ATE402189T1 (de) |
AU (2) | AU2001296608B2 (de) |
CA (1) | CA2425072C (de) |
DE (1) | DE60135005D1 (de) |
ES (1) | ES2311027T3 (de) |
MX (1) | MXPA03002983A (de) |
NZ (1) | NZ540397A (de) |
WO (1) | WO2002028414A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1178956C (zh) | 1998-07-31 | 2004-12-08 | 杉山治夫 | 基于癌抑制基因wt1的产物的癌抗原 |
US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
KR100863853B1 (ko) * | 2001-03-22 | 2008-10-15 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 더블유티1 개변 펩티드 |
US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
JP4566912B2 (ja) | 2003-06-27 | 2010-10-20 | 株式会社癌免疫研究所 | Wt1ワクチン適応患者の選択方法 |
WO2005087260A1 (en) * | 2004-03-04 | 2005-09-22 | Corixa Corporation | Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof |
US20080293916A1 (en) * | 2004-09-17 | 2008-11-27 | Nec Corporation | Hla-Binding Peptide, and Dna Fragment and Recombinant Vector Coding for Said Hla-Binding Peptide |
WO2007047764A2 (en) * | 2005-10-17 | 2007-04-26 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
WO2007070907A2 (en) * | 2005-12-21 | 2007-06-28 | St. Anna Kinderkrebsforschung | Therapeutic compositions |
ES2587980T3 (es) | 2006-02-22 | 2016-10-28 | International Institute Of Cancer Immunology, Inc | Péptido WT1 con restricción HLA-A*3303 y composición farmacéutica que lo contiene |
JP5231997B2 (ja) * | 2006-03-29 | 2013-07-10 | 株式会社癌免疫研究所 | WT117AA(−)アイソフォーム特異的siRNAおよびその利用 |
US9265816B2 (en) * | 2006-04-10 | 2016-02-23 | Sloan Kettering Institute For Cancer Research | Immunogenic WT-1 peptides and methods of use thereof |
AU2012227350C1 (en) * | 2006-12-28 | 2015-11-12 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-Restricted WT1 peptide and pharmaceutical composition comprising the same |
EP2479275B1 (de) * | 2006-12-28 | 2015-10-28 | International Institute of Cancer Immunology, Inc. | HLA-A*1101-beschränktes WT1-Peptid und pharmazeutische Zusammensetzung damit |
MX343633B (es) | 2007-03-05 | 2016-11-11 | Int Inst Cancer Immunology Inc | Gen receptor de celulas t especificas de antigeno cancerigeno, peptido codificado por el gen, y uso de los mismos. |
ITTO20070401A1 (it) * | 2007-06-07 | 2008-12-08 | Univ Degli Studi Torino | Vaccino anti-tumorale |
AR076349A1 (es) * | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
WO2011059835A2 (en) * | 2009-11-11 | 2011-05-19 | Quest Diagnostics Investments Incorporated | Wt1 mutations for prognosis of myeloproliferative disorders |
WO2013002086A1 (ja) | 2011-06-28 | 2013-01-03 | 株式会社癌免疫研究所 | ペプチド癌抗原特異的t細胞のレセプター遺伝子 |
US10316332B2 (en) | 2011-07-29 | 2019-06-11 | Riken | Cell for immunotherapy, including modified nucleic acid construct encoding Wilms tumor gene product |
AU2012291101B2 (en) | 2011-07-29 | 2016-04-07 | Riken | Cell for use in immunotherapy which contains modified nucleic acid construct encoding Wilms tumor gene product or fragment thereof, method for producing said cell, and said nucleic acid construct |
CA2846479A1 (en) * | 2011-09-14 | 2013-03-21 | International Institute Of Cancer Immunology, Inc. | Method for measuring anti-wt1 antibody |
JP6117515B2 (ja) * | 2011-11-01 | 2017-04-19 | 国立大学法人名古屋大学 | 髄膜腫治療用医薬組成物 |
JP6282598B2 (ja) | 2012-01-13 | 2018-02-21 | メモリアル スローン ケタリング キャンサー センター | 免疫原性wt1ペプチド及びその使用方法 |
CA2898099A1 (en) | 2013-01-15 | 2014-07-24 | David A. Scheinberg | Immunogenic wt-1 peptides and methods of use thereof |
US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
JP6250288B2 (ja) * | 2013-01-30 | 2017-12-20 | 株式会社医学生物学研究所 | T細胞レセプターおよびその利用 |
CN108350411B (zh) * | 2015-06-25 | 2021-06-22 | 白川利朗 | 口服肿瘤疫苗 |
KR20200138418A (ko) * | 2016-05-27 | 2020-12-09 | 이투빅스 코포레이션 | 네오에피토프 백신 조성물 및 이의 사용 방법 |
JP7209963B2 (ja) | 2016-11-30 | 2023-01-23 | 住友ファーマ株式会社 | Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ |
JPWO2018181648A1 (ja) | 2017-03-30 | 2020-02-13 | 大日本住友製薬株式会社 | Wt1癌抗原ペプチドおよびこれを含むペプチドコンジュゲート体 |
CA3062591A1 (en) | 2017-05-08 | 2018-11-15 | Gritstone Oncology, Inc. | Alphavirus neoantigen vectors |
EP3735271A4 (de) | 2018-01-04 | 2022-06-15 | Iconic Therapeutics, Inc. | Anti-gewebefaktor-antikörper, antikörperarzneimittel-konjugate und verwandte verfahren |
CN113302285A (zh) * | 2018-08-10 | 2021-08-24 | 优特力克斯有限公司 | 癌抗原特异性cd8+t细胞的制备及冷冻保存方法 |
MX2021003660A (es) | 2018-09-28 | 2021-05-28 | Sumitomo Pharma Co Ltd | Composicion inyectable. |
JP7457733B2 (ja) | 2019-05-30 | 2024-03-28 | グリットストーン バイオ インコーポレイテッド | 改変アデノウイルス |
US20230183316A1 (en) | 2020-05-12 | 2023-06-15 | Sumitomo Pharma Co., Ltd. | Pharmaceutical composition for treating cancer |
WO2022032196A2 (en) | 2020-08-06 | 2022-02-10 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
CA3228494A1 (en) | 2021-08-12 | 2023-02-16 | International Institute Of Cancer Immunology, Inc. | Pharmaceutical composition and method for treating or preventing cancer |
CN115998851A (zh) * | 2022-12-28 | 2023-04-25 | 四川康德赛医疗科技有限公司 | 一种个体化mRNA组合物、载体、mRNA疫苗及其应用 |
CN117552115B (zh) * | 2024-01-12 | 2024-03-26 | 天津鲸鹏生物科技有限责任公司 | 用于诱导肿瘤特异性免疫响应的通用型抗原肽库及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3393867B2 (ja) * | 1989-11-13 | 2003-04-07 | マサチユーセツツ・インステイテユート・オブ・テクノロジー | ウィルムス腫瘍遺伝子の位置決定と特徴付け |
JP3435163B2 (ja) * | 1993-07-20 | 2003-08-11 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 黒色腫阻害蛋白質 |
DE69938970D1 (de) * | 1998-09-30 | 2008-08-07 | Corixa Corp | Zusammensetzungen und verfahren für wt1-spezifische immunotherapie |
AU2001247220A1 (en) * | 2000-02-22 | 2001-09-03 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
-
2001
- 2001-08-24 US US09/938,864 patent/US20030072767A1/en not_active Abandoned
- 2001-10-03 JP JP2002532238A patent/JP4130359B2/ja not_active Expired - Fee Related
- 2001-10-03 NZ NZ540397A patent/NZ540397A/en not_active IP Right Cessation
- 2001-10-03 CA CA2425072A patent/CA2425072C/en not_active Expired - Fee Related
- 2001-10-03 KR KR1020037004933A patent/KR100858231B1/ko not_active IP Right Cessation
- 2001-10-03 AU AU2001296608A patent/AU2001296608B2/en not_active Ceased
- 2001-10-03 DE DE60135005T patent/DE60135005D1/de not_active Expired - Lifetime
- 2001-10-03 MX MXPA03002983A patent/MXPA03002983A/es active IP Right Grant
- 2001-10-03 AU AU9660801A patent/AU9660801A/xx active Pending
- 2001-10-03 CN CNB018191142A patent/CN100545174C/zh not_active Expired - Fee Related
- 2001-10-03 AT AT01977493T patent/ATE402189T1/de not_active IP Right Cessation
- 2001-10-03 EP EP01977493A patent/EP1328287B1/de not_active Expired - Lifetime
- 2001-10-03 ES ES01977493T patent/ES2311027T3/es not_active Expired - Lifetime
- 2001-10-03 WO PCT/US2001/031139 patent/WO2002028414A1/en active IP Right Grant
-
2007
- 2007-12-25 JP JP2007332784A patent/JP2008154588A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN100545174C (zh) | 2009-09-30 |
WO2002028414A1 (en) | 2002-04-11 |
KR100858231B1 (ko) | 2008-09-12 |
MXPA03002983A (es) | 2004-12-06 |
WO2002028414B1 (en) | 2002-07-18 |
JP4130359B2 (ja) | 2008-08-06 |
US20030072767A1 (en) | 2003-04-17 |
EP1328287B1 (de) | 2008-07-23 |
CA2425072C (en) | 2013-11-26 |
KR20030081314A (ko) | 2003-10-17 |
JP2008154588A (ja) | 2008-07-10 |
EP1328287A4 (de) | 2005-09-07 |
AU9660801A (en) | 2002-04-15 |
AU2001296608B2 (en) | 2007-05-24 |
CN1505526A (zh) | 2004-06-16 |
DE60135005D1 (de) | 2008-09-04 |
NZ540397A (en) | 2008-05-30 |
CA2425072A1 (en) | 2002-04-11 |
EP1328287A1 (de) | 2003-07-23 |
ES2311027T3 (es) | 2009-02-01 |
JP2004510425A (ja) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |