HUP0401461A2 - 1-Fenilszulfonil-1,3-dihidro-2H-indol-2-on-származékok, a vegyületek előállítása és terápiás alkalmazása - Google Patents

1-Fenilszulfonil-1,3-dihidro-2H-indol-2-on-származékok, a vegyületek előállítása és terápiás alkalmazása

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Publication number
HUP0401461A2
HUP0401461A2 HU0401461A HUP0401461A HUP0401461A2 HU P0401461 A2 HUP0401461 A2 HU P0401461A2 HU 0401461 A HU0401461 A HU 0401461A HU P0401461 A HUP0401461 A HU P0401461A HU P0401461 A2 HUP0401461 A2 HU P0401461A2
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HU
Hungary
Prior art keywords
group
compounds
halogen atom
receptors
alkoxy group
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Application number
HU0401461A
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English (en)
Inventor
Alain Di Malta
Georges Garcia
Richard Roux
Bruno Schoentjes
Claudine Serradeil-Le-Gal
Bernard Tonnerre
Jean Wagnon
Original Assignee
Sanofi-Synthelabo
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Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0401461A2 publication Critical patent/HUP0401461A2/hu
Publication of HUP0401461A3 publication Critical patent/HUP0401461A3/hu

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Abstract

A találmány tárgya (I) általános képletű vegyületek, a képletben - nértéke 1 vagy 2; - X jelentése -CH2-; -O-; -NH-; -O-CH2-; -NH-CH2-; -NH-CH2-CH2- csoport; - R, jelentése halogénatom; 1-4 szénatomosalkilcsoport; 1-4 szénatomos alkoxicsoport; - R2 jelentésehidrogénatom; halogénatom; alkilcsoport; alkoxicsoport;trifluormetilcsoport; - R3 jelentése halogénatom; alkilcsoport;alkoxicsoport; trifluormetilcsoport; trifluormetoxicsoport; - R4jelentése hidrogénatom; halogénatom; alkilcsoport; alkoxicsoport; - R5jelentése egy 5- vagy 6-tagú heteroaromás csoport; - R6 és R7jelentése alkoxicsoport; és a vegyületek ásványi vagy szerves savakkalalkotott sóira, szolvátjaira és/vagy hidrátjaira vonatkozik, amelyek aV1b arginin-vazopresszin receptorok és/vagy azoxitocin receptorok,ezen túlmenően bizonyos vegyületek a V1a receptorok iránt mutatnakaffinitást. A találmány tárgyát képezi a vegyületek előállításáraalkalmas eljárás, valamint az előállítási eljárás közbenső termékei, avegyületeket tartalmazó gyógyszertermékek és a vegyületekgyógyszertermékek előállítására való alkalmazása. Ó
HU0401461A 2001-07-17 2002-07-15 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use HUP0401461A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0110359A FR2827604B1 (fr) 2001-07-17 2001-07-17 Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2002/002500 WO2003008407A2 (fr) 2001-07-17 2002-07-15 Derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique

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FR2827604B1 (fr) 2003-09-19
BR0211284A (pt) 2004-08-03
JP2004536131A (ja) 2004-12-02
CO5550440A2 (es) 2005-08-31
CA2450437A1 (en) 2003-01-30
PT1419150E (pt) 2005-08-31
AR034792A1 (es) 2004-03-17
DE60203917D1 (de) 2005-06-02
UA77181C2 (en) 2006-11-15
ZA200309717B (en) 2004-12-15
EP1419150B1 (fr) 2005-04-27
IS2485B (is) 2008-12-15
IL159275A0 (en) 2004-06-01
NO20040219L (no) 2004-03-17
CN1224623C (zh) 2005-10-26
ATE294171T1 (de) 2005-05-15
EA200301306A1 (ru) 2004-06-24
NZ530144A (en) 2005-03-24
DE60203917T2 (de) 2006-02-16
MA27049A1 (fr) 2004-12-20
RS204A (en) 2006-12-15
JP4262088B2 (ja) 2009-05-13
WO2003008407A3 (fr) 2003-10-16
AU2002340999B2 (en) 2007-03-01
HRP20040027A2 (en) 2004-06-30
MEP24508A (en) 2010-10-10
HUP0401461A3 (en) 2009-06-29
EP1419150A2 (fr) 2004-05-19
MXPA04000507A (es) 2004-07-23
IS7079A (is) 2003-12-15
KR20040017325A (ko) 2004-02-26
PL366829A1 (en) 2005-02-07
DK1419150T3 (da) 2005-08-29
FR2827604A1 (fr) 2003-01-24
EA006019B1 (ru) 2005-08-25
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CN1533387A (zh) 2004-09-29
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