HUP0400766A2 - Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk - Google Patents

Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk

Info

Publication number
HUP0400766A2
HUP0400766A2 HU0400766A HUP0400766A HUP0400766A2 HU P0400766 A2 HUP0400766 A2 HU P0400766A2 HU 0400766 A HU0400766 A HU 0400766A HU P0400766 A HUP0400766 A HU P0400766A HU P0400766 A2 HUP0400766 A2 HU P0400766A2
Authority
HU
Hungary
Prior art keywords
group
general formula
imidazopyrimidine
imidazopyridine
antiviral
Prior art date
Application number
HU0400766A
Other languages
English (en)
Hungarian (hu)
Inventor
Rita L. Civiello
Keith D. Combrink
Hatice Belgin Gulgeze
Nicholas A. Meanwell
Ny Sin
Brian Lee Venables
Xiangdong Wang
Kuo Long Yu
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0400766A2 publication Critical patent/HUP0400766A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0400766A 2000-06-13 2001-05-08 Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk HUP0400766A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US26336301P 2001-01-22 2001-01-22
PCT/US2001/014775 WO2001095910A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Publications (1)

Publication Number Publication Date
HUP0400766A2 true HUP0400766A2 (hu) 2004-07-28

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400766A HUP0400766A2 (hu) 2000-06-13 2001-05-08 Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk

Country Status (20)

Country Link
US (1) US6489338B2 (https=)
EP (1) EP1311268A4 (https=)
JP (1) JP2004503501A (https=)
KR (1) KR20030008151A (https=)
CN (1) CN1436079A (https=)
AR (1) AR029128A1 (https=)
AU (2) AU2001272906B2 (https=)
BR (1) BR0111569A (https=)
CA (1) CA2412327A1 (https=)
CZ (1) CZ20024078A3 (https=)
HU (1) HUP0400766A2 (https=)
IL (1) IL152889A0 (https=)
MX (1) MXPA02012204A (https=)
NO (1) NO20025977L (https=)
NZ (1) NZ523566A (https=)
PE (1) PE20011348A1 (https=)
PL (1) PL360290A1 (https=)
RU (1) RU2003100828A (https=)
UY (1) UY26758A1 (https=)
WO (1) WO2001095910A1 (https=)

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US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
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GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
BRPI0513811A (pt) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
ES2392863T3 (es) 2005-06-20 2012-12-14 Janssen R&D Ireland Bencimidazoles 2-sustituidos
BRPI0611744B8 (pt) 2005-06-20 2021-05-25 Janssen R & D Ireland benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica
CA2612263C (en) * 2005-06-20 2015-04-14 Tibotec Pharmaceuticals Ltd. 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
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TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
JPWO2011115150A1 (ja) * 2010-03-18 2013-07-04 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
CN103893173B (zh) * 2011-03-23 2016-02-24 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
US9550737B2 (en) * 2012-06-11 2017-01-24 Ucb Biopharma Sprl TNF -α modulating benzimidazoles
WO2013186334A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
KR20150032283A (ko) * 2012-06-15 2015-03-25 얀센 알 앤드 디 아일랜드 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
EA201590023A1 (ru) * 2012-06-15 2015-05-29 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
LT2864323T (lt) * 2012-06-15 2017-07-25 Janssen Sciences Ireland Uc 1,3-dihidro-2h-benzimidazol-2-ono dariniai, turintys heterociklų pakaitų, kaip antivirusiniai agentai prieš respiratorinį sincitinį virusą
BR112015008325B1 (pt) * 2012-10-16 2022-01-25 Janssen Sciences Ireland Uc Compostos antivirais contra o rsv, seu uso e composição farmacêutica que os compreende
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
KR20160075766A (ko) * 2013-10-29 2016-06-29 메디비르 아베 퀴나졸린계 호흡기 세포융합 바이러스 억제제
EP3414234B1 (en) * 2015-10-14 2022-06-29 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
IL292526A (en) * 2019-10-30 2022-06-01 Janssen Sciences Ireland Unlimited Co Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-3,1-dihydro- 2h-Imidazo[5,4-c]pyridin-2-one
EP4051663B1 (en) * 2019-10-30 2024-02-21 Janssen Sciences Ireland Unlimited Company Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine
JP2023528969A (ja) 2020-06-11 2023-07-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
CN118871439A (zh) * 2022-01-28 2024-10-29 英矽智能科技知识产权有限公司 外核苷酸焦磷酸酶-磷酸二酯酶(enpp1)抑制剂及其用途
CN117586250A (zh) * 2022-08-11 2024-02-23 潍坊汇韬化工有限公司 一种人类呼吸道合胞病毒抑制剂中间体的制备方法
CN116589399A (zh) * 2023-05-29 2023-08-15 济南大学 一种3-甲氧基-2-硝基吡啶的制备方法
WO2025026383A1 (en) * 2023-08-02 2025-02-06 Insilico Medicine Ip Limited Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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Also Published As

Publication number Publication date
PL360290A1 (en) 2004-09-06
JP2004503501A (ja) 2004-02-05
BR0111569A (pt) 2003-04-29
CZ20024078A3 (cs) 2003-08-13
AR029128A1 (es) 2003-06-04
NZ523566A (en) 2004-08-27
PE20011348A1 (es) 2002-02-07
IL152889A0 (en) 2003-06-24
US6489338B2 (en) 2002-12-03
WO2001095910A1 (en) 2001-12-20
KR20030008151A (ko) 2003-01-24
US20020016309A1 (en) 2002-02-07
EP1311268A1 (en) 2003-05-21
NO20025977D0 (no) 2002-12-12
CA2412327A1 (en) 2001-12-20
MXPA02012204A (es) 2003-10-15
AU2001272906B2 (en) 2004-08-26
EP1311268A4 (en) 2004-06-30
NO20025977L (no) 2003-01-29
CN1436079A (zh) 2003-08-13
RU2003100828A (ru) 2004-06-27
AU7290601A (en) 2001-12-24
UY26758A1 (es) 2002-01-31

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