HUP0400444A2 - Karbapenem vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Karbapenem vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0400444A2 HUP0400444A2 HU0400444A HUP0400444A HUP0400444A2 HU P0400444 A2 HUP0400444 A2 HU P0400444A2 HU 0400444 A HU0400444 A HU 0400444A HU P0400444 A HUP0400444 A HU P0400444A HU P0400444 A2 HUP0400444 A2 HU P0400444A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- formula
- ch2ch2ch3
- carbapenem compound
- pharmaceutical compositions
- Prior art date
Links
- -1 Carbapenem compound Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya az (I') általános képletű - ahol R1 jelentése -CH2OCOC(CH3)3, -CH2OCO2CH(C2H5)2, -CH(CH3)OCO2 CH(C2H5)2, -CH2OCO2-ciklohexil (a) képletű csoport vagy -CH2OCO2-ciklopentil (b) képletűcsoport R2 jelentése -CH2CH2CH3 vagy -CH2CH3, -CH(CH3)2 képletű csoport,azzal a feltétellel, hogy (i) amikor R1 jelentése -CH2OCOC(CH3)3képletű csoport, akkor R2 jelentésének -CH2CH2CH3 képletű csoportnakkell lennie; (ii) amikor R1 jelentése -CH2OCO2CH(C2H5)2, vagy -CH(CH3)OCO2CH(C2H5)2 képletű csoport, akkor R2 jelentésének -CH2CH2CH3, -CH2CH3 vagy -CH(CH3)2 képletű csoportnak kell lennie; és(iii) amikor R1 jelentése (a) vagy (b) képletű csoport, akkor R2jelentésének -CH2CH2CH3 vagy -CH(CH3)2 képletű csoportnak kell lennie- karbapenem vegyület és az említett vegyületet hatóanyagkénttartalmazó antibakteriális ágens. A találmány szerinti karbapenemvegyületnek nagyon jó a gyomor-bélrendszerből történő felszívhatósága,és kiválóan alkalmas fertőzéses betegségek (főként bakteriálisfertőzéses betegségek) megelőzésére és kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001150874 | 2001-05-21 | ||
| PCT/JP2002/004767 WO2002094829A1 (fr) | 2001-05-21 | 2002-05-17 | Compose de carbapenem |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400444A2 true HUP0400444A2 (hu) | 2004-09-28 |
| HUP0400444A3 HUP0400444A3 (en) | 2007-02-28 |
Family
ID=18995823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400444A HUP0400444A3 (en) | 2001-05-21 | 2002-05-17 | Carbapenem compound, pharmaceutical compositions containing them and their use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040176350A1 (hu) |
| EP (1) | EP1398314A4 (hu) |
| JP (1) | JPWO2002094829A1 (hu) |
| KR (1) | KR20040000466A (hu) |
| CN (1) | CN1511156A (hu) |
| BG (1) | BG108479A (hu) |
| BR (1) | BR0209970A (hu) |
| CA (1) | CA2448670A1 (hu) |
| CZ (1) | CZ296825B6 (hu) |
| HU (1) | HUP0400444A3 (hu) |
| MX (1) | MXPA03010607A (hu) |
| NO (1) | NO20035153D0 (hu) |
| NZ (1) | NZ530170A (hu) |
| PL (1) | PL366943A1 (hu) |
| RU (1) | RU2289582C2 (hu) |
| SK (1) | SK15822003A3 (hu) |
| WO (1) | WO2002094829A1 (hu) |
| YU (1) | YU92003A (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| CN100582106C (zh) * | 2006-01-27 | 2010-01-20 | 上海医药工业研究院 | 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体 |
| CN101357918B (zh) * | 2007-06-22 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有异硫脲基巯基吡咯烷的培南衍生物 |
| CN101367806B (zh) * | 2007-06-28 | 2010-11-17 | 山东轩竹医药科技有限公司 | 甲酰苯胺取代的巯基吡咯烷碳青霉烯类化合物 |
| CN101367811B (zh) * | 2007-06-28 | 2010-11-17 | 山东轩竹医药科技有限公司 | 碳代青霉烯类抗生素 |
| EP2407468B1 (en) * | 2009-03-13 | 2014-04-16 | Daewoong Pharmaceutical Co., Ltd. | Improved method for preparing meropenem using zinc powder |
| BR112015023621A8 (pt) | 2013-03-15 | 2018-01-23 | Kala Pharmaceuticals Inc | derivados de meropenem e suas utilizações |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS61275279A (ja) * | 1984-12-25 | 1986-12-05 | Sankyo Co Ltd | カルバペネム化合物 |
| IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| EP0597821A1 (en) * | 1988-04-01 | 1994-05-18 | Sankyo Company Limited | 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics |
| US5242914A (en) * | 1988-04-01 | 1993-09-07 | Sankyo Company, Limited | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics |
| US5712267A (en) * | 1991-06-04 | 1998-01-27 | Sankyo Company,. Limited | Carbapenem derivatives, their preparation and their use as antibiotics |
| US5360798A (en) * | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
| ATE223411T1 (de) * | 1995-12-21 | 2002-09-15 | Sankyo Co | 1-methylcarbapenem-derivate |
| SK108099A3 (en) * | 1997-02-07 | 2000-03-13 | Kyoto Pharmaceutical Ind | Carbapenem compounds, use thereof, and intermediate compounds of the same |
| BR9910098A (pt) * | 1998-05-01 | 2000-12-26 | Kyoto Pharma Ind | Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos |
| JP2000344774A (ja) * | 1999-06-03 | 2000-12-12 | Meiji Seika Kaisha Ltd | カルバペネム類の製造法 |
-
2002
- 2002-05-17 NZ NZ530170A patent/NZ530170A/en unknown
- 2002-05-17 RU RU2003136767/04A patent/RU2289582C2/ru not_active IP Right Cessation
- 2002-05-17 WO PCT/JP2002/004767 patent/WO2002094829A1/ja not_active Application Discontinuation
- 2002-05-17 JP JP2002591502A patent/JPWO2002094829A1/ja active Pending
- 2002-05-17 KR KR10-2003-7014940A patent/KR20040000466A/ko not_active Application Discontinuation
- 2002-05-17 HU HU0400444A patent/HUP0400444A3/hu unknown
- 2002-05-17 CN CNA028103513A patent/CN1511156A/zh active Pending
- 2002-05-17 EP EP02771714A patent/EP1398314A4/en not_active Withdrawn
- 2002-05-17 CA CA002448670A patent/CA2448670A1/en not_active Abandoned
- 2002-05-17 PL PL02366943A patent/PL366943A1/xx not_active Application Discontinuation
- 2002-05-17 CZ CZ20033507A patent/CZ296825B6/cs not_active IP Right Cessation
- 2002-05-17 BR BR0209970-5A patent/BR0209970A/pt not_active IP Right Cessation
- 2002-05-17 US US10/478,423 patent/US20040176350A1/en not_active Abandoned
- 2002-05-17 SK SK1582-2003A patent/SK15822003A3/sk not_active Application Discontinuation
- 2002-05-17 YU YU92003A patent/YU92003A/sh unknown
- 2002-05-17 MX MXPA03010607A patent/MXPA03010607A/es unknown
-
2003
- 2003-11-20 NO NO20035153A patent/NO20035153D0/no not_active Application Discontinuation
- 2003-12-19 BG BG108479A patent/BG108479A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20035153L (no) | 2003-11-20 |
| BG108479A (bg) | 2005-03-31 |
| EP1398314A1 (en) | 2004-03-17 |
| EP1398314A4 (en) | 2004-10-20 |
| BR0209970A (pt) | 2004-04-06 |
| SK15822003A3 (sk) | 2004-06-08 |
| RU2289582C2 (ru) | 2006-12-20 |
| US20040176350A1 (en) | 2004-09-09 |
| MXPA03010607A (es) | 2004-04-02 |
| NZ530170A (en) | 2005-09-30 |
| WO2002094829A1 (fr) | 2002-11-28 |
| JPWO2002094829A1 (ja) | 2004-09-09 |
| CZ296825B6 (cs) | 2006-06-14 |
| KR20040000466A (ko) | 2004-01-03 |
| CN1511156A (zh) | 2004-07-07 |
| HUP0400444A3 (en) | 2007-02-28 |
| PL366943A1 (en) | 2005-02-07 |
| CZ20033507A3 (en) | 2004-05-12 |
| NO20035153D0 (no) | 2003-11-20 |
| YU92003A (sh) | 2006-05-25 |
| CA2448670A1 (en) | 2002-11-28 |
| RU2003136767A (ru) | 2005-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |