HUP0304083A2 - Radiofarmakon kompozíciók, előállításuk és eljárás radiofarmakonok pufferolására - Google Patents
Radiofarmakon kompozíciók, előállításuk és eljárás radiofarmakonok pufferolásáraInfo
- Publication number
- HUP0304083A2 HUP0304083A2 HU0304083A HUP0304083A HUP0304083A2 HU P0304083 A2 HUP0304083 A2 HU P0304083A2 HU 0304083 A HU0304083 A HU 0304083A HU P0304083 A HUP0304083 A HU P0304083A HU P0304083 A2 HUP0304083 A2 HU P0304083A2
- Authority
- HU
- Hungary
- Prior art keywords
- radiopharmaceuticals
- buffering
- preparation
- radiopharmaceutical composition
- ascorbic acid
- Prior art date
Links
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 4
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 4
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 3
- 230000003139 buffering effect Effects 0.000 title abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 150000000996 L-ascorbic acids Chemical class 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/121—Solutions, i.e. homogeneous liquid formulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27138901P | 2001-02-26 | 2001-02-26 | |
| PCT/US2002/005155 WO2002067859A2 (en) | 2001-02-26 | 2002-02-22 | Ascorbic acid analogs for metalloradiopharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0304083A2 true HUP0304083A2 (hu) | 2004-03-29 |
Family
ID=23035343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0304083A HUP0304083A2 (hu) | 2001-02-26 | 2002-02-22 | Radiofarmakon kompozíciók, előállításuk és eljárás radiofarmakonok pufferolására |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6713042B2 (enExample) |
| EP (1) | EP1365813A4 (enExample) |
| JP (1) | JP2004529884A (enExample) |
| CN (1) | CN1503680A (enExample) |
| AU (1) | AU2002253999A1 (enExample) |
| BR (1) | BR0207315A (enExample) |
| CA (1) | CA2438204A1 (enExample) |
| CZ (1) | CZ20032597A3 (enExample) |
| HU (1) | HUP0304083A2 (enExample) |
| IL (1) | IL157359A0 (enExample) |
| MX (1) | MXPA03007595A (enExample) |
| WO (1) | WO2002067859A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10305463A1 (de) * | 2003-02-04 | 2004-08-12 | Schering Ag | Enantiomerenreines (4S,8S)- und (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triza-3N,6N,9N-tricarboxymethyl-1,11-undecandisäure und deren Abkömmlinge, Verfahren zu deren Herstellung und Verwendung zur Herstellung pharmazeutischer Mittel |
| US20050089471A1 (en) * | 2003-10-24 | 2005-04-28 | Johnson Bruce F. | Labeled ligands for lectin-like oxidized low-density lipoprotein receptor (LOX-1) |
| US20050089470A1 (en) * | 2003-10-24 | 2005-04-28 | Johnson Bruce F. | Labeled peptides for lectin-like oxidized low-density lipoprotein receptor (LOX-1) |
| WO2006020779A2 (en) * | 2004-08-10 | 2006-02-23 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| GB0427392D0 (en) * | 2004-12-15 | 2005-01-19 | Amersham Plc | Stabilised 99mTc compositions |
| TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
| RU2008150377A (ru) * | 2006-05-19 | 2010-06-27 | Нихон Меди-Физикс Ко., Лтд. (Jp) | Новое соединение, обладающее сродством к амилоиду |
| AU2007262786B2 (en) * | 2006-06-21 | 2012-12-06 | Ge Healthcare Limited | Radiopharmaceutical products |
| KR20090025282A (ko) * | 2006-06-21 | 2009-03-10 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
| EP2080526A4 (en) * | 2006-11-09 | 2012-11-07 | Nihon Mediphysics Co Ltd | RADIOACTIVE DIAGNOSTIC IMAGING DAY |
| US20090252680A1 (en) * | 2006-11-17 | 2009-10-08 | Nihon- Medi-Physics Co., Ltd | Novel compound with affinity for amyloid |
| CN101595108A (zh) * | 2006-11-30 | 2009-12-02 | 日本医事物理股份有限公司 | 对淀粉状蛋白具有亲和性的新化合物 |
| KR101497406B1 (ko) * | 2006-12-21 | 2015-03-02 | 니혼 메디피직스 가부시키가이샤 | 방사성 화상 진단제 |
| CN101636183B (zh) | 2007-02-13 | 2014-03-19 | 日本医事物理股份有限公司 | 放射性诊断显像剂的制备方法 |
| GB0718386D0 (en) * | 2007-09-21 | 2007-10-31 | Ge Healthcare As | Improved radiopharmaceutical formulation |
| CN101903381A (zh) * | 2007-10-24 | 2010-12-01 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物 |
| CN101909657A (zh) * | 2007-10-30 | 2010-12-08 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
| AU2008319986A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
| WO2009073698A1 (en) * | 2007-12-04 | 2009-06-11 | Bracco Imaging S.P.A. | Homogenization of a radiopharmaceutical using sonification and/or rotor-stator technology to produce a homogenous suspension, emulsion, mixture or solid suspension of immiscible ingredients |
| EP2328411A1 (en) * | 2008-09-05 | 2011-06-08 | Molecular Insight Pharmaceuticals, Inc. | Pharmaceutical composition of a radioiodinated benzamide derivative and methods of making the same |
| FR2942227B1 (fr) * | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| DK2419096T3 (da) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre |
| US9321095B2 (en) | 2010-06-30 | 2016-04-26 | General Electric Company | Apparatuses and methods for cutting porous substrates |
| WO2013093099A1 (en) * | 2011-12-22 | 2013-06-27 | Piramal Imaging Sa | Stabilization of peptidic radiopharmaceuticals using uric acid or derivatives thereof |
| CN104470547B (zh) * | 2012-05-24 | 2018-01-26 | 未来化学株式会社 | 利用筒状物合成放射性药物的方法 |
| US20140147381A1 (en) * | 2012-11-29 | 2014-05-29 | Gregory David Espenan | 89zr compounds, to include somatostatin, apparatus and products comprising such compounds, methods of making same, and methods of using same for radio imaging and/or treatment |
| WO2014126902A1 (en) * | 2013-02-15 | 2014-08-21 | Thomas Jefferson University | Kit for tumor imaging |
| JP6500105B2 (ja) * | 2014-11-27 | 2019-04-10 | セルトリオン・インコーポレイテッド | ペプチドが結合された安定したアスコルビン酸誘導体、その製造方法、及びそれを含む化粧料組成物 |
| TWI604853B (zh) * | 2016-05-03 | 2017-11-11 | 行政院原子能委員會核能研究所 | 放射免疫複合體、診療劑及套組 |
| CN107167540B (zh) * | 2017-07-08 | 2019-07-30 | 万舒（北京）医药科技有限公司 | 测定人尿液生物样品中的DTPA-Zn的方法 |
| KR102207372B1 (ko) * | 2020-03-31 | 2021-01-27 | 재단법인 아산사회복지재단 | 방사성 의약품의 안정화제 및 이를 포함하는 방사성 의약 조성물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL42204A (en) * | 1972-05-08 | 1976-09-30 | Solco Basel Ag | Process and apparatus for the manufacture of injectable radionuclide preparations |
| US4504462A (en) * | 1982-06-10 | 1985-03-12 | Mallinckrodt, Inc. | Process for making a lyophilized product for use in skeletal imaging |
| US4707353A (en) * | 1982-12-08 | 1987-11-17 | Mallinckrodt, Inc. | Radiographic imaging agents |
| US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
| DK0422713T3 (da) * | 1989-10-09 | 1995-04-10 | Unilever Plc | Spiseligt smøremateriale |
| DE69231469T2 (de) * | 1991-08-29 | 2001-01-25 | Mallinckrodt Medical, Inc. | Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen |
| GB9417873D0 (en) * | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
| WO1997028181A2 (en) * | 1996-02-02 | 1997-08-07 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US6066309A (en) * | 1996-02-02 | 2000-05-23 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
| US20020122768A1 (en) * | 2000-07-06 | 2002-09-05 | Shuang Liu | Stable radiopharmaceutical compositions and methods for preparation thereof |
-
2002
- 2002-02-22 EP EP02723206A patent/EP1365813A4/en not_active Withdrawn
- 2002-02-22 US US10/081,258 patent/US6713042B2/en not_active Expired - Fee Related
- 2002-02-22 CA CA002438204A patent/CA2438204A1/en not_active Abandoned
- 2002-02-22 CN CNA028087186A patent/CN1503680A/zh active Pending
- 2002-02-22 JP JP2002567231A patent/JP2004529884A/ja active Pending
- 2002-02-22 AU AU2002253999A patent/AU2002253999A1/en not_active Abandoned
- 2002-02-22 HU HU0304083A patent/HUP0304083A2/hu unknown
- 2002-02-22 CZ CZ20032597A patent/CZ20032597A3/cs unknown
- 2002-02-22 BR BR0207315-3A patent/BR0207315A/pt not_active IP Right Cessation
- 2002-02-22 IL IL15735902A patent/IL157359A0/xx unknown
- 2002-02-22 WO PCT/US2002/005155 patent/WO2002067859A2/en not_active Ceased
- 2002-02-22 MX MXPA03007595A patent/MXPA03007595A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004529884A (ja) | 2004-09-30 |
| AU2002253999A1 (en) | 2002-09-12 |
| IL157359A0 (en) | 2004-02-19 |
| BR0207315A (pt) | 2004-02-10 |
| WO2002067859A2 (en) | 2002-09-06 |
| US6713042B2 (en) | 2004-03-30 |
| US20020122769A1 (en) | 2002-09-05 |
| CN1503680A (zh) | 2004-06-09 |
| EP1365813A2 (en) | 2003-12-03 |
| EP1365813A4 (en) | 2006-03-22 |
| MXPA03007595A (es) | 2003-12-04 |
| CZ20032597A3 (cs) | 2004-12-15 |
| WO2002067859A3 (en) | 2002-11-28 |
| CA2438204A1 (en) | 2002-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |