HUP0303176A2 - Eljárás N-(1S)-etoxikarbonil-3-fenilpropil)-L-alanin tisztítására - Google Patents

Eljárás N-(1S)-etoxikarbonil-3-fenilpropil)-L-alanin tisztítására

Info

Publication number
HUP0303176A2
HUP0303176A2 HU0303176A HUP0303176A HUP0303176A2 HU P0303176 A2 HUP0303176 A2 HU P0303176A2 HU 0303176 A HU0303176 A HU 0303176A HU P0303176 A HUP0303176 A HU P0303176A HU P0303176 A2 HUP0303176 A2 HU P0303176A2
Authority
HU
Hungary
Prior art keywords
ethoxycarbonyl
alanine
phenylpropyl
purification method
crystallizing
Prior art date
Application number
HU0303176A
Other languages
English (en)
Inventor
Yoshikazu Kogame
Akira Matsumoto
Michio Nomura
Yasuyoshi Ueda
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Publication of HUP0303176A2 publication Critical patent/HUP0303176A2/hu
Publication of HUP0303176A3 publication Critical patent/HUP0303176A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya tisztítási eljárás igen jó minőségű (1) képletű N-[1(S)-etoxikarbonil-3-fenil-propil]-L-alanin előállítására jó hozammalés termelékenységgel, mely eljárás így nagyüzemileg alkalmazható. Atalálmány értelmében úgy járnak el, hogy szennyezett N-[1(S)-etoxikarbonil-3-fenilpropil]-L-alanint alkohol és víz 1:20térfogatarányú elegyéből kristályosítanak - így a szennyezők azanyalúgba kerülnek - majd az N-[1(S)-etoxikarbonil-3-fenilpropil]-L-alanin kristályait elkülönítik Ó
HU0303176A 2001-03-19 2002-03-19 Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine HUP0303176A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001078695 2001-03-19
PCT/JP2002/002570 WO2002074728A1 (en) 2001-03-19 2002-03-19 Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine

Publications (2)

Publication Number Publication Date
HUP0303176A2 true HUP0303176A2 (hu) 2004-01-28
HUP0303176A3 HUP0303176A3 (en) 2008-03-28

Family

ID=18935274

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303176A HUP0303176A3 (en) 2001-03-19 2002-03-19 Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine

Country Status (15)

Country Link
US (1) US7071349B2 (hu)
EP (1) EP1284957B1 (hu)
JP (1) JP4094958B2 (hu)
KR (1) KR100870847B1 (hu)
AR (1) AR033048A1 (hu)
AT (1) ATE394364T1 (hu)
CA (1) CA2407681A1 (hu)
CZ (1) CZ20024011A3 (hu)
DE (1) DE60226382D1 (hu)
ES (1) ES2305206T3 (hu)
HR (1) HRP20030022A2 (hu)
HU (1) HUP0303176A3 (hu)
SI (1) SI21039A (hu)
TW (1) TWI226881B (hu)
WO (1) WO2002074728A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114002337B (zh) * 2021-04-06 2023-10-20 株洲千金药业股份有限公司 一种检测马来酸依那普利中杂质g的方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1327787A3 (ru) 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DK156484A (da) 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
EP0190687B1 (en) 1985-02-04 1988-10-05 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate
ES8705367A1 (es) 1985-12-30 1987-05-01 Torcan Chemical Ltd Un procedimiento para preparar derivados de aminoacidos
JPH08801B2 (ja) 1987-01-13 1996-01-10 ダイセル化学工業株式会社 Ｎ−〔（１ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニンの製造方法
JPS6445350A (en) 1987-08-13 1989-02-17 Sagami Chem Res Production of n-substituted-l-amino acid derivative
JPS6445348A (en) 1987-08-13 1989-02-17 Sagami Chem Res Production of n-substituted-l-amino acid derivative
DE4123248C2 (de) 1991-07-13 1996-03-07 Degussa Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten
AT402639B (de) 1996-02-05 1997-07-25 Chemie Linz Gmbh Verbessertes verfahren zur herstellung von verbessertes verfahren zur herstellung von reinem reinem (s,s)-n-(1-ethoxycarbonyl-3-phenylpropyl)- (s,s)-n-(1-ethoxycarbonyl-3-phenylpropyl)- alanin alanin
JP3792777B2 (ja) 1996-05-10 2006-07-05 株式会社カネカ １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法

Also Published As

Publication number Publication date
KR100870847B1 (ko) 2008-11-27
US7071349B2 (en) 2006-07-04
US20030162991A1 (en) 2003-08-28
WO2002074728A1 (en) 2002-09-26
EP1284957B1 (en) 2008-05-07
KR20030058939A (ko) 2003-07-07
HRP20030022A2 (en) 2004-02-29
EP1284957A1 (en) 2003-02-26
CA2407681A1 (en) 2002-09-26
CZ20024011A3 (cs) 2003-04-16
ATE394364T1 (de) 2008-05-15
HUP0303176A3 (en) 2008-03-28
ES2305206T3 (es) 2008-11-01
SI21039A (sl) 2003-04-30
TWI226881B (en) 2005-01-21
JP2004519501A (ja) 2004-07-02
AR033048A1 (es) 2003-12-03
JP4094958B2 (ja) 2008-06-04
EP1284957A4 (en) 2004-12-29
DE60226382D1 (de) 2008-06-19

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished