HUP0303144A2 - Eljárások szubsztituált 2-(2-piridil-metil)-szulfinil-1H-benzimidazolok előállítására - Google Patents

Eljárások szubsztituált 2-(2-piridil-metil)-szulfinil-1H-benzimidazolok előállítására

Info

Publication number
HUP0303144A2
HUP0303144A2 HU0303144A HUP0303144A HUP0303144A2 HU P0303144 A2 HUP0303144 A2 HU P0303144A2 HU 0303144 A HU0303144 A HU 0303144A HU P0303144 A HUP0303144 A HU P0303144A HU P0303144 A2 HUP0303144 A2 HU P0303144A2
Authority
HU
Hungary
Prior art keywords
substituted
benzimidazoles
pyridylmethyl
sulfinyl
production
Prior art date
Application number
HU0303144A
Other languages
English (en)
Inventor
Ilya Avrutov
Marioara Mendelovici
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HUP0303144A2 publication Critical patent/HUP0303144A2/hu
Publication of HUP0303144A3 publication Critical patent/HUP0303144A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya javított eljárás szubsztituált 2-(2-piridil-metil)-szulfinil-1H- benzimidazolok előállítására. Az eljárás a B képletűtioéter vegyület mely képletben R1, R2 és R4 mindegyike lehethidrogén, szubsztituált vagy nem szubsztituált kis szénatomszámúalkil- és szubsztituált vagy nem szubsztituált kis szénatomszámúalkoxicsoport; és R3 lehet hidrogén és szubsztituált vagy nemszubsztituált kis szénatomszámú alkilcsoport, szelektív oxidációjátfoglalja magában egy oxidáló ágenssel. Ó
HU0303144A 2001-02-02 2002-02-04 Process for the production of substituted 2-(2-pyridylmethyl)sulfinyl-1h-benzimidazoles HUP0303144A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26616201P 2001-02-02 2001-02-02
PCT/US2002/003225 WO2002062786A1 (en) 2001-02-02 2002-02-04 Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles

Publications (2)

Publication Number Publication Date
HUP0303144A2 true HUP0303144A2 (hu) 2004-03-01
HUP0303144A3 HUP0303144A3 (en) 2007-08-28

Family

ID=23013433

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303144A HUP0303144A3 (en) 2001-02-02 2002-02-04 Process for the production of substituted 2-(2-pyridylmethyl)sulfinyl-1h-benzimidazoles

Country Status (19)

Country Link
US (3) US7129358B2 (hu)
EP (2) EP1363901A4 (hu)
JP (1) JP2004524303A (hu)
KR (1) KR20040029966A (hu)
CN (3) CN1876647A (hu)
CA (1) CA2436467A1 (hu)
CZ (1) CZ20032351A3 (hu)
DE (1) DE02706135T1 (hu)
ES (1) ES2209678T1 (hu)
HR (1) HRP20030691A2 (hu)
HU (1) HUP0303144A3 (hu)
IS (1) IS6897A (hu)
MX (1) MXPA03006904A (hu)
NO (1) NO20033433L (hu)
PL (1) PL368563A1 (hu)
SK (1) SK10792003A3 (hu)
WO (1) WO2002062786A1 (hu)
YU (1) YU61103A (hu)
ZA (1) ZA200305652B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1876647A (zh) * 2001-02-02 2006-12-13 特瓦制药工业有限公司 苯并咪唑化合物产品
KR20040093187A (ko) * 2002-03-27 2004-11-04 테바 파마슈티컬 인더스트리즈 리미티드 란소프라졸 다형 및 그것의 제조 방법
EP1467987A1 (en) * 2002-07-26 2004-10-20 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
AU2003258335A1 (en) * 2002-08-21 2004-03-11 Teva Pharmaceutical Industries Ltd. A method for the purification of lansoprazole
PT1465890E (pt) * 2002-11-18 2007-05-31 Teva Pharma Lansoprazole estável contendo mais de 500 ppm, até cerca de 3000 ppm de água e mais de 200 ppm, até cerca de 5000 de álcool
CA2510849A1 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
US7678816B2 (en) * 2003-02-05 2010-03-16 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
US20040235904A1 (en) * 2003-03-12 2004-11-25 Nina Finkelstein Crystalline and amorphous solids of pantoprazole and processes for their preparation
MXPA05013316A (es) * 2003-06-10 2006-03-17 Teva Pharma Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
FR2871800B1 (fr) * 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
DE112005003147T5 (de) * 2004-12-16 2008-01-17 Cipla Ltd. Verfahren
EP1681056A1 (en) 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
AR054113A1 (es) * 2005-05-06 2007-06-06 Medichem Sa Forma cristalina solida de pantoprazol como acido libre, sales derivadas del mismo y proceso para su preparacion
CN1919844B (zh) * 2006-09-01 2010-05-12 武汉工程大学 水相氧化合成兰索拉唑的方法
WO2010039885A2 (en) * 2008-09-30 2010-04-08 Teva Pharmaceutical Industries Ltd. Crystalline forms of dexlansoprazole
WO2010134099A1 (en) * 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN108623564B (zh) * 2017-03-17 2022-11-04 江苏豪森药业集团有限公司 一种雷贝拉唑类似物的制备方法
CN111072633A (zh) * 2019-12-19 2020-04-28 山东达因海洋生物制药股份有限公司 一种埃索美拉唑镁三水合物的制备方法
CN112174934B (zh) * 2020-10-15 2023-12-22 成都百泉生物医药科技有限公司 一种奥美拉唑的合成方法及其合成设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
GB2069492B (en) 1980-02-20 1984-02-29 Wyeth John & Brother Ltd Sulphur compounds
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
DK171989B1 (da) 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
ES2063705B1 (es) * 1993-06-14 1995-07-16 S A L V A T Lab Sa Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion.
SK283805B6 (sk) * 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
JP4546643B2 (ja) * 1997-12-08 2010-09-15 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 酸不安定な活性化合物を含有する新規の坐剤形
GB9805558D0 (en) * 1998-03-17 1998-05-13 Knoll Ag Chemical process`
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
JP4047993B2 (ja) * 1999-01-04 2008-02-13 理想科学工業株式会社 孔版印刷方法
US6245913B1 (en) * 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
ES2163372B1 (es) 2000-03-13 2003-05-01 Esteve Quimica Sa Procedimiento de oxidacion de un grupo tioeter a sulfoxido.
CN1876647A (zh) 2001-02-02 2006-12-13 特瓦制药工业有限公司 苯并咪唑化合物产品

Also Published As

Publication number Publication date
US20030036554A1 (en) 2003-02-20
HUP0303144A3 (en) 2007-08-28
US20080091024A1 (en) 2008-04-17
US20060293363A1 (en) 2006-12-28
YU61103A (sh) 2006-05-25
NO20033433L (no) 2003-09-25
CN1489585A (zh) 2004-04-14
WO2002062786A1 (en) 2002-08-15
JP2004524303A (ja) 2004-08-12
IS6897A (is) 2003-07-29
CA2436467A1 (en) 2002-08-15
CN100347167C (zh) 2007-11-07
PL368563A1 (en) 2005-04-04
US7129358B2 (en) 2006-10-31
EP1970374A1 (en) 2008-09-17
HRP20030691A2 (en) 2005-04-30
KR20040029966A (ko) 2004-04-08
NO20033433D0 (no) 2003-08-01
SK10792003A3 (sk) 2004-07-07
MXPA03006904A (es) 2004-12-06
ES2209678T1 (es) 2004-07-01
ZA200305652B (en) 2004-07-22
EP1363901A1 (en) 2003-11-26
CZ20032351A3 (cs) 2004-08-18
EP1363901A4 (en) 2005-08-31
DE02706135T1 (de) 2004-05-19
CN1781918A (zh) 2006-06-07
CN1876647A (zh) 2006-12-13

Similar Documents

Publication Publication Date Title
HUP0303144A2 (hu) Eljárások szubsztituált 2-(2-piridil-metil)-szulfinil-1H-benzimidazolok előállítására
HUP0302943A2 (hu) Új heterociklusos vegyületek, előállításuk és alkalmazásuk gyógyszerekként, különösen antibakteriális szerekként
BG106622A (en) Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
HUP0102843A2 (hu) Eljárás (3-izoxazolinil)-acil-benzolok előállítására
ATE453618T1 (de) Kristallines und reines modafinil und verfahren zu seiner herstellung
HUP0303526A2 (hu) Azetidinon-intermedier vegyületek enantioszelektiv szintézise
DE60009511D1 (de) Nematizide trifluorbutene
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
WO2003035620A1 (fr) Compose bicyclique
HUP0303590A2 (hu) Eljárás 4,6-diamino-pirimido[5,4-d]pirimidinek előállítására
ATE442363T1 (de) Verfahren zur herstellung von pyridinverbindungen
HUP9901339A2 (hu) Eljárás N-szubsztituált-3-hidroxi-pirazol-származékok előállítására
DE60215685D1 (de) Stabilisierte hydroxylaminlösungen
DK1335913T3 (da) Fremgangsmåde til fremstilling af pantoprazol og intermediære deraf
HUP0000554A2 (hu) Eljárás N-szubsztituált 3-hidroxi-pirazolok előállítására
DE60310609D1 (de) Verfahren zur herstellung von 2-aminomethylpyridin-derivaten
HUP9902040A2 (hu) Új eljárás 4-fenil-1,2,3,6-tetrahidro-piridin-származékok előállítására és az alkalmazott köztitermékek
ATE546432T1 (de) Verfahren zur herstellung von 2- aminomethylpyridin-derivate
SE0003186D0 (sv) New process
HUP0101609A2 (hu) Eljárás peszticid intermedierek előállítására
HUP0202335A2 (hu) Eljárás optikailag aktív, vinil-szubsztituált ciklopropánkarbonsavak racemizálására
HUP0301672A2 (hu) Eljárás peszticid hatású vegyületek előállítására
DE60133674D1 (de) Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
DE60128336D1 (de) Eine zwischenverbindung und verfahren zu deren herstellung
WO2003016285A8 (es) Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees