WO2003016285A8 - Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida - Google Patents

Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida

Info

Publication number
WO2003016285A8
WO2003016285A8 PCT/ES2002/000385 ES0200385W WO03016285A8 WO 2003016285 A8 WO2003016285 A8 WO 2003016285A8 ES 0200385 W ES0200385 W ES 0200385W WO 03016285 A8 WO03016285 A8 WO 03016285A8
Authority
WO
WIPO (PCT)
Prior art keywords
imidazole
formula
preparing
benzenesulphonamide derivatives
benzenesulphonamide
Prior art date
Application number
PCT/ES2002/000385
Other languages
English (en)
French (fr)
Other versions
WO2003016285A1 (es
Inventor
Rosales Carmen Almansa
Gonzalez Concepcion Gonzalez
Original Assignee
Uriach & Cia Sa J
Rosales Carmen Almansa
Gonzalez Concepcion Gonzalez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2456531A priority Critical patent/CA2456531C/en
Priority to MXPA04001147A priority patent/MXPA04001147A/es
Priority to JP2003521211A priority patent/JP4309262B2/ja
Priority to US10/485,950 priority patent/US7351836B2/en
Priority to DK02794802T priority patent/DK1424329T3/da
Priority to KR1020047001749A priority patent/KR100888905B1/ko
Priority to BRPI0211749A priority patent/BRPI0211749B8/pt
Priority to DE60226879T priority patent/DE60226879D1/de
Application filed by Uriach & Cia Sa J, Rosales Carmen Almansa, Gonzalez Concepcion Gonzalez filed Critical Uriach & Cia Sa J
Priority to EP02794802A priority patent/EP1424329B1/en
Publication of WO2003016285A1 publication Critical patent/WO2003016285A1/es
Publication of WO2003016285A8 publication Critical patent/WO2003016285A8/es
Priority to NO20040981A priority patent/NO326162B1/no
Priority to HK04109044A priority patent/HK1066214A1/xx
Priority to US12/060,574 priority patent/US8476456B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms

Abstract

Procedimiento para la preparación de derivados de 4-(imidazol-1-il)bencenosulfonamida de fórmula (I), donde R1 representa arilo o heteroarilo opcionalmente sustituido, caracterizado porque comprende tratar un compuesto de fórmula (II), donde R1 tiene el mismo significado descrito para la fórmula (I) y But representa tert-butilo, con un ácido. Los derivados de 4-(imidazol-1- il)bencenosulfonamida de fórmula (I) son útiles como agentes antiinflamatorios.
PCT/ES2002/000385 2001-08-07 2002-08-01 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida WO2003016285A1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BRPI0211749A BRPI0211749B8 (pt) 2001-08-07 2002-08-01 processo para a preparação de derivados de 4-(imidazol-1- il)benzenossulfonamida
JP2003521211A JP4309262B2 (ja) 2001-08-07 2002-08-01 ４−（イミダゾール−１−イル）ベンゼンスルホンアミド誘導体の製造方法
US10/485,950 US7351836B2 (en) 2001-08-07 2002-08-01 Method of preparing 4-(imidazol-1-yl)benzenesulphonamide derivatives
DK02794802T DK1424329T3 (da) 2001-08-07 2002-08-01 Fremgangsmåde til fremstillingen af 4-(imidazol-1-yl)benzensulfonamid
KR1020047001749A KR100888905B1 (ko) 2001-08-07 2002-08-01 4-(이미다졸-1-일)벤젠술폰아미드 유도체의 제조 방법
CA2456531A CA2456531C (en) 2001-08-07 2002-08-01 Process for the preparation of 4-(imidazole-1-yl)benzenesulfonamide derivatives
DE60226879T DE60226879D1 (de) 2001-08-07 2002-08-01 Verfahren zur herstellung von 4-(imidazol-1-yl)benzolsulfonamidderivaten
MXPA04001147A MXPA04001147A (es) 2001-08-07 2002-08-01 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida.
EP02794802A EP1424329B1 (en) 2001-08-07 2002-08-01 Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives
NO20040981A NO326162B1 (no) 2001-08-07 2004-03-05 Fremgangsmate for fremstilling av 4-(imidazol-1-yl)benzensulfonamidderivater.
HK04109044A HK1066214A1 (en) 2001-08-07 2004-11-17 Process for the preparation of 4-(imidazol-1-yl) benzenesulfonamide derivatives
US12/060,574 US8476456B2 (en) 2001-08-07 2008-04-01 Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200101853A ES2184633B1 (es) 2001-08-07 2001-08-07 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida.
ESP0101853 2001-08-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10485950 A-371-Of-International 2002-08-01
US12/060,574 Division US8476456B2 (en) 2001-08-07 2008-04-01 Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives

Publications (2)

Publication Number Publication Date
WO2003016285A1 WO2003016285A1 (es) 2003-02-27
WO2003016285A8 true WO2003016285A8 (es) 2003-08-28

Family

ID=8498662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2002/000385 WO2003016285A1 (es) 2001-08-07 2002-08-01 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il)bencenosulfonamida

Country Status (17)

Country Link
US (2) US7351836B2 (es)
EP (1) EP1424329B1 (es)
JP (1) JP4309262B2 (es)
KR (1) KR100888905B1 (es)
AR (2) AR037231A1 (es)
AT (1) ATE396976T1 (es)
BR (1) BRPI0211749B8 (es)
CA (1) CA2456531C (es)
CY (1) CY1108861T1 (es)
DE (1) DE60226879D1 (es)
DK (1) DK1424329T3 (es)
ES (2) ES2184633B1 (es)
HK (1) HK1066214A1 (es)
MX (1) MXPA04001147A (es)
NO (1) NO326162B1 (es)
PT (1) PT1424329E (es)
WO (1) WO2003016285A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014009425A1 (en) 2012-07-12 2014-01-16 Chiesi Farmaceutici S.P.A. Inhibition of enzymes
WO2022269384A1 (en) * 2021-06-24 2022-12-29 Ami Organics Ltd. A process for the direct synthesis of fedratinib intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
JP4216475B2 (ja) * 1998-07-02 2009-01-28 クリプターグラフィー リサーチ インコーポレイテッド 漏洩抵抗力を有する暗号索引付き鍵の更新方法及びデバイス
AR024222A1 (es) * 1998-10-16 2002-09-25 Palau Pharma Sa Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen
ES2159489B1 (es) * 2000-03-23 2002-04-16 Uriach & Cia Sa J Nuevos derivados de imidazol con actividad antiinflamatoria.

Also Published As

Publication number Publication date
ES2184633B1 (es) 2004-08-01
ES2184633A1 (es) 2003-04-01
BR0211749A (pt) 2004-10-13
DK1424329T3 (da) 2008-09-29
JP4309262B2 (ja) 2009-08-05
JP2005502659A (ja) 2005-01-27
KR100888905B1 (ko) 2009-03-16
PT1424329E (pt) 2008-08-06
ATE396976T1 (de) 2008-06-15
CY1108861T1 (el) 2014-08-13
EP1424329A1 (en) 2004-06-02
BR0211749B1 (pt) 2013-09-10
US8476456B2 (en) 2013-07-02
ES2307817T3 (es) 2008-12-01
DE60226879D1 (de) 2008-07-10
NO20040981L (no) 2004-03-05
NO326162B1 (no) 2008-10-13
US7351836B2 (en) 2008-04-01
HK1066214A1 (en) 2005-03-18
US20090012307A1 (en) 2009-01-08
WO2003016285A1 (es) 2003-02-27
CA2456531C (en) 2010-12-14
US20040242872A1 (en) 2004-12-02
AR086065A2 (es) 2013-11-13
AR037231A1 (es) 2004-11-03
CA2456531A1 (en) 2003-02-27
MXPA04001147A (es) 2004-07-08
KR20040020079A (ko) 2004-03-06
EP1424329B1 (en) 2008-05-28
BRPI0211749B8 (pt) 2021-05-25

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