AR037231A1 - Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos - Google Patents
Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismosInfo
- Publication number
- AR037231A1 AR037231A1 ARP020102972A ARP020102972A AR037231A1 AR 037231 A1 AR037231 A1 AR 037231A1 AR P020102972 A ARP020102972 A AR P020102972A AR P020102972 A ARP020102972 A AR P020102972A AR 037231 A1 AR037231 A1 AR 037231A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- aryl
- derivatives
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
Abstract
Procedimiento para la preparación de derivados de 4-(imidazol-1-il) bencenosulfonamida de fórmula (1) con actividad intiinflamatoria, caracterizado porque comprende tratar un compuesto de fórmula (2) con un ácido. Se describe también los intermedios de fórmula (2), (3) y (4) utilizados en la obtención de dichos derivados. En los compuestos de fórmulas (1), (2), (3) y (4), R1 representa arilo o heteroarilo opcionalmente sustituido por uno o más grupos elegidos independientemente de entre halógeno, alquilo C1-8, haloalquilo C1-8, R2O alquilo C0-8, R2S alquilo C0-8, ciano, nitro, -NR2R4, -NR2SO2R3, -SOR3, -SO2R3, -SO2NR2R4 o -CONR2R4; R2 representa hidrógeno, alquilo C1-8 o aril alquilo C0-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupo elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano, nitro, R5O alquilo C0-8, R5S alquilo C0-8, -NR5R6, -NR5COR3, -COR5 o -COOR5); R3 representa un grupo alquilo C1-8 o haloalquilo C1-8; R4 representa hidrógeno, alquilo C1-8, aril alquilo C1-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupos elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano. Nitro, R5O alquilo C0-8, R5S alquilo C0-8, NR5R6, -NR5COR3, -COR5, COOR5), -COR6 o -COOR6; R5 representa hidrógeno, alquilo C1-8 o bencilo; R6 representa alquilo C1-8 o haloalquilo C1-8; arilo representa fenilo o naftilo; y heteroarilo representa piridina, pirazina, pirimidina o piridazina, que pueden estar opcionalmente fusionados a un anillo de benceno; en los compuestos de fórmulas (2), (3) y (4) But representa tert-butilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101853A ES2184633B1 (es) | 2001-08-07 | 2001-08-07 | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037231A1 true AR037231A1 (es) | 2004-11-03 |
Family
ID=8498662
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102972A AR037231A1 (es) | 2001-08-07 | 2002-08-06 | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos |
| ARP120101436A AR086065A2 (es) | 2001-08-07 | 2012-04-25 | Compuestos de imidazolsulfonamidas y un proceso para su produccion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101436A AR086065A2 (es) | 2001-08-07 | 2012-04-25 | Compuestos de imidazolsulfonamidas y un proceso para su produccion |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7351836B2 (es) |
| EP (1) | EP1424329B1 (es) |
| JP (1) | JP4309262B2 (es) |
| KR (1) | KR100888905B1 (es) |
| AR (2) | AR037231A1 (es) |
| AT (1) | ATE396976T1 (es) |
| BR (1) | BRPI0211749B8 (es) |
| CA (1) | CA2456531C (es) |
| CY (1) | CY1108861T1 (es) |
| DE (1) | DE60226879D1 (es) |
| DK (1) | DK1424329T3 (es) |
| ES (2) | ES2184633B1 (es) |
| HK (1) | HK1066214A1 (es) |
| MX (1) | MXPA04001147A (es) |
| NO (1) | NO326162B1 (es) |
| PT (1) | PT1424329E (es) |
| WO (1) | WO2003016285A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN00202A (es) | 2012-07-12 | 2015-06-12 | Chiesi Farma Spa | |
| WO2022269384A1 (en) * | 2021-06-24 | 2022-12-29 | Ami Organics Ltd. | A process for the direct synthesis of fedratinib intermediate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE69935913T2 (de) * | 1998-07-02 | 2008-01-10 | Cryptography Research Inc., San Francisco | Leckresistente aktualisierung eines indexierten kryptographischen schlüssels |
| AR024222A1 (es) * | 1998-10-16 | 2002-09-25 | Palau Pharma Sa | Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen |
| ES2159489B1 (es) | 2000-03-23 | 2002-04-16 | Uriach & Cia Sa J | Nuevos derivados de imidazol con actividad antiinflamatoria. |
-
2001
- 2001-08-07 ES ES200101853A patent/ES2184633B1/es not_active Expired - Fee Related
-
2002
- 2002-08-01 CA CA2456531A patent/CA2456531C/en not_active Expired - Lifetime
- 2002-08-01 MX MXPA04001147A patent/MXPA04001147A/es active IP Right Grant
- 2002-08-01 JP JP2003521211A patent/JP4309262B2/ja not_active Expired - Fee Related
- 2002-08-01 DE DE60226879T patent/DE60226879D1/de not_active Expired - Lifetime
- 2002-08-01 AT AT02794802T patent/ATE396976T1/de active
- 2002-08-01 US US10/485,950 patent/US7351836B2/en not_active Expired - Fee Related
- 2002-08-01 EP EP02794802A patent/EP1424329B1/en not_active Expired - Lifetime
- 2002-08-01 ES ES02794802T patent/ES2307817T3/es not_active Expired - Lifetime
- 2002-08-01 WO PCT/ES2002/000385 patent/WO2003016285A1/es active IP Right Grant
- 2002-08-01 BR BRPI0211749A patent/BRPI0211749B8/pt not_active IP Right Cessation
- 2002-08-01 DK DK02794802T patent/DK1424329T3/da active
- 2002-08-01 PT PT02794802T patent/PT1424329E/pt unknown
- 2002-08-01 KR KR1020047001749A patent/KR100888905B1/ko not_active IP Right Cessation
- 2002-08-06 AR ARP020102972A patent/AR037231A1/es not_active Application Discontinuation
-
2004
- 2004-03-05 NO NO20040981A patent/NO326162B1/no not_active IP Right Cessation
- 2004-11-17 HK HK04109044A patent/HK1066214A1/xx not_active IP Right Cessation
-
2008
- 2008-04-01 US US12/060,574 patent/US8476456B2/en not_active Expired - Fee Related
- 2008-08-21 CY CY20081100892T patent/CY1108861T1/el unknown
-
2012
- 2012-04-25 AR ARP120101436A patent/AR086065A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR086065A2 (es) | 2013-11-13 |
| KR20040020079A (ko) | 2004-03-06 |
| ES2184633A1 (es) | 2003-04-01 |
| US8476456B2 (en) | 2013-07-02 |
| MXPA04001147A (es) | 2004-07-08 |
| ES2307817T3 (es) | 2008-12-01 |
| JP2005502659A (ja) | 2005-01-27 |
| CY1108861T1 (el) | 2014-08-13 |
| NO326162B1 (no) | 2008-10-13 |
| KR100888905B1 (ko) | 2009-03-16 |
| CA2456531A1 (en) | 2003-02-27 |
| BR0211749B1 (pt) | 2013-09-10 |
| DE60226879D1 (de) | 2008-07-10 |
| WO2003016285A8 (es) | 2003-08-28 |
| ATE396976T1 (de) | 2008-06-15 |
| EP1424329A1 (en) | 2004-06-02 |
| WO2003016285A1 (es) | 2003-02-27 |
| EP1424329B1 (en) | 2008-05-28 |
| US7351836B2 (en) | 2008-04-01 |
| BR0211749A (pt) | 2004-10-13 |
| US20090012307A1 (en) | 2009-01-08 |
| HK1066214A1 (en) | 2005-03-18 |
| NO20040981L (no) | 2004-03-05 |
| ES2184633B1 (es) | 2004-08-01 |
| BRPI0211749B8 (pt) | 2021-05-25 |
| DK1424329T3 (da) | 2008-09-29 |
| CA2456531C (en) | 2010-12-14 |
| JP4309262B2 (ja) | 2009-08-05 |
| PT1424329E (pt) | 2008-08-06 |
| US20040242872A1 (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |