AR086065A2 - Compuestos de imidazolsulfonamidas y un proceso para su produccion - Google Patents

Compuestos de imidazolsulfonamidas y un proceso para su produccion

Info

Publication number
AR086065A2
AR086065A2 ARP120101436A ARP120101436A AR086065A2 AR 086065 A2 AR086065 A2 AR 086065A2 AR P120101436 A ARP120101436 A AR P120101436A AR P120101436 A ARP120101436 A AR P120101436A AR 086065 A2 AR086065 A2 AR 086065A2
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
aryl
cyano
nitro
Prior art date
Application number
ARP120101436A
Other languages
English (en)
Inventor
Rosales Carmen Almansa
Gonzalez Concepcion Gonzalez
Original Assignee
Palau Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palau Pharma Sa filed Critical Palau Pharma Sa
Publication of AR086065A2 publication Critical patent/AR086065A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms

Abstract

Estos compuestos poseen actividad antiinflamatoria.Reivindicación 1: Un compuesto de fórmula (1), caracterizado porque: R1 representa arilo o heteroarilo opcionalmente sustituido por uno o más grupos elegidos independientemente de entre halógeno, alquilo C1-8, haloalquilo C1-8, R2O-alquilo C0-8, R2S-alquilo C0-8, ciano, nitro, -NR2R4, -NR2SO2R3, -SOR3, -SO2R3, -SO2NR2R4 o -CONR2R4; R2 representa hidrógeno, alquilo C1-8 o aril-alquilo C0-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupos elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano, nitro, R5O-alquilo C0-8, R5S-alquilo C0-8, -NR5R6, -NR5COR3, -COR5 o -COOR5); R3 representa un grupo alquilo C1-8 o haloalquilo C1-8; R4 representa hidrógeno, alquilo C1-8, aril-alquilo C1-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupos elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano, nitro, R5O-alquilo C0-8, R5S-alquilo C0-8, -NR5R6, -NR5COR3, -COR5, -COOR5), -COR6 o -COOR6; R5 representa hidrógeno, alquilo C1-8 o bencilo; R6 representa alquilo C1-8 o haloalquilo C1-8; arilo representa fenilo o naftilo; y heteroarilo representa piridina, pirazina, pirimidina o piridazina, que pueden estar opcionalmente fusionadas a un anillo de benceno; y But representa tert-butilo.
ARP120101436A 2001-08-07 2012-04-25 Compuestos de imidazolsulfonamidas y un proceso para su produccion AR086065A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101853A ES2184633B1 (es) 2001-08-07 2001-08-07 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida.

Publications (1)

Publication Number Publication Date
AR086065A2 true AR086065A2 (es) 2013-11-13

Family

ID=8498662

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020102972A AR037231A1 (es) 2001-08-07 2002-08-06 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos
ARP120101436A AR086065A2 (es) 2001-08-07 2012-04-25 Compuestos de imidazolsulfonamidas y un proceso para su produccion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP020102972A AR037231A1 (es) 2001-08-07 2002-08-06 Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos

Country Status (17)

Country Link
US (2) US7351836B2 (es)
EP (1) EP1424329B1 (es)
JP (1) JP4309262B2 (es)
KR (1) KR100888905B1 (es)
AR (2) AR037231A1 (es)
AT (1) ATE396976T1 (es)
BR (1) BRPI0211749B8 (es)
CA (1) CA2456531C (es)
CY (1) CY1108861T1 (es)
DE (1) DE60226879D1 (es)
DK (1) DK1424329T3 (es)
ES (2) ES2184633B1 (es)
HK (1) HK1066214A1 (es)
MX (1) MXPA04001147A (es)
NO (1) NO326162B1 (es)
PT (1) PT1424329E (es)
WO (1) WO2003016285A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2638537C2 (ru) 2012-07-12 2017-12-14 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Ингибирование ферментов
WO2022269384A1 (en) * 2021-06-24 2022-12-29 Ami Organics Ltd. A process for the direct synthesis of fedratinib intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
AU5458199A (en) * 1998-07-02 2000-01-24 Cryptography Research, Inc. Leak-resistant cryptographic indexed key update
AR024222A1 (es) * 1998-10-16 2002-09-25 Palau Pharma Sa Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen
ES2159489B1 (es) 2000-03-23 2002-04-16 Uriach & Cia Sa J Nuevos derivados de imidazol con actividad antiinflamatoria.

Also Published As

Publication number Publication date
HK1066214A1 (en) 2005-03-18
CY1108861T1 (el) 2014-08-13
AR037231A1 (es) 2004-11-03
BRPI0211749B8 (pt) 2021-05-25
US20040242872A1 (en) 2004-12-02
US20090012307A1 (en) 2009-01-08
US7351836B2 (en) 2008-04-01
NO326162B1 (no) 2008-10-13
BR0211749A (pt) 2004-10-13
US8476456B2 (en) 2013-07-02
BR0211749B1 (pt) 2013-09-10
EP1424329A1 (en) 2004-06-02
WO2003016285A1 (es) 2003-02-27
ES2307817T3 (es) 2008-12-01
PT1424329E (pt) 2008-08-06
CA2456531A1 (en) 2003-02-27
ES2184633B1 (es) 2004-08-01
DK1424329T3 (da) 2008-09-29
JP2005502659A (ja) 2005-01-27
DE60226879D1 (de) 2008-07-10
CA2456531C (en) 2010-12-14
NO20040981L (no) 2004-03-05
JP4309262B2 (ja) 2009-08-05
ES2184633A1 (es) 2003-04-01
KR100888905B1 (ko) 2009-03-16
MXPA04001147A (es) 2004-07-08
KR20040020079A (ko) 2004-03-06
WO2003016285A8 (es) 2003-08-28
EP1424329B1 (en) 2008-05-28
ATE396976T1 (de) 2008-06-15

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