HUP0302239A2 - Eljárás alkoholok fluormetilezésére, halogénező dekarboxilezés útján - Google Patents

Eljárás alkoholok fluormetilezésére, halogénező dekarboxilezés útján

Info

Publication number
HUP0302239A2
HUP0302239A2 HU0302239A HUP0302239A HUP0302239A2 HU P0302239 A2 HUP0302239 A2 HU P0302239A2 HU 0302239 A HU0302239 A HU 0302239A HU P0302239 A HUP0302239 A HU P0302239A HU P0302239 A2 HUP0302239 A2 HU P0302239A2
Authority
HU
Hungary
Prior art keywords
general formula
alpha
fluoromethylation
hydrogen atom
decarboxylation
Prior art date
Application number
HU0302239A
Other languages
English (en)
Inventor
Christopher Behme
Christopher Bieniarz
Kornepati V. Ramakrishna
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HUP0302239A2 publication Critical patent/HUP0302239A2/hu
Publication of HUP0302239A3 publication Critical patent/HUP0302239A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya eljárás alkohol fluormetilezésére halogéneződekarboxilezéssel. Az eljárás abból áll, hogy egy R1C(CX3)2OHáltalános képletű alkoholt egy X2CH2CO2R2 általános képletű alfa-halogén-észterrel reagáltatja alfa-alkoxi-észtert állítanak elő, aholR1 jelentése hidrogénatom vagy alkilcsoport, R2 jelentése hidrogénatomvagy alkilcsoport, X jelentése bármely előfordulásnál egymástólfüggetlenül hidrogénatom, klór-, bróm- vagy fluoratom és X2 jelentésebrómatom vagy klóratom. A kapott alfa-alkoxi-észtertelszappanosítással alfa-alkoxi-savvá alakítják, amelyet ólom-tetraacetáttal és egy klórozószerrel visszafolyató hűtő alatt forralvaR1C(CH3)2OCH2C1 általános képletű kloridvegyületet kapnak. Akloridvegyületet fluorozószerrel reagáltatva R1 C(CX3)2OCH2F általánosképletű fluoridvegyületté alakítják. Ó
HU0302239A 2000-06-01 2001-05-14 Method for fluoromethylation of alcohols via halogenative decarboxylation HUP0302239A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/587,417 US6271422B1 (en) 2000-06-01 2000-06-01 Method for fluoromethylation of alcohols via halogenative decarboxylation
PCT/US2001/015516 WO2001094286A1 (en) 2000-06-01 2001-05-14 Method for fluoromethylation of alcohols via halogenative decarboxylation

Publications (2)

Publication Number Publication Date
HUP0302239A2 true HUP0302239A2 (hu) 2003-10-28
HUP0302239A3 HUP0302239A3 (en) 2006-03-28

Family

ID=24349720

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302239A HUP0302239A3 (en) 2000-06-01 2001-05-14 Method for fluoromethylation of alcohols via halogenative decarboxylation

Country Status (29)

Country Link
US (1) US6271422B1 (hu)
EP (1) EP1286939B1 (hu)
JP (1) JP2004508293A (hu)
KR (1) KR100799895B1 (hu)
CN (1) CN1283606C (hu)
AR (1) AR028664A1 (hu)
AT (1) ATE317839T1 (hu)
AU (2) AU2001261565B2 (hu)
BG (1) BG107336A (hu)
BR (1) BR0110776A (hu)
CA (1) CA2410428A1 (hu)
CZ (1) CZ20023790A3 (hu)
DE (1) DE60117258T2 (hu)
DK (1) DK1286939T3 (hu)
ES (1) ES2258085T3 (hu)
HK (1) HK1054371B (hu)
HU (1) HUP0302239A3 (hu)
IL (2) IL152857A0 (hu)
MX (1) MXPA02011851A (hu)
NO (1) NO20025791L (hu)
NZ (1) NZ522502A (hu)
PE (1) PE20011339A1 (hu)
PL (1) PL364001A1 (hu)
PT (1) PT1286939E (hu)
SK (1) SK17512002A3 (hu)
TW (1) TWI222435B (hu)
UY (1) UY26738A1 (hu)
WO (1) WO2001094286A1 (hu)
ZA (1) ZA200208850B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
WO2005023175A2 (en) * 2003-09-10 2005-03-17 Cristália Produtos Químicos Farmacêuticos Ltda. Stable pharmaceutical composition of fluoroether compound for anesthetic use, method for stabilizing a fluoroether compound, use of stabilizer agent for precluding the degradation of a fluoroether compound
MX2007005899A (es) * 2004-11-17 2007-07-24 Minrad Inc Metodo para la preparacion de sevoflurano.
CN103664584B (zh) * 2013-12-23 2015-06-03 湖南方盛制药股份有限公司 a-氟代丙酰乙酸酯的制备方法
CN104529721B (zh) * 2015-01-16 2017-04-19 河北一品制药有限公司 一种七氟烷的工业化制备方法
CN107698430B (zh) * 2017-11-01 2021-01-08 华东医药（西安）博华制药有限公司 一种七氟烷反应液的后处理方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL32586A (en) * 1968-10-28 1973-11-28 Baxter Laboratories Inc 1,3-polyhalo-2-propyl methyl and halomethyl ethers and their preparation
US3683092A (en) 1970-07-31 1972-08-08 Baxter Laboratories Inc Method of anesthesia
US4250334A (en) 1979-12-26 1981-02-10 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US4314087A (en) 1979-12-26 1982-02-02 Baxter Travenol Laboratories, Inc. Methods of synthesizing hexafluoroisopropanol from impure mixtures and synthesis of a fluoromethyl ether therefrom
US4469898A (en) 1979-12-26 1984-09-04 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
JPS57209235A (en) * 1981-06-18 1982-12-22 Sumitomo Chem Co Ltd Tetrahydronaphthalene derivative and its preparation
US4847427A (en) 1988-04-13 1989-07-11 E. I. Du Pont De Nemours And Company Process for preparing fluorocarbon polyethers
US4874901A (en) * 1988-05-06 1989-10-17 Boc, Inc. Process for the production of polyfluorinated ethers
US4996371A (en) 1990-01-16 1991-02-26 Boc, Inc. Method for fluorodecarboxylation
JP3441735B2 (ja) * 1996-02-21 2003-09-02 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルの製造方法
US5789630A (en) 1996-02-27 1998-08-04 University Of Iowa Research Foundation Process for the synthesis of hexafluoropropanes
US5705710A (en) 1997-01-15 1998-01-06 University Of Iowa Research Foundation Process for the synthesis of hexafluoroisopropyl ethers
US5969193A (en) * 1997-08-18 1999-10-19 Medeva Pharmaceuticals Pa, Inc. Method for the preparation of sevoflurane
US5886239A (en) * 1997-11-21 1999-03-23 Baxter International Inc. Method of preparing monofluoromethyl ethers
US6100434A (en) * 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
US6303831B1 (en) * 2000-06-01 2001-10-16 Abbott Laboratories Synthetic method for fluoromethylation of halogenated alcohols
US6245949B1 (en) * 2000-06-01 2001-06-12 Abbott Laboratories Synthetic method for the fluoromethylation of alcohols

Also Published As

Publication number Publication date
EP1286939A1 (en) 2003-03-05
PL364001A1 (en) 2004-11-29
ES2258085T3 (es) 2006-08-16
MXPA02011851A (es) 2003-05-14
IL152857A0 (en) 2003-06-24
BG107336A (bg) 2003-07-31
CZ20023790A3 (cs) 2003-02-12
DE60117258T2 (de) 2006-11-16
TWI222435B (en) 2004-10-21
US6271422B1 (en) 2001-08-07
PE20011339A1 (es) 2002-01-05
KR100799895B1 (ko) 2008-01-31
HUP0302239A3 (en) 2006-03-28
CA2410428A1 (en) 2001-12-13
ZA200208850B (en) 2003-12-22
JP2004508293A (ja) 2004-03-18
CN1283606C (zh) 2006-11-08
KR20030007751A (ko) 2003-01-23
UY26738A1 (es) 2001-12-28
AR028664A1 (es) 2003-05-21
AU2001261565B2 (en) 2006-07-20
CN1446188A (zh) 2003-10-01
NZ522502A (en) 2004-09-24
DE60117258D1 (de) 2006-04-20
EP1286939B1 (en) 2006-02-15
DK1286939T3 (da) 2006-06-19
IL152857A (en) 2008-11-03
HK1054371A1 (en) 2003-11-28
ATE317839T1 (de) 2006-03-15
NO20025791D0 (no) 2002-12-02
BR0110776A (pt) 2004-06-01
PT1286939E (pt) 2006-06-30
SK17512002A3 (sk) 2003-04-01
NO20025791L (no) 2002-12-02
WO2001094286A1 (en) 2001-12-13
AU6156501A (en) 2001-12-17
HK1054371B (zh) 2006-12-08

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