HUP0302153A2 - Kemokin receptor aktívitás modulátoraiként hatásos piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Kemokin receptor aktívitás modulátoraiként hatásos piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0302153A2
HUP0302153A2 HU0302153A HUP0302153A HUP0302153A2 HU P0302153 A2 HUP0302153 A2 HU P0302153A2 HU 0302153 A HU0302153 A HU 0302153A HU P0302153 A HUP0302153 A HU P0302153A HU P0302153 A2 HUP0302153 A2 HU P0302153A2
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HU
Hungary
Prior art keywords
group
alkynyl
derivetives
modulators
piperidine
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Application number
HU0302153A
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English (en)
Inventor
Jeremy Burrows
Anne Cooper
John Cumming
Thomas Mcinally
Howard Tucker
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Astrazeneca Ab,
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Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0302153A2 publication Critical patent/HUP0302153A2/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek < ahol R1 adottesetben különféleképp szubsztituált alkil-, cikloalkil-, alkenil-,alkinil-, heterociklil-, aril-, ariloxi-, heteroaril- vagy heteroaril-oxi-csoport; R2 hidrogénatom, alkil-, alkenil-, alkinil-, alkinil-,cikloalkil-, aril-, heteroaril-, heterociklilcsoport vagy egyébösszetett csoport, R3 alkil-, alkenil-, alkinil-, cikloalkil-,cikloalkenil-, aril-, heteroaril-, szubsztituált aminocsoport vagyegyéb összetett csoport, R4-R7 egymástól fügegtelenül hidrogénatom,adott esetben szubsztituált alkil-, szubsztituált amino- vagy egyébösszetett csoport; vagy páronként összekapcsolódva az alapvázzalbiciklikus gyűrűt vagy endo-kötést képezhetnek; X =C(O), -S(O)2-, -C(O)-C(O)-csoport, kötés vagy -C(O)-C(O) NR47 csoport; m és p = 0, 1vagy 2 - és sóik és szolvátjaik, előállításuk, alkalmazásuk és ezekettartalmazó gyógyszerkészítmények képezik. Ó
HU0302153A 2000-05-17 2001-05-14 Kemokin receptor aktívitás modulátoraiként hatásos piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények HUP0302153A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0011838.0A GB0011838D0 (en) 2000-05-17 2000-05-17 Chemical compounds
PCT/SE2001/001053 WO2001087839A1 (en) 2000-05-17 2001-05-14 Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
HUP0302153A2 true HUP0302153A2 (hu) 2003-10-28

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HU0302153A HUP0302153A2 (hu) 2000-05-17 2001-05-14 Kemokin receptor aktívitás modulátoraiként hatásos piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Country Status (23)

Country Link
US (1) US20040006081A1 (hu)
EP (1) EP1289957A1 (hu)
JP (1) JP2003533510A (hu)
KR (1) KR20030001511A (hu)
CN (1) CN1441781A (hu)
AR (1) AR032331A1 (hu)
AU (1) AU2001258981A1 (hu)
BR (1) BR0110767A (hu)
CA (1) CA2407258A1 (hu)
CZ (1) CZ20023777A3 (hu)
EE (1) EE200200647A (hu)
GB (1) GB0011838D0 (hu)
HK (1) HK1052507A1 (hu)
HU (1) HUP0302153A2 (hu)
IL (1) IL152418A0 (hu)
IS (1) IS6608A (hu)
MX (1) MXPA02011304A (hu)
NO (1) NO20025430L (hu)
PL (1) PL365118A1 (hu)
RU (1) RU2002128614A (hu)
SK (1) SK16152002A3 (hu)
WO (1) WO2001087839A1 (hu)
ZA (1) ZA200208894B (hu)

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