HUP0301730A2 - Nukleozid vegyületek és ezek alkalmazása - Google Patents
Nukleozid vegyületek és ezek alkalmazásaInfo
- Publication number
- HUP0301730A2 HUP0301730A2 HU0301730A HUP0301730A HUP0301730A2 HU P0301730 A2 HUP0301730 A2 HU P0301730A2 HU 0301730 A HU0301730 A HU 0301730A HU P0301730 A HUP0301730 A HU P0301730A HU P0301730 A2 HUP0301730 A2 HU P0301730A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- acid
- hydrogen atom
- atom
- hydroxyl group
- Prior art date
Links
- -1 Nucleoside compounds Chemical class 0.000 title abstract 3
- 239000002777 nucleoside Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 229960004889 salicylic acid Drugs 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004380 Cholic acid Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229960002471 cholic acid Drugs 0.000 abstract 1
- 229960000956 coumarin Drugs 0.000 abstract 1
- 235000001671 coumarin Nutrition 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229960005102 foscarnet Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- PMOWTIHVNWZYFI-UHFFFAOYSA-N o-Coumaric acid Natural products OC(=O)C=CC1=CC=CC=C1O PMOWTIHVNWZYFI-UHFFFAOYSA-N 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical group NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
- PMOWTIHVNWZYFI-AATRIKPKSA-N trans-2-coumaric acid Chemical compound OC(=O)\C=C\C1=CC=CC=C1O PMOWTIHVNWZYFI-AATRIKPKSA-N 0.000 abstract 1
- 229960001727 tretinoin Drugs 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány szerinti vegyületek (1) általános képletében A, C, és Djelentése egymástól függetlenül N vagy C-R9, ahol R9 jelentésehidrogénatom, halogénatom, rövid szénláncú alkilcsoport,alkenilcsoport, alkinilcsoport, aminocsoport, CN, SH CHO, COOH, CH2OH,vinilhalogenid vagy hidroxilcsoport, B jelentése nitrogénatom vagyszénatom, Z jelentése O, CH2 vagy S, R2' és R3' jelentése egymástólfüggetlenül hidrogénatom, hidroxilcsoport vagy halogénatom, R1, R2,R3, R4 és R5 jelentése egymástól függetlenül hidrogénatom,halogénatom, CN, CH2OH, rövid szénláncú alkilcsoport, vinilcsoportvagy acetiléncsoport, azzal a megszorítással, hogy ha R2 jelentésehidroxilcsoport, akkor R2' jelentése halogénatomtól eltérő, és ha R3jelentése hidroxilcsoport, akkor R3' jelentése halogénatomtól eltérő,R6 jelentése hidrogénatom, hidroxilcsoport, -CH2OH, -CH2CO(OH)2, O-aminosav, O-retinasav, O-koleszterin, O-kolsav, O-kumarinsav, O-szalicilsav, O-szukcinsav, O-epesav, O-lipid, O-P(O)-(O-CH2-CH2-S-CO-CH3)2, O-szteroid, O-monofoszfátszármazék, O-difoszfátszármazék vagyO-trifoszfátszármazék, R7 jelentése hidrogénatom, alkilcsoport,CH3COO-, CH3COO-fenil-CH2-O-CO-, fenilcsoport, -(CH2)n-COOH,kumarinsav, szalicilsav, ditioszukcinoilszármazék, reduktázzalhasítható csoport, foszfonohangyasav vagy foszforamidátcsoport, R8jelentése hidrogénatom, rövid szénláncú alkilcsoport, fenilcsoport,CH3COO-, CH3COO-fenil-CH2-O-CO-, fenilcsoport vagy -(CH2)n-COOH, vagyR7 és R8 jelentése együtt ciklusos szerkezet vagy aminosav, azzal amegszorítással, hogy i) ha R1, R2, R3, R4, R5, R7 és R8 jelentésehidrogénatom, és R2' és R3' jelentése hidroxilcsoport, akkor R6jelentése hidroxilcsoporttól eltérő, ii) ha R1, R2, R3, R4, R5 és R8jelentése hidrogénatom, és R2', R3' és R6 jelentése hidroxilcsoport,akkor R7 jelentése hidrogénatomtól eltérő. A találmány szerintivegyületek vírusfertőzések kezelésére alkalmazhatók. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18967200P | 2000-03-15 | 2000-03-15 | |
US09/594,410 US6495677B1 (en) | 2000-02-15 | 2000-06-16 | Nucleoside compounds |
PCT/US2001/008713 WO2001068663A1 (en) | 2000-03-15 | 2001-03-15 | Nucleoside compounds and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0301730A2 true HUP0301730A2 (hu) | 2003-09-29 |
Family
ID=26885400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302334A HUP0302334A2 (hu) | 2000-03-15 | 2001-03-15 | Vírusellenes hatású nukleozid-vegyületek prekurzorjai, valamint e vegyületek alkalmazása gyógyászati készítmények előállítására |
HU0301730A HUP0301730A2 (hu) | 2000-03-15 | 2001-03-15 | Nukleozid vegyületek és ezek alkalmazása |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302334A HUP0302334A2 (hu) | 2000-03-15 | 2001-03-15 | Vírusellenes hatású nukleozid-vegyületek prekurzorjai, valamint e vegyületek alkalmazása gyógyászati készítmények előállítására |
Country Status (18)
Country | Link |
---|---|
US (1) | US6495677B1 (hu) |
EP (2) | EP1207890A4 (hu) |
JP (2) | JP2003530322A (hu) |
KR (2) | KR20030062227A (hu) |
CN (2) | CN1424913A (hu) |
AU (2) | AU5088101A (hu) |
BR (2) | BR0109143A (hu) |
CA (2) | CA2400370A1 (hu) |
CZ (2) | CZ20023051A3 (hu) |
DE (1) | DE20121305U1 (hu) |
HU (2) | HUP0302334A2 (hu) |
IL (1) | IL151073A0 (hu) |
MX (2) | MXPA02008608A (hu) |
NO (2) | NO20024355L (hu) |
PL (2) | PL365985A1 (hu) |
RU (2) | RU2002121628A (hu) |
SK (2) | SK11502002A3 (hu) |
WO (2) | WO2001068663A1 (hu) |
Families Citing this family (98)
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US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
DE60136620D1 (de) | 2000-04-13 | 2009-01-02 | Pharmasset Inc | 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
US6815542B2 (en) * | 2000-06-16 | 2004-11-09 | Ribapharm, Inc. | Nucleoside compounds and uses thereof |
DE10164711A1 (de) * | 2001-03-13 | 2002-10-17 | Schebo Biotech Ag | Verwendung von Zuckerphosphaten, Zuckerphosphatanalogen, Aminosäuren und/oder Aminosäureanalogen zur Modulation des Glycolyse-Enzym-Komplexes, des Malat Aspartat Shuttles und/oder der Transaminasen |
AU2002330154A1 (en) * | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
CA2477795A1 (en) * | 2002-02-28 | 2003-09-12 | Kandasamy Sakthivel | Nucleoside 5'-monophosphate mimics and their prodrugs |
JP4606027B2 (ja) * | 2002-04-03 | 2011-01-05 | トポターゲット ユーケー リミテッド | Hdac阻害剤としてのピペラジン結合を有するカルバミン酸化合物 |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
AU2003248748A1 (en) * | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
CA2494340C (en) | 2002-08-01 | 2012-01-24 | Pharmasset Inc. | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
KR20050088079A (ko) | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
CA2508656A1 (en) * | 2002-12-10 | 2004-06-24 | F.Hoffmann-La Roche Ag | Antiviral nucleoside derivatives |
CA2509687C (en) | 2002-12-12 | 2012-08-14 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
RU2005123395A (ru) * | 2002-12-23 | 2006-01-27 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 3-нуклеозидных пролекарств |
AU2004216485B2 (en) * | 2003-02-25 | 2009-06-11 | Merck Serono Sa | Combined use of ribavirin and interferon beta in demyelinating diseases |
JP2006524227A (ja) * | 2003-03-28 | 2006-10-26 | ファーマセット,インク. | フラビウイルス科ウイルス感染の治療のための化合物 |
CA2734052A1 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
PL1658302T3 (pl) | 2003-07-25 | 2011-03-31 | Idenix Pharmaceuticals Inc | Analogi nukleozydów purynowych do leczenia chorób spowodowanych przez Flaviviridae obejmujących zapalenie wątroby typu C |
WO2005018330A1 (en) * | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
CA2537878A1 (en) * | 2003-09-11 | 2005-03-17 | F. Hoffmann-La Roche Ag | Polymorphic nucleoside compounds |
CA2537849A1 (en) * | 2003-09-11 | 2005-03-17 | F. Hoffmann-La Roche Ag | Process for preparing antiviral nucleoside derivatives |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
WO2005123087A2 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
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RU2433124C2 (ru) | 2004-09-14 | 2011-11-10 | Фармассет, Инк. | Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных |
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EP2079479B1 (en) | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
EP2076278B1 (en) | 2006-10-24 | 2015-05-06 | Merck Sharp & Dohme Corp. | Macrocyclic HCV NS3 protease inhibitors |
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JPS6426593A (en) | 1987-07-21 | 1989-01-27 | Asahi Glass Co Ltd | Nucleoside derivative |
IL129126A0 (en) | 1996-10-16 | 2000-02-17 | Icn Pharmaceuticals | Monocyclic l-nucleosides analogs and uses thereof |
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2000
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2001
- 2001-03-15 HU HU0302334A patent/HUP0302334A2/hu unknown
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- 2001-03-15 BR BRPI0109143-3A patent/BR0109143A/pt not_active IP Right Cessation
- 2001-03-15 BR BRPI0109144-1A patent/BR0109144A/pt not_active IP Right Cessation
- 2001-03-15 PL PL01365985A patent/PL365985A1/xx unknown
- 2001-03-15 HU HU0301730A patent/HUP0301730A2/hu unknown
- 2001-03-15 CN CN01806350A patent/CN1424913A/zh active Pending
- 2001-03-15 SK SK1150-2002A patent/SK11502002A3/sk unknown
- 2001-03-15 RU RU2002121628/04A patent/RU2002121628A/ru not_active Application Discontinuation
- 2001-03-15 DE DE20121305U patent/DE20121305U1/de not_active Expired - Lifetime
- 2001-03-15 EP EP01924208A patent/EP1207890A4/en not_active Withdrawn
- 2001-03-15 MX MXPA02008608A patent/MXPA02008608A/es unknown
- 2001-03-15 MX MXPA02008609A patent/MXPA02008609A/es unknown
- 2001-03-15 JP JP2001566501A patent/JP2003530322A/ja active Pending
- 2001-03-15 PL PL01366038A patent/PL366038A1/xx unknown
- 2001-03-15 KR KR1020027012033A patent/KR20030062227A/ko not_active Application Discontinuation
- 2001-03-15 WO PCT/US2001/008713 patent/WO2001068663A1/en not_active Application Discontinuation
- 2001-03-15 RU RU2002121631/15A patent/RU2002121631A/ru not_active Application Discontinuation
- 2001-03-15 SK SK1152-2002A patent/SK11522002A3/sk not_active Application Discontinuation
- 2001-03-15 CZ CZ20023119A patent/CZ20023119A3/cs unknown
- 2001-03-15 AU AU50881/01A patent/AU5088101A/en not_active Abandoned
- 2001-03-15 WO PCT/US2001/008769 patent/WO2001068034A2/en not_active Application Discontinuation
- 2001-03-15 CN CN01806351A patent/CN1416431A/zh active Pending
- 2001-03-15 EP EP01920509A patent/EP1268504A1/en not_active Withdrawn
- 2001-03-15 KR KR1020027012034A patent/KR20030032927A/ko not_active Application Discontinuation
- 2001-03-15 JP JP2001567753A patent/JP2004505889A/ja active Pending
- 2001-03-15 CA CA002400370A patent/CA2400370A1/en not_active Abandoned
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