HUP0300882A2 - Új önemulgeáló hatóanyag-beadási rendszer - Google Patents
Új önemulgeáló hatóanyag-beadási rendszerInfo
- Publication number
- HUP0300882A2 HUP0300882A2 HU0300882A HUP0300882A HUP0300882A2 HU P0300882 A2 HUP0300882 A2 HU P0300882A2 HU 0300882 A HU0300882 A HU 0300882A HU P0300882 A HUP0300882 A HU P0300882A HU P0300882 A2 HUP0300882 A2 HU P0300882A2
- Authority
- HU
- Hungary
- Prior art keywords
- oil
- medicinal product
- enantiomer
- alkali metal
- metal salt
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title 1
- 230000001804 emulsifying effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 abstract 3
- 239000003921 oil Substances 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- -1 alkali metal salt Chemical class 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 229920001400 block copolymer Polymers 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229940126409 proton pump inhibitor Drugs 0.000 abstract 1
- 239000000612 proton pump inhibitor Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya orális alkalmazásra szolgáló, emulzió-előkoncentrátum formájában lévő (i) egy vagy több, NO-t szabaddátevőNSAID-ot; (ii) egy vagy több felületaktív anyagot; (iii) adott esetbenegy olajat vagy félszilárd zsírt tartalmazó gyógyszerkészítmény, amelyvizes közeggel, így gastrointestinalis folyadékokkal érintkezve insitu ,,olaj a vízben< emulziót képez. A gyógyszerkészítménytartalmazhat továbbá egy vagy több rövid szénláncú alkoholt, valamintegy bélben oldódó bevonattal ellátott, savra érzékeny protonpumpainhibitort, így omeprazolt, egy alkálifémsóját, egy enantiomerét vagyaz enantiomer alkálifémsóját. A felületaktív anyag lehet egy blokk-kopolimer vagy egy nemionos felületaktív anyag, így egy poloxamer. Azolaj lehet egy növényi vagy állati olaj. A készítményt tartalmazóegységadag tölthető például kapszulákba, így keményzselatin vagylágyzselatin kapszulákba. A gyógyszerkészítmény fájdalmak vagygyulladások kezelésére alkalmazható. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0000773A SE0000773D0 (sv) | 2000-03-08 | 2000-03-08 | New formulation |
PCT/SE2001/000467 WO2001066088A1 (en) | 2000-03-08 | 2001-03-06 | New self emulsifying drug delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300882A2 true HUP0300882A2 (hu) | 2003-09-29 |
HUP0300882A3 HUP0300882A3 (en) | 2005-04-28 |
Family
ID=20278739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300882A HUP0300882A3 (en) | 2000-03-08 | 2001-03-06 | New self emulsifying drug delivery system |
Country Status (31)
Country | Link |
---|---|
US (1) | US20030161846A1 (hu) |
EP (1) | EP1267832B1 (hu) |
JP (1) | JP4663197B2 (hu) |
KR (1) | KR100771317B1 (hu) |
CN (2) | CN101862453A (hu) |
AT (1) | ATE268162T1 (hu) |
AU (2) | AU3787601A (hu) |
BR (1) | BR0109014A (hu) |
CA (1) | CA2401498C (hu) |
CZ (1) | CZ20023005A3 (hu) |
DE (1) | DE60103627T2 (hu) |
DK (1) | DK1267832T3 (hu) |
EE (1) | EE200200500A (hu) |
ES (1) | ES2220728T3 (hu) |
HK (1) | HK1050632A1 (hu) |
HU (1) | HUP0300882A3 (hu) |
IL (1) | IL151427A0 (hu) |
IS (1) | IS6539A (hu) |
MX (1) | MXPA02008657A (hu) |
MY (1) | MY127237A (hu) |
NO (1) | NO20024272L (hu) |
NZ (1) | NZ521009A (hu) |
PL (1) | PL202683B1 (hu) |
PT (1) | PT1267832E (hu) |
RU (1) | RU2270675C9 (hu) |
SE (1) | SE0000773D0 (hu) |
SK (1) | SK285982B6 (hu) |
TR (1) | TR200401906T4 (hu) |
UA (1) | UA82979C2 (hu) |
WO (1) | WO2001066088A1 (hu) |
ZA (1) | ZA200206740B (hu) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
SE0000774D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
SE0102993D0 (sv) * | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
SE0200895D0 (sv) * | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
FR2838349B1 (fr) * | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
US7163958B2 (en) | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
WO2004012659A2 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
FR2845917B1 (fr) * | 2002-10-21 | 2006-07-07 | Negma Gild | Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire |
SE0301880D0 (sv) * | 2003-06-25 | 2003-06-25 | Astrazeneca Uk Ltd | New drug delivery composition |
KR20050034299A (ko) * | 2003-10-09 | 2005-04-14 | 한국유나이티드제약 주식회사 | 아세클로페낙 자가유화에멀젼 및 이를 이용한 연질캅셀제조성물 및 그의 제조방법 |
DK1906938T3 (da) * | 2005-07-26 | 2011-02-07 | Nicox Sa | Farmaceutisk formulering af nitrooxyderivater af NSAID'er |
EP1965774A2 (en) * | 2005-12-30 | 2008-09-10 | Cogentus Pharmaceuticals, Inc. | Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors |
JP2012502015A (ja) | 2008-09-09 | 2012-01-26 | アストラゼネカ・アクチエボラーグ | 必要がある患者に医薬組成物を送達するための方法 |
NZ592970A (en) * | 2008-12-03 | 2013-05-31 | Astellas Deutschland Gmbh | Oral dosage forms of bendamustine |
US20100273730A1 (en) * | 2009-04-27 | 2010-10-28 | Innopharmax, Inc. | Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof |
MX2011013467A (es) | 2009-06-25 | 2012-02-13 | Astrazeneca Ab | Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine). |
DK2451438T3 (da) * | 2009-07-07 | 2014-03-10 | Boehringer Ingelheim Int | Farmaceutisk sammensætning til en hepatitis C-virus-roteaseinhibitor |
US9717703B2 (en) | 2009-10-16 | 2017-08-01 | Glaxosmithkline Llc | Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed |
MX2014007935A (es) | 2011-12-28 | 2014-11-14 | Pozen Inc | Composiciones y metodos mejorados para el suministro de omeprazol y de acido acetilsalicilico. |
CN102614115B (zh) * | 2012-04-26 | 2013-05-15 | 河南中医学院 | 一种双氯芬酸钠自乳化软膏 |
AU2014311570C1 (en) | 2013-08-27 | 2018-08-02 | Vasilios VOUDOURIS | Bendamustine pharmaceutical compositions |
CN107427484A (zh) * | 2015-01-21 | 2017-12-01 | 持田制药株式会社 | ω3脂肪酸的自乳化组合物 |
PL3331568T3 (pl) * | 2015-08-07 | 2022-02-28 | Infirst Healthcare Limited | Kompozycje stałego roztworu dla nlpz |
CN113440481B (zh) * | 2021-08-13 | 2022-06-14 | 湖南慧泽生物医药科技有限公司 | 伊布替尼的自微乳组合物 |
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US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6126816A (en) * | 1999-07-14 | 2000-10-03 | Ruiz, Jr.; Reuben F. | Wastewater treatment device |
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SE0002476D0 (sv) * | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
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-
2000
- 2000-03-08 SE SE0000773A patent/SE0000773D0/xx unknown
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2001
- 2001-03-06 HU HU0300882A patent/HUP0300882A3/hu unknown
- 2001-03-06 UA UA2002086883A patent/UA82979C2/ru unknown
- 2001-03-06 CA CA2401498A patent/CA2401498C/en not_active Expired - Fee Related
- 2001-03-06 RU RU2002122744/15A patent/RU2270675C9/ru not_active IP Right Cessation
- 2001-03-06 EP EP01910305A patent/EP1267832B1/en not_active Expired - Lifetime
- 2001-03-06 PL PL358595A patent/PL202683B1/pl not_active IP Right Cessation
- 2001-03-06 PT PT01910305T patent/PT1267832E/pt unknown
- 2001-03-06 AU AU3787601A patent/AU3787601A/xx active Pending
- 2001-03-06 US US10/220,791 patent/US20030161846A1/en not_active Abandoned
- 2001-03-06 IL IL15142701A patent/IL151427A0/xx active IP Right Grant
- 2001-03-06 MX MXPA02008657A patent/MXPA02008657A/es active IP Right Grant
- 2001-03-06 CZ CZ20023005A patent/CZ20023005A3/cs unknown
- 2001-03-06 BR BR0109014-3A patent/BR0109014A/pt not_active Application Discontinuation
- 2001-03-06 DE DE60103627T patent/DE60103627T2/de not_active Expired - Lifetime
- 2001-03-06 CN CN201010156308A patent/CN101862453A/zh active Pending
- 2001-03-06 ES ES01910305T patent/ES2220728T3/es not_active Expired - Lifetime
- 2001-03-06 KR KR1020027011731A patent/KR100771317B1/ko not_active IP Right Cessation
- 2001-03-06 SK SK1257-2002A patent/SK285982B6/sk not_active IP Right Cessation
- 2001-03-06 CN CN018061613A patent/CN1416335B/zh not_active Expired - Fee Related
- 2001-03-06 AT AT01910305T patent/ATE268162T1/de not_active IP Right Cessation
- 2001-03-06 EE EEP200200500A patent/EE200200500A/xx unknown
- 2001-03-06 TR TR2004/01906T patent/TR200401906T4/ unknown
- 2001-03-06 WO PCT/SE2001/000467 patent/WO2001066088A1/en active Application Filing
- 2001-03-06 DK DK01910305T patent/DK1267832T3/da active
- 2001-03-06 AU AU2001237876A patent/AU2001237876B2/en not_active Ceased
- 2001-03-06 NZ NZ521009A patent/NZ521009A/en unknown
- 2001-03-06 JP JP2001564741A patent/JP4663197B2/ja not_active Expired - Fee Related
- 2001-03-07 MY MYPI20011045A patent/MY127237A/en unknown
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2002
- 2002-08-22 ZA ZA200206740A patent/ZA200206740B/en unknown
- 2002-09-03 IS IS6539A patent/IS6539A/is unknown
- 2002-09-06 NO NO20024272A patent/NO20024272L/no not_active Application Discontinuation
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2003
- 2003-04-16 HK HK03102781A patent/HK1050632A1/xx not_active IP Right Cessation
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