HUP0203638A2 - Béta2-Adrenerg receptor agonista hatóanyagok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Béta2-Adrenerg receptor agonista hatóanyagok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0203638A2 HUP0203638A2 HU0203638A HUP0203638A HUP0203638A2 HU P0203638 A2 HUP0203638 A2 HU P0203638A2 HU 0203638 A HU0203638 A HU 0203638A HU P0203638 A HUP0203638 A HU P0203638A HU P0203638 A2 HUP0203638 A2 HU P0203638A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- ligand
- substituted
- alkylene
- alkyl
- Prior art date
Links
- 239000000048 adrenergic agonist Substances 0.000 title abstract 2
- 229940126157 adrenergic receptor agonist Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 10
- 125000005647 linker group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 206010036590 Premature baby Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Vehicle Body Suspensions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
A jelen találmány tárgya b2 adrenerg receptor agonista hatóanyagkéntalkalmazható többszörös kötődésű (I) általános képletű vegyületek,amelyek alkalmazhatók légzési rendellenességek, például asztma,hörghurut gyógyító és megelőző kezelésére szolgálógyógyszerkészítmények előállításánál. A szóban forgó rendellenességlehet az idegrendszer károsodása és a koraszülés is. A találmánykiterjed a vegyületeket tartalmazó gyógyszerkészítményre is. Az (I)általános képletben p értéke 2 és 10 közötti egész szám; q értéke 1 és 20 közötti egész szám; X jelentése összekötőcsoport; és L jelentése ligandum, azzaljellemezve, hogy az egyik L ligandum (a) általános képletű vegyület,amely képletben: Ar1 és Ar2 jelentése egymástól függetlenül aril-,heteroaril-, cikloalkil-, helyettesített cikloalkil- vagy hetero-ciklil-csoport, azzal jellemezve, hogy az Ar1 és Ar2 csoportok szóbanforgó helyettesítő csoportjainak mindegyike adott esetben a ligandumotegy összekötő csoporthoz kapcsolja; R1 jelentése hidrogénatom, alkil-vagy helyettesített alkilcsoport, vagy R1 jelentése a ligandumot azösszekötőcsoporthoz kapcsoló kovalens kötés; R2 jelentésehidrogénatom, alkil-, aralkil-, acil-, helyettesített alkil-,cikloalkil- vagy helyettesített cikloalkil-csoport, vagy R2 jelentésea ligandumot az összekötőcsoporthoz kapcsoló kovalens kötés; Wjelentése az -NR2-csoportot az Ar2 csoporthoz kapcsoló kovalens kötés,alkilén- vagy helyettesített alkiléncsoport, azzal jellemezve, hogy azemlített alkilén- vagy helyettesített alkiléncsoport egy vagy többszénatomját adott esetben -NRa- (amely képletben Ra jelentésehidrogénatom, alkil-, acilcsoport vagy a ligandumot azösszekötőcsoporthoz kapcsoló kovalens kötés), -O-, -S(O)n (amelyképletben n értéke 0-2 közötti egész szám), -CO-, -PRb- (amelyképletben Rb jelentése alkilcsoport), -P(O)2- vagy -O-P(O)O- képletűcsoport helyettesíti, továbbá az említett alkilén- vagy helyettesítettalkiléncsoport adott esetben a ligandumot egy összekötőcsoporthozkapcsolja, azzal a kikötéssel, hogy az Ar1, Ar2, R1, R2 vagy Wcsoportok közül legalább az egyik kapcsolja a ligandumot azösszekötőcsoporthoz; és a többi ligandum egymástól függetlenül (b)általános képletű vegyület, amely képletben: Ar3 jelentése aril-,heteroaril-, cikloalkil-, helyettesített cikloalkil- vagy heterogyűrűscsoport; a másik ligandumot az összekötőcsoporthoz kapcsoló Q csoportjelentése kovalens kötés, alkilén- vagy helyettesített alkiléncsoport. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45761899A | 1999-12-08 | 1999-12-08 | |
US09/637,899 US6576793B1 (en) | 1999-12-08 | 2000-08-14 | β2-adrenergic receptor agonists |
PCT/US2000/033057 WO2001042193A1 (en) | 1999-12-08 | 2000-12-06 | β2-ADRENERGIC RECEPTOR AGONISTS |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203638A2 true HUP0203638A2 (hu) | 2003-02-28 |
HUP0203638A3 HUP0203638A3 (en) | 2003-04-28 |
Family
ID=27038674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203638A HUP0203638A3 (en) | 1999-12-08 | 2000-12-06 | Betha2-adrenergic receptor agonists and pharmaceutical compositions containing them and their use |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP1235787B1 (hu) |
KR (1) | KR20070039968A (hu) |
CN (1) | CN1402702A (hu) |
AT (1) | ATE253039T1 (hu) |
AU (1) | AU781466B2 (hu) |
BR (1) | BR0015962A (hu) |
CA (1) | CA2391293C (hu) |
CZ (1) | CZ20021831A3 (hu) |
DE (1) | DE60006280T2 (hu) |
DK (1) | DK1235787T3 (hu) |
EA (1) | EA004263B1 (hu) |
ES (1) | ES2208453T3 (hu) |
HR (1) | HRP20020381A2 (hu) |
HU (1) | HUP0203638A3 (hu) |
IL (1) | IL149317A0 (hu) |
IS (1) | IS2164B (hu) |
MX (1) | MXPA02005599A (hu) |
NO (1) | NO327630B1 (hu) |
OA (1) | OA11558A (hu) |
PT (1) | PT1235787E (hu) |
SK (1) | SK287036B6 (hu) |
TR (1) | TR200302010T4 (hu) |
WO (1) | WO2001042193A1 (hu) |
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DE1250450B (de) * | 1962-03-31 | 1967-09-21 | Deutsche Gold- und Silber-Scheideanstalt vormals Roessler, Frankfurt/M | Verfahren zur Herstellung von Aminoalkoholen sowie deren Säureadditionssalzen und quartären Ammoniumverbindungen |
AT322534B (de) * | 1972-03-16 | 1975-05-26 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen optisch aktiven 1-(4'-amino-3'-halogenphenyl)-2-aminoäthanolen und deren säureadditionssalzen |
PT938467E (pt) * | 1996-11-11 | 2002-11-29 | Sepracor Inc | Processo para a preparacao de isomeros opticamente puros de formoterol |
JPH10152460A (ja) * | 1996-11-21 | 1998-06-09 | Kissei Pharmaceut Co Ltd | 2−アミノ−1−(4−ヒドロキシ−2−メチルフェニル)プロパノール誘導体 |
US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
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- 2000-12-06 BR BR0015962-0A patent/BR0015962A/pt not_active Application Discontinuation
- 2000-12-06 DE DE60006280T patent/DE60006280T2/de not_active Expired - Lifetime
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- 2000-12-06 CN CN00816436A patent/CN1402702A/zh active Pending
- 2000-12-06 KR KR1020077004447A patent/KR20070039968A/ko not_active Application Discontinuation
- 2000-12-06 PT PT00986271T patent/PT1235787E/pt unknown
- 2000-12-06 ES ES00986271T patent/ES2208453T3/es not_active Expired - Lifetime
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Also Published As
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EA004263B1 (ru) | 2004-02-26 |
ES2208453T3 (es) | 2004-06-16 |
DE60006280T2 (de) | 2004-07-29 |
EP1235787A1 (en) | 2002-09-04 |
CZ20021831A3 (cs) | 2002-11-13 |
TR200302010T4 (tr) | 2004-01-21 |
KR20070039968A (ko) | 2007-04-13 |
HRP20020381A2 (en) | 2005-12-31 |
AU2254601A (en) | 2001-06-18 |
AU781466B2 (en) | 2005-05-26 |
NO327630B1 (no) | 2009-09-07 |
DE60006280D1 (de) | 2003-12-04 |
PT1235787E (pt) | 2004-03-31 |
EP1235787B1 (en) | 2003-10-29 |
SK287036B6 (sk) | 2009-10-07 |
NO20022655D0 (no) | 2002-06-05 |
IL149317A0 (en) | 2002-11-10 |
SK9922002A3 (en) | 2002-11-06 |
WO2001042193A1 (en) | 2001-06-14 |
CN1402702A (zh) | 2003-03-12 |
CA2391293A1 (en) | 2001-06-14 |
MXPA02005599A (es) | 2002-09-18 |
NO20022655L (no) | 2002-06-05 |
IS2164B (is) | 2006-11-15 |
DK1235787T3 (da) | 2004-03-08 |
CA2391293C (en) | 2008-12-30 |
EA200200647A1 (ru) | 2002-12-26 |
BR0015962A (pt) | 2002-07-30 |
ATE253039T1 (de) | 2003-11-15 |
HUP0203638A3 (en) | 2003-04-28 |
OA11558A (en) | 2004-06-03 |
IS6350A (is) | 2002-04-19 |
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