HUP0202705A3 - Methods and microorganisms or production of panto-compounds - Google Patents

Methods and microorganisms or production of panto-compounds

Info

Publication number
HUP0202705A3
HUP0202705A3 HU0202705A HUP0202705A HUP0202705A3 HU P0202705 A3 HUP0202705 A3 HU P0202705A3 HU 0202705 A HU0202705 A HU 0202705A HU P0202705 A HUP0202705 A HU P0202705A HU P0202705 A3 HUP0202705 A3 HU P0202705A3
Authority
HU
Hungary
Prior art keywords
panto
microorganisms
compounds
production
methods
Prior art date
Application number
HU0202705A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of HUP0202705A2 publication Critical patent/HUP0202705A2/hu
Publication of HUP0202705A3 publication Critical patent/HUP0202705A3/hu
Publication of HU230509B1 publication Critical patent/HU230509B1/hu

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014Hydroxymethyl-, formyl-transferases (2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
HU0202705A 1999-09-21 2000-09-21 Eljárások és mikroorganizmusok panto-vegyületek előállítására HU230509B1 (hu)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40049499A 1999-09-21 1999-09-21
US09/400,494 1999-09-21
US21007200P 2000-06-07 2000-06-07
US60/210,072 2000-06-07
US22183600P 2000-07-28 2000-07-28
US60/221,836 2000-07-28
US22786000P 2000-08-24 2000-08-24
US60/227,860 2000-08-24
PCT/US2000/025993 WO2001021772A2 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Publications (3)

Publication Number Publication Date
HUP0202705A2 HUP0202705A2 (hu) 2002-12-28
HUP0202705A3 true HUP0202705A3 (en) 2011-02-28
HU230509B1 HU230509B1 (hu) 2016-09-28

Family

ID=27498789

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202705A HU230509B1 (hu) 1999-09-21 2000-09-21 Eljárások és mikroorganizmusok panto-vegyületek előállítására

Country Status (16)

Country Link
EP (2) EP1214420B1 (hu)
JP (1) JP5392957B2 (hu)
KR (1) KR20020092912A (hu)
CN (1) CN1420931A (hu)
AU (1) AU7708700A (hu)
BR (1) BRPI0014115B8 (hu)
CA (1) CA2385497A1 (hu)
CZ (1) CZ20021013A3 (hu)
HU (1) HU230509B1 (hu)
IL (1) IL148786A0 (hu)
MX (1) MXPA02003017A (hu)
NO (1) NO20021382L (hu)
PL (1) PL356566A1 (hu)
SK (1) SK5222002A3 (hu)
TR (1) TR200200751T2 (hu)
WO (1) WO2001021772A2 (hu)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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US6830898B2 (en) 2000-08-24 2004-12-14 Omnigene Bioproducts, Inc. Microorganisms and assays for the identification of antibiotics
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
CA2434626A1 (en) * 2001-01-19 2002-08-08 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
SK9022003A3 (en) * 2001-01-19 2003-12-02 Basf Ag Processes for enhanced production of pantothenate
DE10108225A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
DE10108223A1 (de) * 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
US7727748B2 (en) * 2001-02-21 2010-06-01 Basf Se Method for producing D-pantothenic acid and/or salts thereof via purification by anion exchange as an additive for animal feed
CA2438945A1 (en) 2001-02-21 2002-08-29 Basf Aktiengesellschaft Method for the production of d-pantothenic acid and/or salts thereof as adjunct for animal feedstuffs
EP1247868A3 (de) * 2001-04-03 2002-10-30 Degussa AG Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
EP1402047A1 (en) * 2001-07-03 2004-03-31 Degussa AG Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
EP1402046A1 (en) * 2001-07-03 2004-03-31 Degussa AG Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
DE10132178A1 (de) 2001-07-03 2003-01-23 Degussa Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
EP1404840A2 (en) * 2001-07-07 2004-04-07 Degussa AG Process for the preparation of d-pantothenic acid and/or salts thereof
EP1672073A1 (en) * 2001-07-07 2006-06-21 Degussa AG Process for the preparation of D-pantothenic acid and/or salts thereof
JP4532116B2 (ja) 2002-01-18 2010-08-25 ノボザイムズ エー/エス アラニン2,3−アミノムターゼ
JP2006504408A (ja) * 2002-07-03 2006-02-09 ビーエーエスエフ アクチェンゲゼルシャフト パントテン酸の高生産のための微生物及び方法
HUP0500383A2 (hu) * 2002-07-03 2005-08-29 Basf Ag Mikroorganizmusok és eljárások pantotenát fokozott termelésére
CN1809631B (zh) * 2003-06-18 2010-05-26 帝斯曼知识产权资产管理有限公司 用不能形成芽孢的微生物来生产泛酸盐/酯的方法
WO2006104124A1 (ja) * 2005-03-29 2006-10-05 Kaneka Corporation 新規パントテン酸キナーゼ遺伝子及びその利用方法
JP5276986B2 (ja) 2005-10-26 2013-08-28 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 四炭素アルコールの発酵性生産
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
PL389665A1 (pl) 2007-02-09 2010-07-05 The Regents of the University of CaliforniaThe Regents of the University of California Wytwarzanie biopaliwa przez rekombinowane mikroorganizmy
SI2164975T1 (sl) 2007-07-06 2012-06-29 Basf Se Postopek za proizvajanje koncentriranega vodnega glukoznega pripravka iz koruze
NO2265709T3 (hu) * 2008-03-27 2018-04-07
EP2157174A1 (en) * 2008-08-12 2010-02-24 DSM IP Assets B.V. Increased production of pantothenate (vitamin B5)
US9416364B2 (en) * 2011-02-07 2016-08-16 William Marsh Rice University Reverse beta oxidation pathway
US8765426B2 (en) * 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
WO2012175574A1 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased pantothenate (vitamin b5) production
WO2012175575A2 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased vitamin b5 production
WO2014087184A1 (en) * 2012-12-03 2014-06-12 Metabolic Explorer Neopentyl glycol fermentative production by a recombinant microorganism
WO2015061792A1 (en) 2013-10-25 2015-04-30 Retrophin, Inc. Panothenate derivatives for the treatment of neurological disorders
CN104593398B (zh) * 2013-11-01 2017-06-06 中国科学院微生物研究所 一种高L‑天冬氨酸α羧化酶活性的工程菌及其在生产β‑丙氨酸中的应用
CN105368758B (zh) * 2015-03-16 2018-06-19 鲁东大学 一株高产天冬氨酸脱羧酶的菌株及用于生产丙氨酸的方法
CN108486110A (zh) * 2015-03-31 2018-09-04 中国农业科学院生物技术研究所 一种启动子和重组表达载体及其用途
AU2016366977A1 (en) 2015-12-08 2018-07-12 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
KR102683624B1 (ko) 2017-06-30 2024-07-11 피티티 글로벌 케미칼 피씨엘 기능적 dna 서열의 안정화된 카피 수를 갖는 미생물 및 관련 방법
CN108456701B (zh) * 2018-03-23 2020-10-16 精晶药业股份有限公司 一种d-泛解酸内酯的制备方法
EP3810786A4 (en) * 2018-06-25 2022-06-08 Lygos, Inc. RECOMBINED HOST CELLS AND METHODS FOR PRODUCING ASPARTIC ACID AND BETA-ALANINE
SG11202012136YA (en) * 2018-07-09 2021-01-28 Codexis Inc Engineered pantothenate kinase variant enzymes
CN113846127B (zh) * 2020-06-28 2023-11-10 元素驱动(杭州)生物科技有限公司 一种泛解酸、泛酸、泛醇及其盐的制备方法
KR102389327B1 (ko) * 2020-07-01 2022-04-20 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
CN115109736B (zh) * 2021-03-23 2024-05-07 中国科学院天津工业生物技术研究所 一种产泛解酸的微生物及其构建方法和应用
EP4323331A1 (en) 2021-04-15 2024-02-21 DSM IP Assets B.V. Production of panthenol
EP4108654A1 (en) 2021-06-23 2022-12-28 DSM IP Assets B.V. Production of panthenol
CN114085820B (zh) * 2021-11-19 2023-10-20 万华化学集团股份有限公司 来源于Candida viswanathii的酮基泛解酸内酯还原酶
CN114437988B (zh) * 2022-02-28 2023-05-23 贵州医科大学 纤维素降解菌及菌剂、制备方法、应用和降解酒糟的方法
CN115595328A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所(Cn) 天冬氨酸脱羧酶在发酵生产维生素b5中的应用
CN115595314B (zh) * 2022-03-07 2025-06-24 中国科学院微生物研究所 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法
JP2025536557A (ja) 2022-11-21 2025-11-07 ディーエスエム アイピー アセッツ ビー.ブイ. パンテノールの製造
EP4378923A1 (en) 2022-12-01 2024-06-05 DSM IP Assets B.V. Production of panthenol
KR102879056B1 (ko) 2023-01-27 2025-10-30 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
KR102879057B1 (ko) 2023-01-27 2025-10-30 씨제이제일제당 (주) 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
CN116590209A (zh) * 2023-06-13 2023-08-15 浙江工业大学 一种产d-泛酸的基因工程菌、构建方法及应用
CN119709733B (zh) * 2023-09-28 2025-11-28 安徽华恒生物科技股份有限公司 一种动态调控系统、泛解酸生产菌株及其制备方法和应用
CN119220576B (zh) * 2024-12-03 2025-07-25 浙江工业大学 基于一碳单位供应的产d-泛酸基因工程菌及构建与应用
CN120060194B (zh) * 2025-02-27 2025-10-28 中国农业科学院植物保护研究所 一种用于提高放线菌聚酮类天然产物产量的组合模块及含有其重组菌的构建与应用
CN121046335A (zh) * 2025-11-06 2025-12-02 诸城市浩天药业有限公司 一种耐热、半衰期长的泛酸合成酶突变体

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Also Published As

Publication number Publication date
SK5222002A3 (en) 2003-03-04
KR20020092912A (ko) 2002-12-12
JP5392957B2 (ja) 2014-01-22
EP2163629A2 (en) 2010-03-17
HUP0202705A2 (hu) 2002-12-28
WO2001021772A3 (en) 2002-03-07
HU230509B1 (hu) 2016-09-28
CA2385497A1 (en) 2001-03-29
BRPI0014115B1 (pt) 2015-05-05
JP2003527828A (ja) 2003-09-24
AU7708700A (en) 2001-04-24
EP2163629A3 (en) 2010-06-02
EP2163629B1 (en) 2017-03-08
MXPA02003017A (es) 2004-09-06
CN1420931A (zh) 2003-05-28
EP1214420B1 (en) 2016-03-23
BRPI0014115B8 (pt) 2021-05-25
NO20021382L (no) 2002-05-16
TR200200751T2 (tr) 2004-08-23
EP1214420A2 (en) 2002-06-19
PL356566A1 (en) 2004-06-28
WO2001021772A9 (en) 2002-12-05
BR0014115A (pt) 2002-05-21
IL148786A0 (en) 2002-09-12
NO20021382D0 (no) 2002-03-20
CZ20021013A3 (en) 2002-12-11
WO2001021772A2 (en) 2001-03-29

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