HUP0105148A2 - Telmisartan polimorfja, eljárás előállítására és alkalmazása gyógyszerkészítmény előállítására - Google Patents

Telmisartan polimorfja, eljárás előállítására és alkalmazása gyógyszerkészítmény előállítására

Info

Publication number
HUP0105148A2
HUP0105148A2 HU0105148A HUP0105148A HUP0105148A2 HU P0105148 A2 HUP0105148 A2 HU P0105148A2 HU 0105148 A HU0105148 A HU 0105148A HU P0105148 A HUP0105148 A HU P0105148A HU P0105148 A2 HUP0105148 A2 HU P0105148A2
Authority
HU
Hungary
Prior art keywords
telmisartan
polymorph
medicament
preparation
producing same
Prior art date
Application number
HU0105148A
Other languages
English (en)
Inventor
Heinrich Schneider
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of HUP0105148A2 publication Critical patent/HUP0105148A2/hu
Publication of HUP0105148A3 publication Critical patent/HUP0105148A3/hu
Publication of HU227401B1 publication Critical patent/HU227401B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
HU0105148A 1999-01-19 2000-01-07 Telmisartan polymorph, method for producing same and its use in the preparation of a medicament HU227401B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19901921A DE19901921C2 (de) 1999-01-19 1999-01-19 Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
PCT/EP2000/000065 WO2000043370A1 (de) 1999-01-19 2000-01-07 Polymorphe von telmisartan, verfahren zu deren herstellung und deren verwendung zur herstellung eines arzneimittels

Publications (3)

Publication Number Publication Date
HUP0105148A2 true HUP0105148A2 (hu) 2002-07-29
HUP0105148A3 HUP0105148A3 (en) 2003-01-28
HU227401B1 HU227401B1 (en) 2011-05-30

Family

ID=7894715

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105148A HU227401B1 (en) 1999-01-19 2000-01-07 Telmisartan polymorph, method for producing same and its use in the preparation of a medicament

Country Status (36)

Country Link
EP (1) EP1144386B1 (hu)
JP (1) JP4700813B2 (hu)
KR (1) KR100658959B1 (hu)
CN (1) CN1144790C (hu)
AR (1) AR035475A1 (hu)
AT (1) ATE252564T1 (hu)
AU (1) AU765081B2 (hu)
BG (1) BG65027B1 (hu)
BR (1) BR0007584A (hu)
CA (1) CA2352436C (hu)
CO (1) CO5150238A1 (hu)
CZ (1) CZ297412B6 (hu)
DE (2) DE19901921C2 (hu)
DK (1) DK1144386T3 (hu)
EA (1) EA003065B1 (hu)
EE (1) EE04344B1 (hu)
ES (1) ES2208265T3 (hu)
HK (1) HK1041485B (hu)
HR (1) HRP20010514B1 (hu)
HU (1) HU227401B1 (hu)
IL (2) IL143634A0 (hu)
MY (1) MY122755A (hu)
NO (1) NO319823B1 (hu)
NZ (1) NZ513528A (hu)
PE (1) PE20001362A1 (hu)
PL (1) PL211829B1 (hu)
PT (1) PT1144386E (hu)
RS (1) RS50044B (hu)
SA (1) SA99200838B1 (hu)
SK (1) SK285429B6 (hu)
TR (1) TR200102074T2 (hu)
TW (1) TWI280241B (hu)
UA (1) UA56358C2 (hu)
UY (1) UY25980A1 (hu)
WO (1) WO2000043370A1 (hu)
ZA (1) ZA200104771B (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153737A1 (de) * 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US6737432B2 (en) 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
MXPA04006997A (es) 2002-01-16 2004-12-07 Boehringer Ingelheim Pharma Comprimido farmaceutico de dos capas que comprende telmisartan y un diuretico y su preparacion.
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) * 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
CN101039917A (zh) 2004-10-15 2007-09-19 特瓦制药工业有限公司 制备替米沙坦的方法
WO2006044754A2 (en) 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US8637078B2 (en) 2005-11-24 2014-01-28 Boehringer Ingelheim International Gmbh Bilayer tablet comprising telmisartan and diuretic
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
TW201109040A (en) 2009-05-20 2011-03-16 Boehringer Ingelheim Vetmed Oral suspension comprising telmisartan
SI2443094T1 (sl) 2009-06-19 2013-08-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo telmisartana
EP2277866A1 (en) 2009-06-22 2011-01-26 Inke, S.A. Process for preparing telmisartan
WO2011002425A2 (en) 2009-07-02 2011-01-06 Bilgig Mahmut Pharmaceutical composition increasing solubility and stability
WO2011002423A2 (en) 2009-07-02 2011-01-06 Mahmut Bilgic Solubility enhancing pharmaceutical composition
EP2632438A1 (en) 2010-10-27 2013-09-04 KRKA, tovarna zdravil, d.d., Novo mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
EP2612658A1 (en) 2012-01-05 2013-07-10 Laboratorios Lesvi, S.L. Pharmaceutical compositions of 4'-[(1,4'dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid and is 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法
EP2979691A1 (en) 2014-07-30 2016-02-03 Boehringer Ingelheim International GmbH Oral disintegrating tablet
JP6275596B2 (ja) * 2014-09-03 2018-02-07 株式会社トクヤマ テルミサルタンのアンモニウム塩の製造方法
JP5871294B1 (ja) 2015-02-27 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 即時放出経口錠剤
KR20170001921A (ko) 2015-06-26 2017-01-05 대원제약주식회사 안정성이 개선된 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
KR20170012703A (ko) 2015-07-22 2017-02-03 대원제약주식회사 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
JP6411662B2 (ja) 2016-05-30 2018-10-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 固定容量配合剤
KR102044223B1 (ko) * 2016-09-12 2019-11-13 성균관대학교산학협력단 텔미사르탄을 포함하는 고체 분산체 및 이의 제조방법
CN106749036B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-庚二酸共晶及其制备方法和应用
CN106749037B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-戊二酸共晶及其制备方法和应用
EA202090205A1 (ru) 2017-07-07 2020-06-02 Бёрингер Ингельхайм Ветмедика Гмбх Антагонист рецептора ангиотензина ii для предотвращения или лечения системных заболеваний у котов
CN109851562A (zh) * 2019-01-30 2019-06-07 浙江省食品药品检验研究院 一种替米沙坦晶体及其制备方法
WO2023001880A1 (en) 2021-07-22 2023-01-26 Krka, D. D., Novo Mesto Bilayer tablet comprising telmisartan and indapamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5139114A (en) * 1991-03-18 1992-08-18 Abex Corporation Visible brake block wear indicator

Also Published As

Publication number Publication date
EA200100730A1 (ru) 2002-02-28
HK1041485A1 (en) 2002-07-12
DE19901921A1 (de) 2000-08-03
BG65027B1 (bg) 2006-12-29
BG105654A (en) 2002-01-31
KR100658959B1 (ko) 2006-12-19
EA003065B1 (ru) 2002-12-26
DE50004150D1 (de) 2003-11-27
ZA200104771B (en) 2002-12-02
ES2208265T3 (es) 2004-06-16
HK1041485B (zh) 2004-10-08
TR200102074T2 (tr) 2001-12-21
SA99200838B1 (ar) 2006-03-06
SK285429B6 (sk) 2007-01-04
ATE252564T1 (de) 2003-11-15
CN1336920A (zh) 2002-02-20
NO319823B1 (no) 2005-09-19
PE20001362A1 (es) 2000-12-15
UA56358C2 (uk) 2003-05-15
JP2002535315A (ja) 2002-10-22
CA2352436A1 (en) 2000-07-27
UY25980A1 (es) 2001-08-27
JP4700813B2 (ja) 2011-06-15
AU2288100A (en) 2000-08-07
EE200100375A (et) 2002-10-15
AR035475A1 (es) 2004-06-02
WO2000043370A1 (de) 2000-07-27
EP1144386B1 (de) 2003-10-22
HRP20010514B1 (en) 2010-01-31
PL349425A1 (en) 2002-07-29
EP1144386A1 (de) 2001-10-17
DE19901921C2 (de) 2001-01-04
CA2352436C (en) 2010-03-23
RS50044B (sr) 2008-11-28
CZ20012634A3 (cs) 2001-10-17
KR20010101552A (ko) 2001-11-14
BR0007584A (pt) 2001-11-06
HU227401B1 (en) 2011-05-30
CO5150238A1 (es) 2002-04-29
MY122755A (en) 2006-05-31
CZ297412B6 (cs) 2006-12-13
TWI280241B (en) 2007-05-01
NZ513528A (en) 2003-08-29
PT1144386E (pt) 2004-03-31
HRP20010514A2 (en) 2002-08-31
EE04344B1 (et) 2004-08-16
AU765081B2 (en) 2003-09-11
PL211829B1 (pl) 2012-06-29
IL143634A0 (en) 2002-04-21
YU51101A (sh) 2004-05-12
IL143634A (en) 2006-10-05
DK1144386T3 (da) 2004-01-12
CN1144790C (zh) 2004-04-07
SK10202001A3 (sk) 2001-12-03
NO20013560D0 (no) 2001-07-18
HUP0105148A3 (en) 2003-01-28
NO20013560L (no) 2001-09-18

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees