EE04344B1 - Telmisartaani polümorfid, meetodid nende valmistamiseks ja nende kasutamine ravimi valmistamiseks - Google Patents

Telmisartaani polümorfid, meetodid nende valmistamiseks ja nende kasutamine ravimi valmistamiseks

Info

Publication number
EE04344B1
EE04344B1 EEP200100375A EEP200100375A EE04344B1 EE 04344 B1 EE04344 B1 EE 04344B1 EE P200100375 A EEP200100375 A EE P200100375A EE P200100375 A EEP200100375 A EE P200100375A EE 04344 B1 EE04344 B1 EE 04344B1
Authority
EE
Estonia
Prior art keywords
preparation
medicament
methods
telmisartan
polymorphs
Prior art date
Application number
EEP200100375A
Other languages
English (en)
Estonian (et)
Inventor
Schneider Heinrich
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of EE200100375A publication Critical patent/EE200100375A/xx
Publication of EE04344B1 publication Critical patent/EE04344B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
EEP200100375A 1999-01-19 2000-01-07 Telmisartaani polümorfid, meetodid nende valmistamiseks ja nende kasutamine ravimi valmistamiseks EE04344B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19901921A DE19901921C2 (de) 1999-01-19 1999-01-19 Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
PCT/EP2000/000065 WO2000043370A1 (de) 1999-01-19 2000-01-07 Polymorphe von telmisartan, verfahren zu deren herstellung und deren verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number Publication Date
EE200100375A EE200100375A (et) 2002-10-15
EE04344B1 true EE04344B1 (et) 2004-08-16

Family

ID=7894715

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100375A EE04344B1 (et) 1999-01-19 2000-01-07 Telmisartaani polümorfid, meetodid nende valmistamiseks ja nende kasutamine ravimi valmistamiseks

Country Status (36)

Country Link
EP (1) EP1144386B1 (hu)
JP (1) JP4700813B2 (hu)
KR (1) KR100658959B1 (hu)
CN (1) CN1144790C (hu)
AR (1) AR035475A1 (hu)
AT (1) ATE252564T1 (hu)
AU (1) AU765081B2 (hu)
BG (1) BG65027B1 (hu)
BR (1) BR0007584A (hu)
CA (1) CA2352436C (hu)
CO (1) CO5150238A1 (hu)
CZ (1) CZ297412B6 (hu)
DE (2) DE19901921C2 (hu)
DK (1) DK1144386T3 (hu)
EA (1) EA003065B1 (hu)
EE (1) EE04344B1 (hu)
ES (1) ES2208265T3 (hu)
HK (1) HK1041485B (hu)
HR (1) HRP20010514B1 (hu)
HU (1) HU227401B1 (hu)
IL (2) IL143634A0 (hu)
MY (1) MY122755A (hu)
NO (1) NO319823B1 (hu)
NZ (1) NZ513528A (hu)
PE (1) PE20001362A1 (hu)
PL (1) PL211829B1 (hu)
PT (1) PT1144386E (hu)
RS (1) RS50044B (hu)
SA (1) SA99200838B1 (hu)
SK (1) SK285429B6 (hu)
TR (1) TR200102074T2 (hu)
TW (1) TWI280241B (hu)
UA (1) UA56358C2 (hu)
UY (1) UY25980A1 (hu)
WO (1) WO2000043370A1 (hu)
ZA (1) ZA200104771B (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737432B2 (en) 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
DE10153737A1 (de) * 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DK1467712T4 (da) * 2002-01-16 2011-11-21 Boehringer Ingelheim Pharma Fremgangsmåde til at fremstille en tolags farmaceutisk tablet omfattende telmisartan og hydrochlorthiazid
DE10314702A1 (de) 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) * 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
MX2007004426A (es) 2004-10-15 2007-06-14 Teva Pharma Procesos para preparar telmisartan.
EP1805146A4 (en) 2004-10-18 2009-01-14 Reddys Lab Ltd Dr PROCESS FOR THE PREPARATION OF TELMISARTAN
US8637078B2 (en) 2005-11-24 2014-01-28 Boehringer Ingelheim International Gmbh Bilayer tablet comprising telmisartan and diuretic
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
ES2598490T3 (es) 2009-05-20 2017-01-27 Boehringer Ingelheim Vetmedica Gmbh Disolución farmacéutica bebible de telmisartán
WO2010146187A2 (en) 2009-06-19 2010-12-23 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of telmisartan
EP2277866A1 (en) 2009-06-22 2011-01-26 Inke, S.A. Process for preparing telmisartan
EP2448575A2 (en) 2009-07-02 2012-05-09 Bilgic Mahmut Pharmaceutical composition increasing solubility and stability
EP2448576A2 (en) 2009-07-02 2012-05-09 Mahmut Bilgic Solubility enhancing pharmaceutical composition
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
EP2612658A1 (en) 2012-01-05 2013-07-10 Laboratorios Lesvi, S.L. Pharmaceutical compositions of 4'-[(1,4'dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid and is 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法
EP2979691A1 (en) 2014-07-30 2016-02-03 Boehringer Ingelheim International GmbH Oral disintegrating tablet
JP6275596B2 (ja) * 2014-09-03 2018-02-07 株式会社トクヤマ テルミサルタンのアンモニウム塩の製造方法
JP5871294B1 (ja) 2015-02-27 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 即時放出経口錠剤
KR20170001921A (ko) 2015-06-26 2017-01-05 대원제약주식회사 안정성이 개선된 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
KR20170012703A (ko) 2015-07-22 2017-02-03 대원제약주식회사 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
EP3463309B1 (en) 2016-05-30 2020-06-17 Boehringer Ingelheim International GmbH Fixed dose combination of telmisartan, hydrochlorothiazide and amlodipine
KR102044223B1 (ko) * 2016-09-12 2019-11-13 성균관대학교산학협력단 텔미사르탄을 포함하는 고체 분산체 및 이의 제조방법
CN106749036B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-庚二酸共晶及其制备方法和应用
CN106749037B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-戊二酸共晶及其制备方法和应用
CN110785168A (zh) 2017-07-07 2020-02-11 勃林格殷格翰动物保健有限公司 用于预防或治疗猫的全身性疾病的血管收缩素ii受体拮抗剂
CN109851562A (zh) * 2019-01-30 2019-06-07 浙江省食品药品检验研究院 一种替米沙坦晶体及其制备方法
WO2023001880A1 (en) 2021-07-22 2023-01-26 Krka, D. D., Novo Mesto Bilayer tablet comprising telmisartan and indapamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5139114A (en) * 1991-03-18 1992-08-18 Abex Corporation Visible brake block wear indicator

Also Published As

Publication number Publication date
CZ297412B6 (cs) 2006-12-13
PL349425A1 (en) 2002-07-29
ES2208265T3 (es) 2004-06-16
NO319823B1 (no) 2005-09-19
BG105654A (en) 2002-01-31
AR035475A1 (es) 2004-06-02
HRP20010514A2 (en) 2002-08-31
RS50044B (sr) 2008-11-28
EP1144386A1 (de) 2001-10-17
HU227401B1 (en) 2011-05-30
NO20013560L (no) 2001-09-18
PT1144386E (pt) 2004-03-31
EE200100375A (et) 2002-10-15
EP1144386B1 (de) 2003-10-22
AU2288100A (en) 2000-08-07
ATE252564T1 (de) 2003-11-15
CA2352436C (en) 2010-03-23
EA200100730A1 (ru) 2002-02-28
HRP20010514B1 (en) 2010-01-31
HK1041485A1 (en) 2002-07-12
IL143634A (en) 2006-10-05
TWI280241B (en) 2007-05-01
DE19901921A1 (de) 2000-08-03
CA2352436A1 (en) 2000-07-27
JP2002535315A (ja) 2002-10-22
TR200102074T2 (tr) 2001-12-21
NZ513528A (en) 2003-08-29
DE50004150D1 (de) 2003-11-27
SA99200838B1 (ar) 2006-03-06
HUP0105148A3 (en) 2003-01-28
JP4700813B2 (ja) 2011-06-15
SK10202001A3 (sk) 2001-12-03
DK1144386T3 (da) 2004-01-12
PE20001362A1 (es) 2000-12-15
BG65027B1 (bg) 2006-12-29
CN1144790C (zh) 2004-04-07
KR20010101552A (ko) 2001-11-14
HUP0105148A2 (hu) 2002-07-29
ZA200104771B (en) 2002-12-02
YU51101A (sh) 2004-05-12
UA56358C2 (uk) 2003-05-15
HK1041485B (zh) 2004-10-08
NO20013560D0 (no) 2001-07-18
CZ20012634A3 (cs) 2001-10-17
EA003065B1 (ru) 2002-12-26
MY122755A (en) 2006-05-31
WO2000043370A1 (de) 2000-07-27
UY25980A1 (es) 2001-08-27
IL143634A0 (en) 2002-04-21
DE19901921C2 (de) 2001-01-04
CO5150238A1 (es) 2002-04-29
PL211829B1 (pl) 2012-06-29
AU765081B2 (en) 2003-09-11
SK285429B6 (sk) 2007-01-04
BR0007584A (pt) 2001-11-06
KR100658959B1 (ko) 2006-12-19
CN1336920A (zh) 2002-02-20

Similar Documents

Publication Publication Date Title
EE04344B1 (et) Telmisartaani polümorfid, meetodid nende valmistamiseks ja nende kasutamine ravimi valmistamiseks
EE200100431A (et) 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
EE04565B1 (et) Adamantaani derivaadid, nende saamine ja kasutamine
EE200300048A (et) Bensimidasooli derivaadid, nende valmistamine ja terapeutiline kasutamine
EE04236B1 (et) Bensimidasoolid, nende valmistamine ja kasutamineravimitena
EE200200064A (et) Arüülmetüülkarbonüülaminotiasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena
EE04497B1 (et) Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine
EE200100684A (et) Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
NO2013004I2 (no) Axitinib, valgfritt i form av et farmasøytisk aksentabelt salt
EE200200602A (et) Pikatoimelised beetamimeetikumid, meetod nende valmistamiseks ja nende kasutamine ravimitena
EE04151B1 (et) Atsüülpiperasinüülpürimidiinide derivaadid, nendevalmistamine ja kasutamine ravimitena
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE05000B1 (et) 2'-asendatud 1,1'-bifenüül-2-karboksamiidid, nende kasutamine ja farmatseutilised preparaadid
NO20015149D0 (no) Nytt farmasöytisk preparat
EE200100422A (et) Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine
NO20015148L (no) Nytt farmasöytisk preparat
EE200100615A (et) Mikrograanul, selle valmistamismeetod ja farmatseutiline preparaat
HUP0201810A3 (en) Sootepenseone and its derivatives, their preparation and use as medicament
NO20015104D0 (no) Nytt farmasöytisk preparat
EE04837B1 (et) Ehhinokandiini derivaadid, nende valmistamismeetod ja kasutamine antimükootikumidena
NO20015105D0 (no) Nytt farmasöytisk preparat
FI991396A0 (fi) 5-substituoidut 3-hydroksibentsoaatit, menetelmä niiden valmistamiseksi ja niiden käyttö
IT1312082B1 (it) Derivati morfinoidi, procedimento per la loro preparzione e loroimpiego terapeutico.
SI1309594T1 (en) Benzimidazole derivatives, preparation and therapeutic use thereof
IT246525Y1 (it) Manufatto composito perfezionato per impiego in edilizia

Legal Events

Date Code Title Description
HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20150107