HUP0102567A2 - Rezolválási eljárás R-(-)-2-hidroxi-2-(2-klór-fenil)-ecetsav előállítására - Google Patents

Rezolválási eljárás R-(-)-2-hidroxi-2-(2-klór-fenil)-ecetsav előállítására

Info

Publication number
HUP0102567A2
HUP0102567A2 HU0102567A HUP0102567A HUP0102567A2 HU P0102567 A2 HUP0102567 A2 HU P0102567A2 HU 0102567 A HU0102567 A HU 0102567A HU P0102567 A HUP0102567 A HU P0102567A HU P0102567 A2 HUP0102567 A2 HU P0102567A2
Authority
HU
Hungary
Prior art keywords
group
chlorophenyl
hydroxy
acetic acid
producing
Prior art date
Application number
HU0102567A
Other languages
English (en)
Inventor
József Bálint
Zsolt Dombrády
Elemér Fogassy
Nagy Marianna Csatáriné
Charles Suba
Antal Gajáry
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU0102567A priority Critical patent/HU230004B1/hu
Priority to MXPA03011647A priority patent/MXPA03011647A/es
Priority to AT02738416T priority patent/ATE487688T1/de
Priority to SI200230930T priority patent/SI1397335T1/sl
Priority to BR0210512-8A priority patent/BR0210512A/pt
Priority to PL369004A priority patent/PL204820B1/pl
Priority to CA2450490A priority patent/CA2450490C/en
Priority to SK1534-2003A priority patent/SK287975B6/sk
Priority to ES02738416T priority patent/ES2354869T3/es
Priority to JP2003506842A priority patent/JP4184260B2/ja
Priority to DK02738416.3T priority patent/DK1397335T3/da
Priority to DE60238251T priority patent/DE60238251D1/de
Priority to HU0401404A priority patent/HU229402B1/hu
Priority to CZ2004-102A priority patent/CZ305524B6/cs
Priority to CN02812348.4A priority patent/CN1276907C/zh
Priority to EP02738416A priority patent/EP1397335B1/en
Priority to PCT/HU2002/000054 priority patent/WO2003000636A1/en
Priority to US10/480,562 priority patent/US7381835B2/en
Priority to PT02738416T priority patent/PT1397335E/pt
Priority to HR20040057A priority patent/HRP20040057B1/xx
Publication of HUP0102567A2 publication Critical patent/HUP0102567A2/hu
Priority to CY20111100081T priority patent/CY1111606T1/el
Publication of HU230004B1 publication Critical patent/HU230004B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C07C215/36—1-Aryl-2-amino-1,3-propane diols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

A jelen találmány tárgyát az (I) képletű R-(-)-2-hidroxi-2-(2-klór-fenil)-ecetsav előállítása képezi a megfelelő racémmolekula (II)általános képletű aminokkal történő rezolválása útján. A (II)általános képletben R1 jelentése hidroxi-metil-csoport vagykarboxilcsoport, R2 jelentése fenilcsoport, nitro-fenil-csoport vagyaminocsoporttal szubsztituált C1-C4 alkilcsoport, R3 jelentésehidroxilcsoport vagy hidrogénatom. Ó
HU0102567A 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid HU230004B1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
DE60238251T DE60238251D1 (de) 2001-06-21 2002-06-14 Resolutionsverfahren zur herstellung von (r)-(-)-2-hydroxy-2-(2-chlorophenyl)acetischer saeure
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása
AT02738416T ATE487688T1 (de) 2001-06-21 2002-06-14 Resolutionsverfahren zur herstellung von (r)-(-)- 2-hydroxy-2-(2-chlorophenyl)acetischer saeure
BR0210512-8A BR0210512A (pt) 2001-06-21 2002-06-14 Processo de decomposição papa o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético
PL369004A PL204820B1 (pl) 2001-06-21 2002-06-14 Sposób wytwarzania kwasu (R)-(-)-2-hydroksy-2-(2-chlorofenylo)octowego oraz sole diastereoizomeryczne
CA2450490A CA2450490C (en) 2001-06-21 2002-06-14 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
SK1534-2003A SK287975B6 (sk) 2001-06-21 2002-06-14 Process for preparation of (R)-(-)-2-hydroxy-2-(2- chlorophenyl)acetic acid and its salt
ES02738416T ES2354869T3 (es) 2001-06-21 2002-06-14 Procedimiento de resolución para el ácido (r)-(-)-2-hidroxi-2-(2-clorofenil)acético.
CZ2004-102A CZ305524B6 (cs) 2001-06-21 2002-06-14 Způsob separace kyseliny (R)-(-)-2-hydroxy-2-(2-chlorfenyl) octové
DK02738416.3T DK1397335T3 (da) 2001-06-21 2002-06-14 Spaltningsfremgangsmåde til fremstilling af (r)-(-)-2-hydroxy-2-(2-chlorphenyl)eddikesyre
MXPA03011647A MXPA03011647A (es) 2001-06-21 2002-06-14 Procedimiento de resolucion para el acido ( r ) - (-) - 2-hidroxi - 2- (2 - clorofenil) acetico.
SI200230930T SI1397335T1 (sl) 2001-06-21 2002-06-14 Ločevalni postopek za (R)-(-)-2-(2-klorofenil)ocetno kislino
JP2003506842A JP4184260B2 (ja) 2001-06-21 2002-06-14 （ｒ）−（−）−２−ヒドロキシ−２−（２−クロロフェニル）酢酸の分割方法
CN02812348.4A CN1276907C (zh) 2001-06-21 2002-06-14 (r)－(－)－2－羟基－2－(2－氯苯基)乙酸的拆分方法
EP02738416A EP1397335B1 (en) 2001-06-21 2002-06-14 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid
PCT/HU2002/000054 WO2003000636A1 (en) 2001-06-21 2002-06-14 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
US10/480,562 US7381835B2 (en) 2001-06-21 2002-06-14 Resolution process for (R)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
PT02738416T PT1397335E (pt) 2001-06-21 2002-06-14 Processo de resolução para o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético
HR20040057A HRP20040057B1 (en) 2001-06-21 2004-01-20 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
CY20111100081T CY1111606T1 (el) 2001-06-21 2011-01-26 Διαδικασια διαχωρισμου για to (r)-(-)-2-yδροξy-2- (2-χλωροφαινυλ) οξικο οξυ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid

Publications (2)

Publication Number Publication Date
HUP0102567A2 true HUP0102567A2 (hu) 2005-03-29
HU230004B1 HU230004B1 (en) 2015-04-28

Family

ID=89979445

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Country Status (20)

Country Link
US (1) US7381835B2 (hu)
EP (1) EP1397335B1 (hu)
JP (1) JP4184260B2 (hu)
CN (1) CN1276907C (hu)
AT (1) ATE487688T1 (hu)
BR (1) BR0210512A (hu)
CA (1) CA2450490C (hu)
CY (1) CY1111606T1 (hu)
CZ (1) CZ305524B6 (hu)
DE (1) DE60238251D1 (hu)
DK (1) DK1397335T3 (hu)
ES (1) ES2354869T3 (hu)
HR (1) HRP20040057B1 (hu)
HU (2) HU230004B1 (hu)
MX (1) MXPA03011647A (hu)
PL (1) PL204820B1 (hu)
PT (1) PT1397335E (hu)
SI (1) SI1397335T1 (hu)
SK (1) SK287975B6 (hu)
WO (1) WO2003000636A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
CN101253271A (zh) * 2005-09-02 2008-08-27 第一精密化学株式会社 光学活性α-羟基羧酸的制造方法
CN102336653B (zh) * 2011-11-08 2014-04-30 广州市金匮贸易有限公司 光学纯手性邻氯扁桃酸的制备方法
CN102516002B (zh) * 2011-12-09 2014-04-02 中原工学院 一种光学纯α-羟基酸及其衍生物的制备工艺
EP3401929A1 (en) * 2017-05-09 2018-11-14 Borealis AG Cable insulation
CN109232220B (zh) * 2017-09-15 2021-09-10 上海健康医学院 一种3-羟基-3-苯基丙酸类化合物的化学拆分方法
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665657B2 (ja) 1984-11-08 1994-08-24 日本化薬株式会社 光学活性マンデル酸の製法
EP0306585B1 (en) 1987-09-10 1992-07-22 International Business Machines Corporation Data transmission system with a digital alarm facility
DE3814887C1 (hu) 1988-05-02 1989-09-21 Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De
US5380867A (en) 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
JPH10237013A (ja) 1996-12-28 1998-09-08 Fuji Yakuhin Kogyo Kk 光学活性２−ベンジルコハク酸の製造法
JP2002114737A (ja) 2000-10-11 2002-04-16 Japan Hydrazine Co Inc 光学活性ｏ−クロロマンデル酸の製造法

Also Published As

Publication number Publication date
EP1397335A1 (en) 2004-03-17
HRP20040057B1 (en) 2012-02-29
JP4184260B2 (ja) 2008-11-19
BR0210512A (pt) 2004-06-22
CN1547566A (zh) 2004-11-17
HUP0401404A2 (hu) 2004-11-29
CZ305524B6 (cs) 2015-11-18
EP1397335B1 (en) 2010-11-10
PL204820B1 (pl) 2010-02-26
WO2003000636A1 (en) 2003-01-03
HRP20040057A2 (en) 2004-08-31
PT1397335E (pt) 2011-01-20
HUP0401404A3 (en) 2005-02-28
US20040242921A1 (en) 2004-12-02
MXPA03011647A (es) 2004-07-01
CY1111606T1 (el) 2015-10-07
HU229402B1 (hu) 2013-12-30
CZ2004102A3 (cs) 2004-06-16
CA2450490A1 (en) 2003-01-03
CN1276907C (zh) 2006-09-27
PL369004A1 (en) 2005-04-18
JP2004530717A (ja) 2004-10-07
HU230004B1 (en) 2015-04-28
DK1397335T3 (da) 2011-02-28
CA2450490C (en) 2010-04-06
SI1397335T1 (sl) 2011-03-31
SK15342003A3 (sk) 2004-06-08
ATE487688T1 (de) 2010-11-15
SK287975B6 (sk) 2012-08-06
DE60238251D1 (de) 2010-12-23
ES2354869T3 (es) 2011-03-18
US7381835B2 (en) 2008-06-03

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