HRP20040057B1 - Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid - Google Patents
Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acidInfo
- Publication number
- HRP20040057B1 HRP20040057B1 HR20040057A HRP20040057A HRP20040057B1 HR P20040057 B1 HRP20040057 B1 HR P20040057B1 HR 20040057 A HR20040057 A HR 20040057A HR P20040057 A HRP20040057 A HR P20040057A HR P20040057 B1 HRP20040057 B1 HR P20040057B1
- Authority
- HR
- Croatia
- Prior art keywords
- chlorophenyl
- hydroxy
- acetic acid
- resolution process
- propanediol
- Prior art date
Links
- RWOLDZZTBNYTMS-SSDOTTSWSA-N (2r)-2-(2-chlorophenyl)-2-hydroxyacetic acid Chemical compound OC(=O)[C@H](O)C1=CC=CC=C1Cl RWOLDZZTBNYTMS-SSDOTTSWSA-N 0.000 title abstract 2
- JUCGVCVPNPBJIG-IUCAKERBSA-N (1s,2s)-2-amino-1-phenylpropane-1,3-diol Chemical compound OC[C@H](N)[C@@H](O)C1=CC=CC=C1 JUCGVCVPNPBJIG-IUCAKERBSA-N 0.000 abstract 1
- RWOLDZZTBNYTMS-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-hydroxyacetic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1Cl RWOLDZZTBNYTMS-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 229960003646 lysine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
- C07C215/36—1-Aryl-2-amino-1,3-propane diols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0102567A HU230004B1 (en) | 2001-06-21 | 2001-06-21 | Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid |
PCT/HU2002/000054 WO2003000636A1 (en) | 2001-06-21 | 2002-06-14 | Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20040057A2 HRP20040057A2 (en) | 2004-08-31 |
HRP20040057B1 true HRP20040057B1 (en) | 2012-02-29 |
Family
ID=89979445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20040057A HRP20040057B1 (en) | 2001-06-21 | 2004-01-20 | Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid |
Country Status (20)
Country | Link |
---|---|
US (1) | US7381835B2 (xx) |
EP (1) | EP1397335B1 (xx) |
JP (1) | JP4184260B2 (xx) |
CN (1) | CN1276907C (xx) |
AT (1) | ATE487688T1 (xx) |
BR (1) | BR0210512A (xx) |
CA (1) | CA2450490C (xx) |
CY (1) | CY1111606T1 (xx) |
CZ (1) | CZ305524B6 (xx) |
DE (1) | DE60238251D1 (xx) |
DK (1) | DK1397335T3 (xx) |
ES (1) | ES2354869T3 (xx) |
HR (1) | HRP20040057B1 (xx) |
HU (2) | HU230004B1 (xx) |
MX (1) | MXPA03011647A (xx) |
PL (1) | PL204820B1 (xx) |
PT (1) | PT1397335E (xx) |
SI (1) | SI1397335T1 (xx) |
SK (1) | SK287975B6 (xx) |
WO (1) | WO2003000636A1 (xx) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100678287B1 (ko) * | 2005-06-23 | 2007-02-02 | 한미약품 주식회사 | 클로피도그렐의 제조방법 및 이에 사용되는 중간체 |
CN101253271A (zh) * | 2005-09-02 | 2008-08-27 | 第一精密化学株式会社 | 光学活性α-羟基羧酸的制造方法 |
CN102336653B (zh) * | 2011-11-08 | 2014-04-30 | 广州市金匮贸易有限公司 | 光学纯手性邻氯扁桃酸的制备方法 |
CN102516002B (zh) * | 2011-12-09 | 2014-04-02 | 中原工学院 | 一种光学纯α-羟基酸及其衍生物的制备工艺 |
EP3401929A1 (en) * | 2017-05-09 | 2018-11-14 | Borealis AG | Cable insulation |
CN109232220B (zh) * | 2017-09-15 | 2021-09-10 | 上海健康医学院 | 一种3-羟基-3-苯基丙酸类化合物的化学拆分方法 |
CN110627808B (zh) * | 2018-06-21 | 2022-04-01 | 江苏同禾药业有限公司 | 一种硫酸氢氯吡格雷拆分母液的回收处理工艺 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114737A (ja) * | 2000-10-11 | 2002-04-16 | Japan Hydrazine Co Inc | 光学活性o−クロロマンデル酸の製造法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0665657B2 (ja) | 1984-11-08 | 1994-08-24 | 日本化薬株式会社 | 光学活性マンデル酸の製法 |
EP0306585B1 (en) | 1987-09-10 | 1992-07-22 | International Business Machines Corporation | Data transmission system with a digital alarm facility |
DE3814887C1 (xx) | 1988-05-02 | 1989-09-21 | Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De | |
US5380867A (en) | 1992-12-02 | 1995-01-10 | Hoechst Celanese Corporation | Selective precipitation of α-aryl carboxylic acid salts |
JPH10237013A (ja) | 1996-12-28 | 1998-09-08 | Fuji Yakuhin Kogyo Kk | 光学活性2−ベンジルコハク酸の製造法 |
-
2001
- 2001-06-21 HU HU0102567A patent/HU230004B1/hu unknown
-
2002
- 2002-06-14 US US10/480,562 patent/US7381835B2/en not_active Expired - Lifetime
- 2002-06-14 MX MXPA03011647A patent/MXPA03011647A/es active IP Right Grant
- 2002-06-14 CZ CZ2004-102A patent/CZ305524B6/cs not_active IP Right Cessation
- 2002-06-14 SI SI200230930T patent/SI1397335T1/sl unknown
- 2002-06-14 EP EP02738416A patent/EP1397335B1/en not_active Expired - Lifetime
- 2002-06-14 JP JP2003506842A patent/JP4184260B2/ja not_active Expired - Lifetime
- 2002-06-14 DK DK02738416.3T patent/DK1397335T3/da active
- 2002-06-14 WO PCT/HU2002/000054 patent/WO2003000636A1/en active Application Filing
- 2002-06-14 PL PL369004A patent/PL204820B1/pl unknown
- 2002-06-14 HU HU0401404A patent/HU229402B1/hu not_active IP Right Cessation
- 2002-06-14 CA CA2450490A patent/CA2450490C/en not_active Expired - Lifetime
- 2002-06-14 CN CN02812348.4A patent/CN1276907C/zh not_active Expired - Lifetime
- 2002-06-14 ES ES02738416T patent/ES2354869T3/es not_active Expired - Lifetime
- 2002-06-14 SK SK1534-2003A patent/SK287975B6/sk not_active IP Right Cessation
- 2002-06-14 DE DE60238251T patent/DE60238251D1/de not_active Expired - Lifetime
- 2002-06-14 PT PT02738416T patent/PT1397335E/pt unknown
- 2002-06-14 AT AT02738416T patent/ATE487688T1/de active
- 2002-06-14 BR BR0210512-8A patent/BR0210512A/pt not_active Application Discontinuation
-
2004
- 2004-01-20 HR HR20040057A patent/HRP20040057B1/xx not_active IP Right Cessation
-
2011
- 2011-01-26 CY CY20111100081T patent/CY1111606T1/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114737A (ja) * | 2000-10-11 | 2002-04-16 | Japan Hydrazine Co Inc | 光学活性o−クロロマンデル酸の製造法 |
Also Published As
Publication number | Publication date |
---|---|
EP1397335A1 (en) | 2004-03-17 |
JP4184260B2 (ja) | 2008-11-19 |
BR0210512A (pt) | 2004-06-22 |
CN1547566A (zh) | 2004-11-17 |
HUP0401404A2 (hu) | 2004-11-29 |
CZ305524B6 (cs) | 2015-11-18 |
EP1397335B1 (en) | 2010-11-10 |
PL204820B1 (pl) | 2010-02-26 |
WO2003000636A1 (en) | 2003-01-03 |
HRP20040057A2 (en) | 2004-08-31 |
PT1397335E (pt) | 2011-01-20 |
HUP0401404A3 (en) | 2005-02-28 |
US20040242921A1 (en) | 2004-12-02 |
MXPA03011647A (es) | 2004-07-01 |
CY1111606T1 (el) | 2015-10-07 |
HU229402B1 (hu) | 2013-12-30 |
CZ2004102A3 (cs) | 2004-06-16 |
CA2450490A1 (en) | 2003-01-03 |
CN1276907C (zh) | 2006-09-27 |
PL369004A1 (en) | 2005-04-18 |
JP2004530717A (ja) | 2004-10-07 |
HU230004B1 (en) | 2015-04-28 |
DK1397335T3 (da) | 2011-02-28 |
CA2450490C (en) | 2010-04-06 |
SI1397335T1 (sl) | 2011-03-31 |
SK15342003A3 (sk) | 2004-06-08 |
ATE487688T1 (de) | 2010-11-15 |
SK287975B6 (sk) | 2012-08-06 |
DE60238251D1 (de) | 2010-12-23 |
ES2354869T3 (es) | 2011-03-18 |
US7381835B2 (en) | 2008-06-03 |
HUP0102567A2 (hu) | 2005-03-29 |
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Owner name: SANOFI-AVENTIS, FR |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20190506 Year of fee payment: 18 |
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