HUP0401404A2 - (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása - Google Patents

(R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Info

Publication number
HUP0401404A2
HUP0401404A2 HU0401404A HUP0401404A HUP0401404A2 HU P0401404 A2 HUP0401404 A2 HU P0401404A2 HU 0401404 A HU0401404 A HU 0401404A HU P0401404 A HUP0401404 A HU P0401404A HU P0401404 A2 HUP0401404 A2 HU P0401404A2
Authority
HU
Hungary
Prior art keywords
hydroxy
chlorophenyl
acetic acid
resolution process
amino
Prior art date
Application number
HU0401404A
Other languages
English (en)
Inventor
József Bálint
Nagy Marianna Csatáriné
Zsolt Dombrády
Elemér Fogassy
Antal Gajáry
Charles Suba
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU0401404A priority Critical patent/HU229402B1/hu
Publication of HUP0401404A2 publication Critical patent/HUP0401404A2/hu
Publication of HUP0401404A3 publication Critical patent/HUP0401404A3/hu
Publication of HU229402B1 publication Critical patent/HU229402B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C07C215/36—1-Aryl-2-amino-1,3-propane diols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

A jelen találmány tárgya az (I) képletű (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav előállítása a megfelelő racémvegyületből a (II)általános képletű vegyületek használatával. A (II) általános képletbenR1 jelentése hidroxi-metil-csoport vagy karboxilcsoport, R2 jelentésefenilcsoport, nitro-fenil-csoport vagy aminocsoporttal alkalmazott C1-C4 alkilcsoport, R3 jelentése hidroxilcsoport vagy hidrogénatom. Ó
HU0401404A 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása HU229402B1 (hu)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
PCT/HU2002/000054 WO2003000636A1 (en) 2001-06-21 2002-06-14 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Publications (3)

Publication Number Publication Date
HUP0401404A2 true HUP0401404A2 (hu) 2004-11-29
HUP0401404A3 HUP0401404A3 (en) 2005-02-28
HU229402B1 HU229402B1 (hu) 2013-12-30

Family

ID=89979445

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
HU0401404A HU229402B1 (hu) 2001-06-21 2002-06-14 (R)-(-)-2-hidroxi-2-(2-klórfenil)-ecetsav rezolválási eljárása

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0102567A HU230004B1 (en) 2001-06-21 2001-06-21 Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid

Country Status (20)

Country Link
US (1) US7381835B2 (hu)
EP (1) EP1397335B1 (hu)
JP (1) JP4184260B2 (hu)
CN (1) CN1276907C (hu)
AT (1) ATE487688T1 (hu)
BR (1) BR0210512A (hu)
CA (1) CA2450490C (hu)
CY (1) CY1111606T1 (hu)
CZ (1) CZ305524B6 (hu)
DE (1) DE60238251D1 (hu)
DK (1) DK1397335T3 (hu)
ES (1) ES2354869T3 (hu)
HR (1) HRP20040057B1 (hu)
HU (2) HU230004B1 (hu)
MX (1) MXPA03011647A (hu)
PL (1) PL204820B1 (hu)
PT (1) PT1397335E (hu)
SI (1) SI1397335T1 (hu)
SK (1) SK287975B6 (hu)
WO (1) WO2003000636A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
CN101253271A (zh) * 2005-09-02 2008-08-27 第一精密化学株式会社 光学活性α-羟基羧酸的制造方法
CN102336653B (zh) * 2011-11-08 2014-04-30 广州市金匮贸易有限公司 光学纯手性邻氯扁桃酸的制备方法
CN102516002B (zh) * 2011-12-09 2014-04-02 中原工学院 一种光学纯α-羟基酸及其衍生物的制备工艺
EP3401929A1 (en) * 2017-05-09 2018-11-14 Borealis AG Cable insulation
CN109232220B (zh) * 2017-09-15 2021-09-10 上海健康医学院 一种3-羟基-3-苯基丙酸类化合物的化学拆分方法
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665657B2 (ja) 1984-11-08 1994-08-24 日本化薬株式会社 光学活性マンデル酸の製法
EP0306585B1 (en) 1987-09-10 1992-07-22 International Business Machines Corporation Data transmission system with a digital alarm facility
DE3814887C1 (hu) 1988-05-02 1989-09-21 Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De
US5380867A (en) 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
JPH10237013A (ja) 1996-12-28 1998-09-08 Fuji Yakuhin Kogyo Kk 光学活性２−ベンジルコハク酸の製造法
JP2002114737A (ja) 2000-10-11 2002-04-16 Japan Hydrazine Co Inc 光学活性ｏ−クロロマンデル酸の製造法

Also Published As

Publication number Publication date
EP1397335A1 (en) 2004-03-17
HRP20040057B1 (en) 2012-02-29
JP4184260B2 (ja) 2008-11-19
BR0210512A (pt) 2004-06-22
CN1547566A (zh) 2004-11-17
CZ305524B6 (cs) 2015-11-18
EP1397335B1 (en) 2010-11-10
PL204820B1 (pl) 2010-02-26
WO2003000636A1 (en) 2003-01-03
HRP20040057A2 (en) 2004-08-31
PT1397335E (pt) 2011-01-20
HUP0401404A3 (en) 2005-02-28
US20040242921A1 (en) 2004-12-02
MXPA03011647A (es) 2004-07-01
CY1111606T1 (el) 2015-10-07
HU229402B1 (hu) 2013-12-30
CZ2004102A3 (cs) 2004-06-16
CA2450490A1 (en) 2003-01-03
CN1276907C (zh) 2006-09-27
PL369004A1 (en) 2005-04-18
JP2004530717A (ja) 2004-10-07
HU230004B1 (en) 2015-04-28
DK1397335T3 (da) 2011-02-28
CA2450490C (en) 2010-04-06
SI1397335T1 (sl) 2011-03-31
SK15342003A3 (sk) 2004-06-08
ATE487688T1 (de) 2010-11-15
SK287975B6 (sk) 2012-08-06
DE60238251D1 (de) 2010-12-23
ES2354869T3 (es) 2011-03-18
US7381835B2 (en) 2008-06-03
HUP0102567A2 (hu) 2005-03-29

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees