HUP0401189A2 - Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401189A2
HUP0401189A2 HU0401189A HUP0401189A HUP0401189A2 HU P0401189 A2 HUP0401189 A2 HU P0401189A2 HU 0401189 A HU0401189 A HU 0401189A HU P0401189 A HUP0401189 A HU P0401189A HU P0401189 A2 HUP0401189 A2 HU P0401189A2
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HU
Hungary
Prior art keywords
alkyl
group
aryl
formula
thrombin inhibitors
Prior art date
Application number
HU0401189A
Other languages
English (en)
Inventor
Tord Inghardt
Anders Johansson
Arne Svensson
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0102921A external-priority patent/SE0102921D0/xx
Priority claimed from PCT/SE2001/002657 external-priority patent/WO2002044145A1/en
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0401189A2 publication Critical patent/HUP0401189A2/hu

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

A találmány az (I) képletű vegyületre és gyógyászatilag alkalmazhatószármazékaira (köztük előgyógyszer-származékaira) vonatkozik, amelyektrombin-inhibitorokként alkalmazhatók. Az (I) képletű vegyületgyógyászatilag alkalmazható származékai közé tartoznak az (la)általános képletű vegyületek - a képletben R1 -OR2 vagy -C(O)OR3általános képletű csoportot jelent, és az utóbbiakban R2hidrogénatomot, 1-10 szénatomos alkilcsoportot, vagy az alkilláncbanadott esetben egy vagy több oxigénatommal megszakított (1-3 szénatomosalkil)-aril- vagy (1-3 szénatomos alkil)-oxi-aril-csoportot jelent,amelyekben az arilcsoport adott esetben szubsztituálva lehet; és R3adott esetben egy vagy több oxigénatommal megszakított 1-10 szénatomosalkilcsoportot jelent, vagy az alkilláncban adott esetben egy vagytöbb oxigénatommal megszakított és az arilcsoporton adott esetbenszubsztituált (1-3 szénatomos alkil)-aril- vagy (1-3 szénatomosalkil)-oxi-aril-csoportot képvisel. A találmány kiterjed a vegyületekelőállítási eljárására és ezeket tartalmazó gyógyszerkészítményekre. Ó
HU0401189A 2001-08-30 2002-08-30 Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0401189A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102921A SE0102921D0 (sv) 2001-08-30 2001-08-30 Pharmaceutically useful compounds
PCT/SE2001/002657 WO2002044145A1 (en) 2000-12-01 2001-11-30 New mandelic acid derivatives and their use as throbin inhibitors
PCT/SE2002/001557 WO2003018551A1 (en) 2001-08-30 2002-08-30 New mandelic acid derivatives and their use as thrombin inhibitors

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HUP0401189A2 true HUP0401189A2 (hu) 2004-12-28

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HU0401189A HUP0401189A2 (hu) 2001-08-30 2002-08-30 Új mandulasavszármazékok és felhasználásuk trombin inhibitorokként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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EP (1) EP1423362B1 (hu)
JP (1) JP4386724B2 (hu)
CN (1) CN1301969C (hu)
AT (1) ATE435201T1 (hu)
AU (1) AU2002324410B2 (hu)
BR (1) BR0211847A (hu)
CA (1) CA2456426C (hu)
DE (1) DE60232802D1 (hu)
ES (1) ES2326963T3 (hu)
HU (1) HUP0401189A2 (hu)
IL (1) IL160068A0 (hu)
IS (1) IS7162A (hu)
NO (1) NO326496B1 (hu)
NZ (1) NZ531109A (hu)
PL (1) PL369325A1 (hu)
RU (1) RU2341516C2 (hu)
UA (1) UA78195C2 (hu)
UY (1) UY27425A1 (hu)
WO (1) WO2003018551A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
GB0503672D0 (en) * 2005-02-23 2005-03-30 Astrazeneca Ab New process
WO2008135525A2 (en) * 2007-05-02 2008-11-13 Boehringer Ingelheim International Gmbh Substituted azetidines, manufacturing and use thereof as medicaments
AR072278A1 (es) * 2008-06-23 2010-08-18 Astrazeneca Ab Compuestos inhibidores de trombina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AU764121B2 (en) * 1999-01-13 2003-08-07 Astrazeneca Ab New amidinobenzylamine derivatives and their use as thrombin inhibitors

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NO20040813L (no) 2004-02-24
CN1549808A (zh) 2004-11-24
CN1301969C (zh) 2007-02-28
EP1423362A1 (en) 2004-06-02
CA2456426A1 (en) 2003-03-06
WO2003018551A1 (en) 2003-03-06
ES2326963T3 (es) 2009-10-22
PL369325A1 (en) 2005-04-18
NZ531109A (en) 2006-03-31
EP1423362B1 (en) 2009-07-01
UA78195C2 (uk) 2007-03-15
JP4386724B2 (ja) 2009-12-16
RU2341516C2 (ru) 2008-12-20
AU2002324410B2 (en) 2008-04-24
BR0211847A (pt) 2004-09-08
RU2004103625A (ru) 2005-06-20
IS7162A (is) 2004-02-26
UY27425A1 (es) 2003-03-31
JP2005504057A (ja) 2005-02-10
IL160068A0 (en) 2004-06-20
ATE435201T1 (de) 2009-07-15
CA2456426C (en) 2011-01-11
DE60232802D1 (de) 2009-08-13
NO326496B1 (no) 2008-12-15

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