BRPI0417145A - amidas de ácido delta-amina-gama-hidróxi-Èmega-aril-alcanóico e uso como inibidores de renina - Google Patents
amidas de ácido delta-amina-gama-hidróxi-Èmega-aril-alcanóico e uso como inibidores de reninaInfo
- Publication number
- BRPI0417145A BRPI0417145A BRPI0417145-4A BRPI0417145A BRPI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxy
- amine
- acid amides
- delta
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"AMIDAS DE áCIDO DELTA-AMINA-GAMA-HIDRóXI-ÈMEGA-ARIL-ALCANóICO E USO COMO INIBIDORES DE RENINA". A presente invenção refere-se a novas amidas de ácido <sym>-amina<sym>-hidróxi-<sym>-arila alcanóico da fórmula (I) ou um sal do mesmo farmaceuticamente aceitável.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0327839.7A GB0327839D0 (en) | 2003-12-01 | 2003-12-01 | Organic compounds |
PCT/EP2004/013589 WO2005054177A1 (en) | 2003-12-01 | 2004-11-30 | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides and use as renin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417145A true BRPI0417145A (pt) | 2007-03-06 |
Family
ID=29798109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417145-4A BRPI0417145A (pt) | 2003-12-01 | 2004-11-30 | amidas de ácido delta-amina-gama-hidróxi-Èmega-aril-alcanóico e uso como inibidores de renina |
Country Status (11)
Country | Link |
---|---|
US (1) | US20070142475A1 (pt) |
EP (1) | EP1692095A1 (pt) |
JP (1) | JP2007512382A (pt) |
KR (1) | KR20060121119A (pt) |
CN (1) | CN1914153B (pt) |
AU (1) | AU2004295093B2 (pt) |
BR (1) | BRPI0417145A (pt) |
CA (1) | CA2546682A1 (pt) |
GB (1) | GB0327839D0 (pt) |
RU (1) | RU2425027C2 (pt) |
WO (1) | WO2005054177A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008515903A (ja) * | 2004-10-08 | 2008-05-15 | ノバルティス アクチエンゲゼルシャフト | 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用 |
GB2431641A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
GB2431653A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
EP1911762A1 (en) * | 2006-10-04 | 2008-04-16 | Speedel Experimenta AG | Amino alcohols and their use as renin inhibitors |
US20100137403A1 (en) * | 2008-07-10 | 2010-06-03 | Scott Malstrom | Method for enhancing cognition or inhibiting cognitive decline |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
US4559332A (en) | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
CA2018438C (en) | 1989-06-14 | 2000-08-08 | Joseph Alan Finkelstein | Imidazolyl-alkenoic acids |
FR2652087B1 (fr) | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
IL96942A (en) * | 1990-01-31 | 1995-01-24 | Abbott Lab | A pharmaceutical mixture containing a history of amide prevents renin |
DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
PT97078B (pt) | 1990-03-20 | 1997-07-31 | Sanofi Sa | Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem |
US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
IE920540A1 (en) | 1991-02-21 | 1992-08-26 | Sankyo Co | 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
DE4121975A1 (de) | 1991-07-03 | 1993-01-07 | Basf Ag | Thermoplastische formmassen auf der basis von polycarbonaten, styrol/acrylnitril-polymerisaten und polyolefinen |
JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
TW226375B (pt) | 1991-10-24 | 1994-07-11 | American Home Prod | |
JPH06199891A (ja) * | 1992-09-18 | 1994-07-19 | Japan Tobacco Inc | レニン阻害活性を有するアルコール誘導体及びその用途 |
NZ266314A (en) | 1993-04-27 | 1998-10-28 | Smithkline Beecham Corp | Various indane-2-carboxylic acid derivatives substituted by (hetero)aryl-containing moieties and various other indane derivatives as endothelian receptor antagonists and pharmaceutical compositions |
US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
AU675870B2 (en) | 1993-08-18 | 1997-02-20 | Msd K.K. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
US5659065A (en) * | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
ATE219077T1 (de) | 1994-08-19 | 2002-06-15 | Abbott Lab | Endothelin antagoniste |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
TW313568B (pt) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
WO1997022595A1 (fr) | 1995-12-20 | 1997-06-26 | Yamanouchi Pharmaceutical Co., Ltd. | Derives arylethenesulfonamide et composition de medicaments renfermant ces derives |
IT1277737B1 (it) | 1995-12-28 | 1997-11-12 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
AU1319697A (en) | 1996-01-23 | 1997-08-20 | Shionogi & Co., Ltd. | Process for producing oleanolic acid analogs by culturing hairy root |
ES2241047T3 (es) | 1996-04-04 | 2005-10-16 | Banyu Pharmaceutical Co., Ltd. | Antagonistas de la endotelina para tratar la insuficiencia cardiaca. |
US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
ES2274847T3 (es) * | 2000-12-14 | 2007-06-01 | Speedel Pharma Ag | Proceso para preparar ariloctanoil-amidas. |
RU2413716C2 (ru) * | 2003-11-26 | 2011-03-10 | Новартис Аг | АМИДЫ δ-АМИНО-γ-ГИДРОКСИ-ω-АРИЛАЛКАНОВОЙ КИСЛОТЫ |
-
2003
- 2003-12-01 GB GBGB0327839.7A patent/GB0327839D0/en not_active Ceased
-
2004
- 2004-11-30 CN CN2004800412241A patent/CN1914153B/zh not_active Expired - Fee Related
- 2004-11-30 BR BRPI0417145-4A patent/BRPI0417145A/pt not_active Application Discontinuation
- 2004-11-30 RU RU2006123314/04A patent/RU2425027C2/ru not_active IP Right Cessation
- 2004-11-30 EP EP04819639A patent/EP1692095A1/en not_active Withdrawn
- 2004-11-30 KR KR1020067010618A patent/KR20060121119A/ko not_active Application Discontinuation
- 2004-11-30 WO PCT/EP2004/013589 patent/WO2005054177A1/en active Application Filing
- 2004-11-30 AU AU2004295093A patent/AU2004295093B2/en not_active Ceased
- 2004-11-30 CA CA002546682A patent/CA2546682A1/en not_active Abandoned
- 2004-11-30 US US10/580,295 patent/US20070142475A1/en not_active Abandoned
- 2004-11-30 JP JP2006541870A patent/JP2007512382A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US20070142475A1 (en) | 2007-06-21 |
KR20060121119A (ko) | 2006-11-28 |
CN1914153B (zh) | 2011-06-08 |
GB0327839D0 (en) | 2003-12-31 |
RU2006123314A (ru) | 2008-01-20 |
AU2004295093A1 (en) | 2005-06-16 |
RU2425027C2 (ru) | 2011-07-27 |
JP2007512382A (ja) | 2007-05-17 |
EP1692095A1 (en) | 2006-08-23 |
CN1914153A (zh) | 2007-02-14 |
AU2004295093B2 (en) | 2008-08-14 |
CA2546682A1 (en) | 2005-06-16 |
WO2005054177A1 (en) | 2005-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |