HUP0101193A2 - Eljárás enantiomeresen dúsított tetrahidrobenzotiepin-oxidok előállítására - Google Patents

Eljárás enantiomeresen dúsított tetrahidrobenzotiepin-oxidok előállítására

Info

Publication number
HUP0101193A2
HUP0101193A2 HU0101193A HUP0101193A HUP0101193A2 HU P0101193 A2 HUP0101193 A2 HU P0101193A2 HU 0101193 A HU0101193 A HU 0101193A HU P0101193 A HUP0101193 A HU P0101193A HU P0101193 A2 HUP0101193 A2 HU P0101193A2
Authority
HU
Hungary
Prior art keywords
group
general formula
aryl
vii
tetrahydrobenzothiepine
Prior art date
Application number
HU0101193A
Other languages
English (en)
Inventor
Andrew J. Carpenter
Horng-Chih Huang
James Li
David B. Reitz
Victor Snieckus
Ching-Cheng Wang
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Publication of HUP0101193A2 publication Critical patent/HUP0101193A2/hu
Publication of HUP0101193A3 publication Critical patent/HUP0101193A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

A találmány (I) általános képletű tetrahidrobenzotiepin-1-oxid,illetve (VII) általános képletű tetrahidrobenzotiepin-1,1-dioxid - aképletekben R1 és R2 jelentése egymástól függetlenül H, alkilcsoport,alkenilcsoport, alkinilcsoport, cikloalkilcsoport, arilcsoport vagyheteroarilcsoport; R3 jelentése H, alkilcsoport, alkenilcsoport,alkinilcsoport, arilcsoport, cikloalkilcsoport, heterociklusoscsoport, kvaterner heterociklusos csoport, OR24, SR15, S(O)R15, SO2R15vagy SO3R15 általános képletű csoport, R4, R5, R6 és R7 jelentéseegymástól függetlenül hidrogénatom, halogénatom, alkil-, alkenil-,alkinil-, cikloalkil-, aril-, heteroaril-, alkoxi-, ariloxi-, -NO2,vagy -NR9R10 csoport; és R3 és az enantiomeresen dúsítotttetrahidrobenzotiepin-1-oxid vagy -1,1-dioxid 4-es helyzetében lévőhidroxilcsoport szín-konformációban vannak egymáshoz képest; és az (I)általános képletben a 7-tagú gyűrű 1-es helyzetében lévő kénatom és az(I) és (VII) általános képletben 7-tagú gyűrű 4-es és 5-ös helyzetébenlévő szénatomok királis centrumok - előállítására vonatkozik, amelynekértelmében egy enantiomeresen dúsított aril-3- propanálszulfoxidot (I)általános képletű vegyületté ciklizálnak, és kívánt esetben (VII)általános képletű vegyületté oxidálnak. Ó
HU0101193A 1997-12-19 1998-12-16 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides HUP0101193A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6817097P 1997-12-19 1997-12-19
PCT/US1998/026216 WO1999032478A1 (en) 1997-12-19 1998-12-16 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

Publications (2)

Publication Number Publication Date
HUP0101193A2 true HUP0101193A2 (hu) 2001-08-28
HUP0101193A3 HUP0101193A3 (en) 2001-12-28

Family

ID=22080853

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101193A HUP0101193A3 (en) 1997-12-19 1998-12-16 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

Country Status (19)

Country Link
US (2) US6369220B1 (hu)
EP (1) EP1042314B1 (hu)
JP (1) JP2001526284A (hu)
KR (1) KR20010015884A (hu)
CN (2) CN1106395C (hu)
AT (1) ATE234829T1 (hu)
AU (1) AU1721399A (hu)
BR (1) BR9814300A (hu)
DE (1) DE69812419T2 (hu)
DK (1) DK1042314T3 (hu)
ES (1) ES2195428T3 (hu)
HK (1) HK1034971A1 (hu)
HU (1) HUP0101193A3 (hu)
IL (1) IL136864A (hu)
PT (1) PT1042314E (hu)
RU (1) RU2236406C2 (hu)
UA (1) UA67764C2 (hu)
WO (1) WO1999032478A1 (hu)
ZA (1) ZA9811648B (hu)

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US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
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JP2023504647A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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Also Published As

Publication number Publication date
UA67764C2 (uk) 2004-07-15
KR20010015884A (ko) 2001-02-26
DE69812419T2 (de) 2003-08-14
WO1999032478A1 (en) 1999-07-01
HUP0101193A3 (en) 2001-12-28
IL136864A0 (en) 2001-06-14
JP2001526284A (ja) 2001-12-18
EP1042314B1 (en) 2003-03-19
IL136864A (en) 2004-07-25
EP1042314A1 (en) 2000-10-11
BR9814300A (pt) 2002-02-05
ATE234829T1 (de) 2003-04-15
ES2195428T3 (es) 2003-12-01
HK1034971A1 (en) 2001-11-09
US6369220B1 (en) 2002-04-09
DE69812419D1 (de) 2003-04-24
CN1284953A (zh) 2001-02-21
RU2236406C2 (ru) 2004-09-20
US20020188119A1 (en) 2002-12-12
CN1439638A (zh) 2003-09-03
US6875877B2 (en) 2005-04-05
ZA9811648B (en) 1999-12-20
PT1042314E (pt) 2003-07-31
AU1721399A (en) 1999-07-12
DK1042314T3 (da) 2003-07-14
CN1106395C (zh) 2003-04-23

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