ZA9811648B - Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides. - Google Patents

Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides.

Info

Publication number
ZA9811648B
ZA9811648B ZA9811648A ZA9811648A ZA9811648B ZA 9811648 B ZA9811648 B ZA 9811648B ZA 9811648 A ZA9811648 A ZA 9811648A ZA 9811648 A ZA9811648 A ZA 9811648A ZA 9811648 B ZA9811648 B ZA 9811648B
Authority
ZA
South Africa
Prior art keywords
preparing enantiomerically
oxides
enriched tetrahydrobenzothiepine
enriched
tetrahydrobenzothiepine oxides
Prior art date
Application number
ZA9811648A
Other languages
English (en)
Inventor
James Li
Ching-Cheng Wang
David B Reitz
Victor Snieckus
Horng-Chih Huang
Andrew J Carpenter
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA9811648B publication Critical patent/ZA9811648B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9811648A 1997-12-19 1998-12-18 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides. ZA9811648B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6817097P 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
ZA9811648B true ZA9811648B (en) 1999-12-20

Family

ID=22080853

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811648A ZA9811648B (en) 1997-12-19 1998-12-18 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides.

Country Status (19)

Country Link
US (2) US6369220B1 (hu)
EP (1) EP1042314B1 (hu)
JP (1) JP2001526284A (hu)
KR (1) KR20010015884A (hu)
CN (2) CN1106395C (hu)
AT (1) ATE234829T1 (hu)
AU (1) AU1721399A (hu)
BR (1) BR9814300A (hu)
DE (1) DE69812419T2 (hu)
DK (1) DK1042314T3 (hu)
ES (1) ES2195428T3 (hu)
HK (1) HK1034971A1 (hu)
HU (1) HUP0101193A3 (hu)
IL (1) IL136864A (hu)
PT (1) PT1042314E (hu)
RU (1) RU2236406C2 (hu)
UA (1) UA67764C2 (hu)
WO (1) WO1999032478A1 (hu)
ZA (1) ZA9811648B (hu)

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CN104023718B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
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AU2014228850A1 (en) 2013-03-15 2015-10-29 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
CA2952406A1 (en) 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for preventing or reducing coloration thereof
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601744B (zh) 2016-02-09 2022-01-04 阿尔比里奥公司 口服考来烯胺制剂及其用途
RU2750937C2 (ru) 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
CA3071285A1 (en) 2017-08-09 2019-02-14 Albireo Ab Cholestyramine granules, oral cholestyramine formulations and use thereof
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JP7391048B2 (ja) 2018-06-05 2023-12-04 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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CA3100691A1 (en) 2018-06-20 2019-12-26 Albireo Ab Crystal modifications of odevixibat
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
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US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
JP2022520121A (ja) 2019-02-12 2022-03-28 ミルム ファーマシューティカルズ インコーポレイテッド 胆汁うっ滞を治療する方法
CN114786772B (zh) 2019-12-04 2024-04-09 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023504645A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
EP4069247A1 (en) 2019-12-04 2022-10-12 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
EP4243831A1 (en) 2020-11-12 2023-09-20 Albireo AB Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
JP2024500309A (ja) 2020-12-04 2024-01-09 アルビレオ エービー ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用
US20240116891A1 (en) * 2022-09-14 2024-04-11 Mirum Pharmaceuticals, Inc. Maralixibat solid forms, intermediates and processes of making same

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JPS59144777A (ja) 1983-02-04 1984-08-18 Tokawa Tetsuo ベンゾチアゼピン誘導体の光学分割法
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IT1249318B (it) 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
DK0781278T3 (da) * 1994-09-13 2001-04-17 Monsanto Co Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
ATE303378T1 (de) 1996-03-11 2005-09-15 Searle Llc Benzothiepinen mit wirkung als inhibitoren des ileumgallensäuretransports und der taurocholate- aufnahme

Also Published As

Publication number Publication date
HK1034971A1 (en) 2001-11-09
CN1284953A (zh) 2001-02-21
CN1439638A (zh) 2003-09-03
US6875877B2 (en) 2005-04-05
IL136864A (en) 2004-07-25
US20020188119A1 (en) 2002-12-12
UA67764C2 (uk) 2004-07-15
EP1042314A1 (en) 2000-10-11
DK1042314T3 (da) 2003-07-14
DE69812419D1 (de) 2003-04-24
KR20010015884A (ko) 2001-02-26
US6369220B1 (en) 2002-04-09
AU1721399A (en) 1999-07-12
BR9814300A (pt) 2002-02-05
WO1999032478A1 (en) 1999-07-01
ES2195428T3 (es) 2003-12-01
HUP0101193A3 (en) 2001-12-28
PT1042314E (pt) 2003-07-31
IL136864A0 (en) 2001-06-14
CN1106395C (zh) 2003-04-23
DE69812419T2 (de) 2003-08-14
HUP0101193A2 (hu) 2001-08-28
RU2236406C2 (ru) 2004-09-20
JP2001526284A (ja) 2001-12-18
ATE234829T1 (de) 2003-04-15
EP1042314B1 (en) 2003-03-19

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