DK1042314T3 - Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxider - Google Patents
Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxiderInfo
- Publication number
- DK1042314T3 DK1042314T3 DK98962044T DK98962044T DK1042314T3 DK 1042314 T3 DK1042314 T3 DK 1042314T3 DK 98962044 T DK98962044 T DK 98962044T DK 98962044 T DK98962044 T DK 98962044T DK 1042314 T3 DK1042314 T3 DK 1042314T3
- Authority
- DK
- Denmark
- Prior art keywords
- enantiomerically enriched
- preparation
- oxides
- enriched tetrahydrobenzothiepine
- tetrahydrobenzothiepine oxides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6817097P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026216 WO1999032478A1 (en) | 1997-12-19 | 1998-12-16 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1042314T3 true DK1042314T3 (da) | 2003-07-14 |
Family
ID=22080853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98962044T DK1042314T3 (da) | 1997-12-19 | 1998-12-16 | Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxider |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6369220B1 (da) |
| EP (1) | EP1042314B1 (da) |
| JP (1) | JP2001526284A (da) |
| KR (1) | KR20010015884A (da) |
| CN (2) | CN1106395C (da) |
| AT (1) | ATE234829T1 (da) |
| AU (1) | AU1721399A (da) |
| BR (1) | BR9814300A (da) |
| DE (1) | DE69812419T2 (da) |
| DK (1) | DK1042314T3 (da) |
| ES (1) | ES2195428T3 (da) |
| HK (1) | HK1034971A1 (da) |
| HU (1) | HUP0101193A3 (da) |
| IL (1) | IL136864A (da) |
| PT (1) | PT1042314E (da) |
| RU (1) | RU2236406C2 (da) |
| UA (1) | UA67764C2 (da) |
| WO (1) | WO1999032478A1 (da) |
| ZA (1) | ZA9811648B (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| WO2001068637A2 (en) * | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| CN1582151A (zh) | 2001-09-08 | 2005-02-16 | 阿斯特拉曾尼卡有限公司 | 用于治疗高脂血症、具有回肠胆汁酸转运(ibat)抑制活性的苯并硫氮杂䓬和苯并硫杂二氮杂䓬衍生物 |
| JP2005518347A (ja) * | 2001-11-02 | 2005-06-23 | ジー．ディー． サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| CN1930137B (zh) | 2004-02-27 | 2011-07-20 | 旭化成制药株式会社 | 苯并硫氮杂卓和苯并虑平化合物 |
| WO2010062861A2 (en) | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CA2815698C (en) | 2010-11-08 | 2019-04-30 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| SI2637668T1 (sl) | 2010-11-08 | 2016-11-30 | Albiero Ab | IBAT inhibitorji za zdravljenje jetrnih bolezni |
| CN102558250B (zh) * | 2010-12-14 | 2015-01-14 | 王芃 | 一种艾杜糖醛酸及其衍生物的制备方法 |
| CN107375932B (zh) | 2011-10-28 | 2021-12-21 | 夏尔人类遗传性治疗公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| EA029581B1 (ru) | 2011-10-28 | 2018-04-30 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита |
| EP2968262A1 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| US10012627B2 (en) | 2013-03-15 | 2018-07-03 | Georgetown University | Determining stereoisomeric excess, concentration and absolute configuration |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR20220082931A (ko) | 2014-06-25 | 2022-06-17 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN110996915B (zh) | 2017-08-09 | 2023-10-03 | 阿尔比里奥公司 | 考来烯胺丸粒、口服考来烯胺制剂及其用途 |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2019245449A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| WO2020056012A1 (en) | 2018-09-11 | 2020-03-19 | Georgetown University | Quantitative auxiliary-free chirality sensing with a metal probe |
| CN109516971B (zh) * | 2018-11-26 | 2020-09-25 | 山东永浩新材料科技有限公司 | 一种电池级硫酸乙烯酯的合成方法 |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| MX2021009622A (es) | 2019-02-12 | 2021-11-04 | Mirum Pharmaceuticals Inc | Metodos para tratar la colestasis. |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
| CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023504644A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
| EP4255565A1 (en) | 2020-12-04 | 2023-10-11 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2024059163A1 (en) * | 2022-09-14 | 2024-03-21 | Mirum Pharmaceuticals, Inc. | Maralixibat solid forms, intermediates and processes of making same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59144777A (ja) | 1983-02-04 | 1984-08-18 | Tokawa Tetsuo | ベンゾチアゼピン誘導体の光学分割法 |
| US5559017A (en) | 1989-08-09 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Microbial reduction of benzazepines and benzothiazepine derivatives |
| IT1249318B (it) | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| WO1996008484A1 (en) * | 1994-09-13 | 1996-03-21 | Monsanto Company | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| CN1515567A (zh) | 1996-03-11 | 2004-07-28 | G.D.ɪ����˾ | 具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因 |
-
1998
- 1998-12-16 DK DK98962044T patent/DK1042314T3/da active
- 1998-12-16 JP JP2000525415A patent/JP2001526284A/ja active Pending
- 1998-12-16 RU RU2000119611/04A patent/RU2236406C2/ru not_active IP Right Cessation
- 1998-12-16 AT AT98962044T patent/ATE234829T1/de not_active IP Right Cessation
- 1998-12-16 US US09/581,897 patent/US6369220B1/en not_active Expired - Fee Related
- 1998-12-16 UA UA2000074377A patent/UA67764C2/uk unknown
- 1998-12-16 EP EP98962044A patent/EP1042314B1/en not_active Expired - Lifetime
- 1998-12-16 BR BR9814300-0A patent/BR9814300A/pt not_active IP Right Cessation
- 1998-12-16 AU AU17213/99A patent/AU1721399A/en not_active Abandoned
- 1998-12-16 KR KR1020007006795A patent/KR20010015884A/ko not_active Application Discontinuation
- 1998-12-16 HU HU0101193A patent/HUP0101193A3/hu unknown
- 1998-12-16 ES ES98962044T patent/ES2195428T3/es not_active Expired - Lifetime
- 1998-12-16 PT PT98962044T patent/PT1042314E/pt unknown
- 1998-12-16 IL IL13686498A patent/IL136864A/en not_active IP Right Cessation
- 1998-12-16 CN CN98813609A patent/CN1106395C/zh not_active Expired - Fee Related
- 1998-12-16 DE DE69812419T patent/DE69812419T2/de not_active Expired - Fee Related
- 1998-12-16 WO PCT/US1998/026216 patent/WO1999032478A1/en not_active Application Discontinuation
- 1998-12-18 ZA ZA9811648A patent/ZA9811648B/xx unknown
-
2001
- 2001-08-15 HK HK01105743A patent/HK1034971A1/xx not_active IP Right Cessation
-
2002
- 2002-02-11 US US10/072,600 patent/US6875877B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 CN CN03107046A patent/CN1439638A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6369220B1 (en) | 2002-04-09 |
| ATE234829T1 (de) | 2003-04-15 |
| CN1439638A (zh) | 2003-09-03 |
| HUP0101193A3 (en) | 2001-12-28 |
| DE69812419T2 (de) | 2003-08-14 |
| IL136864A (en) | 2004-07-25 |
| CN1106395C (zh) | 2003-04-23 |
| RU2236406C2 (ru) | 2004-09-20 |
| WO1999032478A1 (en) | 1999-07-01 |
| AU1721399A (en) | 1999-07-12 |
| ZA9811648B (en) | 1999-12-20 |
| US20020188119A1 (en) | 2002-12-12 |
| UA67764C2 (uk) | 2004-07-15 |
| KR20010015884A (ko) | 2001-02-26 |
| HK1034971A1 (en) | 2001-11-09 |
| US6875877B2 (en) | 2005-04-05 |
| EP1042314B1 (en) | 2003-03-19 |
| EP1042314A1 (en) | 2000-10-11 |
| PT1042314E (pt) | 2003-07-31 |
| DE69812419D1 (de) | 2003-04-24 |
| HUP0101193A2 (hu) | 2001-08-28 |
| ES2195428T3 (es) | 2003-12-01 |
| BR9814300A (pt) | 2002-02-05 |
| CN1284953A (zh) | 2001-02-21 |
| IL136864A0 (en) | 2001-06-14 |
| JP2001526284A (ja) | 2001-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1042314T3 (da) | Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxider | |
| DK0893434T3 (da) | Mellemprodukter til fremstilling af oximethere | |
| DK1032566T5 (da) | Fremgangsmåde til fremstilling af citalopram | |
| DK0960109T3 (da) | Fremgangsmåde til fremstilling af tolterodin | |
| DK555687D0 (da) | Fremgangsmaade til fremstilling af n,n-diaryl-urinstoffer | |
| DK0754756T3 (da) | Fremgangsmåde til fremstilling af L-lysin | |
| DK1038008T3 (da) | Fremgangsmåde til fremstilling af EGIII-lignende enzymer | |
| DK53087A (da) | Fremgangsmaade til fremstilling af carbonfilm | |
| IS5471A (is) | Aðferð til framleiðslu á afleiðum af taxóíða flokknum | |
| DK0937055T3 (da) | Fremgangsmåde til fremstilling af d,I-alfa-tocopherol | |
| DK90987D0 (da) | Apparat til fremstilling af cigaretter | |
| DK0378455T3 (da) | Fremgangsmåde til fremstilling af derivater af (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-on | |
| DK0805806T3 (da) | Fremgangsmåde til fremstilling af 4,10-diacetoxy-2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxotax-11-en-13alpha- | |
| DK0927766T3 (da) | Enzymatisk fremgangsmåde til fremstilling af (S)-cyanhydriner | |
| DK0846691T3 (da) | Fremgangsmåde til fremstilling af 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxaziner | |
| DK0975601T3 (da) | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor | |
| IS5297A (is) | Aðferð til framleiðslu á handhverfuríkum (enantiomerically enriched) N-afleiddum laktömum | |
| DK191987D0 (da) | Fremgangsmaade til indstilling af ph-vaerdien af en oploesning | |
| DK384285A (da) | Fremgangsmaade til opspaltning af racemiske halvestere | |
| DK0796256T3 (da) | Fremgangsmåde til fremstilling af ranitidin | |
| DK0789700T3 (da) | Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemprodukt | |
| DK0688737T3 (da) | Fremgangsmåde til fremstilling af hvidt carbon | |
| DK0389876T3 (da) | Hidtil ukendt fremgangsmåde til syntese af N-methyl-3,4-dimethoxyphenylethylamin | |
| DK1015442T3 (da) | Fremgangsmåde til fremstilling af 3-isochromanon | |
| DK0418842T3 (da) | Fremgangsmåde til fremstilling af en stempelring |