DK1042314T3 - Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxider - Google Patents
Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxiderInfo
- Publication number
- DK1042314T3 DK1042314T3 DK98962044T DK98962044T DK1042314T3 DK 1042314 T3 DK1042314 T3 DK 1042314T3 DK 98962044 T DK98962044 T DK 98962044T DK 98962044 T DK98962044 T DK 98962044T DK 1042314 T3 DK1042314 T3 DK 1042314T3
- Authority
- DK
- Denmark
- Prior art keywords
- enantiomerically enriched
- preparation
- oxides
- enriched tetrahydrobenzothiepine
- tetrahydrobenzothiepine oxides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6817097P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026216 WO1999032478A1 (en) | 1997-12-19 | 1998-12-16 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1042314T3 true DK1042314T3 (da) | 2003-07-14 |
Family
ID=22080853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98962044T DK1042314T3 (da) | 1997-12-19 | 1998-12-16 | Fremgangsmåde til fremstilling af enantiomert berigede tetrahydrobenzothiepinoxider |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6369220B1 (da) |
| EP (1) | EP1042314B1 (da) |
| JP (1) | JP2001526284A (da) |
| KR (1) | KR20010015884A (da) |
| CN (2) | CN1106395C (da) |
| AT (1) | ATE234829T1 (da) |
| AU (1) | AU1721399A (da) |
| BR (1) | BR9814300A (da) |
| DE (1) | DE69812419T2 (da) |
| DK (1) | DK1042314T3 (da) |
| ES (1) | ES2195428T3 (da) |
| HK (1) | HK1034971A1 (da) |
| HU (1) | HUP0101193A3 (da) |
| IL (1) | IL136864A (da) |
| PT (1) | PT1042314E (da) |
| RU (1) | RU2236406C2 (da) |
| UA (1) | UA67764C2 (da) |
| WO (1) | WO1999032478A1 (da) |
| ZA (1) | ZA9811648B (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| EP1286984A2 (en) * | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| JP3616635B2 (ja) | 2001-09-08 | 2005-02-02 | アストラゼネカ アクチボラグ | 高脂質血症の治療のための回腸胆汁酸運搬（ｉｂａｔ）阻害活性を持つベンゾチアゼピン及びベンゾチアジアゼピン誘導体 |
| WO2003040127A1 (en) * | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| CN102293773A (zh) | 2004-02-27 | 2011-12-28 | 旭化成制药株式会社 | 含有苯并硫氮杂卓和苯并虑平化合物的药物 |
| JP2012509891A (ja) | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ，インク． | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| EP2637668B1 (en) | 2010-11-08 | 2016-05-11 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| SG190433A1 (en) | 2010-11-08 | 2013-06-28 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| CN102558250B (zh) * | 2010-12-14 | 2015-01-14 | 王芃 | 一种艾杜糖醛酸及其衍生物的制备方法 |
| EP2770990A4 (en) | 2011-10-28 | 2015-03-11 | Lumena Pharmaceuticals Inc | Gallic acid refluxing agent for the treatment of hypertension and chronic liver disease |
| EP2771003B1 (en) | 2011-10-28 | 2017-04-19 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US10012627B2 (en) | 2013-03-15 | 2018-07-03 | Georgetown University | Determining stereoisomeric excess, concentration and absolute configuration |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| WO2014144485A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Ｅａファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| RU2750937C2 (ru) | 2016-02-09 | 2021-07-06 | Альбирео Аб | Пероральный состав холестирамина и его применение |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CA3011565C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| WO2019032027A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11860084B2 (en) | 2018-09-11 | 2024-01-02 | Georgetown University | Quantitative auxiliary-free chirality sensing with a metal probe |
| CN109516971B (zh) * | 2018-11-26 | 2020-09-25 | 山东永浩新材料科技有限公司 | 一种电池级硫酸乙烯酯的合成方法 |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| BR112021015815A2 (pt) | 2019-02-12 | 2022-01-18 | Mirum Pharmaceuticals Inc | Métodos para tratar colestase |
| ES2973549T3 (es) | 2019-12-04 | 2024-06-20 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| JP2023504647A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CN116157389A (zh) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| WO2024059163A1 (en) * | 2022-09-14 | 2024-03-21 | Mirum Pharmaceuticals, Inc. | Maralixibat solid forms, intermediates and processes of making same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59144777A (ja) | 1983-02-04 | 1984-08-18 | Tokawa Tetsuo | ベンゾチアゼピン誘導体の光学分割法 |
| US5559017A (en) | 1989-08-09 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Microbial reduction of benzazepines and benzothiazepine derivatives |
| IT1249318B (it) | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
| DK0781278T3 (da) * | 1994-09-13 | 2001-04-17 | Monsanto Co | Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| WO1997033882A1 (en) | 1996-03-11 | 1997-09-18 | G.D. Searle And Co. | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
-
1998
- 1998-12-16 WO PCT/US1998/026216 patent/WO1999032478A1/en not_active Application Discontinuation
- 1998-12-16 UA UA2000074377A patent/UA67764C2/uk unknown
- 1998-12-16 ES ES98962044T patent/ES2195428T3/es not_active Expired - Lifetime
- 1998-12-16 DK DK98962044T patent/DK1042314T3/da active
- 1998-12-16 US US09/581,897 patent/US6369220B1/en not_active Expired - Fee Related
- 1998-12-16 RU RU2000119611/04A patent/RU2236406C2/ru not_active IP Right Cessation
- 1998-12-16 KR KR1020007006795A patent/KR20010015884A/ko not_active Application Discontinuation
- 1998-12-16 EP EP98962044A patent/EP1042314B1/en not_active Expired - Lifetime
- 1998-12-16 CN CN98813609A patent/CN1106395C/zh not_active Expired - Fee Related
- 1998-12-16 DE DE69812419T patent/DE69812419T2/de not_active Expired - Fee Related
- 1998-12-16 HU HU0101193A patent/HUP0101193A3/hu unknown
- 1998-12-16 BR BR9814300-0A patent/BR9814300A/pt not_active IP Right Cessation
- 1998-12-16 IL IL13686498A patent/IL136864A/en not_active IP Right Cessation
- 1998-12-16 AU AU17213/99A patent/AU1721399A/en not_active Abandoned
- 1998-12-16 JP JP2000525415A patent/JP2001526284A/ja active Pending
- 1998-12-16 AT AT98962044T patent/ATE234829T1/de not_active IP Right Cessation
- 1998-12-16 PT PT98962044T patent/PT1042314E/pt unknown
- 1998-12-18 ZA ZA9811648A patent/ZA9811648B/xx unknown
-
2001
- 2001-08-15 HK HK01105743A patent/HK1034971A1/xx not_active IP Right Cessation
-
2002
- 2002-02-11 US US10/072,600 patent/US6875877B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 CN CN03107046A patent/CN1439638A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| UA67764C2 (uk) | 2004-07-15 |
| DE69812419D1 (de) | 2003-04-24 |
| PT1042314E (pt) | 2003-07-31 |
| WO1999032478A1 (en) | 1999-07-01 |
| ZA9811648B (en) | 1999-12-20 |
| US20020188119A1 (en) | 2002-12-12 |
| EP1042314B1 (en) | 2003-03-19 |
| IL136864A0 (en) | 2001-06-14 |
| CN1106395C (zh) | 2003-04-23 |
| ATE234829T1 (de) | 2003-04-15 |
| HUP0101193A2 (hu) | 2001-08-28 |
| US6369220B1 (en) | 2002-04-09 |
| US6875877B2 (en) | 2005-04-05 |
| CN1284953A (zh) | 2001-02-21 |
| RU2236406C2 (ru) | 2004-09-20 |
| IL136864A (en) | 2004-07-25 |
| HUP0101193A3 (en) | 2001-12-28 |
| DE69812419T2 (de) | 2003-08-14 |
| AU1721399A (en) | 1999-07-12 |
| JP2001526284A (ja) | 2001-12-18 |
| ES2195428T3 (es) | 2003-12-01 |
| KR20010015884A (ko) | 2001-02-26 |
| CN1439638A (zh) | 2003-09-03 |
| EP1042314A1 (en) | 2000-10-11 |
| BR9814300A (pt) | 2002-02-05 |
| HK1034971A1 (en) | 2001-11-09 |
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