ATE76407T1 - T-butyl ergolinderivate. - Google Patents
T-butyl ergolinderivate.Info
- Publication number
- ATE76407T1 ATE76407T1 AT87305570T AT87305570T ATE76407T1 AT E76407 T1 ATE76407 T1 AT E76407T1 AT 87305570 T AT87305570 T AT 87305570T AT 87305570 T AT87305570 T AT 87305570T AT E76407 T1 ATE76407 T1 AT E76407T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen atom
- group
- ergoline derivatives
- butyl
- butyl ergoline
- Prior art date
Links
- -1 T-BUTYL ERGOLINE DERIVATIVES Chemical class 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Liquid Developers In Electrophotography (AREA)
- Graft Or Block Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868615471A GB8615471D0 (en) | 1986-06-25 | 1986-06-25 | T-butyl ergoline derivatives |
| EP87305570A EP0251652B1 (de) | 1986-06-25 | 1987-06-23 | t-Butyl Ergolinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE76407T1 true ATE76407T1 (de) | 1992-06-15 |
Family
ID=10600059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87305570T ATE76407T1 (de) | 1986-06-25 | 1987-06-23 | T-butyl ergolinderivate. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4843073A (de) |
| EP (1) | EP0251652B1 (de) |
| JP (1) | JPH0745498B2 (de) |
| KR (1) | KR950008970B1 (de) |
| AT (1) | ATE76407T1 (de) |
| AU (1) | AU597672B2 (de) |
| CA (1) | CA1339533C (de) |
| DE (1) | DE3779190D1 (de) |
| DK (1) | DK170099B1 (de) |
| ES (1) | ES2042567T3 (de) |
| FI (1) | FI85702C (de) |
| GB (1) | GB8615471D0 (de) |
| GR (1) | GR3005115T3 (de) |
| HU (1) | HU196201B (de) |
| IE (1) | IE61319B1 (de) |
| IL (1) | IL82946A (de) |
| NZ (1) | NZ220543A (de) |
| PT (1) | PT85152B (de) |
| SU (1) | SU1547708A3 (de) |
| ZA (1) | ZA874569B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61245164A (ja) * | 1985-04-23 | 1986-10-31 | Seiko Instr & Electronics Ltd | パタ−ン修正装置 |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
| US6060483A (en) * | 1996-06-27 | 2000-05-09 | Pharmacia & Upjohn S.P.A. | Antineurodegenerative ergoline derivatives |
| WO2014195849A2 (en) * | 2013-06-03 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of cerebrovascular diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228942A (en) * | 1966-01-11 | Methyl and i,g-dimeti-iyl ergoline i compounds | ||
| US3228941A (en) * | 1966-01-11 | Methyl and i,g-dimethyl-ergoline i derivatives | ||
| US3228945A (en) * | 1966-01-11 | Methyl and i,g-dimethyl-b-(a-hydroxy- alkyl)-ergoline i derivatives | ||
| DE203721C (de) * | 1908-05-05 | |||
| US3232942A (en) * | 1964-06-02 | 1966-02-01 | Sandoz Ltd | 1-substituted (+)-lysergol |
| US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
| USRE30218E (en) * | 1974-12-06 | 1980-02-19 | Eli Lilly And Company | 8,8-Disubstituted-6-methylergolines and related compounds |
| US3959288A (en) * | 1974-12-13 | 1976-05-25 | Eli Lilly And Company | 8-Oxymethylergolines and process therefor |
| US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
| DE2656344A1 (de) * | 1975-12-23 | 1977-07-07 | Sandoz Ag | Ergolinderivate, ihre verwendung und herstellung |
| IT1192260B (it) * | 1977-07-05 | 1988-03-31 | Simes | Derivati di ergoline-2-tioeteri e loro solfossidi |
| GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
| DE3403067A1 (de) * | 1984-01-30 | 1985-08-14 | Eckart Prof. Dr. 6500 Mainz Eich | Ergolin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
| IT1213206B (it) * | 1984-08-07 | 1989-12-14 | Inverni Della Beffa Spa | Procedimento per la preparazione di derivati del lisergolo. |
| GB8612366D0 (en) * | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
| AU7914587A (en) * | 1987-08-24 | 1989-03-31 | Molecular Control Corporation | Liquid crystal micelles, display, having concentric spheres |
-
1986
- 1986-06-25 GB GB868615471A patent/GB8615471D0/en active Pending
-
1987
- 1987-06-03 NZ NZ220543A patent/NZ220543A/xx unknown
- 1987-06-22 IL IL82946A patent/IL82946A/xx not_active IP Right Cessation
- 1987-06-22 IE IE165287A patent/IE61319B1/en not_active IP Right Cessation
- 1987-06-22 JP JP62155265A patent/JPH0745498B2/ja not_active Expired - Lifetime
- 1987-06-22 FI FI872752A patent/FI85702C/fi not_active IP Right Cessation
- 1987-06-23 ES ES87305570T patent/ES2042567T3/es not_active Expired - Lifetime
- 1987-06-23 AU AU74632/87A patent/AU597672B2/en not_active Ceased
- 1987-06-23 AT AT87305570T patent/ATE76407T1/de not_active IP Right Cessation
- 1987-06-23 DE DE8787305570T patent/DE3779190D1/de not_active Expired - Lifetime
- 1987-06-23 US US07/065,597 patent/US4843073A/en not_active Expired - Fee Related
- 1987-06-23 KR KR1019870006362A patent/KR950008970B1/ko not_active Expired - Fee Related
- 1987-06-23 PT PT85152A patent/PT85152B/pt not_active IP Right Cessation
- 1987-06-23 CA CA000540338A patent/CA1339533C/en not_active Expired - Fee Related
- 1987-06-23 EP EP87305570A patent/EP0251652B1/de not_active Expired - Lifetime
- 1987-06-24 HU HU872871A patent/HU196201B/hu not_active IP Right Cessation
- 1987-06-24 DK DK322587A patent/DK170099B1/da not_active IP Right Cessation
- 1987-06-24 ZA ZA874569A patent/ZA874569B/xx unknown
- 1987-06-24 SU SU874202786A patent/SU1547708A3/ru active
-
1989
- 1989-03-24 US US07/328,518 patent/US5079364A/en not_active Expired - Fee Related
-
1992
- 1992-07-08 GR GR920401458T patent/GR3005115T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL82946A0 (en) | 1987-12-20 |
| NZ220543A (en) | 1989-06-28 |
| US4843073A (en) | 1989-06-27 |
| SU1547708A3 (ru) | 1990-02-28 |
| GB8615471D0 (en) | 1986-07-30 |
| IL82946A (en) | 1991-04-15 |
| FI872752L (fi) | 1987-12-26 |
| FI872752A0 (fi) | 1987-06-22 |
| IE871652L (en) | 1987-12-25 |
| JPH0745498B2 (ja) | 1995-05-17 |
| DE3779190D1 (de) | 1992-06-25 |
| DK170099B1 (da) | 1995-05-22 |
| CA1339533C (en) | 1997-11-11 |
| PT85152B (pt) | 1990-03-30 |
| AU7463287A (en) | 1988-01-07 |
| DK322587A (da) | 1987-12-26 |
| ZA874569B (en) | 1988-02-24 |
| DK322587D0 (da) | 1987-06-24 |
| FI85702B (fi) | 1992-02-14 |
| EP0251652A2 (de) | 1988-01-07 |
| ES2042567T3 (es) | 1993-12-16 |
| HUT44543A (en) | 1988-03-28 |
| KR950008970B1 (ko) | 1995-08-10 |
| EP0251652A3 (en) | 1989-04-05 |
| US5079364A (en) | 1992-01-07 |
| KR880000429A (ko) | 1988-03-25 |
| FI85702C (fi) | 1992-05-25 |
| PT85152A (en) | 1987-07-01 |
| GR3005115T3 (de) | 1993-05-24 |
| AU597672B2 (en) | 1990-06-07 |
| IE61319B1 (en) | 1994-11-02 |
| HU196201B (en) | 1988-10-28 |
| JPS6322577A (ja) | 1988-01-30 |
| EP0251652B1 (de) | 1992-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |