HUP0100818A2 - Térhálós, magas amilóztartalmú, funkcionális csoportokkal rendelkező keményítő, mint gyógyszer hatóanyagok lassú kibocsátását biztosító mátrix - Google Patents

Térhálós, magas amilóztartalmú, funkcionális csoportokkal rendelkező keményítő, mint gyógyszer hatóanyagok lassú kibocsátását biztosító mátrix

Info

Publication number
HUP0100818A2
HUP0100818A2 HU0100818A HUP0100818A HUP0100818A2 HU P0100818 A2 HUP0100818 A2 HU P0100818A2 HU 0100818 A HU0100818 A HU 0100818A HU P0100818 A HUP0100818 A HU P0100818A HU P0100818 A2 HUP0100818 A2 HU P0100818A2
Authority
HU
Hungary
Prior art keywords
cross
high amylose
amylose starch
matrix
functional groups
Prior art date
Application number
HU0100818A
Other languages
English (en)
Inventor
Francois Chouinard
Pompilia Ispas-Szabó
Vincent Lenaerts
Mircea A. Mateescu
Original Assignee
Francois Chouinard
Pompilia Ispas-Szabó
Vincent Lenaerts
Mircea A. Mateescu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francois Chouinard, Pompilia Ispas-Szabó, Vincent Lenaerts, Mircea A. Mateescu filed Critical Francois Chouinard
Publication of HUP0100818A2 publication Critical patent/HUP0100818A2/hu
Publication of HUP0100818A3 publication Critical patent/HUP0100818A3/hu
Publication of HU225045B1 publication Critical patent/HU225045B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya szilárd, szabályozott hatóanyag leadású gyógyszerdózisegység tabletta formájában, amely tartalmaz (a) gyógyszerterméket; (b) magas amilóztartalmú keményítőt, mely 10-60 tömeg%-banamilopektint és 40-90 tömeg%-ban amilózt tartalmaz; és (c)poliszacharidot vagy poliolt; ahol a magas amilóz tartalmú keményítőtés poliszacharidot vagy poliolt együttesen, kovalens kötéseklétrehozására alkalmas térhálósítószerrel térhálósítják (co-cross-link), mely térhálósítás során kb.0,1 g-kb.30 g térhálósftószertalkalmaznak 100 g magas amilóz tartalmú keményítőre számítva. Ó
HU0100818A 1998-02-24 1999-02-24 Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents HU225045B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/028,385 US6284273B1 (en) 1998-02-24 1998-02-24 Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
PCT/CA1999/000169 WO1999043305A1 (en) 1998-02-24 1999-02-24 Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents

Publications (3)

Publication Number Publication Date
HUP0100818A2 true HUP0100818A2 (hu) 2001-08-28
HUP0100818A3 HUP0100818A3 (en) 2001-12-28
HU225045B1 HU225045B1 (en) 2006-05-29

Family

ID=21843160

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100818A HU225045B1 (en) 1998-02-24 1999-02-24 Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents

Country Status (19)

Country Link
US (2) US6284273B1 (hu)
EP (1) EP1059915B1 (hu)
JP (1) JP2002504508A (hu)
KR (1) KR100713702B1 (hu)
CN (1) CN1298297A (hu)
AT (1) ATE277604T1 (hu)
AU (1) AU755069B2 (hu)
BR (1) BR9908187A (hu)
CA (1) CA2321461C (hu)
CZ (1) CZ301010B6 (hu)
DE (1) DE69920669T2 (hu)
HU (1) HU225045B1 (hu)
IL (1) IL137955A (hu)
NO (1) NO329257B1 (hu)
NZ (1) NZ506437A (hu)
PL (1) PL192468B1 (hu)
PT (1) PT1059915E (hu)
TR (1) TR200003014T2 (hu)
WO (1) WO1999043305A1 (hu)

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DE19927688A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
CA2445110A1 (en) * 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
BR0315657A (pt) * 2002-10-25 2005-09-13 Labopharm Inc Formulação de dosagem sólida, comprimido para liberação controlada, método de fabricar uma medicação de liberação controlada, composição farmacêutica e uso de uma composição
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
WO2005074976A1 (en) * 2004-02-09 2005-08-18 Transfert Plus Société En Commandite Composition comprising polymeric material and uses thereof
CA2491665A1 (fr) * 2004-12-24 2006-06-24 Louis Cartilier Formulation de comprime pour liberation soutenue de principe actif
BRPI0615860B8 (pt) 2005-09-09 2021-05-25 Labopharm Barbados Ltd composição farmacêutica de liberação prolongada monolítica sólida
CA2621597C (en) * 2005-09-21 2014-06-10 Surmodics, Inc. In vivo formed matrices including natural biodegradable polysaccharides and ophthalmic uses thereof
US8512736B2 (en) * 2005-09-21 2013-08-20 Surmodics, Inc. Coatings including natural biodegradable polysaccharides and uses thereof
US20090074829A1 (en) * 2006-03-14 2009-03-19 Masao Tanihara Novel Heparin Alternative Material and Method for Producing the Same
CA2590821A1 (en) * 2007-06-07 2008-12-07 Universite De Montreal High-amylose sodium carboxymethyl starch sustained release excipient and process for preparing the same
WO2009049405A1 (en) * 2007-10-16 2009-04-23 Labopharm Inc. Bilayer composition for the sustained release of acetaminophen and tramadol
CN101161684B (zh) * 2007-11-23 2010-05-19 华南理工大学 交联羧甲基淀粉的红外线合成方法
US8486448B2 (en) 2007-12-17 2013-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
CA2709888A1 (en) * 2007-12-21 2009-07-02 Akzo Nobel N.V. Thermosetting polymers
WO2009137689A2 (en) 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US20100068268A1 (en) * 2008-09-15 2010-03-18 Miloud Rahmouni Starch-based microparticles for the release of agents disposed therein
JP5667575B2 (ja) 2008-12-16 2015-02-12 パラディン ラブス インコーポレーテッド 誤用を防止する放出制御製剤
EP2590636A1 (en) 2010-07-06 2013-05-15 Grünenthal GmbH Novel gastro- retentive dosage forms comprising a gaba analog and an opioid
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012116434A1 (en) * 2011-03-01 2012-09-07 4413261 Canada Inc. (Spencer Canada) Two speed monolithic system for controlled release of drugs
CA2977835C (en) * 2014-02-27 2022-04-26 B-Organic Films Corp. Bioactive agents under water dispersible solid forms for food, nutraceutical, agricultural and pharmaceutical applications
CA2968104A1 (en) 2014-12-19 2016-06-23 Baxter International Inc. Flowable hemostatic composition
CN104784738B (zh) * 2015-04-03 2016-12-07 四川大学 一种天然缓释多效医用海绵
CN106279453B (zh) * 2015-05-28 2019-12-10 易媛 交联的高分子化合物及其制备方法、水凝胶、水基压裂液和用途
CN105536058A (zh) * 2016-01-22 2016-05-04 青岛中腾生物技术有限公司 一种医用淀粉海绵及其制备方法和用途
GB2567493B (en) * 2017-10-13 2019-12-18 Altus Formulation Inc Starch-based release modifying excipients and pharmaceutical compositions derived therefrom
CN111072791A (zh) * 2019-12-27 2020-04-28 河南新孚望新材料科技有限公司 一种包膜剂用高直链淀粉的制备方法
JP7348412B2 (ja) * 2021-03-31 2023-09-20 長瀬産業株式会社 水溶性ポリマーの製造方法、および吸水性樹脂の製造方法
JP7125216B1 (ja) 2021-03-31 2022-08-24 長瀬産業株式会社 水溶性ポリマーの製造方法、および吸水性樹脂の製造方法

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US4072535A (en) * 1970-12-28 1978-02-07 A. E. Staley Manufacturing Company Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
US4369308A (en) * 1981-07-24 1983-01-18 National Starch And Chemical Corporation Low swelling starches as tablet disintegrants
JPH0791240B2 (ja) * 1987-04-01 1995-10-04 株式会社日本触媒 ２−ハロエチルアミンハロゲン化水素酸塩の製造方法
CA2041774C (en) * 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
JPH06271704A (ja) * 1993-03-22 1994-09-27 Asahi Chem Ind Co Ltd 水性易燃性組成物
US5616343A (en) * 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
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US5593503A (en) * 1995-06-07 1997-01-14 National Starch And Chemical Investment Holding Corporation Process for producing amylase resistant granular starch
US5667637A (en) * 1995-11-03 1997-09-16 Weyerhaeuser Company Paper and paper-like products including water insoluble fibrous carboxyalkyl cellulose
CA2173818A1 (fr) * 1996-04-10 1997-10-11 Francois Chouinard Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
US5879707A (en) * 1996-10-30 1999-03-09 Universite De Montreal Substituted amylose as a matrix for sustained drug release
US5807575A (en) * 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds

Also Published As

Publication number Publication date
NZ506437A (en) 2003-03-28
PT1059915E (pt) 2005-02-28
HU225045B1 (en) 2006-05-29
CZ20003097A3 (en) 2001-06-13
IL137955A0 (en) 2001-10-31
HUP0100818A3 (en) 2001-12-28
JP2002504508A (ja) 2002-02-12
EP1059915A1 (en) 2000-12-20
CZ301010B6 (cs) 2009-10-14
US6419957B1 (en) 2002-07-16
NO329257B1 (no) 2010-09-20
DE69920669D1 (de) 2004-11-04
TR200003014T2 (tr) 2001-02-21
AU755069B2 (en) 2002-12-05
CA2321461C (en) 2008-04-29
AU3242099A (en) 1999-09-15
PL342596A1 (en) 2001-06-18
KR100713702B1 (ko) 2007-05-02
IL137955A (en) 2005-12-18
PL192468B1 (pl) 2006-10-31
DE69920669T2 (de) 2005-11-03
CA2321461A1 (en) 1999-09-02
ATE277604T1 (de) 2004-10-15
BR9908187A (pt) 2000-10-31
KR20010034531A (ko) 2001-04-25
NO20004208L (no) 2000-08-23
NO20004208D0 (no) 2000-08-23
WO1999043305A1 (en) 1999-09-02
CN1298297A (zh) 2001-06-06
US6284273B1 (en) 2001-09-04
EP1059915B1 (en) 2004-09-29

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees