MX9304459A - Material polihidroxilico de enlace curzado para la liberacion de farmacos controlada por enzimas. - Google Patents

Material polihidroxilico de enlace curzado para la liberacion de farmacos controlada por enzimas.

Info

Publication number
MX9304459A
MX9304459A MX9304459A MX9304459A MX9304459A MX 9304459 A MX9304459 A MX 9304459A MX 9304459 A MX9304459 A MX 9304459A MX 9304459 A MX9304459 A MX 9304459A MX 9304459 A MX9304459 A MX 9304459A
Authority
MX
Mexico
Prior art keywords
amylase
alpha
enzyme
cross
drug release
Prior art date
Application number
MX9304459A
Other languages
English (en)
Inventor
Vincent Lenaerts
Mircea A Mateescu
Yves Dumoulin
Louis Cartilier
Original Assignee
Univ Quebec Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Quebec Montreal filed Critical Univ Quebec Montreal
Publication of MX9304459A publication Critical patent/MX9304459A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente solicitud se refiere a una unidad de dosificación farmacéutica sólida de liberación lenta. En forma especifica, la invención se enfoca hacia una tableta preparados mediante compresión directa de amilosa de enlace cruzado (CLA) que tiene un grado definido de enlace cruzado, alfa-amilasa y un agente farmacéutico. La presencia de la amilosa de enlace cruzado permite una liberación sostenida del fármaco, mientras que la alfa-amilasa permite la modulación del tiempo de liberación. En otras palabras, el tiempo de liberación del fármaco depende de la cantidad de alfa-amilasa en la tableta. La cantidad de alfa-amilasa se define en términos de unidades de enzima.
MX9304459A 1992-07-24 1993-07-23 Material polihidroxilico de enlace curzado para la liberacion de farmacos controlada por enzimas. MX9304459A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91976292A 1992-07-24 1992-07-24

Publications (1)

Publication Number Publication Date
MX9304459A true MX9304459A (es) 1994-04-29

Family

ID=25442612

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304459A MX9304459A (es) 1992-07-24 1993-07-23 Material polihidroxilico de enlace curzado para la liberacion de farmacos controlada por enzimas.

Country Status (18)

Country Link
EP (1) EP0651634B1 (es)
JP (1) JP3647859B2 (es)
KR (1) KR100304997B1 (es)
AT (1) ATE137668T1 (es)
AU (1) AU668198B2 (es)
CA (1) CA2140032C (es)
CZ (1) CZ283395B6 (es)
DE (1) DE69302580T2 (es)
ES (1) ES2086949T3 (es)
FI (1) FI950301A0 (es)
GR (1) GR3020476T3 (es)
HU (1) HU221591B (es)
MX (1) MX9304459A (es)
NO (1) NO308024B1 (es)
NZ (1) NZ254048A (es)
PL (1) PL173249B1 (es)
RU (1) RU2136270C1 (es)
WO (1) WO1994002121A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2173818A1 (fr) * 1996-04-10 1997-10-11 Francois Chouinard Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
DE19640062B4 (de) * 1996-09-28 2006-04-27 Lts Lohmann Therapie-Systeme Ag Orale Zubereitung, enthaltend in einer in wässrigem Medium quellbaren Matrix wenigstens einen pharmazeutischen Wirkstoff
US5879707A (en) * 1996-10-30 1999-03-09 Universite De Montreal Substituted amylose as a matrix for sustained drug release
US5807575A (en) * 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds
US6077537A (en) * 1997-05-21 2000-06-20 Warner-Lambert Company Non-sedating acrivastine product
CA2217238C (en) * 1997-10-24 2005-09-20 Louis Cartilier Cross-linked cellulose as a tablet excipient
CA2393231A1 (en) 1999-12-06 2001-06-07 Edward Mendell Co., Inc. Pharmaceutical superdisintegrant
US6607748B1 (en) 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
JP5269595B2 (ja) 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー 1日1回投与用トラゾドン組成物
EP1946780B1 (en) 2005-11-11 2012-01-11 Asahi Kasei Chemicals Corporation Controlled release solid preparation
WO2012003968A1 (en) 2010-07-06 2012-01-12 Grünenthal GmbH Novel gastro- retentive dosage forms comprising a gaba analog and an opioid
WO2012007159A2 (en) 2010-07-14 2012-01-19 Grünenthal GmbH Novel gastro-retentive dosage forms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3181998A (en) * 1960-08-12 1965-05-04 Joseph L Kanig Tablet disintegration
US3493652A (en) * 1962-09-14 1970-02-03 Charles W Hartman Controlled release medicament
SE420565B (sv) * 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
DE3721574A1 (de) * 1987-06-30 1989-01-12 Kettelhack Riker Pharma Gmbh Arzneimittel in form von pellets mit enzymatisch kontrollierter arzneistoff-freisetzung

Also Published As

Publication number Publication date
NO950251L (no) 1995-01-23
GR3020476T3 (en) 1996-10-31
CA2140032A1 (en) 1994-02-03
PL307234A1 (en) 1995-05-15
DE69302580T2 (de) 1996-09-26
KR100304997B1 (ko) 2002-04-24
HU9500197D0 (en) 1995-03-28
CA2140032C (en) 1999-01-26
CZ15295A3 (en) 1995-09-13
JPH08502036A (ja) 1996-03-05
AU668198B2 (en) 1996-04-26
PL173249B1 (pl) 1998-02-27
RU2136270C1 (ru) 1999-09-10
CZ283395B6 (cs) 1998-04-15
FI950301A (fi) 1995-01-24
HU221591B (hu) 2002-11-28
NO950251D0 (no) 1995-01-23
ATE137668T1 (de) 1996-05-15
NO308024B1 (no) 2000-07-10
NZ254048A (en) 1995-09-26
EP0651634A1 (en) 1995-05-10
AU4555993A (en) 1994-02-14
EP0651634B1 (en) 1996-05-08
WO1994002121A1 (en) 1994-02-03
JP3647859B2 (ja) 2005-05-18
ES2086949T3 (es) 1996-07-01
HUT75673A (en) 1997-05-28
FI950301A0 (fi) 1995-01-24
DE69302580D1 (de) 1996-06-13

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