HUP0000851A3 - Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
HUP0000851A3
HUP0000851A3 HU0000851A HUP0000851A HUP0000851A3 HU P0000851 A3 HUP0000851 A3 HU P0000851A3 HU 0000851 A HU0000851 A HU 0000851A HU P0000851 A HUP0000851 A HU P0000851A HU P0000851 A3 HUP0000851 A3 HU P0000851A3
Authority
HU
Hungary
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
pyrimidine derivatives
Prior art date
Application number
HU0000851A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of HUP0000851A1 publication Critical patent/HUP0000851A1/hu
Publication of HUP0000851A3 publication Critical patent/HUP0000851A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0000851A 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them HUP0000851A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970010862 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
HUP0000851A1 HUP0000851A1 (hu) 2001-04-28
HUP0000851A3 true HUP0000851A3 (en) 2002-04-29

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000851A HUP0000851A3 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US6352993B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP1015444B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3176379B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100278857B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1118464C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR012181A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE241613T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU720385B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9808070A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2284795C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69815126T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK1015444T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2200324T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUP0000851A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN188411B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT1015444E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2203894C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (1) TR199902383T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW542831B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UY (1) UY24938A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1998043968A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
US7816353B2 (en) * 2003-10-24 2010-10-19 Exelixis, Inc. P70S6 kinase modulators and method of use
WO2005041961A1 (en) 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
US20090124645A1 (en) * 2005-10-14 2009-05-14 Neurosearch A/S Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CN102171210B (zh) 2008-08-05 2014-04-23 第一三共株式会社 咪唑并吡啶-2-酮衍生物
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
JP5980236B2 (ja) 2011-02-25 2016-08-31 ユーハン・コーポレイションＹＵＨＡＮ Ｃｏｒｐｏｒａｔｉｏｎ ジアミノピリミジン誘導体及びその製造方法
US9447051B2 (en) * 2012-02-17 2016-09-20 Abbvie Inc. Diaminopyrimidines and uses thereof
CA2873674A1 (en) 2012-05-29 2013-12-05 Momentive Performance Materials Gmbh Preparation of isocyanato silanes
JP6412503B2 (ja) 2012-11-21 2018-10-24 ピーティーシー セラピューティクス， インコーポレイテッド 置換逆ピリミジンＢｍｉ−１阻害剤
WO2014139326A1 (en) 2013-03-13 2014-09-18 Genentech, Inc. Pyrazolo compounds and uses thereof
JP6524094B2 (ja) * 2013-08-30 2019-06-05 ピーティーシー セラピューティクス， インコーポレイテッド 置換ピリミジンＢｍｉ−１阻害剤
US10125144B2 (en) 2013-10-07 2018-11-13 Kadmon Corporation, Llc Rho kinase inhibitors
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
WO2016064970A1 (en) * 2014-10-22 2016-04-28 The Board Of Regents Of The University Of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
CA3009573A1 (en) * 2016-01-04 2017-07-13 ObsEva S.A. Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
JP7107962B2 (ja) * 2017-04-05 2022-07-27 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ２－アミノ－５－オキシアルキル－ピリミジン誘導体および望ましくない植物成長を防除するためのその使用
US12023335B2 (en) 2018-08-17 2024-07-02 Ptc Therapeutics, Inc. Method for treating pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
EP0388838B1 (de) 1989-03-22 1996-01-10 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
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KR930702292A (ko) 1990-11-06 1993-09-08 알렌 제이. 스피겔 종양 치료 활성을 증대시키기 위한 퀴나졸린 유도체
DE9290039U1 (de) 1991-04-17 1993-12-09 Pfizer Inc., New York, N.Y. Pyrimidinderivate zur Verbesserung der Anti-Tumor-Aktivität
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
SK16396A3 (en) * 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
JP2896532B2 (ja) 1994-08-13 1999-05-31 ユーハン コーポレーション 新規なピリミジン誘導体およびその製造方法
JP3160297B2 (ja) 1996-05-04 2001-04-25 ユーハン・コーポレイション ピリミジン誘導体の製造方法

Also Published As

Publication number Publication date
KR19980080789A (ko) 1998-11-25
CA2284795A1 (en) 1998-10-08
WO1998043968A1 (en) 1998-10-08
RU2203894C2 (ru) 2003-05-10
AR012181A1 (es) 2000-09-27
UY24938A1 (es) 2001-01-31
EP1015444B1 (en) 2003-05-28
JP2000513014A (ja) 2000-10-03
TW542831B (en) 2003-07-21
DE69815126T2 (de) 2004-04-08
DE69815126D1 (de) 2003-07-03
US6352993B1 (en) 2002-03-05
AU6523998A (en) 1998-10-22
JP3176379B2 (ja) 2001-06-18
TR199902383T2 (xx) 2000-06-21
AU720385B2 (en) 2000-06-01
CN1118464C (zh) 2003-08-20
BR9808070A (pt) 2000-03-08
HK1026418A1 (en) 2000-12-15
CA2284795C (en) 2004-01-20
ES2200324T3 (es) 2004-03-01
CN1251586A (zh) 2000-04-26
ATE241613T1 (de) 2003-06-15
PT1015444E (pt) 2003-10-31
HUP0000851A1 (hu) 2001-04-28
EP1015444A1 (en) 2000-07-05
IN188411B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-09-21
DK1015444T3 (da) 2003-08-18
KR100278857B1 (ko) 2001-01-15

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees