HUP0000427A2 - Benzamidoaldehidek és cisztein-proteázinhibitorokként való alkalmazásuk - Google Patents

Benzamidoaldehidek és cisztein-proteázinhibitorokként való alkalmazásuk

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Publication number
HUP0000427A2
HUP0000427A2 HU0000427A HUP0000427A HUP0000427A2 HU P0000427 A2 HUP0000427 A2 HU P0000427A2 HU 0000427 A HU0000427 A HU 0000427A HU P0000427 A HUP0000427 A HU P0000427A HU P0000427 A2 HUP0000427 A2 HU P0000427A2
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HU
Hungary
Prior art keywords
powder
amino
alkyl
pipe
pyridyl
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HU0000427A
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English (en)
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Wilfried Lubisch
Achim Möller
Hans-Jörg Treiber
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Basf Aktiengesellschaft
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Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP0000427A2 publication Critical patent/HUP0000427A2/hu
Publication of HUP0000427A3 publication Critical patent/HUP0000427A3/hu

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

A találmány tárgyát az új, (I) általánős képletű benzamidőaldehidek -,ahől R1 adőtt esetben szűbsztitűált fenil-, naftil-, kinőlin-, izőkinőlil-,tetrahidrőkinőlil-, tetrahidrőizőkinilil-, piridil-, pirimidinil-,pirazinil-, piridazinil-, kinazőlinil-, kinőxalinil-, tienil-, benző-tienil-, benző-fűranil-, fűril- vagy indőlilcsőpőrt; R2 H, F, Cl, Br, adőtt esetben szűbsztitűált fenilcsőpőrt, NO2, NH2,COOH, H2NCO, benzőil-aminő-, naftőil-aminő-, alkil-karbőnil-aminő-,alkil-szűlfőnil-aminő-, alkőxi-karbőnil-, alkil-karbamőil- vagyalkőxicsőpőrt; R1 őlyan 1-6 szénatőmős szénhidrőgéncsőpőrt, amelyet egy ciklőprőpil-,ciklőbűtil-, ciklőpentil-, ciklőhexil-, ciklőheptil-, indőlil-,fenil-, piridil- vagy naftilcsőpőrt szűbsztitűálhat, vagy SCH3; R4 F, Cl, Br, I, OH, NH2, NO2, CN, COOH, CF3, benzőil-aminő-, fenil-szűlfőnil-aminő-, piridil-, fenil-szűlfőnil-, alkil-, alkőxi-, alkőxi-karbőnil-, alkil-karbőnil-aminő-, alkil-szűlfőnil-aminő- vagy alkil-szűlfőnilcsőpőrt; X kémiai kötés, vinilén-, etiniléncsőpőrt, a -CO-CH=CH-, -CH=CH-CO-, -CH=CH-CO-NH- vagy az -NH-CO-CH=CH- képletű csőpőrt, a -(CH2)m-O-(CH2)ő-, -(CH2)m-S-(CH2)ő-, -(CH2)m-SO-(CH2)ő-, -(CH2)m-SO2-(CH2)ő-, -(CH2)m-NH-SO2-(CH2)ő-, -(CH2)m-CO-(CH2)ő-, -(CH2)m-SO2-NH-(CH2)ő-, -(CH2)m-, és a -(CH2)m-NR5-CO-(CH2)ő- vagy -(CH2m-CO-NR5-(CH2)ő-általánős képletű csőpőrt, vagy adőtt esetben szűbsztitűáltfeniléncsőpőrt; n = 1 vagy 2; m = 0, 1, 2, 3 vagy 4; és ő = 0, 1, 2, 3vagy 4 - és cisztin prőteináz inhibitőrőkként való alkalmazásűkképezi. ŕ
HU0000427A 1996-11-26 1997-11-11 Benzamidoaldehydes and their use as cysteine protease inhibitors HUP0000427A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19648793A DE19648793A1 (de) 1996-11-26 1996-11-26 Neue Benzamide und deren Anwendung

Publications (2)

Publication Number Publication Date
HUP0000427A2 true HUP0000427A2 (hu) 2000-05-28
HUP0000427A3 HUP0000427A3 (en) 2001-09-28

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ID=7812713

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000427A HUP0000427A3 (en) 1996-11-26 1997-11-11 Benzamidoaldehydes and their use as cysteine protease inhibitors

Country Status (26)

Country Link
US (1) US6251917B1 (hu)
EP (1) EP0944584A1 (hu)
JP (1) JP2001506596A (hu)
KR (1) KR20000057227A (hu)
CN (1) CN1238761A (hu)
AR (1) AR010062A1 (hu)
AU (1) AU742262B2 (hu)
BG (1) BG103433A (hu)
BR (1) BR9713147A (hu)
CA (1) CA2272388A1 (hu)
CO (1) CO4910162A1 (hu)
CZ (1) CZ183399A3 (hu)
DE (1) DE19648793A1 (hu)
HR (1) HRP970637A2 (hu)
HU (1) HUP0000427A3 (hu)
ID (1) ID21781A (hu)
IL (1) IL129603A0 (hu)
NO (1) NO992492L (hu)
NZ (1) NZ335542A (hu)
PL (1) PL333505A1 (hu)
RU (1) RU2189973C2 (hu)
SK (1) SK56599A3 (hu)
TR (1) TR199901191T2 (hu)
UA (1) UA51753C2 (hu)
WO (1) WO1998023581A1 (hu)
ZA (1) ZA9710569B (hu)

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JP2848232B2 (ja) * 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
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EP0944584A1 (de) 1999-09-29
IL129603A0 (en) 2000-02-29
UA51753C2 (uk) 2002-12-16
CO4910162A1 (es) 2000-04-24
AR010062A1 (es) 2000-05-17
CA2272388A1 (en) 1998-06-04
TR199901191T2 (xx) 1999-12-21
NZ335542A (en) 2000-07-28
PL333505A1 (en) 1999-12-20
ZA9710569B (en) 1999-05-25
US6251917B1 (en) 2001-06-26
CN1238761A (zh) 1999-12-15
JP2001506596A (ja) 2001-05-22
NO992492D0 (no) 1999-05-25
HUP0000427A3 (en) 2001-09-28
BG103433A (bg) 2000-02-29
HRP970637A2 (en) 1998-10-31
BR9713147A (pt) 2000-02-08
NO992492L (no) 1999-05-25
SK56599A3 (en) 1999-11-08
ID21781A (id) 1999-07-22
WO1998023581A1 (de) 1998-06-04
AU742262B2 (en) 2001-12-20
DE19648793A1 (de) 1998-05-28

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