HUE034908T2 - Anti-CS1 antitestek terápiás alkalmazása - Google Patents

Info

Publication number

HUE034908T2

HUE034908T2 HUE14178061A HUE14178061A HUE034908T2 HU E034908 T2 HUE034908 T2 HU E034908T2 HU E14178061 A HUE14178061 A HU E14178061A HU E14178061 A HUE14178061 A HU E14178061A HU E034908 T2 HUE034908 T2 HU E034908T2

Authority

HU

Hungary

Prior art keywords

cells

antibody

antibodies

seq

protein

Prior art date

2003-05-08

Links

• Espacenet
• Global Dossier
• Discuss

• 230000001225 therapeutic effect Effects 0.000 title description 8
• 238000000034 method Methods 0.000 claims abstract description 118
• 239000012634 fragment Substances 0.000 claims abstract description 81
• 230000027455 binding Effects 0.000 claims abstract description 76
• 239000000427 antigen Substances 0.000 claims abstract description 57
• 108091007433 antigens Proteins 0.000 claims abstract description 55
• 102000036639 antigens Human genes 0.000 claims abstract description 55
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 44
• 239000005557 antagonist Substances 0.000 claims abstract description 30
• 108090000623 proteins and genes Proteins 0.000 claims description 210
• 102000004169 proteins and genes Human genes 0.000 claims description 140
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 111
• 201000000050 myeloid neoplasm Diseases 0.000 claims description 79
• 108060003951 Immunoglobulin Proteins 0.000 claims description 46
• 102000018358 immunoglobulin Human genes 0.000 claims description 46
• 238000011282 treatment Methods 0.000 claims description 45
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
• 238000004519 manufacturing process Methods 0.000 claims description 42
• 239000003795 chemical substances by application Substances 0.000 claims description 23
• 150000001875 compounds Chemical class 0.000 claims description 22
• 239000012636 effector Substances 0.000 claims description 21
• 230000028327 secretion Effects 0.000 claims description 19
• 230000003042 antagnostic effect Effects 0.000 claims description 12
• 230000000692 anti-sense effect Effects 0.000 claims description 11
• 239000003814 drug Substances 0.000 claims description 10
• 229940127089 cytotoxic agent Drugs 0.000 claims description 7
• 239000003242 anti bacterial agent Substances 0.000 claims description 6
• 230000001419 dependent effect Effects 0.000 claims description 5
• 239000002254 cytotoxic agent Substances 0.000 claims description 4
• 231100000599 cytotoxic agent Toxicity 0.000 claims description 4
• 239000002246 antineoplastic agent Substances 0.000 claims description 3
• 230000003115 biocidal effect Effects 0.000 claims description 3
• 239000002955 immunomodulating agent Substances 0.000 claims description 3
• 229940121354 immunomodulator Drugs 0.000 claims description 3
• 230000000843 anti-fungal effect Effects 0.000 claims description 2
• 229940121375 antifungal agent Drugs 0.000 claims description 2
• 239000002975 chemoattractant Substances 0.000 claims description 2
• 230000036210 malignancy Effects 0.000 claims description 2
• 235000013361 beverage Nutrition 0.000 claims 2
• 241000237852 Mollusca Species 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 238000009175 antibody therapy Methods 0.000 claims 1
• 230000029142 excretion Effects 0.000 claims 1
• 230000002584 immunomodulator Effects 0.000 claims 1
• 206010025482 malaise Diseases 0.000 claims 1
• 229920001542 oligosaccharide Polymers 0.000 claims 1
• 150000002482 oligosaccharides Chemical class 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 34
• 208000023275 Autoimmune disease Diseases 0.000 abstract description 32
• 201000010099 disease Diseases 0.000 abstract description 26
• 201000011510 cancer Diseases 0.000 abstract description 22
• 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 abstract description 5
• 239000008194 pharmaceutical composition Substances 0.000 abstract description 4
• 230000004071 biological effect Effects 0.000 abstract description 2
• 210000004027 cell Anatomy 0.000 description 263
• 235000018102 proteins Nutrition 0.000 description 121
• 150000007523 nucleic acids Chemical class 0.000 description 116
• 230000014509 gene expression Effects 0.000 description 115
• 102000039446 nucleic acids Human genes 0.000 description 97
• 108020004707 nucleic acids Proteins 0.000 description 97
• 241000282414 Homo sapiens Species 0.000 description 85
• 108090000765 processed proteins & peptides Proteins 0.000 description 80
• 125000003275 alpha amino acid group Chemical group 0.000 description 77
• 102000004196 processed proteins & peptides Human genes 0.000 description 72
• 229920001184 polypeptide Polymers 0.000 description 70
• 239000000523 sample Substances 0.000 description 65
• 108091034117 Oligonucleotide Proteins 0.000 description 61
• 239000002299 complementary DNA Substances 0.000 description 57
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 42
• 235000001014 amino acid Nutrition 0.000 description 42
• 210000003719 b-lymphocyte Anatomy 0.000 description 41
• 238000009396 hybridization Methods 0.000 description 40
• 238000003752 polymerase chain reaction Methods 0.000 description 39
• 241000699666 Mus <mouse, genus> Species 0.000 description 38
• 241000699670 Mus sp. Species 0.000 description 38
• 229940024606 amino acid Drugs 0.000 description 37
• 150000001413 amino acids Chemical class 0.000 description 37
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 37
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 35
• 229960004137 elotuzumab Drugs 0.000 description 35
• 238000003556 assay Methods 0.000 description 34
• 210000001519 tissue Anatomy 0.000 description 34
• 108020004414 DNA Proteins 0.000 description 33
• 239000013615 primer Substances 0.000 description 30
• 239000013604 expression vector Substances 0.000 description 27
• 210000004408 hybridoma Anatomy 0.000 description 27
• 230000003013 cytotoxicity Effects 0.000 description 25
• 231100000135 cytotoxicity Toxicity 0.000 description 25
• 210000004698 lymphocyte Anatomy 0.000 description 25
• 210000004180 plasmocyte Anatomy 0.000 description 25
• 208000034578 Multiple myelomas Diseases 0.000 description 24
• 108020004999 messenger RNA Proteins 0.000 description 24
• 239000000203 mixture Substances 0.000 description 23
• 238000001727 in vivo Methods 0.000 description 22
• 230000001965 increasing effect Effects 0.000 description 21
• 239000000872 buffer Substances 0.000 description 20
• 238000001514 detection method Methods 0.000 description 20
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
• 238000002965 ELISA Methods 0.000 description 19
• 230000000694 effects Effects 0.000 description 19
• 238000000338 in vitro Methods 0.000 description 19
• 125000003729 nucleotide group Chemical group 0.000 description 19
• 239000002773 nucleotide Substances 0.000 description 18
• 239000013612 plasmid Substances 0.000 description 18
• 210000000265 leukocyte Anatomy 0.000 description 17
• 206010039073 rheumatoid arthritis Diseases 0.000 description 17
• 238000010186 staining Methods 0.000 description 17
• 239000013598 vector Substances 0.000 description 17
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 16
• 239000002253 acid Substances 0.000 description 16
• 108020001507 fusion proteins Proteins 0.000 description 16
• 102000037865 fusion proteins Human genes 0.000 description 16
• 238000006467 substitution reaction Methods 0.000 description 16
• 239000000758 substrate Substances 0.000 description 16
• -1 CDw40 Proteins 0.000 description 15
• 208000011231 Crohn disease Diseases 0.000 description 15
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 15
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 15
• 238000004422 calculation algorithm Methods 0.000 description 15
• 208000024891 symptom Diseases 0.000 description 15
• 108010033737 Pokeweed Mitogens Proteins 0.000 description 14
• 238000006243 chemical reaction Methods 0.000 description 14
• 208000031223 plasma cell leukemia Diseases 0.000 description 14
• 238000003753 real-time PCR Methods 0.000 description 14
• 239000000126 substance Substances 0.000 description 14
• 102000004190 Enzymes Human genes 0.000 description 13
• 108090000790 Enzymes Proteins 0.000 description 13
• 229940088598 enzyme Drugs 0.000 description 13
• 210000002381 plasma Anatomy 0.000 description 13
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 12
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 12
• 230000001939 inductive effect Effects 0.000 description 12
• 230000004048 modification Effects 0.000 description 12
• 238000012986 modification Methods 0.000 description 12
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 11
• 108091093037 Peptide nucleic acid Proteins 0.000 description 11
• 210000001744 T-lymphocyte Anatomy 0.000 description 11
• 230000003321 amplification Effects 0.000 description 11
• 238000004458 analytical method Methods 0.000 description 11
• 238000013459 approach Methods 0.000 description 11
• 230000009089 cytolysis Effects 0.000 description 11
• 238000003745 diagnosis Methods 0.000 description 11
• 238000003199 nucleic acid amplification method Methods 0.000 description 11
• 239000002853 nucleic acid probe Substances 0.000 description 11
• 230000035755 proliferation Effects 0.000 description 11
• 238000000746 purification Methods 0.000 description 11
• 230000002829 reductive effect Effects 0.000 description 11
• 210000002966 serum Anatomy 0.000 description 11
• 239000006228 supernatant Substances 0.000 description 11
• 238000005406 washing Methods 0.000 description 11
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
• 101710178046 Chorismate synthase 1 Proteins 0.000 description 10
• 101710152695 Cysteine synthase 1 Proteins 0.000 description 10
• 102100032831 Protein ITPRID2 Human genes 0.000 description 10
• 210000001185 bone marrow Anatomy 0.000 description 10
• 230000001413 cellular effect Effects 0.000 description 10
• 239000003153 chemical reaction reagent Substances 0.000 description 10
• 230000006378 damage Effects 0.000 description 10
• 206010025135 lupus erythematosus Diseases 0.000 description 10
• 102000040430 polynucleotide Human genes 0.000 description 10
• 108091033319 polynucleotide Proteins 0.000 description 10
• 239000002157 polynucleotide Substances 0.000 description 10
• 230000001105 regulatory effect Effects 0.000 description 10
• 238000012360 testing method Methods 0.000 description 10
• 238000013518 transcription Methods 0.000 description 10
• 230000035897 transcription Effects 0.000 description 10
• 206010009900 Colitis ulcerative Diseases 0.000 description 9
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 9
• 241001465754 Metazoa Species 0.000 description 9
• 108091028043 Nucleic acid sequence Proteins 0.000 description 9
• 238000011579 SCID mouse model Methods 0.000 description 9
• 201000006704 Ulcerative Colitis Diseases 0.000 description 9
• 238000010171 animal model Methods 0.000 description 9
• 230000001580 bacterial effect Effects 0.000 description 9
• 210000004369 blood Anatomy 0.000 description 9
• 239000008280 blood Substances 0.000 description 9
• 210000000988 bone and bone Anatomy 0.000 description 9
• 238000005516 engineering process Methods 0.000 description 9
• 239000012091 fetal bovine serum Substances 0.000 description 9
• 230000001404 mediated effect Effects 0.000 description 9
• 239000002777 nucleoside Substances 0.000 description 9
• 230000009467 reduction Effects 0.000 description 9
• 238000002560 therapeutic procedure Methods 0.000 description 9
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 8
• 206010057248 Cell death Diseases 0.000 description 8
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
• 241000700159 Rattus Species 0.000 description 8
• 230000006907 apoptotic process Effects 0.000 description 8
• 230000000295 complement effect Effects 0.000 description 8
• 230000007423 decrease Effects 0.000 description 8
• 208000035475 disorder Diseases 0.000 description 8
• 239000000499 gel Substances 0.000 description 8
• 230000013595 glycosylation Effects 0.000 description 8
• 238000006206 glycosylation reaction Methods 0.000 description 8
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 8
• 230000001900 immune effect Effects 0.000 description 8
• 210000003734 kidney Anatomy 0.000 description 8
• 230000035772 mutation Effects 0.000 description 8
• 239000008188 pellet Substances 0.000 description 8
• 238000002360 preparation method Methods 0.000 description 8
• 239000000047 product Substances 0.000 description 8
• 238000011160 research Methods 0.000 description 8
• 238000012216 screening Methods 0.000 description 8
• 241000894006 Bacteria Species 0.000 description 7
• 108020004705 Codon Proteins 0.000 description 7
• 241000588724 Escherichia coli Species 0.000 description 7
• 206010061218 Inflammation Diseases 0.000 description 7
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 7
• 150000007513 acids Chemical class 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 229940098773 bovine serum albumin Drugs 0.000 description 7
• 210000004556 brain Anatomy 0.000 description 7
• 150000001720 carbohydrates Chemical class 0.000 description 7
• 238000011161 development Methods 0.000 description 7
• 230000018109 developmental process Effects 0.000 description 7
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 7
• 230000002068 genetic effect Effects 0.000 description 7
• 230000006698 induction Effects 0.000 description 7
• 230000004054 inflammatory process Effects 0.000 description 7
• 238000002372 labelling Methods 0.000 description 7
• 125000005647 linker group Chemical group 0.000 description 7
• 239000003550 marker Substances 0.000 description 7
• 239000000463 material Substances 0.000 description 7
• 210000005259 peripheral blood Anatomy 0.000 description 7
• 239000011886 peripheral blood Substances 0.000 description 7
• 238000001742 protein purification Methods 0.000 description 7
• 102000005962 receptors Human genes 0.000 description 7
• 108020003175 receptors Proteins 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 238000001890 transfection Methods 0.000 description 7
• 239000011534 wash buffer Substances 0.000 description 7
• 108020004463 18S ribosomal RNA Proteins 0.000 description 6
• 101150034556 CS1 gene Proteins 0.000 description 6
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 6
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 6
• 241000238631 Hexapoda Species 0.000 description 6
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 6
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 6
• 241000124008 Mammalia Species 0.000 description 6
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 6
• 101000633785 Mus musculus SLAM family member 7 Proteins 0.000 description 6
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
• 108010004729 Phycoerythrin Proteins 0.000 description 6
• 239000004698 Polyethylene Substances 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
• 108010090804 Streptavidin Proteins 0.000 description 6
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 6
• 238000002835 absorbance Methods 0.000 description 6
• 230000004913 activation Effects 0.000 description 6
• 125000000539 amino acid group Chemical group 0.000 description 6
• 125000003277 amino group Chemical group 0.000 description 6
• 210000001772 blood platelet Anatomy 0.000 description 6
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
• 238000010367 cloning Methods 0.000 description 6
• 206010009887 colitis Diseases 0.000 description 6
• 230000002950 deficient Effects 0.000 description 6
• 229940079593 drug Drugs 0.000 description 6
• 238000006062 fragmentation reaction Methods 0.000 description 6
• 230000005764 inhibitory process Effects 0.000 description 6
• 238000003780 insertion Methods 0.000 description 6
• 230000037431 insertion Effects 0.000 description 6
• 210000004962 mammalian cell Anatomy 0.000 description 6
• 238000010172 mouse model Methods 0.000 description 6
• 238000002703 mutagenesis Methods 0.000 description 6
• 231100000350 mutagenesis Toxicity 0.000 description 6
• 238000010606 normalization Methods 0.000 description 6
• 150000003833 nucleoside derivatives Chemical class 0.000 description 6
• 238000004393 prognosis Methods 0.000 description 6
• 230000002285 radioactive effect Effects 0.000 description 6
• 239000007787 solid Substances 0.000 description 6
• 210000000952 spleen Anatomy 0.000 description 6
• 238000010561 standard procedure Methods 0.000 description 6
• 238000003786 synthesis reaction Methods 0.000 description 6
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 5
• 108091026890 Coding region Proteins 0.000 description 5
• 108020004635 Complementary DNA Proteins 0.000 description 5
• 238000000018 DNA microarray Methods 0.000 description 5
• 108010087819 Fc receptors Proteins 0.000 description 5
• 102000009109 Fc receptors Human genes 0.000 description 5
• 239000004471 Glycine Substances 0.000 description 5
• 102000012153 HLA-B27 Antigen Human genes 0.000 description 5
• 108010061486 HLA-B27 Antigen Proteins 0.000 description 5
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 5
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 5
• 241000699660 Mus musculus Species 0.000 description 5
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 5
• 208000007452 Plasmacytoma Diseases 0.000 description 5
• 108020004511 Recombinant DNA Proteins 0.000 description 5
• 239000002671 adjuvant Substances 0.000 description 5
• 210000005058 airway cell Anatomy 0.000 description 5
• 210000004102 animal cell Anatomy 0.000 description 5
• 239000012472 biological sample Substances 0.000 description 5
• 229960002685 biotin Drugs 0.000 description 5
• 235000020958 biotin Nutrition 0.000 description 5
• 239000011616 biotin Substances 0.000 description 5
• 210000000481 breast Anatomy 0.000 description 5
• 235000014633 carbohydrates Nutrition 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 238000002512 chemotherapy Methods 0.000 description 5
• 230000001186 cumulative effect Effects 0.000 description 5
• 238000012217 deletion Methods 0.000 description 5
• 230000037430 deletion Effects 0.000 description 5
• 239000012149 elution buffer Substances 0.000 description 5
• 210000001671 embryonic stem cell Anatomy 0.000 description 5
• 239000003623 enhancer Substances 0.000 description 5
• 238000013467 fragmentation Methods 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 230000012010 growth Effects 0.000 description 5
• 210000002216 heart Anatomy 0.000 description 5
• 210000005260 human cell Anatomy 0.000 description 5
• 229940124452 immunizing agent Drugs 0.000 description 5
• 230000002998 immunogenetic effect Effects 0.000 description 5
• 239000003018 immunosuppressive agent Substances 0.000 description 5
• 230000002637 immunotoxin Effects 0.000 description 5
• 239000002596 immunotoxin Substances 0.000 description 5
• 229940051026 immunotoxin Drugs 0.000 description 5
• 231100000608 immunotoxin Toxicity 0.000 description 5
• 239000003112 inhibitor Substances 0.000 description 5
• 230000002401 inhibitory effect Effects 0.000 description 5
• 238000002347 injection Methods 0.000 description 5
• 239000007924 injection Substances 0.000 description 5
• 238000007912 intraperitoneal administration Methods 0.000 description 5
• 208000032839 leukemia Diseases 0.000 description 5
• 210000004072 lung Anatomy 0.000 description 5
• 210000001165 lymph node Anatomy 0.000 description 5
• 210000001161 mammalian embryo Anatomy 0.000 description 5
• 238000012544 monitoring process Methods 0.000 description 5
• 210000000822 natural killer cell Anatomy 0.000 description 5
• 239000013642 negative control Substances 0.000 description 5
• 229920000642 polymer Polymers 0.000 description 5
• 210000000813 small intestine Anatomy 0.000 description 5
• 241000894007 species Species 0.000 description 5
• 230000002103 transcriptional effect Effects 0.000 description 5
• 238000011830 transgenic mouse model Methods 0.000 description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 4
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 4
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 4
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 4
• 241000283707 Capra Species 0.000 description 4
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
• 108700024394 Exon Proteins 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 4
• 240000005979 Hordeum vulgare Species 0.000 description 4
• 235000007340 Hordeum vulgare Nutrition 0.000 description 4
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 4
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
• 239000004367 Lipase Substances 0.000 description 4
• 108090001060 Lipase Proteins 0.000 description 4
• 102000004882 Lipase Human genes 0.000 description 4
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 4
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
• 239000004472 Lysine Substances 0.000 description 4
• 241001529936 Murinae Species 0.000 description 4
• 108091005461 Nucleic proteins Proteins 0.000 description 4
• 108010047620 Phytohemagglutinins Proteins 0.000 description 4
• 241000276498 Pollachius virens Species 0.000 description 4
• 201000004681 Psoriasis Diseases 0.000 description 4
• 241000283984 Rodentia Species 0.000 description 4
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 4
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
• 239000000654 additive Substances 0.000 description 4
• 235000004279 alanine Nutrition 0.000 description 4
• 238000012197 amplification kit Methods 0.000 description 4
• 229940088710 antibiotic agent Drugs 0.000 description 4
• 230000000903 blocking effect Effects 0.000 description 4
• 230000005889 cellular cytotoxicity Effects 0.000 description 4
• 230000000112 colonic effect Effects 0.000 description 4
• 238000002474 experimental method Methods 0.000 description 4
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
• 239000007850 fluorescent dye Substances 0.000 description 4
• 230000004927 fusion Effects 0.000 description 4
• 238000010353 genetic engineering Methods 0.000 description 4
• 230000036541 health Effects 0.000 description 4
• 230000002163 immunogen Effects 0.000 description 4
• 229940124589 immunosuppressive drug Drugs 0.000 description 4
• 230000002757 inflammatory effect Effects 0.000 description 4
• 210000003292 kidney cell Anatomy 0.000 description 4
• 210000002429 large intestine Anatomy 0.000 description 4
• 235000019421 lipase Nutrition 0.000 description 4
• 210000004185 liver Anatomy 0.000 description 4
• 239000002609 medium Substances 0.000 description 4
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 4
• 229930182817 methionine Natural products 0.000 description 4
• 238000002493 microarray Methods 0.000 description 4
• 210000004877 mucosa Anatomy 0.000 description 4
• 125000003835 nucleoside group Chemical group 0.000 description 4
• 210000002741 palatine tonsil Anatomy 0.000 description 4
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
• 230000001885 phytohemagglutinin Effects 0.000 description 4
• 238000010839 reverse transcription Methods 0.000 description 4
• 230000002269 spontaneous effect Effects 0.000 description 4
• 208000011580 syndromic disease Diseases 0.000 description 4
• 230000009261 transgenic effect Effects 0.000 description 4
• NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 3
• 208000023761 AL amyloidosis Diseases 0.000 description 3
• 239000004475 Arginine Substances 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 206010009944 Colon cancer Diseases 0.000 description 3
• 241000699800 Cricetinae Species 0.000 description 3
• 238000001712 DNA sequencing Methods 0.000 description 3
• 241000192125 Firmicutes Species 0.000 description 3
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 3
• 208000037147 Hypercalcaemia Diseases 0.000 description 3
• 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 3
• 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 3
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
• 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 description 3
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
• 102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
• 108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
• 230000004988 N-glycosylation Effects 0.000 description 3
• 108700020796 Oncogene Proteins 0.000 description 3
• 239000002202 Polyethylene glycol Substances 0.000 description 3
• 229920001213 Polysorbate 20 Polymers 0.000 description 3
• 206010036673 Primary amyloidosis Diseases 0.000 description 3
• 241000288906 Primates Species 0.000 description 3
• 108010076504 Protein Sorting Signals Proteins 0.000 description 3
• 239000012979 RPMI medium Substances 0.000 description 3
• 206010038063 Rectal haemorrhage Diseases 0.000 description 3
• 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
• 102100029198 SLAM family member 7 Human genes 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• 208000021386 Sjogren Syndrome Diseases 0.000 description 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
• 239000004473 Threonine Substances 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 230000002159 abnormal effect Effects 0.000 description 3
• 230000004075 alteration Effects 0.000 description 3
• 208000007502 anemia Diseases 0.000 description 3
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
• 230000001363 autoimmune Effects 0.000 description 3
• 210000000649 b-lymphocyte subset Anatomy 0.000 description 3
• 102000015736 beta 2-Microglobulin Human genes 0.000 description 3
• 108010081355 beta 2-Microglobulin Proteins 0.000 description 3
• 230000001588 bifunctional effect Effects 0.000 description 3
• 210000002798 bone marrow cell Anatomy 0.000 description 3
• 238000010804 cDNA synthesis Methods 0.000 description 3
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 3
• 238000003776 cleavage reaction Methods 0.000 description 3
• 230000000875 corresponding effect Effects 0.000 description 3
• 238000004132 cross linking Methods 0.000 description 3
• 201000003278 cryoglobulinemia Diseases 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 230000003247 decreasing effect Effects 0.000 description 3
• 238000013461 design Methods 0.000 description 3
• 238000010790 dilution Methods 0.000 description 3
• 239000012895 dilution Substances 0.000 description 3
• 238000010828 elution Methods 0.000 description 3
• 230000002255 enzymatic effect Effects 0.000 description 3
• 210000003743 erythrocyte Anatomy 0.000 description 3
• 201000006569 extramedullary plasmacytoma Diseases 0.000 description 3
• 238000000684 flow cytometry Methods 0.000 description 3
• 210000004602 germ cell Anatomy 0.000 description 3
• 239000008103 glucose Substances 0.000 description 3
• 230000000148 hypercalcaemia Effects 0.000 description 3
• 208000030915 hypercalcemia disease Diseases 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 210000000987 immune system Anatomy 0.000 description 3
• 230000003053 immunization Effects 0.000 description 3
• 238000002649 immunization Methods 0.000 description 3
• 230000016784 immunoglobulin production Effects 0.000 description 3
• 229940072221 immunoglobulins Drugs 0.000 description 3
• 238000011534 incubation Methods 0.000 description 3
• 230000003993 interaction Effects 0.000 description 3
• 238000007737 ion beam deposition Methods 0.000 description 3
• 208000002551 irritable bowel syndrome Diseases 0.000 description 3
• 238000002955 isolation Methods 0.000 description 3
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 3
• 229960000310 isoleucine Drugs 0.000 description 3
• 230000003902 lesion Effects 0.000 description 3
• 210000005229 liver cell Anatomy 0.000 description 3
• 201000000564 macroglobulinemia Diseases 0.000 description 3
• 210000002540 macrophage Anatomy 0.000 description 3
• 230000003211 malignant effect Effects 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 210000001616 monocyte Anatomy 0.000 description 3
• 201000006417 multiple sclerosis Diseases 0.000 description 3
• 206010028417 myasthenia gravis Diseases 0.000 description 3
• 210000000581 natural killer T-cell Anatomy 0.000 description 3
• 210000000056 organ Anatomy 0.000 description 3
• 238000002823 phage display Methods 0.000 description 3
• 230000008488 polyadenylation Effects 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
• 210000005267 prostate cell Anatomy 0.000 description 3
• 238000011002 quantification Methods 0.000 description 3
• 239000011541 reaction mixture Substances 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 230000007017 scission Effects 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 238000000926 separation method Methods 0.000 description 3
• 238000012163 sequencing technique Methods 0.000 description 3
• 210000002027 skeletal muscle Anatomy 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 238000003153 stable transfection Methods 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 3
• 210000001258 synovial membrane Anatomy 0.000 description 3
• 208000001608 teratocarcinoma Diseases 0.000 description 3
• 239000003053 toxin Substances 0.000 description 3
• 231100000765 toxin Toxicity 0.000 description 3
• 108700012359 toxins Proteins 0.000 description 3
• 230000009466 transformation Effects 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 230000004614 tumor growth Effects 0.000 description 3
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
• TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 2
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
• 208000004998 Abdominal Pain Diseases 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• 108700028369 Alleles Proteins 0.000 description 2
• USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
• 108050008874 Annexin Proteins 0.000 description 2
• 102000000412 Annexin Human genes 0.000 description 2
• XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 2
• 244000063299 Bacillus subtilis Species 0.000 description 2
• 235000014469 Bacillus subtilis Nutrition 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• 102100027207 CD27 antigen Human genes 0.000 description 2
• 102100037904 CD9 antigen Human genes 0.000 description 2
• 108010032001 CS1 peptide Proteins 0.000 description 2
• 206010008479 Chest Pain Diseases 0.000 description 2
• 206010010305 Confusional state Diseases 0.000 description 2
• 239000004971 Cross linker Substances 0.000 description 2
• 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 description 2
• 239000003155 DNA primer Substances 0.000 description 2
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
• 206010012735 Diarrhoea Diseases 0.000 description 2
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• 208000000059 Dyspnea Diseases 0.000 description 2
• 206010013975 Dyspnoeas Diseases 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 229920001917 Ficoll Polymers 0.000 description 2
• 208000018522 Gastrointestinal disease Diseases 0.000 description 2
• 208000015872 Gaucher disease Diseases 0.000 description 2
• 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 2
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
• 102000005744 Glycoside Hydrolases Human genes 0.000 description 2
• 108010031186 Glycoside Hydrolases Proteins 0.000 description 2
• 102000006354 HLA-DR Antigens Human genes 0.000 description 2
• 108010058597 HLA-DR Antigens Proteins 0.000 description 2
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
• 206010019233 Headaches Diseases 0.000 description 2
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 2
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 2
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 2
• 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 2
• 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 description 2
• 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 2
• 208000019758 Hypergammaglobulinemia Diseases 0.000 description 2
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 2
• 229930010555 Inosine Natural products 0.000 description 2
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
• 102100034343 Integrase Human genes 0.000 description 2
• 108090000174 Interleukin-10 Proteins 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical class CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
• 206010055046 Lichen myxoedematosus Diseases 0.000 description 2
• 101710085938 Matrix protein Proteins 0.000 description 2
• 101710127721 Membrane protein Proteins 0.000 description 2
• 101100236305 Mus musculus Ly9 gene Proteins 0.000 description 2
• 102000005717 Myeloma Proteins Human genes 0.000 description 2
• 108010045503 Myeloma Proteins Proteins 0.000 description 2
• 102100032965 Myomesin-2 Human genes 0.000 description 2
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 2
• 102000003729 Neprilysin Human genes 0.000 description 2
• 108090000028 Neprilysin Proteins 0.000 description 2
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 2
• 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 description 2
• 239000004677 Nylon Substances 0.000 description 2
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
• 108700026244 Open Reading Frames Proteins 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 238000012408 PCR amplification Methods 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 208000037273 Pathologic Processes Diseases 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
• 101710083287 SLAM family member 7 Proteins 0.000 description 2
• 238000010818 SYBR green PCR Master Mix Methods 0.000 description 2
• 208000001941 Scleromyxedema Diseases 0.000 description 2
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
• 241000700584 Simplexvirus Species 0.000 description 2
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
• 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 2
• 101710120037 Toxin CcdB Proteins 0.000 description 2
• 102000004357 Transferases Human genes 0.000 description 2
• 108090000992 Transferases Proteins 0.000 description 2
• 208000025865 Ulcer Diseases 0.000 description 2
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
• 108700005077 Viral Genes Proteins 0.000 description 2
• 241000700605 Viruses Species 0.000 description 2
• 230000005856 abnormality Effects 0.000 description 2
• 230000021736 acetylation Effects 0.000 description 2
• 238000006640 acetylation reaction Methods 0.000 description 2
• 239000011543 agarose gel Substances 0.000 description 2
• 150000001412 amines Chemical group 0.000 description 2
• 229960003896 aminopterin Drugs 0.000 description 2
• 230000033115 angiogenesis Effects 0.000 description 2
• 238000000137 annealing Methods 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 235000009582 asparagine Nutrition 0.000 description 2
• 229960001230 asparagine Drugs 0.000 description 2
• 235000003704 aspartic acid Nutrition 0.000 description 2
• OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• 235000013405 beer Nutrition 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
• 239000012148 binding buffer Substances 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 238000010322 bone marrow transplantation Methods 0.000 description 2
• 229910002091 carbon monoxide Inorganic materials 0.000 description 2
• 231100000357 carcinogen Toxicity 0.000 description 2
• 239000003183 carcinogenic agent Substances 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000007910 cell fusion Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 238000012512 characterization method Methods 0.000 description 2
• 238000004587 chromatography analysis Methods 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 210000004922 colonic epithelial cell Anatomy 0.000 description 2
• 239000000470 constituent Substances 0.000 description 2
• 238000010276 construction Methods 0.000 description 2
• 230000008878 coupling Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• 238000005859 coupling reaction Methods 0.000 description 2
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
• NXAKDBCNODQXBZ-YSZCVPRFSA-N cs1 peptide Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(O)=O)C(C)C)[C@@H](C)O)C1=CN=CN1 NXAKDBCNODQXBZ-YSZCVPRFSA-N 0.000 description 2
• 239000012228 culture supernatant Substances 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 2
• SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 2
• RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 2
• HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 2
• NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 2
• 210000004443 dendritic cell Anatomy 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 210000005069 ears Anatomy 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 210000002257 embryonic structure Anatomy 0.000 description 2
• 210000002889 endothelial cell Anatomy 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 230000007613 environmental effect Effects 0.000 description 2
• 201000010063 epididymitis Diseases 0.000 description 2
• 239000003797 essential amino acid Substances 0.000 description 2
• 235000020776 essential amino acid Nutrition 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 210000003527 eukaryotic cell Anatomy 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 239000012997 ficoll-paque Substances 0.000 description 2
• 210000003811 finger Anatomy 0.000 description 2
• 230000002496 gastric effect Effects 0.000 description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 235000013922 glutamic acid Nutrition 0.000 description 2
• 239000001963 growth medium Substances 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• 238000003306 harvesting Methods 0.000 description 2
• 231100000869 headache Toxicity 0.000 description 2
• 208000025750 heavy chain disease Diseases 0.000 description 2
• 229940094991 herring sperm dna Drugs 0.000 description 2
• 238000002744 homologous recombination Methods 0.000 description 2
• 230000006801 homologous recombination Effects 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 238000003384 imaging method Methods 0.000 description 2
• 238000003018 immunoassay Methods 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 238000007901 in situ hybridization Methods 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 230000028709 inflammatory response Effects 0.000 description 2
• 229960003786 inosine Drugs 0.000 description 2
• 230000000968 intestinal effect Effects 0.000 description 2
• 210000000936 intestine Anatomy 0.000 description 2
• 238000011835 investigation Methods 0.000 description 2
• DRAVOWXCEBXPTN-UHFFFAOYSA-N isoguanine Chemical compound NC1=NC(=O)NC2=C1NC=N2 DRAVOWXCEBXPTN-UHFFFAOYSA-N 0.000 description 2
• 208000019207 lichen myxedematosus Diseases 0.000 description 2
• 229920006008 lipopolysaccharide Polymers 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 229920002521 macromolecule Polymers 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 210000004379 membrane Anatomy 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 210000001806 memory b lymphocyte Anatomy 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• 239000000178 monomer Substances 0.000 description 2
• 238000011527 multiparameter analysis Methods 0.000 description 2
• 210000001331 nose Anatomy 0.000 description 2
• 229920001778 nylon Polymers 0.000 description 2
• 239000002751 oligonucleotide probe Substances 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 235000006408 oxalic acid Nutrition 0.000 description 2
• 230000009054 pathological process Effects 0.000 description 2
• 230000000149 penetrating effect Effects 0.000 description 2
• 210000004976 peripheral blood cell Anatomy 0.000 description 2
• 102000013415 peroxidase activity proteins Human genes 0.000 description 2
• 108040007629 peroxidase activity proteins Proteins 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 2
• PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 208000010626 plasma cell neoplasm Diseases 0.000 description 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
• 229920000573 polyethylene Polymers 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
• 230000008569 process Effects 0.000 description 2
• 238000000159 protein binding assay Methods 0.000 description 2
• 238000010791 quenching Methods 0.000 description 2
• 230000000171 quenching effect Effects 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• 230000008929 regeneration Effects 0.000 description 2
• 239000012557 regeneration buffer Substances 0.000 description 2
• 238000011069 regeneration method Methods 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 108091008146 restriction endonucleases Proteins 0.000 description 2
• 230000001177 retroviral effect Effects 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 150000003290 ribose derivatives Chemical group 0.000 description 2
• 210000003705 ribosome Anatomy 0.000 description 2
• 102220240796 rs553605556 Human genes 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 208000013220 shortness of breath Diseases 0.000 description 2
• 239000000377 silicon dioxide Substances 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 229910001415 sodium ion Inorganic materials 0.000 description 2
• 210000000278 spinal cord Anatomy 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 235000000346 sugar Nutrition 0.000 description 2
• 239000013589 supplement Substances 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 210000003371 toe Anatomy 0.000 description 2
• 238000011824 transgenic rat model Methods 0.000 description 2
• 230000003827 upregulation Effects 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 239000004474 valine Substances 0.000 description 2
• 238000011179 visual inspection Methods 0.000 description 2
• 239000008215 water for injection Substances 0.000 description 2
• 230000003442 weekly effect Effects 0.000 description 2
• 230000004580 weight loss Effects 0.000 description 2
• 208000016261 weight loss Diseases 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• FXYPGCIGRDZWNR-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSCCC(=O)ON1C(=O)CCC1=O FXYPGCIGRDZWNR-UHFFFAOYSA-N 0.000 description 1
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
• UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
• 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 1
• JTTIOYHBNXDJOD-UHFFFAOYSA-N 2,4,6-triaminopyrimidine Chemical compound NC1=CC(N)=NC(N)=N1 JTTIOYHBNXDJOD-UHFFFAOYSA-N 0.000 description 1
• 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
• PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical group NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 description 1
• JRYMOPZHXMVHTA-DAGMQNCNSA-N 2-amino-7-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JRYMOPZHXMVHTA-DAGMQNCNSA-N 0.000 description 1
• OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 description 1
• SNBCLPGEMZEWLU-QXFUBDJGSA-N 2-chloro-n-[[(2r,3s,5r)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]acetamide Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CNC(=O)CCl)[C@@H](O)C1 SNBCLPGEMZEWLU-QXFUBDJGSA-N 0.000 description 1
• PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 1
• UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
• BIGBDMFRWJRLGJ-UHFFFAOYSA-N 3-benzyl-1,5-didiazoniopenta-1,4-diene-2,4-diolate Chemical compound [N-]=[N+]=CC(=O)C(C(=O)C=[N+]=[N-])CC1=CC=CC=C1 BIGBDMFRWJRLGJ-UHFFFAOYSA-N 0.000 description 1
• NLPWSMKACWGINL-UHFFFAOYSA-N 4-azido-2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(N=[N+]=[N-])C=C1O NLPWSMKACWGINL-UHFFFAOYSA-N 0.000 description 1
• QRXMUCSWCMTJGU-UHFFFAOYSA-N 5-bromo-4-chloro-3-indolyl phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP(O)(=O)O)=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-N 0.000 description 1
• 102100040623 60S ribosomal protein L41 Human genes 0.000 description 1
• 206010000097 Abdominal tenderness Diseases 0.000 description 1
• 240000005020 Acaciella glauca Species 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 102100022900 Actin, cytoplasmic 1 Human genes 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 description 1
• 102100021266 Alpha-(1,6)-fucosyltransferase Human genes 0.000 description 1
• 102100022749 Aminopeptidase N Human genes 0.000 description 1
• 239000005695 Ammonium acetate Substances 0.000 description 1
• 241000203069 Archaea Species 0.000 description 1
• 206010003694 Atrophy Diseases 0.000 description 1
• 102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
• 108090001008 Avidin Proteins 0.000 description 1
• 208000023328 Basedow disease Diseases 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 206010061728 Bone lesion Diseases 0.000 description 1
• 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 1
• 229940124295 CD38 monoclonal antibody Drugs 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 241000222128 Candida maltosa Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 231100000023 Cell-mediated cytotoxicity Toxicity 0.000 description 1
• 206010057250 Cell-mediated cytotoxicity Diseases 0.000 description 1
• 102000019034 Chemokines Human genes 0.000 description 1
• 108010012236 Chemokines Proteins 0.000 description 1
• 206010061764 Chromosomal deletion Diseases 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 206010053567 Coagulopathies Diseases 0.000 description 1
• 208000011038 Cold agglutinin disease Diseases 0.000 description 1
• 206010009868 Cold type haemolytic anaemia Diseases 0.000 description 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
• 208000032170 Congenital Abnormalities Diseases 0.000 description 1
• 241000557626 Corvus corax Species 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
• 102000012410 DNA Ligases Human genes 0.000 description 1
• 108010061982 DNA Ligases Proteins 0.000 description 1
• 108050009160 DNA polymerase 1 Proteins 0.000 description 1
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
• 102000016911 Deoxyribonucleases Human genes 0.000 description 1
• 108010053770 Deoxyribonucleases Proteins 0.000 description 1
• AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 1
• 206010012438 Dermatitis atopic Diseases 0.000 description 1
• 206010012468 Dermatitis herpetiformis Diseases 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 206010014989 Epidermolysis bullosa Diseases 0.000 description 1
• 241000283073 Equus caballus Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 101710185409 Fusarin C synthetase Proteins 0.000 description 1
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 206010018364 Glomerulonephritis Diseases 0.000 description 1
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• 102100035716 Glycophorin-A Human genes 0.000 description 1
• 108091005250 Glycophorins Proteins 0.000 description 1
• 206010018691 Granuloma Diseases 0.000 description 1
• 208000015023 Graves' disease Diseases 0.000 description 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 101150105462 HIS6 gene Proteins 0.000 description 1
• 208000001204 Hashimoto Disease Diseases 0.000 description 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
• LYCVKHSJGDMDLM-LURJTMIESA-N His-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CN=CN1 LYCVKHSJGDMDLM-LURJTMIESA-N 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000674326 Homo sapiens 60S ribosomal protein L41 Proteins 0.000 description 1
• 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 description 1
• 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 1
• 101000819490 Homo sapiens Alpha-(1,6)-fucosyltransferase Proteins 0.000 description 1
• 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 1
• 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
• 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 description 1
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
• 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 description 1
• 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
• 101001004946 Homo sapiens Lactoylglutathione lyase Proteins 0.000 description 1
• 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 1
• 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
• 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
• 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 description 1
• 101000957437 Homo sapiens Mitochondrial carnitine/acylcarnitine carrier protein Proteins 0.000 description 1
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
• 101000724418 Homo sapiens Neutral amino acid transporter B(0) Proteins 0.000 description 1
• 101000994307 Homo sapiens Protein ITPRID2 Proteins 0.000 description 1
• 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 1
• 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 description 1
• 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 description 1
• 101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 description 1
• 206010020772 Hypertension Diseases 0.000 description 1
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
• 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 206010062016 Immunosuppression Diseases 0.000 description 1
• 208000026350 Inborn Genetic disease Diseases 0.000 description 1
• 101710203526 Integrase Proteins 0.000 description 1
• 102100025306 Integrin alpha-IIb Human genes 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 102000004889 Interleukin-6 Human genes 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 241001138401 Kluyveromyces lactis Species 0.000 description 1
• 241000235058 Komagataella pastoris Species 0.000 description 1
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
• QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 description 1
• QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 description 1
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• 241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
• 102100026004 Lactoylglutathione lyase Human genes 0.000 description 1
• 241000270322 Lepidosauria Species 0.000 description 1
• 208000012309 Linear IgA disease Diseases 0.000 description 1
• 239000012097 Lipofectamine 2000 Substances 0.000 description 1
• 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 1
• 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
• 239000006142 Luria-Bertani Agar Substances 0.000 description 1
• 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 240000004658 Medicago sativa Species 0.000 description 1
• 235000010624 Medicago sativa Nutrition 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
• 102100038738 Mitochondrial carnitine/acylcarnitine carrier protein Human genes 0.000 description 1
• 101710154541 Modulator protein Proteins 0.000 description 1
• 241000713333 Mouse mammary tumor virus Species 0.000 description 1
• 206010048723 Multiple-drug resistance Diseases 0.000 description 1
• 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
• 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
• 101150114886 NECTIN1 gene Proteins 0.000 description 1
• 102100023064 Nectin-1 Human genes 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 241000221960 Neurospora Species 0.000 description 1
• 101100384865 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cot-1 gene Proteins 0.000 description 1
• 101100395023 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) his-7 gene Proteins 0.000 description 1
• 101100353526 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pca-2 gene Proteins 0.000 description 1
• 102100028267 Neutral amino acid transporter B(0) Human genes 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 101710163270 Nuclease Proteins 0.000 description 1
• 230000004989 O-glycosylation Effects 0.000 description 1
• 241000320412 Ogataea angusta Species 0.000 description 1
• 102000043276 Oncogene Human genes 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 241000282577 Pan troglodytes Species 0.000 description 1
• 241000237988 Patellidae Species 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 206010034277 Pemphigoid Diseases 0.000 description 1
• 201000011152 Pemphigus Diseases 0.000 description 1
• 241000721454 Pemphigus Species 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 241000157426 Pernis Species 0.000 description 1
• 241000235648 Pichia Species 0.000 description 1
• 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
• 206010036790 Productive cough Diseases 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• 238000012341 Quantitative reverse-transcriptase PCR Methods 0.000 description 1
• 108020004518 RNA Probes Proteins 0.000 description 1
• 238000002123 RNA extraction Methods 0.000 description 1
• 239000003391 RNA probe Substances 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 108091030071 RNAI Proteins 0.000 description 1
• 208000012322 Raynaud phenomenon Diseases 0.000 description 1
• 206010057071 Rectal tenesmus Diseases 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 102100038081 Signal transducer CD24 Human genes 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• 101100043635 Solanum tuberosum SS2 gene Proteins 0.000 description 1
• 208000006045 Spondylarthropathies Diseases 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 235000014962 Streptococcus cremoris Nutrition 0.000 description 1
• 238000000692 Student's t-test Methods 0.000 description 1
• 241000282898 Sus scrofa Species 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 102000040945 Transcription factor Human genes 0.000 description 1
• 108091023040 Transcription factor Proteins 0.000 description 1
• 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
• 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 241000219793 Trifolium Species 0.000 description 1
• 101710162629 Trypsin inhibitor Proteins 0.000 description 1
• 229940122618 Trypsin inhibitor Drugs 0.000 description 1
• 102000004243 Tubulin Human genes 0.000 description 1
• 108090000704 Tubulin Proteins 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 206010046851 Uveitis Diseases 0.000 description 1
• 206010047115 Vasculitis Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 241000235015 Yarrowia lipolytica Species 0.000 description 1
• 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
• 108091022873 acetoacetate decarboxylase Proteins 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 210000004100 adrenal gland Anatomy 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 238000004220 aggregation Methods 0.000 description 1
• PPQRONHOSHZGFQ-LMVFSUKVSA-N aldehydo-D-ribose 5-phosphate Chemical group OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PPQRONHOSHZGFQ-LMVFSUKVSA-N 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• 230000009435 amidation Effects 0.000 description 1
• 238000007112 amidation reaction Methods 0.000 description 1
• 229940043376 ammonium acetate Drugs 0.000 description 1
• 235000019257 ammonium acetate Nutrition 0.000 description 1
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 230000003172 anti-dna Effects 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000000845 anti-microbial effect Effects 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 239000003430 antimalarial agent Substances 0.000 description 1
• 229910052787 antimony Inorganic materials 0.000 description 1
• WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
• 210000000436 anus Anatomy 0.000 description 1
• 210000001765 aortic valve Anatomy 0.000 description 1
• 239000008365 aqueous carrier Substances 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229910052786 argon Inorganic materials 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 201000008937 atopic dermatitis Diseases 0.000 description 1
• 230000037444 atrophy Effects 0.000 description 1
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 238000011888 autopsy Methods 0.000 description 1
• 238000000376 autoradiography Methods 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• 238000013357 binding ELISA Methods 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000008512 biological response Effects 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 230000001851 biosynthetic effect Effects 0.000 description 1
• 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
• 229940126587 biotherapeutics Drugs 0.000 description 1
• 208000034158 bleeding Diseases 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 230000023555 blood coagulation Effects 0.000 description 1
• 238000009534 blood test Methods 0.000 description 1
• 210000002449 bone cell Anatomy 0.000 description 1
• 230000037182 bone density Effects 0.000 description 1
• 238000009583 bone marrow aspiration Methods 0.000 description 1
• 210000000621 bronchi Anatomy 0.000 description 1
• 239000008366 buffered solution Substances 0.000 description 1
• 208000000594 bullous pemphigoid Diseases 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 229940095731 candida albicans Drugs 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 239000011545 carbonate/bicarbonate buffer Substances 0.000 description 1
• UHBYWPGGCSDKFX-UHFFFAOYSA-N carboxyglutamic acid Chemical compound OC(=O)C(N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-UHFFFAOYSA-N 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 238000000423 cell based assay Methods 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000003833 cell viability Effects 0.000 description 1
• 230000005890 cell-mediated cytotoxicity Effects 0.000 description 1
• 230000036755 cellular response Effects 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 230000009920 chelation Effects 0.000 description 1
• 239000013043 chemical agent Substances 0.000 description 1
• 238000009614 chemical analysis method Methods 0.000 description 1
• 125000003636 chemical group Chemical group 0.000 description 1
• 239000012829 chemotherapy agent Substances 0.000 description 1
• 238000009104 chemotherapy regimen Methods 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229960005091 chloramphenicol Drugs 0.000 description 1
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
• UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 238000009535 clinical urine test Methods 0.000 description 1
• 230000035602 clotting Effects 0.000 description 1
• 230000006690 co-activation Effects 0.000 description 1
• 230000008951 colonic inflammation Effects 0.000 description 1
• 238000005056 compaction Methods 0.000 description 1
• 230000000052 comparative effect Effects 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 230000001268 conjugating effect Effects 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 210000004351 coronary vessel Anatomy 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 229940109239 creatinine Drugs 0.000 description 1
• 230000002089 crippling effect Effects 0.000 description 1
• 239000003431 cross linking reagent Substances 0.000 description 1
• 230000009260 cross reactivity Effects 0.000 description 1
• 210000004748 cultured cell Anatomy 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 230000001351 cycling effect Effects 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 229940104302 cytosine Drugs 0.000 description 1
• 238000002784 cytotoxicity assay Methods 0.000 description 1
• 231100000263 cytotoxicity test Toxicity 0.000 description 1
• 230000006240 deamidation Effects 0.000 description 1
• 230000022811 deglycosylation Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 230000000368 destabilizing effect Effects 0.000 description 1
• 230000009025 developmental regulation Effects 0.000 description 1
• 229960003957 dexamethasone Drugs 0.000 description 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
• 238000012631 diagnostic technique Methods 0.000 description 1
• 210000000188 diaphragm Anatomy 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
• 235000011180 diphosphates Nutrition 0.000 description 1
• UKWLRLAKGMZXJC-QIECWBMSSA-L disodium;[4-chloro-3-[(3r,5s)-1-chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane]-3'-yl]phenyl] phosphate Chemical compound [Na+].[Na+].O1OC2([C@@H]3CC4C[C@H]2CC(Cl)(C4)C3)C1(OC)C1=CC(OP([O-])([O-])=O)=CC=C1Cl UKWLRLAKGMZXJC-QIECWBMSSA-L 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 210000004696 endometrium Anatomy 0.000 description 1
• 230000009144 enzymatic modification Effects 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• 210000000918 epididymis Anatomy 0.000 description 1
• 230000001037 epileptic effect Effects 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 208000037888 epithelial cell injury Diseases 0.000 description 1
• 210000000267 erythroid cell Anatomy 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• 238000012869 ethanol precipitation Methods 0.000 description 1
• 206010016256 fatigue Diseases 0.000 description 1
• 206010016531 fetishism Diseases 0.000 description 1
• 235000019688 fish Nutrition 0.000 description 1
• 229920002457 flexible plastic Polymers 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 231100000221 frame shift mutation induction Toxicity 0.000 description 1
• 230000037433 frameshift Effects 0.000 description 1
• 230000033581 fucosylation Effects 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 230000009368 gene silencing by RNA Effects 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 208000016361 genetic disease Diseases 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 229960001031 glucose Drugs 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• 229930182470 glycoside Natural products 0.000 description 1
• 150000002338 glycosides Chemical class 0.000 description 1
• 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 208000007475 hemolytic anemia Diseases 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 230000002962 histologic effect Effects 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 102000053426 human ITPRID2 Human genes 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000033444 hydroxylation Effects 0.000 description 1
• 238000005805 hydroxylation reaction Methods 0.000 description 1
• 229960002591 hydroxyproline Drugs 0.000 description 1
• 150000002463 imidates Chemical class 0.000 description 1
• 230000014726 immortalization of host cell Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 230000000984 immunochemical effect Effects 0.000 description 1
• 238000003125 immunofluorescent labeling Methods 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 238000010324 immunological assay Methods 0.000 description 1
• 230000008975 immunomodulatory function Effects 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 230000001506 immunosuppresive effect Effects 0.000 description 1
• 229940125721 immunosuppressive agent Drugs 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 208000027138 indeterminate colitis Diseases 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 208000027866 inflammatory disease Diseases 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 210000005007 innate immune system Anatomy 0.000 description 1
• 108090000237 interleukin-24 Proteins 0.000 description 1
• 102000003898 interleukin-24 Human genes 0.000 description 1
• 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 230000000155 isotopic effect Effects 0.000 description 1
• 229960000318 kanamycin Drugs 0.000 description 1
• 229930027917 kanamycin Natural products 0.000 description 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
• 229930182823 kanamycin A Natural products 0.000 description 1
• 230000003907 kidney function Effects 0.000 description 1
• 238000012933 kinetic analysis Methods 0.000 description 1
• 238000011005 laboratory method Methods 0.000 description 1
• 238000002843 lactate dehydrogenase assay Methods 0.000 description 1
• 210000000867 larynx Anatomy 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 238000012917 library technology Methods 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 210000000088 lip Anatomy 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 238000013507 mapping Methods 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• 230000011987 methylation Effects 0.000 description 1
• 238000007069 methylation reaction Methods 0.000 description 1
• 125000006357 methylene carbonyl group Chemical group [H]C([H])([*:1])C([*:2])=O 0.000 description 1
• LSDPWZHWYPCBBB-UHFFFAOYSA-O methylsulfide anion Chemical compound [SH2+]C LSDPWZHWYPCBBB-UHFFFAOYSA-O 0.000 description 1
• 239000010445 mica Substances 0.000 description 1
• 229910052618 mica group Inorganic materials 0.000 description 1
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 238000000386 microscopy Methods 0.000 description 1
• 108091005601 modified peptides Proteins 0.000 description 1
• 102000035118 modified proteins Human genes 0.000 description 1
• 108091005573 modified proteins Proteins 0.000 description 1
• 238000001823 molecular biology technique Methods 0.000 description 1
• 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 description 1
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 1
• 230000004660 morphological change Effects 0.000 description 1
• 210000002200 mouth mucosa Anatomy 0.000 description 1
• 210000003097 mucus Anatomy 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 229960000951 mycophenolic acid Drugs 0.000 description 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
• 230000002107 myocardial effect Effects 0.000 description 1
• 210000000754 myometrium Anatomy 0.000 description 1
• CJWXCNXHAIFFMH-AVZHFPDBSA-N n-[(2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5r)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxy-3,5-dihydroxy-6-methyloxan-4-yl]acetamide Chemical compound C[C@H]1O[C@@H](O[C@@H]([C@@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)[C@H](O)[C@@H](NC(C)=O)[C@@H]1O CJWXCNXHAIFFMH-AVZHFPDBSA-N 0.000 description 1
• 230000031942 natural killer cell mediated cytotoxicity Effects 0.000 description 1
• 230000005401 negative regulation of immunoglobulin production Effects 0.000 description 1
• 230000031673 negative regulation of immunoglobulin secretion Effects 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 231100000417 nephrotoxicity Toxicity 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 238000007826 nucleic acid assay Methods 0.000 description 1
• 230000000414 obstructive effect Effects 0.000 description 1
• 229920002113 octoxynol Polymers 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 238000002966 oligonucleotide array Methods 0.000 description 1
• 210000002747 omentum Anatomy 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000000399 orthopedic effect Effects 0.000 description 1
• 210000002997 osteoclast Anatomy 0.000 description 1
• 230000000010 osteolytic effect Effects 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 125000004043 oxo group Chemical group O=* 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 230000000849 parathyroid Effects 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 201000001976 pemphigus vulgaris Diseases 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
• 239000012466 permeate Substances 0.000 description 1
• 150000002978 peroxides Chemical class 0.000 description 1
• 210000001986 peyer's patch Anatomy 0.000 description 1
• 150000004713 phosphodiesters Chemical class 0.000 description 1
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
• 230000002186 photoactivation Effects 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 238000009832 plasma treatment Methods 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
• 229920001748 polybutylene Polymers 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 229920002635 polyurethane Polymers 0.000 description 1
• 239000004814 polyurethane Substances 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 1
• 239000001103 potassium chloride Substances 0.000 description 1
• 235000011164 potassium chloride Nutrition 0.000 description 1
• 229960004618 prednisone Drugs 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 230000004952 protein activity Effects 0.000 description 1
• 229940076372 protein antagonist Drugs 0.000 description 1
• 108020001580 protein domains Proteins 0.000 description 1
• 230000012743 protein tagging Effects 0.000 description 1
• 201000001474 proteinuria Diseases 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 229940048084 pyrophosphate Drugs 0.000 description 1
• 150000003254 radicals Chemical class 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 238000002708 random mutagenesis Methods 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 235000003499 redwood Nutrition 0.000 description 1
• 230000001172 regenerating effect Effects 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 210000001525 retina Anatomy 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 239000012146 running buffer Substances 0.000 description 1
• 210000003079 salivary gland Anatomy 0.000 description 1
• 238000003118 sandwich ELISA Methods 0.000 description 1
• 201000000306 sarcoidosis Diseases 0.000 description 1
• 238000007423 screening assay Methods 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
• 239000004017 serum-free culture medium Substances 0.000 description 1
• 230000035938 sexual maturation Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 150000003376 silicon Chemical class 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 230000000391 smoking effect Effects 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• POECFFCNUXZPJT-UHFFFAOYSA-M sodium;carbonic acid;hydrogen carbonate Chemical compound [Na+].OC(O)=O.OC([O-])=O POECFFCNUXZPJT-UHFFFAOYSA-M 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• 238000002798 spectrophotometry method Methods 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 230000003393 splenic effect Effects 0.000 description 1
• 201000005671 spondyloarthropathy Diseases 0.000 description 1
• 210000003802 sputum Anatomy 0.000 description 1
• 208000024794 sputum Diseases 0.000 description 1
• 238000011255 standard chemotherapy Methods 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 210000005222 synovial tissue Anatomy 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
• 238000012353 t test Methods 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 208000012271 tenesmus Diseases 0.000 description 1
• 210000001550 testis Anatomy 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 230000008719 thickening Effects 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 229940113082 thymine Drugs 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 206010043778 thyroiditis Diseases 0.000 description 1
• 210000002105 tongue Anatomy 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 201000002516 toxic megacolon Diseases 0.000 description 1
• 210000003437 trachea Anatomy 0.000 description 1
• FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 238000003146 transient transfection Methods 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
• 239000002753 trypsin inhibitor Substances 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 231100000588 tumorigenic Toxicity 0.000 description 1
• 230000000381 tumorigenic effect Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 230000036269 ulceration Effects 0.000 description 1
• 238000013060 ultrafiltration and diafiltration Methods 0.000 description 1
• 210000003954 umbilical cord Anatomy 0.000 description 1
• 210000003606 umbilical vein Anatomy 0.000 description 1
• 241000701161 unidentified adenovirus Species 0.000 description 1
• 241000701447 unidentified baculovirus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 229940035893 uracil Drugs 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 210000003932 urinary bladder Anatomy 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 210000001215 vagina Anatomy 0.000 description 1
• 210000001186 vagus nerve Anatomy 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 230000036642 wellbeing Effects 0.000 description 1
• 229940075420 xanthine Drugs 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1
• 238000001086 yeast two-hybrid system Methods 0.000 description 1