HUE032758T2 - Regorafenibet tartalmazó bevont gyógyszerészeti készítmény - Google Patents

Regorafenibet tartalmazó bevont gyógyszerészeti készítmény Download PDF

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Publication number
HUE032758T2
HUE032758T2 HUE13762967A HUE13762967A HUE032758T2 HU E032758 T2 HUE032758 T2 HU E032758T2 HU E13762967 A HUE13762967 A HU E13762967A HU E13762967 A HUE13762967 A HU E13762967A HU E032758 T2 HUE032758 T2 HU E032758T2
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HU
Hungary
Prior art keywords
ély
ifik
regorafenib
siis
coating
Prior art date
Application number
HUE13762967A
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English (en)
Inventor
Susanne Skrabs
Adrian Funke
Mayk Kresse
Ulrich Oberdieck
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE032758(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HUE032758T2 publication Critical patent/HUE032758T2/hu

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (2)

1 ; kAxigv^gssxH.xrii k’v-j.ííini'íiiy, sïskdy kinidmkgdíggkllilháí, níggisfesld kkklíják íAiílsdgx iííöalldspk v<5|y lyögys;iöxdyg^ í;AgV caA poihxkxHliu, és Agskíkb ·:α\ îdpîk^xkvgigag yblgadkisiA xkgAkaíygga·, amd;s gygyvsAngsAdi kgsduygay pi>ü(vi«|^alfechOi} 4ΐ«ρ4 pidbegít és silöSí n m * \ n"\ ^ ν' ' v ' ' \ v 's ν' n s s ' ésYisssi-ï;! í;cví>né aha; a miPsliíslí a kk'viX;: x/<>k íifekSakgíipÖkttpg vásssákéé: 4^ié-f^4^¾lé?'-3·' (uélsonïisékk *' fAAälAAMpikksYAp'Xs:!!:· 14υ;Γ<\>Χ.:5!<?:4· ; (> ·,? J kis-· Hs-ké-v- '·· 0s kíl körntet s § jfm iljksí karaid i jam kiöl 4 -- 4 smstg 550x1] -1 4 k gkxsx im gí 5! }pi f sd] m é- feg HlMgm kl 4s [4 4 ] ( A-bigf - s -(u : dsOrYiCÍH ?;V:Y : Ikiubs: :Κ;5 0 rmsssy:· >· l'IsSïlïSSIS i Síérké:s· k'h:í :u>>S:i:í:d #.4s|4k(]^4-yí)r-3-(5í:|!:YnSX:í5édV:é;|k;KbS::X;4;;:5': X Π^^Γ5:ΧΥ:ν;5;·η;ν1ί:!· é'k;:;5u>'S:;í:Xlk”;:\Rl 1 Λ>· Is pgimpmS xgedii· ; kéSíiisiSísíV; ímieíg mgdrídkíidbgi kutiddsag hisikék51 yisgk4síí.
4. Ag is Ys|y 2. íséí5 yfíi>isisx«iií5d kgxgdínépy. .am-h í.skkm,:. 4. ' 's \ ' ' s ' \ t>\S'1\ls'-v'v^ s' ' s 5. A,· 1*4, glíiymsmak éáííxssiysSx aggrkid Mygdsiigdy, ahoi 0. ormi v ásd-aHsshai: skia; pidmsÁ' ágy hklygdgék p«g; vhakmkoiu::: · pakasass mrixfegssim kkkodAík spísHívésí-slköhöd pöliíiims ósAgigmi pgl(vdíd-•dk-dKg: ρ·>::Χη:Α iSAÁ pídsadgo-giikoik:! kgpXSg: kapídifíiÍXg Víígv ://vk kgXiÍi'gkií, 4. 4x ' igaoyposk •'Se:';::!; k::;--.Adism;. .éné é pdéYSsIkékiXxé! alapo isomara· íaaUx-aícs: aldKdraág pó]Kv45d-a!kAh«l} pöfímxr, ~. 4/ 5-4 igessypamek é;:nssc5yi::s \/i:n:s?: këxxgralxy, akid a peHévkíSp-pIksílípi) a kuk· pdbíggí'y ipljgy éíYiíísmiPmoggik vissiiäikaiädsiiss xrh'dï ígkikggS osooo·;. acsík-o axg jgbm, k As k-'l iggiiyphatiik bapPidyikP sggdPp k#ApTigiiy:; ahm sí bevässä mihshssa.A·:;: kigydökésk a kovptkexdksi; pidiPiddambkoh gkjpdgmgbkph sgyPbd, mlggriih ?oaim. xílík sgakgd. erén·, gdíkrmkrxifelk PkdhSdmdrm, írsíí-ss-siSíá: ;xrad-ku:d:-i. kía·, ggxíoskinscras·. ygtgimpgas:, kAggpgs pggd písgbppfíésk, vssgy eggk haveréba ’ \ > ! \ V ! <. s ' s I í ll Síé A 1, vagy 4. igggypeik xgeiTpii kgpbinPisyy riiigl g Isgydipgyr 4 idles ΡρίορίΜ rdipgiggy xoííaíköxíaívs S-dÖ 5dsiipg;kx SiiSanyAggtes vííP stka; 5 i Λk :- Uí iggiskpöiddk MdpélyÉé Pépdíik íal-sxüssbg xikgly :;as-iaj;rigk ivsyssidi-iabis ::ísX;kn;;/á SXé;4d éÎSgpkrXlëî, kl A 5 : s ' ' -. ' ' , s < sN ;iXikgysé«ídséPl!ög éifögsdMid 5i4mxét gkai s íMifik ·\%ί%$Μ%Μ pdllvdlfddrpiydpk Vmilÿsïlfî>|M>ä siispoba-cit. jVíiséksisí·-gkkcäp hklxiskilkili, hiiks^iidiakaicsdccikikv·. kίΐ·!?;:;>;tsîv;tk-Ys-iUls? sí, aédiïiiïY-k;5r::::SK:î;se;;:.<S::ssi:SS5. gl kCX5ï kikig, ::^ί::·Υ:; iks îkiulâi. «Jig 4 VÍííik-íiliUíkpí}· {, pikgA SH b áSC5S5)-í S ΧΐρίΪ-5iîks>ï;:g viiSii.sYiMS! iPpíiíkísgík ;ηΊ:gi!\.s;:s;g· gikïgllkpk siiîÎâiisîgiiiîîi!, k;irr;5gèîiï,:kiî<sx;d5k klssk, p<sbgcx:· i:-g gii-xirg-:;, kykkiggviígí, Ipfispylgk sgiígixlfpi, 'kki<>kí.;, ggíktixí. piaîiéx;, s-skguíéxi:, sgíííbíípí, kskdkg, sp&amp;ssltBk msfeiäiöi.; eïïSî'itsi: ίΐΐίί/ίΐϊΗ,. kekpöy.L 'îMsïs^ïôt ikuPrsi.. 4rRpi4Pö:4tripL p-gűcíftífcstHí'U:; pädm^ipmplHk ;.:4:Ηχ!<·<;?!·Η vay\ ?fí-í^íiíÉs|v&amp;gÿ èkik kg:vÿ?f4sk !3. 4 Π.. >my Ip' ípayixlnt sAÁpAi pykpiyAkx. sipoly s.ί^ΐ^ο.ΓΐίΐίΜ^-ϊδίέ'ϊ..s :ΐΐ:;5 - ί :2δ u}n:Cy4iáiíyh<in um;ürnwsn. 14,. λ : 1 :I·-· ! 3:. igpyypyylop pár;«;ίpipé syyiiyü issspijsícpv, ámspy t:Sît;pïS;Si: $x^sXáíémP<A A? f^!ivií:4yirroU<i:íiK, sí5ílyryslyΐIsíál>«s:ç«Uisîμ5:ί;S.: ; 5 A 14 iycuyi'H-Bl ••xírhh k; :;. ::??«?<·;·>, s|«é4y s p;|:QS'á|y4s|k| pká k!-.>%/k5K:S;4k^ikínur:; ykvágy mifeekHslälyos gyllylóxPssyggsí ;> /0,¾ -1 :pp Oxsk-g-x ΧίΠηΙ·^;*//;»
HUE13762967A 2012-09-06 2013-09-05 Regorafenibet tartalmazó bevont gyógyszerészeti készítmény HUE032758T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12183331 2012-09-06

Publications (1)

Publication Number Publication Date
HUE032758T2 true HUE032758T2 (hu) 2017-10-30

Family

ID=46963450

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13762967A HUE032758T2 (hu) 2012-09-06 2013-09-05 Regorafenibet tartalmazó bevont gyógyszerészeti készítmény

Country Status (43)

Country Link
US (1) US20140065212A1 (hu)
EP (2) EP3243508A1 (hu)
JP (1) JP6445436B2 (hu)
KR (1) KR102162036B1 (hu)
CN (5) CN104902878A (hu)
AP (1) AP2015008292A0 (hu)
AR (1) AR092439A1 (hu)
AU (1) AU2013312531B2 (hu)
BR (1) BR112015004936B1 (hu)
CA (1) CA2883767C (hu)
CL (1) CL2015000544A1 (hu)
CO (1) CO7310528A2 (hu)
CR (1) CR20150114A (hu)
CU (1) CU24244B1 (hu)
CY (1) CY1118839T1 (hu)
DK (1) DK2892507T3 (hu)
EA (1) EA027685B1 (hu)
ES (1) ES2623205T3 (hu)
GT (1) GT201500053A (hu)
HK (1) HK1214170A1 (hu)
HR (1) HRP20170620T1 (hu)
HU (1) HUE032758T2 (hu)
IL (1) IL237350B (hu)
IN (1) IN2015DN01673A (hu)
JO (1) JO3479B1 (hu)
LT (1) LT2892507T (hu)
MA (1) MA37888B1 (hu)
MX (1) MX359922B (hu)
MY (1) MY176135A (hu)
NZ (1) NZ705578A (hu)
PE (1) PE20151005A1 (hu)
PH (1) PH12015500460B1 (hu)
PL (1) PL2892507T3 (hu)
PT (1) PT2892507T (hu)
RS (1) RS56019B1 (hu)
SA (1) SA515360113B1 (hu)
SG (1) SG11201501683WA (hu)
SI (1) SI2892507T1 (hu)
TW (1) TWI640329B (hu)
UA (1) UA115994C2 (hu)
UY (1) UY35006A (hu)
WO (1) WO2014039677A1 (hu)
ZA (1) ZA201501394B (hu)

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AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
DK3043778T3 (da) * 2013-09-13 2017-11-27 Bayer Pharma AG Farmaceutiske sammensætninger, der indeholder refametinib
CN104586808B (zh) * 2014-12-27 2017-08-18 北京元延医药科技股份有限公司 抗肿瘤药物组合物
CN105136956A (zh) * 2015-09-11 2015-12-09 江苏嘉逸医药有限公司 一种快速测定瑞戈非尼含量的方法
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
CN106880607A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种含有瑞戈非尼的口腔崩解片及其制备方法
CN106880615A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种瑞戈非尼的口服固体制剂及其制备方法
CN105496975B (zh) * 2015-12-17 2019-01-04 河南润弘制药股份有限公司 一种瑞戈非尼片剂及其制备方法
CN106913527A (zh) * 2015-12-28 2017-07-04 江苏先声药业有限公司 一种瑞戈非尼速释微丸及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
CN107661296A (zh) * 2016-07-27 2018-02-06 江苏先声药业有限公司 一种瑞戈非尼固体分散体及其制备方法
FI3630112T3 (fi) 2017-06-02 2024-05-02 Bayer Healthcare Llc Regorafenibin ja nivolumabin yhdistelmä syövän hoidossa
WO2020010058A1 (en) * 2018-07-06 2020-01-09 Agios Pharmaceuticals, Inc. Ivosidenib forms and pharmaceutical compositions
CN111053751A (zh) * 2018-10-16 2020-04-24 正大天晴药业集团股份有限公司 瑞戈非尼的缓释片剂及其制备方法
TWI799599B (zh) * 2019-06-06 2023-04-21 華納國際生物科技股份有限公司 醫藥或保健品自乳化固體分散組成物
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
CN112587485A (zh) * 2021-01-08 2021-04-02 湖南南新制药股份有限公司 一种药物固体分散体及其制备方法
CN113018274A (zh) * 2021-03-10 2021-06-25 药源生物科技(启东)有限公司 一种含羟丙甲纤维素的药物组合物及其制备方法
WO2024191389A1 (en) * 2023-03-10 2024-09-19 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A pharmaceutical composition of regorafenib

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CN100544717C (zh) * 2002-09-20 2009-09-30 华生制药公司 含有双胍和噻唑烷二酮衍生物的药物剂型
CN1265793C (zh) * 2002-11-18 2006-07-26 杭州容立医药科技有限公司 左西替利嗪伪麻黄碱复方口服制剂及制备方法
AU2004259760B9 (en) * 2003-07-23 2011-02-03 Bayer Healthcare Llc Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
MY191349A (en) * 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
WO2007068381A1 (en) * 2005-12-15 2007-06-21 Bayer Healthcare Ag Diaryl ureas for treating inflammatory skin, eye and/or ear diseases
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
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EA200970552A1 (ru) * 2006-12-07 2009-10-30 Эли Лилли Энд Компани Изделие с празугрелом
WO2009054550A1 (en) * 2007-10-25 2009-04-30 Bayer Yakuhin, Ltd. Nifedipine-containing press coated tablet and method of preparing the same
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
RU2602911C2 (ru) * 2011-05-20 2016-11-20 Астразенека Юкей Лимитед Фармацевтическая композиция, содержащая кальциевую соль розувастатина

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WO2014039677A1 (en) 2014-03-13
EP2892507B1 (en) 2017-02-01
PL2892507T3 (pl) 2017-09-29
AU2013312531A1 (en) 2015-03-12
CO7310528A2 (es) 2015-06-30
US20140065212A1 (en) 2014-03-06
UA115994C2 (uk) 2018-01-25
AU2013312531B2 (en) 2017-10-19
CY1118839T1 (el) 2018-01-10
SG11201501683WA (en) 2015-04-29
HRP20170620T1 (hr) 2017-06-30
BR112015004936A2 (pt) 2017-07-04
HK1214170A1 (zh) 2016-07-22
MY176135A (en) 2020-07-24
CL2015000544A1 (es) 2015-08-21
CA2883767C (en) 2018-11-13
EA201590520A1 (ru) 2015-10-30
IL237350B (en) 2020-11-30
UY35006A (es) 2014-03-31
BR112015004936B1 (pt) 2022-12-06
LT2892507T (lt) 2017-06-12
PT2892507T (pt) 2017-05-02
TW201414510A (zh) 2014-04-16
MX359922B (es) 2018-10-16
KR20150048872A (ko) 2015-05-07
JP6445436B2 (ja) 2018-12-26
MA37888B1 (fr) 2019-08-30
AR092439A1 (es) 2015-04-22
JO3479B1 (ar) 2020-07-05
IL237350A0 (en) 2015-04-30
CR20150114A (es) 2015-05-11
CU24244B1 (es) 2017-02-02
NZ705578A (en) 2017-10-27
JP2015527395A (ja) 2015-09-17
AP2015008292A0 (en) 2015-02-28
ZA201501394B (en) 2016-07-27
DK2892507T3 (en) 2017-05-01
CN111249247A (zh) 2020-06-09
RS56019B1 (sr) 2017-09-29
KR102162036B1 (ko) 2020-10-07
CA2883767A1 (en) 2014-03-13
TWI640329B (zh) 2018-11-11
ES2623205T3 (es) 2017-07-10
CU20150020A7 (es) 2015-05-28
MX2015002815A (es) 2015-05-15
PH12015500460A1 (en) 2015-04-20
MA37888A1 (fr) 2018-07-31
IN2015DN01673A (hu) 2015-07-03
PH12015500460B1 (en) 2015-04-20
SI2892507T1 (sl) 2017-08-31
PE20151005A1 (es) 2015-06-27
CN116392485A (zh) 2023-07-07
CN104902878A (zh) 2015-09-09
EA027685B1 (ru) 2017-08-31
CN116392484A (zh) 2023-07-07
CN116392598A (zh) 2023-07-07
GT201500053A (es) 2015-10-12
SA515360113B1 (ar) 2016-08-10
EP2892507A1 (en) 2015-07-15
EP3243508A1 (en) 2017-11-15

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