HUE032132T2 - Kalcitonin génnel kapcsolatos peptid receptor - Google Patents
Kalcitonin génnel kapcsolatos peptid receptor Download PDFInfo
- Publication number
- HUE032132T2 HUE032132T2 HUE03736721A HUE03736721A HUE032132T2 HU E032132 T2 HUE032132 T2 HU E032132T2 HU E03736721 A HUE03736721 A HU E03736721A HU E03736721 A HUE03736721 A HU E03736721A HU E032132 T2 HUE032132 T2 HU E032132T2
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- HU
- Hungary
- Prior art keywords
- oxo
- dihydro
- mmol
- piperidine
- mhz
- Prior art date
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- PZVNRRWYHIGMFK-UHFFFAOYSA-N ethyl 4-[(2-aminophenyl)methyl]piperidine-4-carboxylate;hydrochloride Chemical compound Cl.C=1C=CC=C(N)C=1CC1(C(=O)OCC)CCNCC1 PZVNRRWYHIGMFK-UHFFFAOYSA-N 0.000 description 3
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- FTYSEFMWALXSIQ-JOCHJYFZSA-N methyl (2r)-3-[2-methyl-1-(2-trimethylsilylethylsulfonyl)benzimidazol-5-yl]-2-(phenylmethoxycarbonylamino)propanoate Chemical compound N([C@H](CC=1C=C2N=C(C)N(C2=CC=1)S(=O)(=O)CC[Si](C)(C)C)C(=O)OC)C(=O)OCC1=CC=CC=C1 FTYSEFMWALXSIQ-JOCHJYFZSA-N 0.000 description 3
- WATCXBSKZDOOIA-UHFFFAOYSA-N methyl 2-(phenylmethoxycarbonylamino)-3-(6-phenylmethoxypyridin-3-yl)prop-2-enoate Chemical compound C=1C=C(OCC=2C=CC=CC=2)N=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 WATCXBSKZDOOIA-UHFFFAOYSA-N 0.000 description 3
- HWDHVGFDINBYEZ-UHFFFAOYSA-N methyl 2-(phenylmethoxycarbonylamino)-3-(6-phenylmethoxypyridin-3-yl)propanoate Chemical compound C=1C=CC=CC=1COC(=O)NC(C(=O)OC)CC(C=N1)=CC=C1OCC1=CC=CC=C1 HWDHVGFDINBYEZ-UHFFFAOYSA-N 0.000 description 3
- BBFPXRJVCWOQCZ-UHFFFAOYSA-N methyl 2-[(7-methyl-1h-indazol-5-yl)methyl]-4-oxo-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]butanoate Chemical compound CC1=C2NN=CC2=CC(CC(CC(=O)N2CCC(CC2)N2C(NC3=CC=CC=C3C2)=O)C(=O)OC)=C1 BBFPXRJVCWOQCZ-UHFFFAOYSA-N 0.000 description 3
- BCNULXAVPAFXEZ-UHFFFAOYSA-N methyl 2-amino-3-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propanoate Chemical compound C1N(CC(N)C(=O)OC)CCC2=C1C=NN2 BCNULXAVPAFXEZ-UHFFFAOYSA-N 0.000 description 3
- MWBVKTVGSBMFMW-UHFFFAOYSA-N methyl 2-amino-3-(2-methoxypyrimidin-5-yl)propanoate Chemical compound COC(=O)C(N)CC1=CN=C(OC)N=C1 MWBVKTVGSBMFMW-UHFFFAOYSA-N 0.000 description 3
- RLPGMNKVKSPIRO-UHFFFAOYSA-N methyl 2-amino-3-(6-methoxypyridin-3-yl)propanoate Chemical compound COC(=O)C(N)CC1=CC=C(OC)N=C1 RLPGMNKVKSPIRO-UHFFFAOYSA-N 0.000 description 3
- RUJNOFDNYSMIFF-UHFFFAOYSA-N methyl 2-amino-3-(6-phenylmethoxypyridin-3-yl)propanoate Chemical compound N1=CC(CC(N)C(=O)OC)=CC=C1OCC1=CC=CC=C1 RUJNOFDNYSMIFF-UHFFFAOYSA-N 0.000 description 3
- NNTXZUCCVNHSTI-UHFFFAOYSA-N methyl 2-amino-3-(7,7-dimethyl-4,6-dihydro-1h-pyrazolo[4,3-c]pyridin-5-yl)propanoate Chemical compound CC1(C)CN(CC(N)C(=O)OC)CC2=C1NN=C2 NNTXZUCCVNHSTI-UHFFFAOYSA-N 0.000 description 3
- BEUQXXJKIQGBQT-UHFFFAOYSA-N methyl 2-amino-3-(7-chloro-1h-indazol-5-yl)propanoate Chemical compound COC(=O)C(N)CC1=CC(Cl)=C2NN=CC2=C1 BEUQXXJKIQGBQT-UHFFFAOYSA-N 0.000 description 3
- XVBDOJTZMGJLDM-UHFFFAOYSA-N methyl 2-amino-3-(7-ethyl-1h-indazol-5-yl)propanoate Chemical compound CCC1=CC(CC(N)C(=O)OC)=CC2=C1NN=C2 XVBDOJTZMGJLDM-UHFFFAOYSA-N 0.000 description 3
- IWYBATOKIPKBEJ-UHFFFAOYSA-N methyl 2-amino-3-(7-methyl-1h-indazol-5-yl)propanoate Chemical compound COC(=O)C(N)CC1=CC(C)=C2NN=CC2=C1 IWYBATOKIPKBEJ-UHFFFAOYSA-N 0.000 description 3
- PWBWAHCCNNJFQQ-UHFFFAOYSA-N methyl 3-(2-methoxypyrimidin-5-yl)-2-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]propanoate Chemical compound C1CC(N2C(NC3=CC=CC=C3C2)=O)CCN1C(=O)NC(C(=O)OC)CC1=CN=C(OC)N=C1 PWBWAHCCNNJFQQ-UHFFFAOYSA-N 0.000 description 3
- ALDHNPXBSNOFKR-UHFFFAOYSA-N methyl 3-(3,4-dinitrophenyl)-2-(phenylmethoxycarbonylamino)prop-2-enoate Chemical compound C=1C=C([N+]([O-])=O)C([N+]([O-])=O)=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 ALDHNPXBSNOFKR-UHFFFAOYSA-N 0.000 description 3
- OQEOZHLDJSIOQP-UHFFFAOYSA-N methyl 3-(6-methoxypyridin-3-yl)-2-(phenylmethoxycarbonylamino)prop-2-enoate Chemical compound C=1C=C(OC)N=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 OQEOZHLDJSIOQP-UHFFFAOYSA-N 0.000 description 3
- HPOIXMWHYQEAET-UHFFFAOYSA-N methyl 3-(7-chloro-1h-indazol-5-yl)-2-(phenylmethoxycarbonylamino)prop-2-enoate Chemical compound C=1C(Cl)=C2NN=CC2=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 HPOIXMWHYQEAET-UHFFFAOYSA-N 0.000 description 3
- GWCIGKFDGWQDIS-UHFFFAOYSA-N methyl 3-(7-chloro-1h-indazol-5-yl)-2-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]propanoate Chemical compound C1C2=CC=CC=C2NC(=O)N1C(CC1)CCN1C(=O)NC(C(=O)OC)CC1=CC(Cl)=C(NN=C2)C2=C1 GWCIGKFDGWQDIS-UHFFFAOYSA-N 0.000 description 3
- VZJRITDQVIMYSE-UHFFFAOYSA-N methyl 3-(7-ethyl-1h-indazol-5-yl)-2-(phenylmethoxycarbonylamino)prop-2-enoate Chemical compound C=1C=2C=NNC=2C(CC)=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 VZJRITDQVIMYSE-UHFFFAOYSA-N 0.000 description 3
- BMWIRDFPIYOOPI-UHFFFAOYSA-N methyl 3-(7-methyl-1h-indazol-5-yl)-2-(phenylmethoxycarbonylamino)prop-2-enoate Chemical compound C=1C(C)=C2NN=CC2=CC=1C=C(C(=O)OC)NC(=O)OCC1=CC=CC=C1 BMWIRDFPIYOOPI-UHFFFAOYSA-N 0.000 description 3
- YPEWACCONYNYCH-UHFFFAOYSA-N methyl 3-(7-methyl-1h-indazol-5-yl)-2-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]propanoate Chemical compound C1C2=CC=CC=C2NC(=O)N1C(CC1)CCN1C(=O)NC(C(=O)OC)CC1=CC(C)=C(NN=C2)C2=C1 YPEWACCONYNYCH-UHFFFAOYSA-N 0.000 description 3
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- Gastroenterology & Hepatology (AREA)
Claims (5)
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HUE032132T2 true HUE032132T2 (hu) | 2017-09-28 |
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Application Number | Title | Priority Date | Filing Date |
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HUE03736721A HUE032132T2 (hu) | 2002-06-05 | 2003-05-27 | Kalcitonin génnel kapcsolatos peptid receptor |
Country Status (24)
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US (2) | US20040063735A1 (hu) |
EP (1) | EP1539766B1 (hu) |
JP (1) | JP4490809B2 (hu) |
KR (2) | KR20050008790A (hu) |
CN (1) | CN100558728C (hu) |
AU (1) | AU2003237255B8 (hu) |
BR (1) | BRPI0311812B8 (hu) |
CA (1) | CA2487976C (hu) |
CY (1) | CY1118764T1 (hu) |
DK (1) | DK1539766T3 (hu) |
ES (1) | ES2616539T3 (hu) |
GE (1) | GEP20074231B (hu) |
HR (1) | HRP20041147A2 (hu) |
HU (1) | HUE032132T2 (hu) |
IS (1) | IS7583A (hu) |
LT (1) | LT1539766T (hu) |
MX (1) | MXPA04011960A (hu) |
NO (1) | NO332691B1 (hu) |
NZ (1) | NZ537315A (hu) |
PL (1) | PL374017A1 (hu) |
PT (1) | PT1539766T (hu) |
RS (1) | RS52552B (hu) |
TW (1) | TWI308151B (hu) |
WO (1) | WO2003104236A1 (hu) |
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CA2836649C (en) | 2011-05-20 | 2020-06-23 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
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BR112013029951B1 (pt) | 2011-05-20 | 2020-10-20 | Alderbio Holdings Llc | composição farmacêutica e uso de anticorpos ou fragmentos de anticorpos anti-cgrp para tratar ou prevenir formas de diarreia crônicas e agudas |
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KR20200126018A (ko) | 2014-03-21 | 2020-11-05 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 칼시토닌 유전자-관련 펩티드에 대한 길항제 항체 및 그의 사용 방법 |
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-
2003
- 2003-05-27 BR BRPI0311812A patent/BRPI0311812B8/pt active IP Right Grant
- 2003-05-27 GE GEAP8575A patent/GEP20074231B/en unknown
- 2003-05-27 DK DK03736721.6T patent/DK1539766T3/en active
- 2003-05-27 PT PT37367216T patent/PT1539766T/pt unknown
- 2003-05-27 KR KR10-2004-7019744A patent/KR20050008790A/ko active Application Filing
- 2003-05-27 AU AU2003237255A patent/AU2003237255B8/en not_active Expired
- 2003-05-27 ES ES03736721.6T patent/ES2616539T3/es not_active Expired - Lifetime
- 2003-05-27 RS YU104004A patent/RS52552B/en unknown
- 2003-05-27 US US10/445,523 patent/US20040063735A1/en not_active Abandoned
- 2003-05-27 WO PCT/US2003/016576 patent/WO2003104236A1/en active Application Filing
- 2003-05-27 EP EP03736721.6A patent/EP1539766B1/en not_active Expired - Lifetime
- 2003-05-27 CN CNB038184753A patent/CN100558728C/zh not_active Expired - Lifetime
- 2003-05-27 MX MXPA04011960A patent/MXPA04011960A/es active IP Right Grant
- 2003-05-27 KR KR1020117028478A patent/KR20120004541A/ko not_active Application Discontinuation
- 2003-05-27 HU HUE03736721A patent/HUE032132T2/hu unknown
- 2003-05-27 JP JP2004511306A patent/JP4490809B2/ja not_active Expired - Lifetime
- 2003-05-27 PL PL03374017A patent/PL374017A1/xx not_active Application Discontinuation
- 2003-05-27 NZ NZ537315A patent/NZ537315A/en not_active IP Right Cessation
- 2003-05-27 CA CA2487976A patent/CA2487976C/en not_active Expired - Lifetime
- 2003-05-27 LT LTEP03736721.6T patent/LT1539766T/lt unknown
- 2003-06-03 TW TW092115067A patent/TWI308151B/zh not_active IP Right Cessation
-
2004
- 2004-11-29 NO NO20045219A patent/NO332691B1/no not_active IP Right Cessation
- 2004-12-01 HR HR20041147A patent/HRP20041147A2/hr not_active Application Discontinuation
- 2004-12-03 IS IS7583A patent/IS7583A/is unknown
-
2006
- 2006-12-19 US US11/641,974 patent/US20070148093A1/en not_active Abandoned
-
2017
- 2017-03-20 CY CY20171100344T patent/CY1118764T1/el unknown
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