HUE031582T2 - Dihidropiridon mint xia-faktor inhibitorok - Google Patents
Dihidropiridon mint xia-faktor inhibitorok Download PDFInfo
- Publication number
- HUE031582T2 HUE031582T2 HUE13747624A HUE13747624A HUE031582T2 HU E031582 T2 HUE031582 T2 HU E031582T2 HU E13747624 A HUE13747624 A HU E13747624A HU E13747624 A HUE13747624 A HU E13747624A HU E031582 T2 HUE031582 T2 HU E031582T2
- Authority
- HU
- Hungary
- Prior art keywords
- oxo
- methyl
- mmol
- íció
- carbamate
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Claims (2)
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JS.I? -kíttó· 5- si MM; N-fí'ÍÖS 4RM4MM4M444;í4MM?:}4-rí.;>·;4Λ4;;'ΐΜ5Μ;φ;π4?Μ-:ΜΜ-^Μ].. 5-oxö-H,iÄ-<i{i}KstKi.iklfi t J θ' jsu-síi,* M t !4 '4,0 > 1 hv>.4.n-''i!\Âiw. Mo.äil N-4;ök ME).;<i~;MJ-k!6r44-&4>iOífc4í).fcvíí><jM.43.6*?^^«df opinai«·Î4}-HMrMM £-0**>· SJ RdtoinoRfcJ ii.).j .{4 ’jtâcaaiîeka' U 19).2.4 4. i .1 î ?· MxsMM-RIMMssM; N·Î{Ï-ÎS).'.«H*-* 4%Md#^<!i i3 J. i.O* vjaoaas*k*í (SPX.2Í ?*J,5 J3,i 7'te*èn»34ljk«rfe*«i&; Mb$: bi>£fl4$} 44.t4-i^kW'?Jyi&iÄÄlyMy4>d5&^ !4^{U^-<«0“S?-jiistsK(lbö ' 3 '; .θ’ ·]«οί»^«- i ϊ. i&U,4&i ί\ 1 '? -h^ae^S'iiltebamáí. & ®y&$y&i#ièmà fcossg*«}«^ «η#4ν «μ*»!«?«* a? \ *5. igèKypoaiok bitnyik» *a*B|Äy«gy^:«k' Sî&Âogyoi. vagy ô%ïî ës p^ysAiîôsi^jlsg 4p?p#tó bortafoKtyagov vagy b%0§s^ft, % -M- b& i0i^mmU t>ázmfyú$ ψ^ΜΜί vagySt«» vagy annak eatapeöfeomeí*, Ut«lomer»v vagy 0é0sa&x$mii®eig sí^sábaaS MJa ysgy a? 5; igénypont saaHfi« J$mpo?.óoé &lb**>»li4*«r* győgys>'«fk«nt k. :M· f·#. Igèîiyp#sïâïk bátaseiyikí 8»»Ιλ:α vegyfeiet« '•agy msak «wtPMxorere, iauwt»»«, vagy <0ibp4i#ó séjs v&gy « & ^fénypont s«?*»o kompozíció fcFnaæsiïàiâsr» tbrpmfeoeasMiku? iißMkoeMg Sce*ete$i?Tsi 4vvaj^:|»»4?«stíaá*»;.: % A& ívsgytüervagy keaajKsiÄ á&í kWMfa&ßtäSä» ki va© y|k;^|y4 anéfiá* «anüemcviiro khpatabo^mfeoliksa ïaœfeSaesasâ&vic,. vés*á& «aïdksæsaiifcrk îhnïaêôeaîbîxUkiua rc«ddle«ességak, gfeivkiMiw vagy p-ílktislis kedagáa íps^aöm-s^gf.í köatU.. íSi Λ 8« ipssçoMï 3z«:»o vegyâiet vagy köxapOxid«. , absd » St: VSsy váks&vs sz Instabil aegonu aksu koronát» sain&ówa. »I^arfíbröláeik: siÿeomdffe isÉfteos, isÄSlfeaa tsefc*œiàs tséass* stroke, *tb«os<>kroaSs. pan&oáli«· oklüásív srsbrilils betegség, vénás tîa-ïiflbôïis, siéiyvgnàs íhroí-íbór-y O^ptsfenphicböls, artériás oa*boiiz.rassj 'fceroeáHás soeoàôs thmatbos'.s.. cöíehraKx artariaiis únwob:«K ocrisbrsläs ctnhnlixnoja, ve·«} esífekesmisi, tSáb etnbnbMttv» e* «vos; fsapUfîïtàswî.voi'bêl, bm'íxk-sésskbóK vsjí>· eljárásukból kbvrikozè ík'Oftíhosiv, aJH&îyektiÿÎ vet '.sí; kitïîv« iw.««r5dgcs fc'âk'îRcîf atneíy ihönásc"*',&s sagst κ!&
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201261679197P | 2012-08-03 | 2012-08-03 | |
US201361786992P | 2013-03-15 | 2013-03-15 |
Publications (1)
Publication Number | Publication Date |
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HUE031582T2 true HUE031582T2 (hu) | 2017-07-28 |
Family
ID=48949289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HUE13747624A HUE031582T2 (hu) | 2012-08-03 | 2013-08-02 | Dihidropiridon mint xia-faktor inhibitorok |
Country Status (26)
Country | Link |
---|---|
US (2) | US20140038969A1 (hu) |
EP (1) | EP2882734B1 (hu) |
JP (1) | JP6082462B2 (hu) |
KR (1) | KR20150038369A (hu) |
AR (1) | AR093759A1 (hu) |
AU (1) | AU2013296258A1 (hu) |
BR (1) | BR112015002293A2 (hu) |
CA (1) | CA2880898A1 (hu) |
CY (1) | CY1118450T1 (hu) |
DK (1) | DK2882734T3 (hu) |
EA (1) | EA025392B1 (hu) |
ES (1) | ES2605824T3 (hu) |
HR (1) | HRP20161378T1 (hu) |
HU (1) | HUE031582T2 (hu) |
IL (1) | IL237012A0 (hu) |
LT (1) | LT2882734T (hu) |
MX (1) | MX361370B (hu) |
PL (1) | PL2882734T3 (hu) |
PT (1) | PT2882734T (hu) |
RS (1) | RS55581B1 (hu) |
SG (1) | SG11201500270RA (hu) |
SI (1) | SI2882734T1 (hu) |
SM (1) | SMT201700003B (hu) |
TW (1) | TW201410666A (hu) |
UY (1) | UY34959A (hu) |
WO (1) | WO2014022766A1 (hu) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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2013
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- 2013-08-02 RS RS20170019A patent/RS55581B1/sr unknown
- 2013-08-02 CA CA2880898A patent/CA2880898A1/en not_active Abandoned
- 2013-08-02 KR KR20157004959A patent/KR20150038369A/ko not_active Application Discontinuation
- 2013-08-02 EA EA201590284A patent/EA025392B1/ru not_active IP Right Cessation
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- 2013-08-02 EP EP13747624.8A patent/EP2882734B1/en active Active
- 2013-08-02 SI SI201330344A patent/SI2882734T1/sl unknown
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- 2013-08-02 UY UY0001034959A patent/UY34959A/es unknown
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- 2013-08-02 BR BR112015002293A patent/BR112015002293A2/pt not_active Application Discontinuation
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2016
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2017
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MX2015000919A (es) | 2015-09-21 |
PT2882734T (pt) | 2016-12-09 |
RS55581B1 (sr) | 2017-06-30 |
WO2014022766A1 (en) | 2014-02-06 |
CY1118450T1 (el) | 2017-06-28 |
DK2882734T3 (en) | 2017-01-30 |
CN104520289A (zh) | 2015-04-15 |
JP6082462B2 (ja) | 2017-02-15 |
US9376444B2 (en) | 2016-06-28 |
US20150166550A1 (en) | 2015-06-18 |
SG11201500270RA (en) | 2015-03-30 |
AU2013296258A1 (en) | 2015-03-19 |
EA201590284A1 (ru) | 2015-05-29 |
EP2882734B1 (en) | 2016-10-12 |
EP2882734A1 (en) | 2015-06-17 |
IL237012A0 (en) | 2015-03-31 |
HRP20161378T1 (hr) | 2016-12-02 |
JP2015524443A (ja) | 2015-08-24 |
TW201410666A (zh) | 2014-03-16 |
BR112015002293A2 (pt) | 2017-07-04 |
UY34959A (es) | 2014-01-31 |
ES2605824T3 (es) | 2017-03-16 |
EA025392B1 (ru) | 2016-12-30 |
KR20150038369A (ko) | 2015-04-08 |
CA2880898A1 (en) | 2014-02-06 |
AR093759A1 (es) | 2015-06-24 |
MX361370B (es) | 2018-12-05 |
LT2882734T (lt) | 2016-12-12 |
PL2882734T3 (pl) | 2017-05-31 |
SMT201700003B (it) | 2017-03-08 |
SI2882734T1 (sl) | 2017-01-31 |
US20140038969A1 (en) | 2014-02-06 |
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