HUE027358T2 - Anti-mezotelin ellenanyagok és alkalmazásaik - Google Patents
Anti-mezotelin ellenanyagok és alkalmazásaik Download PDFInfo
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- HUE027358T2 HUE027358T2 HUE08855189A HUE08855189A HUE027358T2 HU E027358 T2 HUE027358 T2 HU E027358T2 HU E08855189 A HUE08855189 A HU E08855189A HU E08855189 A HUE08855189 A HU E08855189A HU E027358 T2 HUE027358 T2 HU E027358T2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
- t. kóláit hantán ellenanyag vagy fánkodnál» |^mense: amely a SEQ 1D NO· 370 szerinti szekvenciája mezöteiiare speemktis aniigénkötö régka Pi&lroax, ahol ü ellenanyag vagy ftmkcionahs Sagroense a meszeli» olyas epitöpját nmed fel, amelyet sem maszkot a 125-ös fákaníigán (CA125). és ahol az eilanástyag vagy funkeieMtis fegménse iateráalMiédik az mezntélint azpresszáíé sejtekbe és olyat •ani%#tM|ő íigiöja.'va*k::$pl az antigénkötö régié BÜDR 1, HCD8 2, HCDIi 3, LCDS 1» LCOR 2 és LCÓR 3 íégiókat tartalma*» ahol: a) a BCDR 1 a SEQ1D NO. 5 szerimg b) a HCOR2 « SEQ 1.0 NO: 39 szerinti, e) a HCDR3 a SEQ ID NO: 71 szerinti, 4) az LCOR 1 a SEQ ID NO: I 03 szerinti, e) az LCDR2 a SEQ i D NO: .133 szerinti m 0 az LC0R3 a SEQ ÍO NO: 169 szerinti;
- 2. Az 1. igénypont szeműi ellenanyagoméi)· a S£Q 10 NO 312 szerinti atotnosavsszekveaselájti variábilis nehézláneot tartalmai,
- 3. Az 1. igénypont: perirsti áleaaavag asoéiy a, 4. táblázatbeli MF-T VL variábilis könnyoláne amtSisav-szckversclái tartalmaz,
- 4. .Az Ni. igénypontit ftármely ike szerinti ellenanyag, amely IgG.
- 5. Az 1 O.igénypontök'iármeiy ikc szerinti ellenanyag izolált iunkciösális lra|mesíSé:,; mnely Mbivagy: :p|y ellencmyag-íragtneas. ék Izolált nökiéinsavskkekveneia, amely az 1-#. igénypontok bimselyike szerinti hamárt ellenanyag vagy Épkélptálls Ragmesse aptigénlöm régiépikMolja,
- 7, Vektor, anrely 6. Igésrytmat szerinti nukieinsas-kzekveneiát tanalksaz.
- 8.. Izolált sejt, anseíy 7, igénypont szerinti vektort tartalmaz,
- 9, Ál, rpnyposi szerinti izolált sejt, atari a sejt bakteriális vagy emlős sejk Ifi. Qyégyászati készítmény, amely 1-5. igénypontok bátnselyike szerinti ellenanyagot vagy fánkomnál is fragménsf ás gyógyászatliag eiRsgaribsté hordozót vagy excipienst tartalmaz.
- 11, Az 3N& igénypontok bármely ike szerinti ellenanyag w^·:· fm§pp$,: i^éat alkalmazása.
- 12. Az l-Sv igéayponták barmélylke szerinti barnán eilen^tyag abol g íttanán ellenaayag sziatetlías .hunul-5 ellenanyag.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US437807P | 2007-11-26 | 2007-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE027358T2 true HUE027358T2 (hu) | 2016-09-28 |
Family
ID=40351874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE08855189A HUE027358T2 (hu) | 2007-11-26 | 2008-11-19 | Anti-mezotelin ellenanyagok és alkalmazásaik |
Country Status (31)
Country | Link |
---|---|
US (3) | US9023351B2 (hu) |
EP (3) | EP2634196A1 (hu) |
JP (3) | JP5608091B2 (hu) |
KR (1) | KR101559599B1 (hu) |
CN (2) | CN101952319B (hu) |
AU (1) | AU2008329221B2 (hu) |
BR (1) | BRPI0819909B8 (hu) |
CA (1) | CA2706529C (hu) |
CO (1) | CO6280409A2 (hu) |
CR (1) | CR11456A (hu) |
CU (1) | CU23833A3 (hu) |
CY (1) | CY1117437T1 (hu) |
DK (1) | DK2215121T3 (hu) |
DO (1) | DOP2010000150A (hu) |
EC (1) | ECSP10010191A (hu) |
ES (1) | ES2569513T3 (hu) |
GT (1) | GT201000148A (hu) |
HK (2) | HK1148541A1 (hu) |
HN (1) | HN2010001062A (hu) |
HR (1) | HRP20160485T1 (hu) |
HU (1) | HUE027358T2 (hu) |
IL (1) | IL205681A0 (hu) |
MA (1) | MA31862B1 (hu) |
MX (1) | MX2010005603A (hu) |
MY (1) | MY157164A (hu) |
NZ (1) | NZ585551A (hu) |
PL (1) | PL2215121T3 (hu) |
SI (1) | SI2215121T1 (hu) |
TN (1) | TN2010000234A1 (hu) |
UA (1) | UA106036C2 (hu) |
WO (1) | WO2009068204A1 (hu) |
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