HUE025723T2 - Dialkoxikinazolin-származékok mint KDR inhibitorok - Google Patents
Dialkoxikinazolin-származékok mint KDR inhibitorok Download PDFInfo
- Publication number
- HUE025723T2 HUE025723T2 HUE09743783A HUE09743783A HUE025723T2 HU E025723 T2 HUE025723 T2 HU E025723T2 HU E09743783 A HUE09743783 A HU E09743783A HU E09743783 A HUE09743783 A HU E09743783A HU E025723 T2 HUE025723 T2 HU E025723T2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- compound
- aryl
- heteroaryl
- rti
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (3)
- Szabadalmi igénypontok L ügy alább; képied vegyidet:* a képletben Rj.. M.2? %, íip R* és Räe mfodegvskértek jelentése egymástól függetlenül 11, halogén, nitro, amine, ciano, hklroxik l-IO szénatomot tartalmazó alkil, 2-10 szénatomot tartabnaml síken 11, 2-1Ö szénatomot tartalmazó alkmtl, 6 szénatomot tartalmazó monocMusos, 10 szénatomot tartalmazó bicikfosos vágj·· 34 szénatomot tartalmazó trieik Insos árit, .1-12 szénatomot tartalmazó cikloaikil, 3-S-lagú moaodkíosos, k- i 2~tagé btcíkittsos vagy 11'14-tsgó trieiklusos· heierodkloalklh Jt-S-tagiV monoeikhtsos, 8- )2-tsg{j. bictklusos vagy 11 *i4*tagó trt-elklusos heteroaril, aikoxi, afkiltto, alktikarbonii, karboxi, aikoxikarbontf, ammokarbonri or aminoszulfom!; Il ï 6s R, mindegyikének jelentése alkod;, kijelentése alkil; jelentése rtSlOJNI’y^, ahol RB és % mindegyikének jelentése egymástól foggetforfoi H,; alkil, a&eml, alklnll, adt, dkfoaidl, heleroeskloalksl vagy hetmtaril, vagy Rs és együtt 3 - S-tagn, 1-3 hétéro-atomot tartalmazó gyűrűt képeznek azzal a. oíRogtfoaíonnnah amelyhez kapcsolódnak; X jelentése O, és Z jelentése· X: ahol az alkil, álként!, síkból, dkloalkll, heteróeikloaÉíi, aril, heteroaril és alkod csoportok- mindegyike magába .foglal helveítesltetlee vagy hehettedioit csoportokat, és a. helyettesítők, a következük közül vannak megválásává· halogén, htátoxtl, amino, ctano, -mrro, merkapto, alkoxikarborsii, amidé, ksrboxt,afkánsad&all, alkilkarbonil. karban) tdo, karbamlt, karhoz ti, ttonretéo,· tsociaPáixt, szalfonamido, alkil, alkenti, alklnil slkoxs, aril, heteroaril, cikloalkH és betetodkloslkil,
- 2, Az 1 igénypont szerinti vegytllet, áltól az alkil, atkeoll, aikmii, dktóalfell. heteroelklfodkil, aril, hetentaril és alkoxi «sopoaek. mindegyike helyetted teilen, .3. Áz 1, igénypont .szerinti· vegyitlei, ahol Rfi jelentése nreíth 4 Az I, Igénypert szerinti vegytlet, ahol Ra és % mindegyikének jelentése egymástól riggeíienill fi, alkil vagy clkloalkE 5. A 4. igénypont szerinti vegyüld, ahol Rg jelentése H ás Rä, jelentése metik é, A 4. Igénypont szerinti vegyidét, -aholR.^ és :R4 mindegyikének jelentése metoxt. 7. ,½ ?. igánypordsaemá yegy öletek kWf a» sláfeEiak valamelyike:képletn vegySkt.
- 9. Gyógyászati készítmény amely magába foglal egy í. igénypont szmtät vegyületsí és egy győgyásza- tilag: s-ífogiAalö :'í:>íd->aóai!yag;>t i(í< Egy L igénypont: szerinti vsgyülst érkèpxÔdëssei {mgh^sésk} kapcsolatos; rendellenesség: kezelésére való alkalmazásra, íl.> A 3Ö. igénypont szerinti vegyidet, a&ol az érképzédésset (agglogesézis) kapcsolatos rendellenesség rák, MSs korra! Összetlíggő macnla-degenerácio vagy krónikás gyniladlisos feeíegság;,
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/118,019 US7829574B2 (en) | 2008-05-09 | 2008-05-09 | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE025723T2 true HUE025723T2 (hu) | 2016-04-28 |
Family
ID=41265455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE09743783A HUE025723T2 (hu) | 2008-05-09 | 2009-05-08 | Dialkoxikinazolin-származékok mint KDR inhibitorok |
Country Status (21)
Country | Link |
---|---|
US (3) | US7829574B2 (hu) |
EP (1) | EP2297115B1 (hu) |
JP (2) | JP5856842B2 (hu) |
KR (2) | KR20160045925A (hu) |
AU (1) | AU2009244130B2 (hu) |
BR (1) | BRPI0908675B1 (hu) |
CA (1) | CA2723148C (hu) |
CY (1) | CY1117222T1 (hu) |
DK (1) | DK2297115T3 (hu) |
ES (1) | ES2550245T3 (hu) |
HR (1) | HRP20150954T1 (hu) |
HU (1) | HUE025723T2 (hu) |
MX (2) | MX2010012168A (hu) |
MY (1) | MY155566A (hu) |
NZ (1) | NZ588900A (hu) |
PL (1) | PL2297115T3 (hu) |
PT (1) | PT2297115E (hu) |
RU (1) | RU2506261C2 (hu) |
SI (1) | SI2297115T1 (hu) |
TW (1) | TWI458724B (hu) |
WO (1) | WO2009137797A2 (hu) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7829574B2 (en) * | 2008-05-09 | 2010-11-09 | Hutchison Medipharma Enterprises Limited | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
PT2396307E (pt) * | 2009-02-11 | 2015-02-04 | Merck Patent Gmbh | Novas carboxamidas azaheterocíclicas de amino |
EP3575288B1 (en) | 2009-09-03 | 2021-10-27 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
CN105461702A (zh) * | 2014-09-10 | 2016-04-06 | 和记黄埔医药(上海)有限公司 | 6-(6,7-二甲氧基喹唑啉-4-基氧基)-n,2-二甲基苯并呋喃-3-甲酰胺晶型 |
MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
WO2017189483A1 (en) | 2016-04-25 | 2017-11-02 | The Johns Hopkins University | Znt8 assays for drug development and pharmaceutical compositions |
US11892457B2 (en) | 2017-07-12 | 2024-02-06 | The Johns Hopkins University | Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis |
CN116987069A (zh) * | 2018-03-30 | 2023-11-03 | 杭州领业医药科技有限公司 | 呋喹替尼的共晶、其制备方法、组合物和用途 |
CN111184698A (zh) * | 2018-11-15 | 2020-05-22 | 和记黄埔医药(上海)有限公司 | 呋喹替尼制剂及其应用 |
CN110898065A (zh) * | 2019-11-25 | 2020-03-24 | 南通大学 | 呋喹替尼或其盐在制备治疗脉络膜新生血管药物中的用途 |
Family Cites Families (33)
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GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
ES2351699T3 (es) * | 1999-02-10 | 2011-02-09 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de la angiogénesis e intermedios de los mismos. |
US6943161B2 (en) | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
DE10009267A1 (de) * | 2000-02-26 | 2001-08-30 | Goedecke Ag | Verfahren zur einfachen Herstellung von (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazolin-4-yl]-amin |
AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
UA73993C2 (uk) * | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
WO2002030926A1 (en) * | 2000-10-13 | 2002-04-18 | Astrazeneca Ab | Quinazoline derivatives |
US6849625B2 (en) * | 2000-10-13 | 2005-02-01 | Astrazeneca Ab | Quinazoline derivatives with anti-tumour activity |
US20040092750A1 (en) | 2001-03-01 | 2004-05-13 | Tomoyuki Hasegawa | 2-methylindole-4-acetic acid, process for producing the same, and process for producing intermediate therefor |
AU2002347336A1 (en) * | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Quinoline derivatives |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
UA77303C2 (en) * | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
CN1845924A (zh) * | 2003-07-02 | 2006-10-11 | 弗·哈夫曼-拉罗切有限公司 | 芳基胺取代的喹唑啉酮化合物 |
US7442698B2 (en) | 2003-07-24 | 2008-10-28 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
GB0318423D0 (en) | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
GB0321710D0 (en) | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
CA2551508C (en) | 2003-12-23 | 2011-08-09 | Pfizer Inc. | Novel quinoline derivatives |
WO2005097137A2 (en) * | 2004-03-31 | 2005-10-20 | The Scripps Research Institute | Advanced quinazoline based protein kinase inhibitors |
WO2005115145A2 (en) | 2004-05-20 | 2005-12-08 | Wyeth | Quinone substituted quinazoline and quinoline kinase inhibitors |
US20080268460A1 (en) * | 2004-05-20 | 2008-10-30 | Wyeth | Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases |
KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
WO2006071079A1 (en) | 2004-12-29 | 2006-07-06 | Hanmi Pharm. Co., Ltd. | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof |
WO2006138304A2 (en) | 2005-06-14 | 2006-12-28 | Taigen Biotechnology | Pyrimidine compounds |
JP2009518382A (ja) | 2005-12-05 | 2009-05-07 | ファイザー・プロダクツ・インク | Vegf−r阻害剤を調製する方法 |
US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
GB0604937D0 (en) * | 2006-03-10 | 2006-04-19 | Novartis Ag | Organic compounds |
JP2010505386A (ja) | 2006-05-15 | 2010-02-25 | セネックス バイオテクノロジー,インク. | Cdki経路阻害剤の同定 |
TW200922590A (en) * | 2007-09-10 | 2009-06-01 | Curis Inc | VEGFR inhibitors containing a zinc binding moiety |
US7829574B2 (en) * | 2008-05-09 | 2010-11-09 | Hutchison Medipharma Enterprises Limited | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
-
2008
- 2008-05-09 US US12/118,019 patent/US7829574B2/en active Active
- 2008-07-04 TW TW097125278A patent/TWI458724B/zh active
-
2009
- 2009-05-08 PT PT97437834T patent/PT2297115E/pt unknown
- 2009-05-08 CA CA2723148A patent/CA2723148C/en active Active
- 2009-05-08 JP JP2011508714A patent/JP5856842B2/ja active Active
- 2009-05-08 ES ES09743783.4T patent/ES2550245T3/es active Active
- 2009-05-08 SI SI200931257T patent/SI2297115T1/sl unknown
- 2009-05-08 PL PL09743783T patent/PL2297115T3/pl unknown
- 2009-05-08 MY MYPI2010005148A patent/MY155566A/en unknown
- 2009-05-08 AU AU2009244130A patent/AU2009244130B2/en active Active
- 2009-05-08 NZ NZ588900A patent/NZ588900A/xx unknown
- 2009-05-08 RU RU2010150345/04A patent/RU2506261C2/ru active
- 2009-05-08 MX MX2010012168A patent/MX2010012168A/es active IP Right Grant
- 2009-05-08 EP EP09743783.4A patent/EP2297115B1/en active Active
- 2009-05-08 KR KR1020167009777A patent/KR20160045925A/ko not_active Application Discontinuation
- 2009-05-08 HU HUE09743783A patent/HUE025723T2/hu unknown
- 2009-05-08 WO PCT/US2009/043347 patent/WO2009137797A2/en active Application Filing
- 2009-05-08 MX MX2014001023A patent/MX340021B/es active IP Right Grant
- 2009-05-08 KR KR1020107024889A patent/KR101686679B1/ko active IP Right Grant
- 2009-05-08 BR BRPI0908675-7A patent/BRPI0908675B1/pt active IP Right Grant
- 2009-05-08 DK DK09743783.4T patent/DK2297115T3/en active
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2010
- 2010-09-29 US US12/893,872 patent/US8212033B2/en active Active
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2012
- 2012-06-04 US US13/487,434 patent/US8497372B2/en active Active
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2014
- 2014-07-04 JP JP2014138608A patent/JP2014177499A/ja active Pending
-
2015
- 2015-08-06 CY CY20151100689T patent/CY1117222T1/el unknown
- 2015-09-09 HR HRP20150954TT patent/HRP20150954T1/hr unknown
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