HUE025723T2 - Dialkoxikinazolin-származékok mint KDR inhibitorok - Google Patents

Dialkoxikinazolin-származékok mint KDR inhibitorok Download PDF

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Publication number
HUE025723T2
HUE025723T2 HUE09743783A HUE09743783A HUE025723T2 HU E025723 T2 HUE025723 T2 HU E025723T2 HU E09743783 A HUE09743783 A HU E09743783A HU E09743783 A HUE09743783 A HU E09743783A HU E025723 T2 HUE025723 T2 HU E025723T2
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Hungary
Prior art keywords
alkyl
compound
aryl
heteroaryl
rti
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HUE09743783A
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English (en)
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Wei-Guo Su
Weihan Zhang
Xiaoqiang Yan
Yumin Cui
Yongxin Ren
Jifeng Duan
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Hutchison Medipharma Entpr Ltd
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Application filed by Hutchison Medipharma Entpr Ltd filed Critical Hutchison Medipharma Entpr Ltd
Publication of HUE025723T2 publication Critical patent/HUE025723T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (3)

  1. Szabadalmi igénypontok L ügy alább; képied vegyidet:
    * a képletben Rj.. M.2? %, íip R* és Räe mfodegvskértek jelentése egymástól függetlenül 11, halogén, nitro, amine, ciano, hklroxik l-IO szénatomot tartalmazó alkil, 2-10 szénatomot tartabnaml síken 11, 2-1Ö szénatomot tartalmazó alkmtl, 6 szénatomot tartalmazó monocMusos, 10 szénatomot tartalmazó bicikfosos vágj·· 34 szénatomot tartalmazó trieik Insos árit, .1-12 szénatomot tartalmazó cikloaikil, 3-S-lagú moaodkíosos, k- i 2~tagé btcíkittsos vagy 11'14-tsgó trieiklusos· heierodkloalklh Jt-S-tagiV monoeikhtsos, 8- )2-tsg{j. bictklusos vagy 11 *i4*tagó trt-elklusos heteroaril, aikoxi, afkiltto, alktikarbonii, karboxi, aikoxikarbontf, ammokarbonri or aminoszulfom!; Il ï 6s R, mindegyikének jelentése alkod;, kijelentése alkil; jelentése rtSlOJNI’y^, ahol RB és % mindegyikének jelentése egymástól foggetforfoi H,; alkil, a&eml, alklnll, adt, dkfoaidl, heleroeskloalksl vagy hetmtaril, vagy Rs és együtt 3 - S-tagn, 1-3 hétéro-atomot tartalmazó gyűrűt képeznek azzal a. oíRogtfoaíonnnah amelyhez kapcsolódnak; X jelentése O, és Z jelentése· X: ahol az alkil, álként!, síkból, dkloalkll, heteróeikloaÉíi, aril, heteroaril és alkod csoportok- mindegyike magába .foglal helveítesltetlee vagy hehettedioit csoportokat, és a. helyettesítők, a következük közül vannak megválásává· halogén, htátoxtl, amino, ctano, -mrro, merkapto, alkoxikarborsii, amidé, ksrboxt,afkánsad&all, alkilkarbonil. karban) tdo, karbamlt, karhoz ti, ttonretéo,· tsociaPáixt, szalfonamido, alkil, alkenti, alklnil slkoxs, aril, heteroaril, cikloalkH és betetodkloslkil,
  2. 2, Az 1 igénypont szerinti vegytllet, áltól az alkil, atkeoll, aikmii, dktóalfell. heteroelklfodkil, aril, hetentaril és alkoxi «sopoaek. mindegyike helyetted teilen, .3. Áz 1, igénypont .szerinti· vegyitlei, ahol Rfi jelentése nreíth 4 Az I, Igénypert szerinti vegytlet, ahol Ra és % mindegyikének jelentése egymástól riggeíienill fi, alkil vagy clkloalkE 5. A 4. igénypont szerinti vegyüld, ahol Rg jelentése H ás Rä, jelentése metik é, A 4. Igénypont szerinti vegyidét, -aholR.^ és :R4 mindegyikének jelentése metoxt. 7. ,½ ?. igánypordsaemá yegy öletek kWf a» sláfeEiak valamelyike:
    képletn vegySkt.
  3. 9. Gyógyászati készítmény amely magába foglal egy í. igénypont szmtät vegyületsí és egy győgyásza- tilag: s-ífogiAalö :'í:>íd->aóai!yag;>t i(í< Egy L igénypont: szerinti vsgyülst érkèpxÔdëssei {mgh^sésk} kapcsolatos; rendellenesség: kezelésére való alkalmazásra, íl.> A 3Ö. igénypont szerinti vegyidet, a&amp;ol az érképzédésset (agglogesézis) kapcsolatos rendellenesség rák, MSs korra! Összetlíggő macnla-degenerácio vagy krónikás gyniladlisos feeíegság;,
HUE09743783A 2008-05-09 2009-05-08 Dialkoxikinazolin-származékok mint KDR inhibitorok HUE025723T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/118,019 US7829574B2 (en) 2008-05-09 2008-05-09 Substituted quinazoline compounds and their use in treating angiogenesis-related diseases

Publications (1)

Publication Number Publication Date
HUE025723T2 true HUE025723T2 (hu) 2016-04-28

Family

ID=41265455

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE09743783A HUE025723T2 (hu) 2008-05-09 2009-05-08 Dialkoxikinazolin-származékok mint KDR inhibitorok

Country Status (21)

Country Link
US (3) US7829574B2 (hu)
EP (1) EP2297115B1 (hu)
JP (2) JP5856842B2 (hu)
KR (2) KR20160045925A (hu)
AU (1) AU2009244130B2 (hu)
BR (1) BRPI0908675B1 (hu)
CA (1) CA2723148C (hu)
CY (1) CY1117222T1 (hu)
DK (1) DK2297115T3 (hu)
ES (1) ES2550245T3 (hu)
HR (1) HRP20150954T1 (hu)
HU (1) HUE025723T2 (hu)
MX (2) MX2010012168A (hu)
MY (1) MY155566A (hu)
NZ (1) NZ588900A (hu)
PL (1) PL2297115T3 (hu)
PT (1) PT2297115E (hu)
RU (1) RU2506261C2 (hu)
SI (1) SI2297115T1 (hu)
TW (1) TWI458724B (hu)
WO (1) WO2009137797A2 (hu)

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JP6740354B2 (ja) 2015-10-05 2020-08-12 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
US11016085B2 (en) 2016-04-25 2021-05-25 The Johns Hopkins University ZNT8 assays for drug development and pharmaceutical compositions
CN111316099A (zh) 2017-07-12 2020-06-19 约翰霍普金斯大学 用于1型糖尿病诊断的基于脂蛋白体的znt8自身抗原
WO2019183916A1 (zh) * 2018-03-30 2019-10-03 杭州领业医药科技有限公司 呋喹替尼的共晶、其制备方法、组合物和用途
CN113166241A (zh) 2018-08-16 2021-07-23 约翰霍普金斯大学 人类znt8抗体
CN111184698A (zh) * 2018-11-15 2020-05-22 和记黄埔医药（上海）有限公司 呋喹替尼制剂及其应用
CN110898065A (zh) * 2019-11-25 2020-03-24 南通大学 呋喹替尼或其盐在制备治疗脉络膜新生血管药物中的用途
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環

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Also Published As

Publication number Publication date
NZ588900A (en) 2012-12-21
TWI458724B (zh) 2014-11-01
MX2014001023A (es) 2014-05-22
BRPI0908675B1 (pt) 2022-01-25
WO2009137797A3 (en) 2010-02-25
PT2297115E (pt) 2015-10-26
US8497372B2 (en) 2013-07-30
MX2010012168A (es) 2011-02-18
US20110015213A1 (en) 2011-01-20
CA2723148C (en) 2015-01-20
MX340021B (es) 2016-06-22
MY155566A (en) 2015-10-30
CY1117222T1 (el) 2017-04-05
AU2009244130A1 (en) 2009-11-12
EP2297115A4 (en) 2012-03-14
TW201002694A (en) 2010-01-16
US20090281130A1 (en) 2009-11-12
US7829574B2 (en) 2010-11-09
EP2297115B1 (en) 2015-07-22
AU2009244130B2 (en) 2012-11-01
PL2297115T3 (pl) 2015-12-31
WO2009137797A2 (en) 2009-11-12
SI2297115T1 (sl) 2015-10-30
US8212033B2 (en) 2012-07-03
JP2014177499A (ja) 2014-09-25
KR20110013381A (ko) 2011-02-09
DK2297115T3 (en) 2015-08-10
ES2550245T3 (es) 2015-11-05
JP2011519956A (ja) 2011-07-14
BRPI0908675A2 (pt) 2015-08-04
EP2297115A2 (en) 2011-03-23
CA2723148A1 (en) 2009-11-12
RU2010150345A (ru) 2012-06-20
RU2506261C2 (ru) 2014-02-10
US20120238572A1 (en) 2012-09-20
JP5856842B2 (ja) 2016-02-10
HRP20150954T1 (hr) 2015-10-09
KR20160045925A (ko) 2016-04-27
KR101686679B1 (ko) 2016-12-14

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