HU229992B1 - Antivirális hatású aza-indol-származékok - Google Patents

Antivirális hatású aza-indol-származékok

Info

Publication number
HU229992B1
HU229992B1 HUP0301508A HUP0301508A HU229992B1 HU 229992 B1 HU229992 B1 HU 229992B1 HU P0301508 A HUP0301508 A HU P0301508A HU P0301508 A HUP0301508 A HU P0301508A HU 229992 B1 HU229992 B1 HU 229992B1
Authority
HU
Hungary
Prior art keywords
group
carbon
atom
hydrogen
formula
Prior art date
Application number
HUP0301508A
Other languages
English (en)
Hungarian (hu)
Inventor
Tao Wang
Owen B Wallace
Zhongxing Zhang
Nicholas A Meanwell
John A Bender
Original Assignee
Bristol-Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22675206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HU229992(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Co filed Critical Bristol-Myers Squibb Co
Publication of HUP0301508A2 publication Critical patent/HUP0301508A2/hu
Publication of HUP0301508A3 publication Critical patent/HUP0301508A3/hu
Publication of HU229992B1 publication Critical patent/HU229992B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUP0301508A 2000-02-22 2001-01-19 Antivirális hatású aza-indol-származékok HU229992B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18400400P 2000-02-22 2000-02-22
PCT/US2001/002009 WO2001062255A1 (en) 2000-02-22 2001-01-19 Antiviral azaindole derivatives

Publications (3)

Publication Number Publication Date
HUP0301508A2 HUP0301508A2 (hu) 2003-09-29
HUP0301508A3 HUP0301508A3 (en) 2004-08-30
HU229992B1 true HU229992B1 (hu) 2015-04-28

Family

ID=22675206

Family Applications (1)

Application Number Title Priority Date Filing Date
HUP0301508A HU229992B1 (hu) 2000-02-22 2001-01-19 Antivirális hatású aza-indol-származékok

Country Status (31)

Country Link
US (1) US20020061892A1 (enExample)
EP (1) EP1257276B1 (enExample)
JP (1) JP3868814B2 (enExample)
KR (1) KR100496574B1 (enExample)
CN (1) CN1404392A (enExample)
AR (1) AR029469A1 (enExample)
AT (1) ATE314072T1 (enExample)
AU (2) AU2001232895B2 (enExample)
BR (1) BRPI0108485B1 (enExample)
CA (1) CA2400700C (enExample)
CO (1) CO5271657A1 (enExample)
CY (1) CY1107460T1 (enExample)
DE (1) DE60116260T2 (enExample)
DK (1) DK1257276T3 (enExample)
EG (1) EG24669A (enExample)
ES (1) ES2254367T3 (enExample)
HU (1) HU229992B1 (enExample)
IL (1) IL150734A0 (enExample)
MX (1) MXPA02008113A (enExample)
MY (1) MY128458A (enExample)
NO (1) NO323564B1 (enExample)
NZ (1) NZ520317A (enExample)
PE (1) PE20020786A1 (enExample)
PL (1) PL357434A1 (enExample)
PT (1) PT1257276E (enExample)
RU (1) RU2259372C2 (enExample)
TR (1) TR200201961T2 (enExample)
TW (1) TWI293629B (enExample)
UY (1) UY26593A1 (enExample)
WO (1) WO2001062255A1 (enExample)
ZA (1) ZA200206073B (enExample)

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US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
PL364279A1 (en) * 2001-02-02 2004-12-13 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
US20040162298A1 (en) * 2002-02-23 2004-08-19 Hsu-Tso Ho Method of treating HIV infection by preventing interaction of CD4 and gp120
US20040063744A1 (en) * 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
CN1953985B (zh) * 2004-03-15 2010-06-09 布里斯托尔-迈尔斯斯奎布公司 哌嗪和取代的哌啶抗病毒药物的前药
US20050252408A1 (en) * 2004-05-17 2005-11-17 Richardson H W Particulate wood preservative and method for producing same
DK1753764T3 (da) 2004-06-09 2009-02-16 Glaxo Group Ltd Pyrrolopyridin-derivater
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
EP1910573B1 (en) 2005-07-22 2013-09-04 CytoDyn, Inc. Methods for reducing viral load in hiv-1-infected patients
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
US7622466B2 (en) * 2005-11-18 2009-11-24 Hoffman-La Roche Inc. Azaindole-2-carboxamide derivatives
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
MX2009013431A (es) * 2007-06-18 2010-01-15 Sanofi Aventis Derivados de pirrol como antagonistas de p2y12.
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
WO2009011912A1 (en) * 2007-07-18 2009-01-22 Bristol-Myers Squibb Company A composition for treating hiv comprising virus-like particles
CA2712701A1 (en) 2008-01-31 2009-08-06 Henning Steinhagen Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
CN102143739B (zh) * 2008-09-04 2014-12-17 百时美施贵宝公司 用于最优化传递hiv附着抑制剂的稳定的药用组合物
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
US8912195B2 (en) 2010-12-02 2014-12-16 Bristol-Myers Squibb Company Alkyl amides as HIV attachment inhibitors
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
WO2012142080A1 (en) 2011-04-12 2012-10-18 Bristol-Myers Squibb Company Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
EP2751119B1 (en) 2011-08-29 2016-11-23 VIIV Healthcare UK (No.5) Limited Fused bicyclic diamine derivatives as hiv attachment inhibitors
WO2013033059A1 (en) 2011-08-29 2013-03-07 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as hiv attachment inhibitors
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN102746295B (zh) * 2012-06-20 2014-10-15 上海阿达玛斯试剂有限公司 4位取代-7-氮杂吲哚的制备方法
WO2014025854A1 (en) 2012-08-09 2014-02-13 Bristol-Myers Squibb Company Piperidine amide derivatives as hiv attachment inhibitors
ES2616432T3 (es) 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de alquenos tricíclicos como inhibidores de la unión del VIH
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
CA3196620A1 (en) 2020-10-05 2022-04-14 Enliven Therapeutics, Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
CN118515629A (zh) * 2020-11-24 2024-08-20 中国人民解放军海军军医大学 一类取代苯甲酰哌嗪类化合物及其应用
CN115855899B (zh) * 2022-11-24 2025-06-10 常熟理工学院 一种荧光探针检测二氧化硫衍生物的应用

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Also Published As

Publication number Publication date
PE20020786A1 (es) 2002-09-06
EG24669A (en) 2010-04-11
DE60116260T2 (de) 2006-08-31
CA2400700A1 (en) 2001-08-30
HUP0301508A2 (hu) 2003-09-29
RU2002125494A (ru) 2004-03-20
HK1052132A1 (en) 2003-09-05
KR100496574B1 (ko) 2005-06-22
AU3289501A (en) 2001-09-03
TWI293629B (enExample) 2008-02-21
EP1257276B1 (en) 2005-12-28
UY26593A1 (es) 2001-09-28
MY128458A (en) 2007-02-28
PT1257276E (pt) 2006-05-31
NO323564B1 (no) 2007-06-11
CO5271657A1 (es) 2003-04-30
US20020061892A1 (en) 2002-05-23
PL357434A1 (en) 2004-07-26
JP3868814B2 (ja) 2007-01-17
DK1257276T3 (da) 2006-04-10
HUP0301508A3 (en) 2004-08-30
IL150734A0 (en) 2003-02-12
NO20023981D0 (no) 2002-08-21
AU2001232895B2 (en) 2005-03-17
RU2259372C2 (ru) 2005-08-27
NO20023981L (no) 2002-10-17
NZ520317A (en) 2004-05-28
TR200201961T2 (tr) 2002-12-23
WO2001062255A1 (en) 2001-08-30
AR029469A1 (es) 2003-07-02
MXPA02008113A (es) 2003-01-28
KR20020073598A (ko) 2002-09-27
DE60116260D1 (de) 2006-02-02
CA2400700C (en) 2010-10-26
EP1257276A4 (en) 2004-10-27
ES2254367T3 (es) 2006-06-16
BRPI0108485B1 (pt) 2016-08-23
ZA200206073B (en) 2003-10-30
ATE314072T1 (de) 2006-01-15
CN1404392A (zh) 2003-03-19
CY1107460T1 (el) 2012-12-19
EP1257276A1 (en) 2002-11-20
BR0108485A (pt) 2003-04-22
JP2003523392A (ja) 2003-08-05

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: VIIV HEALTHCARE UK (NO.5) LIMITED, GB

Free format text: FORMER OWNER(S): BRISTOL-MYERS SQUIBB CO., US

MM4A Lapse of definitive patent protection due to non-payment of fees