AR029469A1 - Compuesto de azaindol, compuesto de azaindol de utilidad como intermediario para preparar el anterior, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima - Google Patents
Compuesto de azaindol, compuesto de azaindol de utilidad como intermediario para preparar el anterior, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultimaInfo
- Publication number
- AR029469A1 AR029469A1 ARP010100742A ARP010100742A AR029469A1 AR 029469 A1 AR029469 A1 AR 029469A1 AR P010100742 A ARP010100742 A AR P010100742A AR P010100742 A ARP010100742 A AR P010100742A AR 029469 A1 AR029469 A1 AR 029469A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- compound
- prepare
- azaindol
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 16
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- -1 azaindole compound Chemical class 0.000 abstract 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18400400P | 2000-02-22 | 2000-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029469A1 true AR029469A1 (es) | 2003-07-02 |
Family
ID=22675206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010100742A AR029469A1 (es) | 2000-02-22 | 2001-02-19 | Compuesto de azaindol, compuesto de azaindol de utilidad como intermediario para preparar el anterior, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20020061892A1 (enExample) |
| EP (1) | EP1257276B1 (enExample) |
| JP (1) | JP3868814B2 (enExample) |
| KR (1) | KR100496574B1 (enExample) |
| CN (1) | CN1404392A (enExample) |
| AR (1) | AR029469A1 (enExample) |
| AT (1) | ATE314072T1 (enExample) |
| AU (2) | AU3289501A (enExample) |
| BR (1) | BRPI0108485B1 (enExample) |
| CA (1) | CA2400700C (enExample) |
| CO (1) | CO5271657A1 (enExample) |
| CY (1) | CY1107460T1 (enExample) |
| DE (1) | DE60116260T2 (enExample) |
| DK (1) | DK1257276T3 (enExample) |
| EG (1) | EG24669A (enExample) |
| ES (1) | ES2254367T3 (enExample) |
| HU (1) | HU229992B1 (enExample) |
| IL (1) | IL150734A0 (enExample) |
| MX (1) | MXPA02008113A (enExample) |
| MY (1) | MY128458A (enExample) |
| NO (1) | NO323564B1 (enExample) |
| NZ (1) | NZ520317A (enExample) |
| PE (1) | PE20020786A1 (enExample) |
| PL (1) | PL357434A1 (enExample) |
| PT (1) | PT1257276E (enExample) |
| RU (1) | RU2259372C2 (enExample) |
| TR (1) | TR200201961T2 (enExample) |
| TW (1) | TWI293629B (enExample) |
| UY (1) | UY26593A1 (enExample) |
| WO (1) | WO2001062255A1 (enExample) |
| ZA (1) | ZA200206073B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| RU2303038C2 (ru) * | 2001-02-02 | 2007-07-20 | Бристол-Маерс Сквибб Компани | Азаиндолоксоуксусные производные пиперазины и фармацевтическая композиция на их основе |
| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
| US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
| WO2003072028A2 (en) * | 2002-02-23 | 2003-09-04 | Bristol-Myers Squibb Company | Method of treating hiv infection by preventing interaction of cd4 and gp120 |
| US20040063744A1 (en) * | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
| PL1696920T3 (pl) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
| UA88297C2 (ru) * | 2004-03-15 | 2009-10-12 | Бристол-Майэрс Сквибб Компани | Пиперазиновые пролекарства и замещенные пиперидиновые антивирусные средства |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| US20050252408A1 (en) * | 2004-05-17 | 2005-11-17 | Richardson H W | Particulate wood preservative and method for producing same |
| JP2008501758A (ja) | 2004-06-09 | 2008-01-24 | グラクソ グループ リミテッド | ピロロピリジン誘導体 |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US7183284B2 (en) * | 2004-12-29 | 2007-02-27 | Bristol-Myers Squibb Company | Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents |
| US7601715B2 (en) | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
| KR20080035653A (ko) | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법 |
| US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
| US7396830B2 (en) * | 2005-10-04 | 2008-07-08 | Bristol-Myers Squibb Company | Piperazine amidines as antiviral agents |
| RU2417226C2 (ru) * | 2005-11-18 | 2011-04-27 | Ф.Хоффманн-Ля Рош Аг | Производные азаиндол-2-карбоксамида |
| US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| US7807671B2 (en) * | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| CA2690243A1 (en) * | 2007-06-18 | 2008-12-24 | Sanofi-Aventis | Pyrrole derivatives as p2y12 antagonists |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2009011912A1 (en) * | 2007-07-18 | 2009-01-22 | Bristol-Myers Squibb Company | A composition for treating hiv comprising virus-like particles |
| KR101577943B1 (ko) | 2008-01-31 | 2015-12-16 | 사노피 | 사이클릭 아자인돌-3-카복스아미드, 이들의 제조방법 및 약제로서의 이들의 용도 |
| EP2323633B1 (en) * | 2008-09-04 | 2012-03-21 | Bristol-Myers Squibb Company | Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor |
| HUE027598T2 (en) | 2009-04-03 | 2016-10-28 | Hoffmann La Roche | Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses |
| ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
| WO2012075235A1 (en) | 2010-12-02 | 2012-06-07 | Bristol-Myers Squibb Company | Alkyl amides as hiv attachment inhibitors |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| ES2636312T3 (es) | 2011-04-12 | 2017-10-05 | VIIV Healthcare UK (No.5) Limited | Derivados de tioamida, amidoxima y amidrazona como inhibidores de la fijación del VIH |
| US8664213B2 (en) | 2011-08-29 | 2014-03-04 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as HIV attachment inhibitors |
| WO2013033061A1 (en) | 2011-08-29 | 2013-03-07 | Bristol-Myers Squibb Company | Fused bicyclic diamine derivatives as hiv attachment inhibitors |
| WO2013138436A1 (en) | 2012-03-14 | 2013-09-19 | Bristol-Myers Squibb Company | Cyclolic hydrazine derivatives as hiv attachment inhibitors |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| CN102746295B (zh) * | 2012-06-20 | 2014-10-15 | 上海阿达玛斯试剂有限公司 | 4位取代-7-氮杂吲哚的制备方法 |
| EP2895472B1 (en) | 2012-08-09 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Tricyclic alkene derivatives as HIV attachment inhibitors |
| US9505752B2 (en) | 2012-08-09 | 2016-11-29 | Viiv Healthcare Uk (No. 5) Limited | Piperidine amide derivatives as HIV attachment inhibitors |
| CN109528749B (zh) * | 2017-09-22 | 2023-04-28 | 上海交通大学医学院附属瑞金医院 | 长链非编码rna-h19在制备治疗垂体瘤药物中的用途 |
| US11767321B2 (en) | 2020-10-05 | 2023-09-26 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
| CN118515629A (zh) * | 2020-11-24 | 2024-08-20 | 中国人民解放军海军军医大学 | 一类取代苯甲酰哌嗪类化合物及其应用 |
| CN115855899B (zh) * | 2022-11-24 | 2025-06-10 | 常熟理工学院 | 一种荧光探针检测二氧化硫衍生物的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2071529C (en) * | 1989-12-28 | 2001-03-20 | Donna Lee Romero | Diaromatic substituted anti-aids compounds |
| US5424329A (en) * | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
-
2001
- 2001-01-18 US US09/765,189 patent/US20020061892A1/en not_active Abandoned
- 2001-01-19 KR KR10-2002-7010888A patent/KR100496574B1/ko not_active Expired - Fee Related
- 2001-01-19 DE DE60116260T patent/DE60116260T2/de not_active Expired - Lifetime
- 2001-01-19 TR TR2002/01961T patent/TR200201961T2/xx unknown
- 2001-01-19 WO PCT/US2001/002009 patent/WO2001062255A1/en not_active Ceased
- 2001-01-19 CN CN01805504A patent/CN1404392A/zh active Pending
- 2001-01-19 MX MXPA02008113A patent/MXPA02008113A/es active IP Right Grant
- 2001-01-19 JP JP2001561320A patent/JP3868814B2/ja not_active Expired - Fee Related
- 2001-01-19 EP EP01904970A patent/EP1257276B1/en not_active Expired - Lifetime
- 2001-01-19 BR BRPI0108485A patent/BRPI0108485B1/pt not_active IP Right Cessation
- 2001-01-19 AT AT01904970T patent/ATE314072T1/de active
- 2001-01-19 CA CA2400700A patent/CA2400700C/en not_active Expired - Fee Related
- 2001-01-19 PT PT01904970T patent/PT1257276E/pt unknown
- 2001-01-19 NZ NZ520317A patent/NZ520317A/en not_active IP Right Cessation
- 2001-01-19 HU HU0301508A patent/HU229992B1/hu not_active IP Right Cessation
- 2001-01-19 DK DK01904970T patent/DK1257276T3/da active
- 2001-01-19 AU AU3289501A patent/AU3289501A/xx active Pending
- 2001-01-19 PL PL01357434A patent/PL357434A1/xx not_active Application Discontinuation
- 2001-01-19 AU AU2001232895A patent/AU2001232895B2/en not_active Ceased
- 2001-01-19 IL IL15073401A patent/IL150734A0/xx unknown
- 2001-01-19 ES ES01904970T patent/ES2254367T3/es not_active Expired - Lifetime
- 2001-01-19 RU RU2002125494/04A patent/RU2259372C2/ru not_active IP Right Cessation
- 2001-02-06 MY MYPI20010516A patent/MY128458A/en unknown
- 2001-02-07 TW TW090102639A patent/TWI293629B/zh not_active IP Right Cessation
- 2001-02-19 AR ARP010100742A patent/AR029469A1/es active IP Right Grant
- 2001-02-19 EG EG20010152A patent/EG24669A/xx active
- 2001-02-20 CO CO01013156A patent/CO5271657A1/es not_active Application Discontinuation
- 2001-02-21 UY UY26593A patent/UY26593A1/es not_active IP Right Cessation
- 2001-02-22 PE PE2001000190A patent/PE20020786A1/es not_active Application Discontinuation
-
2002
- 2002-07-30 ZA ZA200206073A patent/ZA200206073B/en unknown
- 2002-08-21 NO NO20023981A patent/NO323564B1/no not_active IP Right Cessation
-
2006
- 2006-03-27 CY CY20061100420T patent/CY1107460T1/el unknown
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