PT1257276E - Derivados de azaindole antivirais - Google Patents
Derivados de azaindole antiviraisInfo
- Publication number
- PT1257276E PT1257276E PT01904970T PT01904970T PT1257276E PT 1257276 E PT1257276 E PT 1257276E PT 01904970 T PT01904970 T PT 01904970T PT 01904970 T PT01904970 T PT 01904970T PT 1257276 E PT1257276 E PT 1257276E
- Authority
- PT
- Portugal
- Prior art keywords
- azaindole
- antiviral derivatives
- antiviral
- derivatives
- azaindole antiviral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18400400P | 2000-02-22 | 2000-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1257276E true PT1257276E (pt) | 2006-05-31 |
Family
ID=22675206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01904970T PT1257276E (pt) | 2000-02-22 | 2001-01-19 | Derivados de azaindole antivirais |
Country Status (32)
Country | Link |
---|---|
US (1) | US20020061892A1 (pt) |
EP (1) | EP1257276B1 (pt) |
JP (1) | JP3868814B2 (pt) |
KR (1) | KR100496574B1 (pt) |
CN (1) | CN1404392A (pt) |
AR (1) | AR029469A1 (pt) |
AT (1) | ATE314072T1 (pt) |
AU (2) | AU3289501A (pt) |
BR (1) | BRPI0108485B1 (pt) |
CA (1) | CA2400700C (pt) |
CO (1) | CO5271657A1 (pt) |
CY (1) | CY1107460T1 (pt) |
DE (1) | DE60116260T2 (pt) |
DK (1) | DK1257276T3 (pt) |
EG (1) | EG24669A (pt) |
ES (1) | ES2254367T3 (pt) |
HK (1) | HK1052132A1 (pt) |
HU (1) | HU229992B1 (pt) |
IL (1) | IL150734A0 (pt) |
MX (1) | MXPA02008113A (pt) |
MY (1) | MY128458A (pt) |
NO (1) | NO323564B1 (pt) |
NZ (1) | NZ520317A (pt) |
PE (1) | PE20020786A1 (pt) |
PL (1) | PL357434A1 (pt) |
PT (1) | PT1257276E (pt) |
RU (1) | RU2259372C2 (pt) |
TR (1) | TR200201961T2 (pt) |
TW (1) | TWI293629B (pt) |
UY (1) | UY26593A1 (pt) |
WO (1) | WO2001062255A1 (pt) |
ZA (1) | ZA200206073B (pt) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
CZ303750B6 (cs) * | 2001-02-02 | 2013-04-17 | Bristol-Myers Squibb Company | Prostredky obsahující substituované deriváty azaindoloxoacetylpiperazinu a jejich antivirová aktivita |
US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
US20040162298A1 (en) * | 2002-02-23 | 2004-08-19 | Hsu-Tso Ho | Method of treating HIV infection by preventing interaction of CD4 and gp120 |
US20040063744A1 (en) * | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
CN1953985B (zh) * | 2004-03-15 | 2010-06-09 | 布里斯托尔-迈尔斯斯奎布公司 | 哌嗪和取代的哌啶抗病毒药物的前药 |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
US20050252408A1 (en) * | 2004-05-17 | 2005-11-17 | Richardson H W | Particulate wood preservative and method for producing same |
KR20070034049A (ko) | 2004-06-09 | 2007-03-27 | 글락소 그룹 리미티드 | 피롤로피리딘 유도체 |
US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US7183284B2 (en) * | 2004-12-29 | 2007-02-27 | Bristol-Myers Squibb Company | Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents |
US7601715B2 (en) | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
MX2008000984A (es) | 2005-07-22 | 2008-04-04 | Progenics Pharm Inc | Metodos para reducir la carga viral en pacientes infectados con vih-1. |
US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
US7396830B2 (en) * | 2005-10-04 | 2008-07-08 | Bristol-Myers Squibb Company | Piperazine amidines as antiviral agents |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
MY148901A (en) * | 2007-06-18 | 2013-06-14 | Sanofi Aventis | Pyrrole derivatives as p2y12 antagonists |
BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
WO2009011912A1 (en) * | 2007-07-18 | 2009-01-22 | Bristol-Myers Squibb Company | A composition for treating hiv comprising virus-like particles |
JP5727793B2 (ja) | 2008-01-31 | 2015-06-03 | サノフイ | 環状アザインドール−3−カルボキサミド、その製造および医薬としてのその使用 |
JP5638527B2 (ja) * | 2008-09-04 | 2014-12-10 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Hiv結合阻害剤の最適な送達のための安定な医薬組成物 |
AU2010232670B2 (en) | 2009-04-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof |
BR112012012156A2 (pt) | 2009-11-06 | 2015-09-08 | Plexxikon Inc | compostos e métodos para modulação de cinase, e indicações para esta |
ES2585396T3 (es) | 2010-12-02 | 2016-10-05 | VIIV Healthcare UK (No.5) Limited | Alquilamidas como inhibidores de la unión del VIH |
BR112013020041B1 (pt) | 2011-02-07 | 2021-11-23 | Plexxikon, Inc | Compostos e composições para a modulação de quinases e uso dos mesmos |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
US8685982B2 (en) | 2011-04-12 | 2014-04-01 | Bristol-Myers Squibb Company | Thioamide, amidoxime and amidrazone derivatives as HIV attachment inhibitors |
ES2616268T3 (es) | 2011-08-29 | 2017-06-12 | VIIV Healthcare UK (No.5) Limited | Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH |
EP2751118B1 (en) | 2011-08-29 | 2016-10-12 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as hiv attachment inhibitors |
US9193725B2 (en) | 2012-03-14 | 2015-11-24 | Bristol-Meyers Squibb Company | Cyclic hydrazine derivatives as HIV attachment inhibitors |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
CN102746295B (zh) * | 2012-06-20 | 2014-10-15 | 上海阿达玛斯试剂有限公司 | 4位取代-7-氮杂吲哚的制备方法 |
EP2895472B1 (en) | 2012-08-09 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Tricyclic alkene derivatives as HIV attachment inhibitors |
EP2895471B1 (en) | 2012-08-09 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Piperidine amide derivatives as hiv attachment inhibitors |
CN109528749B (zh) * | 2017-09-22 | 2023-04-28 | 上海交通大学医学院附属瑞金医院 | 长链非编码rna-h19在制备治疗垂体瘤药物中的用途 |
IL301739A (en) | 2020-10-05 | 2023-05-01 | Enliven Therapeutics Inc | 5- and 6-Azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
CN112430223B (zh) * | 2020-11-24 | 2022-11-25 | 中国人民解放军海军军医大学 | 一类取代苯甲酰哌嗪类化合物及其应用 |
-
2001
- 2001-01-18 US US09/765,189 patent/US20020061892A1/en not_active Abandoned
- 2001-01-19 AT AT01904970T patent/ATE314072T1/de active
- 2001-01-19 CA CA2400700A patent/CA2400700C/en not_active Expired - Fee Related
- 2001-01-19 DE DE60116260T patent/DE60116260T2/de not_active Expired - Lifetime
- 2001-01-19 HU HU0301508A patent/HU229992B1/hu not_active IP Right Cessation
- 2001-01-19 MX MXPA02008113A patent/MXPA02008113A/es active IP Right Grant
- 2001-01-19 IL IL15073401A patent/IL150734A0/xx unknown
- 2001-01-19 BR BRPI0108485A patent/BRPI0108485B1/pt not_active IP Right Cessation
- 2001-01-19 KR KR10-2002-7010888A patent/KR100496574B1/ko not_active IP Right Cessation
- 2001-01-19 PT PT01904970T patent/PT1257276E/pt unknown
- 2001-01-19 RU RU2002125494/04A patent/RU2259372C2/ru not_active IP Right Cessation
- 2001-01-19 JP JP2001561320A patent/JP3868814B2/ja not_active Expired - Fee Related
- 2001-01-19 ES ES01904970T patent/ES2254367T3/es not_active Expired - Lifetime
- 2001-01-19 CN CN01805504A patent/CN1404392A/zh active Pending
- 2001-01-19 TR TR2002/01961T patent/TR200201961T2/xx unknown
- 2001-01-19 NZ NZ520317A patent/NZ520317A/en not_active IP Right Cessation
- 2001-01-19 WO PCT/US2001/002009 patent/WO2001062255A1/en active IP Right Grant
- 2001-01-19 EP EP01904970A patent/EP1257276B1/en not_active Expired - Lifetime
- 2001-01-19 PL PL01357434A patent/PL357434A1/xx not_active Application Discontinuation
- 2001-01-19 AU AU3289501A patent/AU3289501A/xx active Pending
- 2001-01-19 DK DK01904970T patent/DK1257276T3/da active
- 2001-01-19 AU AU2001232895A patent/AU2001232895B2/en not_active Ceased
- 2001-02-06 MY MYPI20010516A patent/MY128458A/en unknown
- 2001-02-07 TW TW090102639A patent/TWI293629B/zh not_active IP Right Cessation
- 2001-02-19 AR ARP010100742A patent/AR029469A1/es active IP Right Grant
- 2001-02-19 EG EG20010152A patent/EG24669A/xx active
- 2001-02-20 CO CO01013156A patent/CO5271657A1/es not_active Application Discontinuation
- 2001-02-21 UY UY26593A patent/UY26593A1/es not_active IP Right Cessation
- 2001-02-22 PE PE2001000190A patent/PE20020786A1/es not_active Application Discontinuation
-
2002
- 2002-07-30 ZA ZA200206073A patent/ZA200206073B/en unknown
- 2002-08-21 NO NO20023981A patent/NO323564B1/no not_active IP Right Cessation
-
2003
- 2003-04-23 HK HK03102905A patent/HK1052132A1/xx not_active IP Right Cessation
-
2006
- 2006-03-27 CY CY20061100420T patent/CY1107460T1/el unknown
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