HU221629B1 - Béta-amiloid fehérje képződést gátló peptidek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Béta-amiloid fehérje képződést gátló peptidek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények Download PDFInfo
- Publication number
- HU221629B1 HU221629B1 HU9600832A HU9600832A HU221629B1 HU 221629 B1 HU221629 B1 HU 221629B1 HU 9600832 A HU9600832 A HU 9600832A HU 9600832 A HU9600832 A HU 9600832A HU 221629 B1 HU221629 B1 HU 221629B1
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- Hungary
- Prior art keywords
- formula
- group
- alkyl
- compounds
- compound
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93402398 | 1993-10-01 | ||
| PCT/US1994/010679 WO1995009838A1 (en) | 1993-10-01 | 1994-09-20 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9600832D0 HU9600832D0 (en) | 1996-05-28 |
| HUT74004A HUT74004A (en) | 1996-10-28 |
| HU221629B1 true HU221629B1 (hu) | 2002-12-28 |
Family
ID=8214751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9600832A HU221629B1 (hu) | 1993-10-01 | 1994-09-20 | Béta-amiloid fehérje képződést gátló peptidek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0721449B1 (enExample) |
| JP (1) | JPH09505281A (enExample) |
| KR (1) | KR100316865B1 (enExample) |
| CN (1) | CN1078886C (enExample) |
| AT (1) | ATE211129T1 (enExample) |
| AU (1) | AU687449B2 (enExample) |
| CA (1) | CA2171882C (enExample) |
| DE (1) | DE69429527T2 (enExample) |
| DK (1) | DK0721449T3 (enExample) |
| ES (1) | ES2170104T3 (enExample) |
| FI (1) | FI961438A0 (enExample) |
| HU (1) | HU221629B1 (enExample) |
| IL (1) | IL111078A (enExample) |
| NO (1) | NO308029B1 (enExample) |
| NZ (1) | NZ274074A (enExample) |
| PT (1) | PT721449E (enExample) |
| TW (1) | TW264480B (enExample) |
| WO (1) | WO1995009838A1 (enExample) |
| ZA (1) | ZA947529B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU690986B2 (en) * | 1994-06-02 | 1998-05-07 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
| NZ287604A (en) * | 1994-06-02 | 1998-12-23 | Merrell Pharma Inc | Acylated enol derivatives as prodrugs of elastase inhibitors |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US5691368A (en) * | 1995-01-11 | 1997-11-25 | Hoechst Marion Roussel, Inc. | Substituted oxazolidine calpain and/or cathepsin B inhibitors |
| US5783434A (en) * | 1995-06-06 | 1998-07-21 | Tung; Jay S. | Cathepsin and methods and compositions for inhibition thereof |
| US5849711A (en) * | 1995-06-06 | 1998-12-15 | Athena Neurosciences, Inc. | Cathepsin and methods and compositions for inhibition thereof |
| CA2221684A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
| US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
| CA2191924A1 (en) | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
| US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
| AR016751A1 (es) * | 1996-11-22 | 2001-08-01 | Athena Neurosciences Inc | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo |
| US6642261B2 (en) | 1997-11-21 | 2003-11-04 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6191166B1 (en) | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6096782A (en) | 1996-11-22 | 2000-08-01 | Athena Neurosciences, Inc. | N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6211235B1 (en) | 1996-11-22 | 2001-04-03 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6207710B1 (en) | 1996-11-22 | 2001-03-27 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| AU5354398A (en) * | 1996-11-22 | 1998-06-10 | Elan Pharmaceuticals, Inc. | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions compri sing same, and methods for inhibiting beta-amyloid peptide release and/or it s synthesis by use of such compounds |
| US6153652A (en) | 1996-11-22 | 2000-11-28 | Elan Pharmaceuticals, Inc. | N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6117901A (en) | 1996-11-22 | 2000-09-12 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use |
| DE19648793A1 (de) | 1996-11-26 | 1998-05-28 | Basf Ag | Neue Benzamide und deren Anwendung |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
| US6506782B1 (en) | 1998-02-27 | 2003-01-14 | Athena Neurosciences, Inc. | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| WO2001087354A2 (en) | 2000-05-17 | 2001-11-22 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
| US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| CA2440042C (en) | 2001-03-05 | 2011-09-27 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| CN1235583C (zh) | 2001-03-05 | 2006-01-11 | 特兰斯泰克制药公司 | 用作治疗剂的苯并咪唑衍生物 |
| EP1482931B1 (en) | 2002-03-05 | 2011-10-19 | TransTech Pharma, Inc. | Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| KR100851035B1 (ko) | 2005-08-23 | 2008-08-11 | 대한민국 | ＧＣＰ-Ⅱ를 유효성분으로 함유하는 β-아밀로이드의 뇌내축적 예방 및 치료용 약학적 조성물과 치료제 스크리닝용조성물 및 이를 이용한 스크리닝 방법 |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| NZ600786A (en) | 2009-12-22 | 2013-12-20 | Cephalon Inc | Proteasome inhibitors and processes for their preparation, purification and use |
| KR20150064743A (ko) | 2012-10-05 | 2015-06-11 | 트랜스테크 파르마 엘엘씨 | 경도 및 중등도 알츠하이머 병의 치료 |
| JP6722289B2 (ja) | 2015-12-30 | 2020-07-15 | 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． | βアミロイドタンパク質に特異的に結合する化合物 |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| JP7179721B2 (ja) | 2016-06-21 | 2022-11-29 | オリオン・オフサルモロジー・エルエルシー | 複素環式プロリンアミド誘導体 |
| JP7315564B2 (ja) * | 2018-02-02 | 2023-07-26 | アジレント・テクノロジーズ・インク | グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット |
| WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| JP7464591B2 (ja) | 2018-10-10 | 2024-04-09 | ブイティーブイ・セラピューティクス・エルエルシー | ［３－（４－｛２－ブチル－１－［４－（４－クロロ－フェノキシ）－フェニル］－１ｈ－イミダゾール－４－イル｝－フェノキシ）－プロピル］－ジエチル－アミンの代謝産物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| ZA905737B (en) * | 1989-07-26 | 1991-05-29 | Merrell Dow Pharma | Novel peptidase inhibitors |
| WO1992014696A2 (en) * | 1991-02-22 | 1992-09-03 | The Du Pont Merck Pharmaceutical Company | SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES |
| CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
-
1994
- 1994-09-20 ES ES94928637T patent/ES2170104T3/es not_active Expired - Lifetime
- 1994-09-20 CA CA002171882A patent/CA2171882C/en not_active Expired - Fee Related
- 1994-09-20 DK DK94928637T patent/DK0721449T3/da active
- 1994-09-20 WO PCT/US1994/010679 patent/WO1995009838A1/en not_active Ceased
- 1994-09-20 NZ NZ274074A patent/NZ274074A/en not_active IP Right Cessation
- 1994-09-20 CN CN94193598A patent/CN1078886C/zh not_active Expired - Fee Related
- 1994-09-20 JP JP7510830A patent/JPH09505281A/ja not_active Withdrawn
- 1994-09-20 EP EP94928637A patent/EP0721449B1/en not_active Expired - Lifetime
- 1994-09-20 HU HU9600832A patent/HU221629B1/hu not_active IP Right Cessation
- 1994-09-20 AU AU77998/94A patent/AU687449B2/en not_active Ceased
- 1994-09-20 FI FI961438A patent/FI961438A0/fi not_active Application Discontinuation
- 1994-09-20 PT PT94928637T patent/PT721449E/pt unknown
- 1994-09-20 AT AT94928637T patent/ATE211129T1/de not_active IP Right Cessation
- 1994-09-20 DE DE69429527T patent/DE69429527T2/de not_active Expired - Fee Related
- 1994-09-20 KR KR1019960701686A patent/KR100316865B1/ko not_active Expired - Fee Related
- 1994-09-27 ZA ZA947529A patent/ZA947529B/xx unknown
- 1994-09-29 IL IL11107894A patent/IL111078A/en not_active IP Right Cessation
- 1994-09-29 TW TW083108992A patent/TW264480B/zh active
-
1996
- 1996-04-01 NO NO961326A patent/NO308029B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9600832D0 (en) | 1996-05-28 |
| ZA947529B (en) | 1995-05-29 |
| HUT74004A (en) | 1996-10-28 |
| EP0721449B1 (en) | 2001-12-19 |
| CA2171882C (en) | 2001-12-04 |
| KR100316865B1 (ko) | 2002-11-29 |
| FI961438A7 (fi) | 1996-03-29 |
| DK0721449T3 (da) | 2002-04-22 |
| NO961326D0 (no) | 1996-04-01 |
| AU687449B2 (en) | 1998-02-26 |
| ES2170104T3 (es) | 2002-08-01 |
| PT721449E (pt) | 2002-06-28 |
| KR960704839A (ko) | 1996-10-09 |
| IL111078A0 (en) | 1994-11-28 |
| EP0721449A1 (en) | 1996-07-17 |
| CN1078886C (zh) | 2002-02-06 |
| NZ274074A (en) | 1997-11-24 |
| JPH09505281A (ja) | 1997-05-27 |
| AU7799894A (en) | 1995-05-01 |
| FI961438L (fi) | 1996-03-29 |
| DE69429527T2 (de) | 2002-07-18 |
| CN1132504A (zh) | 1996-10-02 |
| IL111078A (en) | 1999-03-12 |
| DE69429527D1 (de) | 2002-01-31 |
| WO1995009838A1 (en) | 1995-04-13 |
| ATE211129T1 (de) | 2002-01-15 |
| NO961326L (no) | 1996-04-01 |
| TW264480B (enExample) | 1995-12-01 |
| CA2171882A1 (en) | 1995-04-13 |
| NO308029B1 (no) | 2000-07-10 |
| FI961438A0 (fi) | 1996-03-29 |
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Owner name: MERRELL PHARMACEUTICALS INC., US |
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Owner name: AVENTIS INC., US Free format text: FORMER OWNER(S): SCOIS NOVA INC., US; MERRELL PHARMACEUTICALS INC., US; MERRELL DOW PHARMACEUTICALSINC., US; MERRELL PHARMACEUTICALS INC., US |
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