HU221499B - 27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof - Google Patents
27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof Download PDFInfo
- Publication number
- HU221499B HU221499B HU9500432A HU9500432A HU221499B HU 221499 B HU221499 B HU 221499B HU 9500432 A HU9500432 A HU 9500432A HU 9500432 A HU9500432 A HU 9500432A HU 221499 B HU221499 B HU 221499B
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- HU
- Hungary
- Prior art keywords
- rapamycin
- hydroxy
- comp
- pharmaceutically acceptable
- compound
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- 150000002334 glycols Chemical class 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
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- 239000012133 immunoprecipitate Substances 0.000 description 1
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- 239000007943 implant Substances 0.000 description 1
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- 125000000468 ketone group Chemical group 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
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- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
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- 150000005846 sugar alcohols Polymers 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- STMPXDBGVJZCEX-UHFFFAOYSA-N triethylsilyl trifluoromethanesulfonate Chemical compound CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F STMPXDBGVJZCEX-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93012492A | 1992-08-13 | 1992-08-13 | |
| US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
| PCT/US1993/007581 WO1994004540A1 (en) | 1992-08-13 | 1993-08-12 | 27-hydroxyrapamycin and derivatives thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9500432D0 HU9500432D0 (en) | 1995-04-28 |
| HUT71614A HUT71614A (en) | 1996-01-29 |
| HU221499B true HU221499B (en) | 2002-10-28 |
Family
ID=26679675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9500432A HU221499B (en) | 1992-08-13 | 1993-08-12 | 27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0655065B1 (enExample) |
| JP (1) | JPH08501084A (enExample) |
| AT (1) | ATE146179T1 (enExample) |
| AU (1) | AU5007193A (enExample) |
| CA (1) | CA2142288A1 (enExample) |
| DE (1) | DE69306585T2 (enExample) |
| DK (1) | DK0655065T3 (enExample) |
| ES (1) | ES2096941T3 (enExample) |
| GR (1) | GR3022730T3 (enExample) |
| HU (1) | HU221499B (enExample) |
| MX (1) | MX9304868A (enExample) |
| WO (1) | WO1994004540A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| JP4105761B2 (ja) * | 1993-11-19 | 2008-06-25 | アボット・ラボラトリーズ | ラパミシン（マクロライド）の半合成類似体免疫調節剤 |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| JP3226545B2 (ja) | 1995-06-09 | 2001-11-05 | ノバルティス・アクチエンゲゼルシャフト | ラパマイシン誘導体 |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| EP1212331B1 (en) | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| ES2485841T3 (es) | 2002-02-01 | 2014-08-14 | Ariad Pharmaceuticals, Inc | Compuestos que contienen fósforo y usos de los mismos |
| DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| EP2094241A4 (en) | 2006-11-14 | 2013-04-17 | Ariad Pharma Inc | ORAL FORMULATIONS |
| US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| EP3008192B1 (en) | 2013-06-11 | 2019-07-17 | Takara Bio USA, Inc. | Protein enriched microvesicles and methods of making and using the same |
| MX2020011564A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina unidos a c26 como inhibidores de mtor. |
| US20190336609A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors |
| AU2022253019A1 (en) * | 2021-04-09 | 2023-11-16 | Revolution Medicines, Inc. | Synthesis of rapamycin analog compounds |
| US20240082249A1 (en) | 2022-05-25 | 2024-03-14 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en not_active Ceased
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9500432D0 (en) | 1995-04-28 |
| ES2096941T3 (es) | 1997-03-16 |
| DE69306585D1 (de) | 1997-01-23 |
| MX9304868A (es) | 1994-05-31 |
| EP0655065B1 (en) | 1996-12-11 |
| DE69306585T2 (de) | 1997-04-17 |
| WO1994004540A1 (en) | 1994-03-03 |
| DK0655065T3 (enExample) | 1997-02-24 |
| CA2142288A1 (en) | 1994-03-03 |
| ATE146179T1 (de) | 1996-12-15 |
| GR3022730T3 (en) | 1997-06-30 |
| HUT71614A (en) | 1996-01-29 |
| JPH08501084A (ja) | 1996-02-06 |
| EP0655065A1 (en) | 1995-05-31 |
| AU5007193A (en) | 1994-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: WYETH, US |
|
| HMM4 | Cancellation of final prot. due to non-payment of fee |