GR3022730T3 - 27-hydroxyrapamycin and derivatives thereof. - Google Patents
27-hydroxyrapamycin and derivatives thereof.Info
- Publication number
- GR3022730T3 GR3022730T3 GR970400422T GR970400422T GR3022730T3 GR 3022730 T3 GR3022730 T3 GR 3022730T3 GR 970400422 T GR970400422 T GR 970400422T GR 970400422 T GR970400422 T GR 970400422T GR 3022730 T3 GR3022730 T3 GR 3022730T3
- Authority
- GR
- Greece
- Prior art keywords
- hydroxyrapamycin
- derivatives
- formula
- compound
- deoxo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93012492A | 1992-08-13 | 1992-08-13 | |
| US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
| PCT/US1993/007581 WO1994004540A1 (en) | 1992-08-13 | 1993-08-12 | 27-hydroxyrapamycin and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3022730T3 true GR3022730T3 (en) | 1997-06-30 |
Family
ID=26679675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400422T GR3022730T3 (en) | 1992-08-13 | 1997-03-03 | 27-hydroxyrapamycin and derivatives thereof. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0655065B1 (enExample) |
| JP (1) | JPH08501084A (enExample) |
| AT (1) | ATE146179T1 (enExample) |
| AU (1) | AU5007193A (enExample) |
| CA (1) | CA2142288A1 (enExample) |
| DE (1) | DE69306585T2 (enExample) |
| DK (1) | DK0655065T3 (enExample) |
| ES (1) | ES2096941T3 (enExample) |
| GR (1) | GR3022730T3 (enExample) |
| HU (1) | HU221499B (enExample) |
| MX (1) | MX9304868A (enExample) |
| WO (1) | WO1994004540A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| KR100400620B1 (ko) * | 1995-06-09 | 2004-02-18 | 노파르티스 아게 | 라파마이신유도체 |
| CA2383451A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| PT1478648E (pt) | 2002-02-01 | 2014-07-15 | Ariad Pharma Inc | Compostos contendo fósforo e suas utilizações |
| US20040225077A1 (en) | 2002-12-30 | 2004-11-11 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| WO2008060546A2 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| JP6525971B2 (ja) | 2013-06-11 | 2019-06-05 | タカラ バイオ ユーエスエー， インコーポレイテッド | タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法 |
| IL278335B2 (en) | 2018-05-01 | 2024-09-01 | Revolution Medicines Inc | C26-linked rapamycin analogs as mtor inhibitors |
| FI3788049T3 (fi) | 2018-05-01 | 2023-05-30 | Revolution Medicines Inc | C40-, c28- ja c-32-liittyneitä rapamysiinianalogeja mtor-estäjinä |
| AU2022253019A1 (en) * | 2021-04-09 | 2023-11-16 | Revolution Medicines, Inc. | Synthesis of rapamycin analog compounds |
| CA3256390A1 (en) | 2022-05-25 | 2023-11-30 | Revolution Medicines Inc | CANCER TREATMENT METHODS USING AN MTOR INHIBITOR |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en not_active Ceased
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69306585D1 (de) | 1997-01-23 |
| AU5007193A (en) | 1994-03-15 |
| HU9500432D0 (en) | 1995-04-28 |
| HUT71614A (en) | 1996-01-29 |
| JPH08501084A (ja) | 1996-02-06 |
| EP0655065B1 (en) | 1996-12-11 |
| ES2096941T3 (es) | 1997-03-16 |
| DE69306585T2 (de) | 1997-04-17 |
| DK0655065T3 (enExample) | 1997-02-24 |
| HU221499B (en) | 2002-10-28 |
| MX9304868A (es) | 1994-05-31 |
| WO1994004540A1 (en) | 1994-03-03 |
| EP0655065A1 (en) | 1995-05-31 |
| ATE146179T1 (de) | 1996-12-15 |
| CA2142288A1 (en) | 1994-03-03 |
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