HU220072B - Naftiridon-karbonsav-származékok, ezeket tartalmazó gyógyászati készítmények, eljárás előállításukra, valamint intermedierjeik - Google Patents
Naftiridon-karbonsav-származékok, ezeket tartalmazó gyógyászati készítmények, eljárás előállításukra, valamint intermedierjeik Download PDFInfo
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- HU220072B HU220072B HU9603455A HU9603455A HU220072B HU 220072 B HU220072 B HU 220072B HU 9603455 A HU9603455 A HU 9603455A HU 9603455 A HU9603455 A HU 9603455A HU 220072 B HU220072 B HU 220072B
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- Prior art keywords
- formula
- carboxylic acid
- compound
- hydrogen
- amino
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- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims description 11
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- 239000001257 hydrogen Substances 0.000 claims abstract description 32
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- YSLIPUSJNFIFAB-UHFFFAOYSA-N 2-oxopyridine-1-carboxylic acid Chemical class OC(=O)N1C=CC=CC1=O YSLIPUSJNFIFAB-UHFFFAOYSA-N 0.000 claims abstract description 23
- 125000001424 substituent group Chemical group 0.000 claims abstract description 22
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 4
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- C—CHEMISTRY; METALLURGY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15657894 | 1994-06-14 | ||
| JP19792194 | 1994-07-28 | ||
| JP30691494 | 1994-11-15 | ||
| JP33995694 | 1994-12-28 | ||
| JP8170595 | 1995-03-13 | ||
| PCT/JP1995/001110 WO1995034559A1 (en) | 1994-06-14 | 1995-06-06 | Novel compound, process for producing the same, and antitumor agent |
Publications (3)
| Publication Number | Publication Date |
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| HU9603455D0 HU9603455D0 (en) | 1997-02-28 |
| HUT75777A HUT75777A (en) | 1997-05-28 |
| HU220072B true HU220072B (hu) | 2001-10-28 |
Family
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| HU9603455A HU220072B (hu) | 1994-06-14 | 1995-06-06 | Naftiridon-karbonsav-származékok, ezeket tartalmazó gyógyászati készítmények, eljárás előállításukra, valamint intermedierjeik |
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| RO (1) | RO117793B1 (member.php) |
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| SI (1) | SI0787726T1 (member.php) |
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| WO (1) | WO1995034559A1 (member.php) |
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| ES2424676T3 (es) * | 2003-09-10 | 2013-10-07 | Kyorin Pharmaceutical Co., Ltd. | Derivado de ácido 7-(3-ciclopropilaminometil-1-pirrolidinil 4-sustituido)quinoloncarboxílico |
| DE10352979A1 (de) * | 2003-11-13 | 2005-06-09 | Merck Patent Gmbh | Pyridopyrimidinone |
| CN101703508A (zh) * | 2004-03-15 | 2010-05-12 | 逊尼希思制药公司 | Sns-595及其使用方法 |
| AU2013201203C1 (en) * | 2004-03-15 | 2015-04-23 | Sumitomo Dainippon Pharma Co., Ltd. | Sns-595 and methods of using the same |
| MX2007004274A (es) * | 2004-10-14 | 2007-05-16 | Hoffmann La Roche | Quinazolinilmetilentiazolinonas como inhibidores de cdk1. |
| BRPI0516488A (pt) * | 2004-10-14 | 2008-09-09 | Hoffmann La Roche | azolidinonas de 1,5-naftiridina tendo atividade antiproliferativa de cdk1 |
| RU2420524C2 (ru) * | 2005-05-19 | 2011-06-10 | Дайити Санкио Компани, Лимитед | Производные три- или тетра-замещенного-3-аминопирролидина |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
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| AU2013219242C1 (en) * | 2005-09-02 | 2016-09-22 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| EP1931339B1 (en) * | 2005-09-02 | 2018-05-16 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CA2845095A1 (en) * | 2005-09-02 | 2007-03-08 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CN104873502A (zh) * | 2005-09-02 | 2015-09-02 | 逊尼希思制药公司 | 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法 |
| RU2428983C2 (ru) * | 2005-09-02 | 2011-09-20 | Санесис Фармасьютикалз, Инк. | Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака |
| US7642270B2 (en) | 2005-09-14 | 2010-01-05 | Janssen Pharmaceutica N.V. | 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase |
| TW200800983A (en) | 2005-09-14 | 2008-01-01 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase |
| BRPI0615838A2 (pt) * | 2005-09-14 | 2011-05-31 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihidro-pirido-pirimidinas como inibidores de ofc-fms cinase |
| US8124773B2 (en) | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
| US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| ES2556677T3 (es) * | 2006-08-02 | 2016-01-19 | Sunesis Pharmaceuticals, Inc. | Utilización combinada de ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridin-3-carboxílico y citarabina (Ara-C) para el tratamiento de la leucemia |
| EP2214662B1 (en) * | 2007-10-22 | 2016-07-13 | Sunesis Pharmaceuticals, Inc. | (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination with gemcitabine for use in treating cancer |
| EP2249831A2 (en) * | 2007-12-10 | 2010-11-17 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| WO2010078294A1 (en) * | 2008-12-31 | 2010-07-08 | Sunesis Pharmaceutical, Inc. | Method of preparing (+)-1,4-dihydro-7-[(3s,4s)-3methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| SG173855A1 (en) | 2009-02-27 | 2011-09-29 | Sunesis Pharmaceuticals Inc | Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| SI2712358T1 (sl) | 2011-05-13 | 2017-03-31 | Array Biopharma, Inc. | Spojine pirolidinil sečnine, pirolidinil tiosečnine in pirolidinil gvanidina kot inhibitorji kinaze trka |
| CN103497186B (zh) * | 2013-09-24 | 2015-02-25 | 浙江司太立制药股份有限公司 | 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法 |
| US11286255B2 (en) | 2017-03-24 | 2022-03-29 | Wakunaga Pharmaceutical Co., Ltd. | Pyridone carboxylic acid derivative or salt thereof |
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| US3988463A (en) * | 1974-05-06 | 1976-10-26 | Merck & Co., Inc. | Method of preventing metastasis of H. Ep. No. 3 |
| US4384001A (en) * | 1978-12-21 | 1983-05-17 | Gosalvez Mario | Treatment of tumors with thiazolidine-4-carboxylic acid |
| US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
| DE3577089D1 (de) * | 1984-01-26 | 1990-05-17 | Abbott Lab | Antibakterielle chinolinderivate. |
| NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
| JPS61152682A (ja) * | 1984-12-27 | 1986-07-11 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| JPS61251667A (ja) * | 1985-04-30 | 1986-11-08 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| PT82752B (pt) * | 1985-06-13 | 1988-12-15 | Schering Corp | Processo para a preparacao de derivados policiclicos de quinolina, naftiridina e pirazinopiridina |
| US4851425A (en) * | 1985-06-14 | 1989-07-25 | The Upjohn Company | Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents |
| JPS6233176A (ja) * | 1985-08-05 | 1987-02-13 | Toyama Chem Co Ltd | １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩 |
| JP2704428B2 (ja) * | 1988-06-15 | 1998-01-26 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| JPH06233176A (ja) * | 1993-01-29 | 1994-08-19 | Sony Corp | ビデオカメラ |
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1995
- 1995-06-06 SI SI9530567T patent/SI0787726T1/xx unknown
- 1995-06-06 HK HK97101948A patent/HK1000495A1/en not_active IP Right Cessation
- 1995-06-06 WO PCT/JP1995/001110 patent/WO1995034559A1/ja not_active Ceased
- 1995-06-06 AU AU25767/95A patent/AU679859B2/en not_active Expired
- 1995-06-06 CZ CZ19963643A patent/CZ292631B6/cs not_active IP Right Cessation
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- 1995-06-06 CA CA002192824A patent/CA2192824C/en not_active Expired - Lifetime
- 1995-06-06 ES ES95920265T patent/ES2163512T3/es not_active Expired - Lifetime
- 1995-06-06 PT PT95920265T patent/PT787726E/pt unknown
- 1995-06-06 NZ NZ287139A patent/NZ287139A/en not_active IP Right Cessation
- 1995-06-06 BR BR9508037A patent/BR9508037A/pt not_active IP Right Cessation
- 1995-06-06 US US08/765,232 patent/US5817669A/en not_active Expired - Lifetime
- 1995-06-06 KR KR1019960707029A patent/KR100350921B1/ko not_active Expired - Lifetime
- 1995-06-06 DK DK95920265T patent/DK0787726T3/da active
- 1995-06-06 SK SK1574-96A patent/SK281341B6/sk not_active IP Right Cessation
- 1995-06-06 HU HU9603455A patent/HU220072B/hu unknown
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- 1995-06-06 PL PL95317726A patent/PL181867B1/pl unknown
- 1995-06-06 RU RU97100718/04A patent/RU2151770C1/ru active
- 1995-06-06 RO RO96-02349A patent/RO117793B1/ro unknown
- 1995-06-06 DE DE69524251T patent/DE69524251T2/de not_active Expired - Lifetime
- 1995-06-13 TW TW084106000A patent/TW319769B/zh not_active IP Right Cessation
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1996
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- 1996-12-13 FI FI965020A patent/FI112485B/fi not_active IP Right Cessation
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