HU215912B - Eljárás 3,4-dihidro-2H-1-benzopiránok hidrazidszármazékai, és ezeket tartalmazó gyógyszerkészítmények előállítására - Google Patents

Eljárás 3,4-dihidro-2H-1-benzopiránok hidrazidszármazékai, és ezeket tartalmazó gyógyszerkészítmények előállítására Download PDF

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Publication number
HU215912B
HU215912B HU9402882A HU9402882A HU215912B HU 215912 B HU215912 B HU 215912B HU 9402882 A HU9402882 A HU 9402882A HU 9402882 A HU9402882 A HU 9402882A HU 215912 B HU215912 B HU 215912B
Authority
HU
Hungary
Prior art keywords
formula
compounds
preparation
alkyl
dihydro
Prior art date
Application number
HU9402882A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT68833A (en
HU9402882D0 (en
Inventor
Frank Bolkenius
J. Martin Grisar
Margaret A. Petty
Original Assignee
Merrell Dow Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc. filed Critical Merrell Dow Pharmaceuticals Inc.
Publication of HU9402882D0 publication Critical patent/HU9402882D0/hu
Publication of HUT68833A publication Critical patent/HUT68833A/hu
Publication of HU215912B publication Critical patent/HU215912B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
HU9402882A 1992-04-07 1993-03-12 Eljárás 3,4-dihidro-2H-1-benzopiránok hidrazidszármazékai, és ezeket tartalmazó gyógyszerkészítmények előállítására HU215912B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92400972 1992-04-07

Publications (3)

Publication Number Publication Date
HU9402882D0 HU9402882D0 (en) 1995-01-30
HUT68833A HUT68833A (en) 1995-08-28
HU215912B true HU215912B (hu) 1999-03-29

Family

ID=8211648

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9402882A HU215912B (hu) 1992-04-07 1993-03-12 Eljárás 3,4-dihidro-2H-1-benzopiránok hidrazidszármazékai, és ezeket tartalmazó gyógyszerkészítmények előállítására

Country Status (19)

Country Link
EP (1) EP0635011B1 (index.php)
JP (1) JP3226174B2 (index.php)
KR (1) KR950700680A (index.php)
AT (1) ATE146466T1 (index.php)
AU (1) AU675784B2 (index.php)
CA (1) CA2132831C (index.php)
DE (1) DE69306770T2 (index.php)
DK (1) DK0635011T3 (index.php)
ES (1) ES2098730T3 (index.php)
FI (1) FI944678A7 (index.php)
GR (1) GR3022122T3 (index.php)
HU (1) HU215912B (index.php)
IL (1) IL105319A (index.php)
MX (1) MX9301979A (index.php)
NO (1) NO943760L (index.php)
NZ (1) NZ251174A (index.php)
TW (1) TW278076B (index.php)
WO (1) WO1993020059A1 (index.php)
ZA (1) ZA932414B (index.php)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
EP0369083A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터

Also Published As

Publication number Publication date
EP0635011B1 (en) 1996-12-18
FI944678A0 (fi) 1994-10-06
WO1993020059A1 (en) 1993-10-14
CA2132831A1 (en) 1993-10-14
DE69306770D1 (de) 1997-01-30
JPH07505625A (ja) 1995-06-22
DE69306770T2 (de) 1997-06-12
NZ251174A (en) 1996-01-26
TW278076B (index.php) 1996-06-11
MX9301979A (es) 1993-11-01
ZA932414B (en) 1993-10-22
GR3022122T3 (en) 1997-03-31
IL105319A (en) 1998-02-22
ES2098730T3 (es) 1997-05-01
AU675784B2 (en) 1997-02-20
HUT68833A (en) 1995-08-28
HU9402882D0 (en) 1995-01-30
DK0635011T3 (da) 1997-01-06
EP0635011A1 (en) 1995-01-25
NO943760L (no) 1994-12-06
FI944678L (fi) 1994-10-06
FI944678A7 (fi) 1994-10-06
ATE146466T1 (de) 1997-01-15
JP3226174B2 (ja) 2001-11-05
AU3807293A (en) 1993-11-08
NO943760D0 (no) 1994-10-06
KR950700680A (ko) 1995-02-20
IL105319A0 (en) 1993-08-18
CA2132831C (en) 1998-06-16

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HMM4 Cancellation of final prot. due to non-payment of fee