MX9301979A - Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos. - Google Patents

Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos.

Info

Publication number
MX9301979A
MX9301979A MX9301979A MX9301979A MX9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A
Authority
MX
Mexico
Prior art keywords
alkyl
dihydro
benzopyranes
free radical
radical scavengers
Prior art date
Application number
MX9301979A
Other languages
English (en)
Inventor
J Martin Grisar
Margaret A Petty
Frank Bolkenius
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MX9301979A publication Critical patent/MX9301979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se relacion con nuevos derivados hidrazida-acilhidrazinio de ciertos 3,4-dihidro-2H-benzopiranos, con los intermediarios, con procesos y técnicas para su preparación con su capacidad para manifestar la propiedad de ser depuradores de radicales libres, y con su aplicación en el uso final en el tratamiento de enfermedades capaces de ser aliviadas por los depuradores de radicales libres.
MX9301979A 1992-04-07 1993-04-06 Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos. MX9301979A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92400972 1992-04-07

Publications (1)

Publication Number Publication Date
MX9301979A true MX9301979A (es) 1993-11-01

Family

ID=8211648

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301979A MX9301979A (es) 1992-04-07 1993-04-06 Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos.

Country Status (19)

Country Link
EP (1) EP0635011B1 (es)
JP (1) JP3226174B2 (es)
KR (1) KR950700680A (es)
AT (1) ATE146466T1 (es)
AU (1) AU675784B2 (es)
CA (1) CA2132831C (es)
DE (1) DE69306770T2 (es)
DK (1) DK0635011T3 (es)
ES (1) ES2098730T3 (es)
FI (1) FI944678A0 (es)
GR (1) GR3022122T3 (es)
HU (1) HU215912B (es)
IL (1) IL105319A (es)
MX (1) MX9301979A (es)
NO (1) NO943760L (es)
NZ (1) NZ251174A (es)
TW (1) TW278076B (es)
WO (1) WO1993020059A1 (es)
ZA (1) ZA932414B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
EP0369083A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터

Also Published As

Publication number Publication date
ATE146466T1 (de) 1997-01-15
CA2132831C (en) 1998-06-16
DE69306770T2 (de) 1997-06-12
GR3022122T3 (en) 1997-03-31
DK0635011T3 (da) 1997-01-06
HU215912B (hu) 1999-03-29
ES2098730T3 (es) 1997-05-01
HU9402882D0 (en) 1995-01-30
AU675784B2 (en) 1997-02-20
IL105319A (en) 1998-02-22
FI944678A (fi) 1994-10-06
HUT68833A (en) 1995-08-28
CA2132831A1 (en) 1993-10-14
FI944678A0 (fi) 1994-10-06
KR950700680A (ko) 1995-02-20
JP3226174B2 (ja) 2001-11-05
DE69306770D1 (de) 1997-01-30
ZA932414B (en) 1993-10-22
WO1993020059A1 (en) 1993-10-14
AU3807293A (en) 1993-11-08
NO943760D0 (no) 1994-10-06
JPH07505625A (ja) 1995-06-22
EP0635011B1 (en) 1996-12-18
NZ251174A (en) 1996-01-26
IL105319A0 (en) 1993-08-18
NO943760L (no) 1994-12-06
EP0635011A1 (en) 1995-01-25
TW278076B (es) 1996-06-11

Similar Documents

Publication Publication Date Title
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
MY105494A (en) Triazole antifungal agents.
DE69500660D1 (de) Ophthalmische Zusammensetzung enthaltend ein 1,5-Benzoxathiepin-Derivat zur Behandlung von Glaukoma
PT97700A (pt) Processo de preparacao de agentes terapeuticos anti-diabeticos
MX9301979A (es) Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos.
DE69005984D1 (de) 2-Hydroxy-3-phenoxypropylaminoverbindungen.
DK0424194T3 (da) Benzanilider
ATE236162T1 (de) Pyrroloazepinderivate
DK0420224T3 (da) Anthihepatopatisk middel
ATE24915T1 (de) Synergistin-derivate und ihre herstellung.
ES8900162A1 (es) Procedimiento para la obtencion de 3-acilaminobenzisotiazol-s,s-dioxidos
EP1112998A4 (en) AMINE DERIVATIVES
PT90815A (pt) Processo de preparacao de derivados da fenotiazina
ATE165829T1 (de) Nootrope wirkstoffe
ES527842A0 (es) Procedimiento para preparar derivados de benzoato de propilo o pseudopropilo
SE9402596D0 (sv) Karboximetylidencykloheptimidazolderivat, förfarande för deras framställning och terapeutiska medel innehållande dessa
DE3271277D1 (en) Tropyl and pseudotropyl alkyl-benzoates and their use in migraine treatment
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees