MX9301979A - Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos. - Google Patents

Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos.

Info

Publication number
MX9301979A
MX9301979A MX9301979A MX9301979A MX9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A MX 9301979 A MX9301979 A MX 9301979A
Authority
MX
Mexico
Prior art keywords
alkyl
dihydro
benzopyranes
free radical
radical scavengers
Prior art date
Application number
MX9301979A
Other languages
English (en)
Inventor
J Martin Grisar
Margaret A Petty
Frank Bolkenius
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MX9301979A publication Critical patent/MX9301979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se relacion con nuevos derivados hidrazida-acilhidrazinio de ciertos 3,4-dihidro-2H-benzopiranos, con los intermediarios, con procesos y técnicas para su preparación con su capacidad para manifestar la propiedad de ser depuradores de radicales libres, y con su aplicación en el uso final en el tratamiento de enfermedades capaces de ser aliviadas por los depuradores de radicales libres.
MX9301979A 1992-04-07 1993-04-06 Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos. MX9301979A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92400972 1992-04-07

Publications (1)

Publication Number Publication Date
MX9301979A true MX9301979A (es) 1993-11-01

Family

ID=8211648

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301979A MX9301979A (es) 1992-04-07 1993-04-06 Derivados de hidrazina de los 3,4-dihidro-2h-1-benzopiranos.

Country Status (19)

Country Link
EP (1) EP0635011B1 (es)
JP (1) JP3226174B2 (es)
KR (1) KR950700680A (es)
AT (1) ATE146466T1 (es)
AU (1) AU675784B2 (es)
CA (1) CA2132831C (es)
DE (1) DE69306770T2 (es)
DK (1) DK0635011T3 (es)
ES (1) ES2098730T3 (es)
FI (1) FI944678A0 (es)
GR (1) GR3022122T3 (es)
HU (1) HU215912B (es)
IL (1) IL105319A (es)
MX (1) MX9301979A (es)
NO (1) NO943760L (es)
NZ (1) NZ251174A (es)
TW (1) TW278076B (es)
WO (1) WO1993020059A1 (es)
ZA (1) ZA932414B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
EP0369083A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터

Also Published As

Publication number Publication date
ATE146466T1 (de) 1997-01-15
CA2132831C (en) 1998-06-16
DE69306770T2 (de) 1997-06-12
GR3022122T3 (en) 1997-03-31
DK0635011T3 (da) 1997-01-06
HU215912B (hu) 1999-03-29
ES2098730T3 (es) 1997-05-01
HU9402882D0 (en) 1995-01-30
AU675784B2 (en) 1997-02-20
IL105319A (en) 1998-02-22
FI944678A (fi) 1994-10-06
HUT68833A (en) 1995-08-28
CA2132831A1 (en) 1993-10-14
FI944678A0 (fi) 1994-10-06
KR950700680A (ko) 1995-02-20
JP3226174B2 (ja) 2001-11-05
DE69306770D1 (de) 1997-01-30
ZA932414B (en) 1993-10-22
WO1993020059A1 (en) 1993-10-14
AU3807293A (en) 1993-11-08
NO943760D0 (no) 1994-10-06
JPH07505625A (ja) 1995-06-22
EP0635011B1 (en) 1996-12-18
NZ251174A (en) 1996-01-26
IL105319A0 (en) 1993-08-18
NO943760L (no) 1994-12-06
EP0635011A1 (en) 1995-01-25
TW278076B (es) 1996-06-11

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees