HU198024B - Process for production of new derivatives of imidasolil-alkyl-guanidin and medical preparatives containing these substances - Google Patents

Process for production of new derivatives of imidasolil-alkyl-guanidin and medical preparatives containing these substances Download PDF

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Publication number
HU198024B
HU198024B HU854424A HU442485A HU198024B HU 198024 B HU198024 B HU 198024B HU 854424 A HU854424 A HU 854424A HU 442485 A HU442485 A HU 442485A HU 198024 B HU198024 B HU 198024B
Authority
HU
Hungary
Prior art keywords
formula
compound
propyl
hydrogen
defined above
Prior art date
Application number
HU854424A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT41392A (en
Inventor
Armin Baschauer
Walter Schunack
Helmut Schickaneder
Siguard Elz
Istvan Szelenyi
Gerd Baumann
Kurt Ahrens
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853512084 external-priority patent/DE3512084A1/de
Priority claimed from DE19853528215 external-priority patent/DE3528215A1/de
Priority claimed from DE19853528214 external-priority patent/DE3528214A1/de
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of HUT41392A publication Critical patent/HUT41392A/hu
Publication of HU198024B publication Critical patent/HU198024B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HU854424A 1985-04-02 1985-11-20 Process for production of new derivatives of imidasolil-alkyl-guanidin and medical preparatives containing these substances HU198024B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19853512084 DE3512084A1 (de) 1985-04-02 1985-04-02 Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE19853528215 DE3528215A1 (de) 1985-08-06 1985-08-06 Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE19853528214 DE3528214A1 (de) 1985-08-06 1985-08-06 Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
HUT41392A HUT41392A (en) 1987-04-28
HU198024B true HU198024B (en) 1989-07-28

Family

ID=27192965

Family Applications (1)

Application Number Title Priority Date Filing Date
HU854424A HU198024B (en) 1985-04-02 1985-11-20 Process for production of new derivatives of imidasolil-alkyl-guanidin and medical preparatives containing these substances

Country Status (13)

Country Link
US (1) US5021431A (env)
EP (1) EP0199845B1 (env)
KR (1) KR930011491B1 (env)
AU (1) AU589586B2 (env)
CA (1) CA1266657A (env)
DE (1) DE3579000D1 (env)
DK (1) DK165367C (env)
ES (4) ES8802042A1 (env)
GR (1) GR852852B (env)
HU (1) HU198024B (env)
IE (1) IE58777B1 (env)
PT (1) PT81605B (env)
YU (2) YU45929B (env)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726381A1 (de) * 1987-08-07 1989-02-16 Heumann Pharma Gmbh & Co Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0437645B1 (de) * 1990-01-15 1995-03-29 HEUMANN PHARMA GMBH & CO Imidazolylpropylguanidinderivat, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
DE59006842D1 (de) * 1990-03-30 1994-09-22 Heumann Pharma Gmbh & Co Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung.
EP0573542B1 (en) * 1991-02-27 1997-10-15 Seed Capital Investments( Sci) B.V. Imidazole-derivatives having antagonistic activity on the histamine h3-receptor
DE4119696A1 (de) * 1991-06-14 1992-12-17 Edmund Dr Neugebauer Verwendung von guanidinderivaten zur herstellung eines arzneimittels zur behandlung des sepsis-syndroms, des sepsis-like syndroms und des septischen schocks
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
JP2001526625A (ja) * 1995-11-13 2001-12-18 オールバニ メジカル カレッジ 鎮痛性化合物およびその使用
US6127343A (en) * 1996-05-14 2000-10-03 Novo Nordisk A/S Somatostatin agonists and antagonists
ZA974147B (en) * 1996-05-14 1997-11-14 Novo Nordisk As Somatostatin agonists and antagonists.
WO1998018786A1 (en) * 1996-10-31 1998-05-07 Novo Nordisk A/S Constrained somatostatin agonists and antagonists
DE19755016A1 (de) 1997-12-11 1999-06-17 Bayer Ag Substituierte 2,4-Diamino-1,3,5-triazine
GB9803536D0 (en) 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
US6232316B1 (en) 1998-06-16 2001-05-15 Targacept, Inc. Methods for treatment of CNS disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048319A (en) * 1969-10-29 1977-09-13 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with quanidine compounds
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1431589A (en) 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US4062967A (en) * 1974-02-07 1977-12-13 Smith Kline & French Laboratories Limited Bis-guanidino-alkane compounds
US4109003A (en) * 1974-03-12 1978-08-22 Smith Kline & French Laboratories Limited Pharmacologically active compounds
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
DK221081A (da) * 1980-05-31 1981-12-01 Smith Kline French Lab Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
HUT41392A (en) 1987-04-28
EP0199845A1 (de) 1986-11-05
ES8802042A1 (es) 1988-04-01
IE853319L (en) 1986-10-02
ES550875A0 (es) 1988-04-01
YU45469B (en) 1992-05-28
ES8801821A1 (es) 1988-03-01
ES8801819A1 (es) 1988-03-01
DK165367B (da) 1992-11-16
DK538885A (da) 1986-10-03
PT81605A (de) 1986-01-01
ES8801820A1 (es) 1988-03-01
AU589586B2 (en) 1989-10-19
DK538885D0 (da) 1985-11-21
YU207285A (en) 1988-06-30
PT81605B (pt) 1987-10-20
KR930011491B1 (ko) 1993-12-08
EP0199845B1 (de) 1990-08-01
DK165367C (da) 1993-04-05
AU5182886A (en) 1986-10-09
YU210187A (en) 1988-10-31
GR852852B (env) 1986-08-11
KR860008147A (ko) 1986-11-12
IE58777B1 (en) 1993-11-17
ES557692A0 (es) 1988-03-01
DE3579000D1 (de) 1990-09-06
US5021431A (en) 1991-06-04
ES557691A0 (es) 1988-03-01
YU45929B (sh) 1992-09-07
ES557693A0 (es) 1988-03-01
CA1266657A (en) 1990-03-13

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee