ES8801821A1 - Procedimiento para preparar derivados de imidazolilalquilguanidina - Google Patents

Procedimiento para preparar derivados de imidazolilalquilguanidina

Info

Publication number
ES8801821A1
ES8801821A1 ES557693A ES557693A ES8801821A1 ES 8801821 A1 ES8801821 A1 ES 8801821A1 ES 557693 A ES557693 A ES 557693A ES 557693 A ES557693 A ES 557693A ES 8801821 A1 ES8801821 A1 ES 8801821A1
Authority
ES
Spain
Prior art keywords
group
stands
denotes
hydrogen atom
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557693A
Other languages
English (en)
Other versions
ES557693A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853512084 external-priority patent/DE3512084A1/de
Priority claimed from DE19853528214 external-priority patent/DE3528214A1/de
Priority claimed from DE19853528215 external-priority patent/DE3528215A1/de
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Publication of ES8801821A1 publication Critical patent/ES8801821A1/es
Publication of ES557693A0 publication Critical patent/ES557693A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

DERIVADOS (I) DE LA IMIDAZOLILALQUILGUANIDINA, DONDE R ES UN RESTO TIPO (II), (III) Y (IV), ENTRE OTROS, X ES HIDROGENO O BENZOILO, RK ES HIDROGENO O METILO, P ES 2 O 3 Y DONDE HAY OTROS RADICALES VARIOS; SE PREPARAN POR REACCION DE UN COMPUESTO (V) CON R-NH2, EN UN DISOLVENTE POLAR COMO LA PIRIDINA, ENTRE 3 A 5 HORAS, A LA TEMPERATURA DEL REFLUJO DEL DISOLVENTE. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTAGONISTA -H1 Y AGONISTA -H2.
ES557693A 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina Expired ES8801821A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19853512084 DE3512084A1 (de) 1985-04-02 1985-04-02 Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE19853528214 DE3528214A1 (de) 1985-08-06 1985-08-06 Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE19853528215 DE3528215A1 (de) 1985-08-06 1985-08-06 Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8801821A1 true ES8801821A1 (es) 1988-03-01
ES557693A0 ES557693A0 (es) 1988-03-01

Family

ID=27192965

Family Applications (4)

Application Number Title Priority Date Filing Date
ES550875A Expired ES8802042A1 (es) 1985-04-02 1986-01-14 Procedimiento para preparar derivados de imidazolilalquil- quilguanidina
ES557692A Expired ES8801820A1 (es) 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina
ES557693A Expired ES8801821A1 (es) 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina
ES557691A Expired ES8801819A1 (es) 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES550875A Expired ES8802042A1 (es) 1985-04-02 1986-01-14 Procedimiento para preparar derivados de imidazolilalquil- quilguanidina
ES557692A Expired ES8801820A1 (es) 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557691A Expired ES8801819A1 (es) 1985-04-02 1987-08-28 Procedimiento para preparar derivados de imidazolilalquilguanidina

Country Status (13)

Country Link
US (1) US5021431A (es)
EP (1) EP0199845B1 (es)
KR (1) KR930011491B1 (es)
AU (1) AU589586B2 (es)
CA (1) CA1266657A (es)
DE (1) DE3579000D1 (es)
DK (1) DK165367C (es)
ES (4) ES8802042A1 (es)
GR (1) GR852852B (es)
HU (1) HU198024B (es)
IE (1) IE58777B1 (es)
PT (1) PT81605B (es)
YU (2) YU45929B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726381A1 (de) * 1987-08-07 1989-02-16 Heumann Pharma Gmbh & Co Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE120461T1 (de) * 1990-01-15 1995-04-15 Heumann Pharma Gmbh & Co Imidazolylpropylguanidinderivat, verfahren zu seiner herstellung und diese verbindung enthaltende arzneimittel.
ATE109979T1 (de) * 1990-03-30 1994-09-15 Heumann Pharma Gmbh & Co Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung.
AU662135B2 (en) * 1991-02-27 1995-08-24 Seed Capital Investments (Sci) B.V. Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor
DE4119696A1 (de) * 1991-06-14 1992-12-17 Edmund Dr Neugebauer Verwendung von guanidinderivaten zur herstellung eines arzneimittels zur behandlung des sepsis-syndroms, des sepsis-like syndroms und des septischen schocks
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
WO1997017954A1 (en) * 1995-11-13 1997-05-22 Albany Medical College Analgesic compounds and uses thereof
AU2764797A (en) * 1996-05-14 1997-12-05 Novo Nordisk A/S Somatostatin agonists and antagonists
US6127343A (en) * 1996-05-14 2000-10-03 Novo Nordisk A/S Somatostatin agonists and antagonists
ZA979701B (en) * 1996-10-31 1998-05-21 Novo Nordisk As Novo Nordisk A Constrained somatostatin agonists and antagonists.Constrained somatostatin agonists and antagonists.
DE19755016A1 (de) 1997-12-11 1999-06-17 Bayer Ag Substituierte 2,4-Diamino-1,3,5-triazine
GB9803536D0 (en) 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
US6232316B1 (en) 1998-06-16 2001-05-15 Targacept, Inc. Methods for treatment of CNS disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048319A (en) * 1969-10-29 1977-09-13 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with quanidine compounds
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1431589A (en) 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US4062967A (en) * 1974-02-07 1977-12-13 Smith Kline & French Laboratories Limited Bis-guanidino-alkane compounds
US4109003A (en) * 1974-03-12 1978-08-22 Smith Kline & French Laboratories Limited Pharmacologically active compounds
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
DK221081A (da) * 1980-05-31 1981-12-01 Smith Kline French Lab Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
CA1266657A (en) 1990-03-13
DK165367B (da) 1992-11-16
YU45929B (sh) 1992-09-07
IE58777B1 (en) 1993-11-17
HUT41392A (en) 1987-04-28
KR860008147A (ko) 1986-11-12
AU589586B2 (en) 1989-10-19
ES8802042A1 (es) 1988-04-01
ES557693A0 (es) 1988-03-01
DK538885A (da) 1986-10-03
HU198024B (en) 1989-07-28
GR852852B (es) 1986-08-11
DK165367C (da) 1993-04-05
DK538885D0 (da) 1985-11-21
AU5182886A (en) 1986-10-09
YU45469B (en) 1992-05-28
ES557691A0 (es) 1988-03-01
PT81605A (de) 1986-01-01
ES8801820A1 (es) 1988-03-01
YU207285A (en) 1988-06-30
ES8801819A1 (es) 1988-03-01
PT81605B (pt) 1987-10-20
KR930011491B1 (ko) 1993-12-08
EP0199845B1 (de) 1990-08-01
YU210187A (en) 1988-10-31
US5021431A (en) 1991-06-04
IE853319L (en) 1986-10-02
ES550875A0 (es) 1988-04-01
DE3579000D1 (de) 1990-09-06
EP0199845A1 (de) 1986-11-05
ES557692A0 (es) 1988-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001