ES8104239A1 - Se persona en el expediente el agente que pasa a ser carlos fernandez candelas. - Google Patents

Se persona en el expediente el agente que pasa a ser carlos fernandez candelas.

Info

Publication number
ES8104239A1
ES8104239A1 ES489354A ES489354A ES8104239A1 ES 8104239 A1 ES8104239 A1 ES 8104239A1 ES 489354 A ES489354 A ES 489354A ES 489354 A ES489354 A ES 489354A ES 8104239 A1 ES8104239 A1 ES 8104239A1
Authority
ES
Spain
Prior art keywords
pharmaceuticals
naphthyl
propyl
making
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489354A
Other languages
English (en)
Other versions
ES489354A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES489354A0 publication Critical patent/ES489354A0/es
Publication of ES8104239A1 publication Critical patent/ES8104239A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 1-(NAFTIL-N-PROPIL) IMIDAZOL, DE FORMULA (I), O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE, DONDE Z ES HIDROXIMETILO, HIDROXIMETILO ESTERIFICADO, ALCOXIMETILENO, CARBONILO O CARBONILO CETAL-PROTEGIDO. EL PROCESO SE REALIZA EN DOS ETAPAS; EN LA PRIMERA, SE HACE REACCIONAR UNA VINIL-NAFTIL-CETONA CON IMIDAZOL A UNA TEMPERATURA COMPRENDIDA ENTRE -10 Y 40GC, OBTENIENDOSE UN COMPUESTO COMO (I), EN DONDE Z ES CARBONILO, EN UNA SEGUNDA ETAPA, SE REDUCE EL COMPUESTO OBTENIDO A UNA TEMPERATURA ENTRE -20 Y 20GC A UN COMPUESTO (I), DONDE Z ES AHORA HIDROXIMETILENO, QUE BIEN POSTERIORMENTE PUEDE SUFRIR UNA ESTERIFICACION O UNA ALQUILACION, CON LO CUAL SE OBTIENE EL PRODUCTO DESEADO. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD ANTIHIPERTENSIVA Y ESPERMASTOSTATICA. *FORMULA* E
ES489354A 1979-03-09 1980-03-08 Se persona en el expediente el agente que pasa a ser carlos fernandez candelas. Expired ES8104239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/019,201 US4293561A (en) 1979-03-09 1979-03-09 1-(Naphthyl-n-propyl)imidazole derivatives

Publications (2)

Publication Number Publication Date
ES489354A0 ES489354A0 (es) 1981-04-16
ES8104239A1 true ES8104239A1 (es) 1981-07-01

Family

ID=21791960

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489354A Expired ES8104239A1 (es) 1979-03-09 1980-03-08 Se persona en el expediente el agente que pasa a ser carlos fernandez candelas.

Country Status (7)

Country Link
US (1) US4293561A (es)
EP (1) EP0015750B1 (es)
JP (1) JPS55162777A (es)
AT (1) ATE1859T1 (es)
CA (1) CA1134368A (es)
DE (1) DE3061125D1 (es)
ES (1) ES8104239A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590063A (en) * 1983-06-24 1986-05-20 Adria Laboratories, Inc. Anticonvulsants
US4540814A (en) * 1983-06-24 1985-09-10 Adria Laboratories, Inc. 1,4-Dimethoxy naphthalenecarboxamide anticonvulsants
US4533715A (en) * 1983-09-07 1985-08-06 Hexcel Corporation Single package epoxy resin system
US5145541A (en) * 1989-07-07 1992-09-08 Hexcel Corporation Low energy cured composite repair system based on imidazole-blocked naphthyl-diisocyanates
US5086149A (en) * 1989-07-07 1992-02-04 Hexcel Corporation Low energy cured composite repair system based on epoxy resin with imidazole blocked naphthyl diisocyanate catalyst having extended shelf life
JPH03115267A (ja) * 1989-09-28 1991-05-16 Maruho Kk プロピオフエノン誘導体、その製造方法、それを含む中枢性筋弛緩剤および抗痙攣剤
JP3294961B2 (ja) * 1993-12-10 2002-06-24 杏林製薬株式会社 新規イミダゾール誘導体及びその製造法
WO1999003835A1 (fr) * 1997-07-18 1999-01-28 Nippon Kayaku Kabushiki Kaisha Derives cetoniques aromatiques et leurs utilisations
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
EP2027087A2 (en) 2006-05-18 2009-02-25 MannKind Corporation Intracellular kinase inhibitors
CN102026988B (zh) * 2008-06-05 2013-07-03 爱思开生物制药株式会社 3-取代的丙胺化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
US4172141A (en) * 1976-03-17 1979-10-23 Syntex (U.S.A.) Inc. N-(naphthylethyl)imidazole derivatives
US4141908A (en) * 1976-10-15 1979-02-27 Janssen Pharmaceutica N.V. 2-Aryl-1,3-dioxolanes
US4150153A (en) * 1977-05-13 1979-04-17 Syntex (U.S.A.) Inc. 1-(Naphthylethyl)imidazole derivatives
DE2738725A1 (de) * 1977-08-27 1979-03-08 Basf Ag Azolylalkohole
IT1097314B (it) * 1978-07-26 1985-08-31 Recordati Chem Pharm Derivati dell'imidazolo ad attivita' anticonvulsivante

Also Published As

Publication number Publication date
JPS55162777A (en) 1980-12-18
US4293561A (en) 1981-10-06
EP0015750A1 (en) 1980-09-17
ES489354A0 (es) 1981-04-16
ATE1859T1 (de) 1982-12-15
EP0015750B1 (en) 1982-11-24
CA1134368A (en) 1982-10-26
DE3061125D1 (en) 1982-12-30

Similar Documents

Publication Publication Date Title
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
ES8401468A1 (es) Un procedimiento para preparar derivados de nicotinamida.
ES461526A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1h-1,2,4-triazol.
ES8104239A1 (es) Se persona en el expediente el agente que pasa a ser carlos fernandez candelas.
IL96924A0 (en) Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE3170937D1 (en) 2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
ES8200093A1 (es) Un procedimiento para la preparacion de 1-(2-(alquil y ari sulfonil)-2- propenil y propil) piperidinas.
ES8106289A1 (es) Procedimiento de preparacion de nuevos derivados del a-fe- nil-2-pirrolidin-metanol
ES8104241A1 (es) Un procedimiento para la preparacion de compuestos derivadosde 1-((naftil substituido)etil)imidazol
ES8307224A1 (es) Un metodo para preparar derivados de pirazolina.
GB1519580A (en) Aminomethylazole derivatives and their use as fungicides and plant-growth rugalators
ES8801633A1 (es) Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
IE56917B1 (en) N-sulphenylated hydantoins,a process for their preparation and their use as microbicides
ES8205219A1 (es) Un metodo para producir un compuesto de hidrouracilo
ES8802033A1 (es) Procedimiento para preparar compuestos de imidazolilo
IL58457A (en) 2-phenoxy-2-(1,2,4-triazolyl)acetic acid derivatives,their preparation and their use as fungicides
IL85640A (en) 1-(1-aryl-2-hydroxyethyl)-imidazoles and salts thereof,processes for the preparation thereof and pharmaceutical compositions containing them
ES8307768A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,2,4 triazol.
ES8206544A1 (es) Procedimiento para la preparacion de 4-carbamoiloxi-oxaza- fosforinas
IE812641L (en) Imidazoles
ES8502096A1 (es) Un procedimiento para la preparacion de 4-amino-1,2-hidro- carbilpirazolidinas
ES8104198A1 (es) Un procedimiento para la preparacion de un derivado de mo- noamida del acido tereftalico
CH609344A5 (en) Process for the preparation of novel 1-(5-nitrothiazol-2-yl)imidazole derivatives
ES472491A1 (es) Un procedimiento para la preparacion de nuevos derivados de imidazol