HU187090B - Process for producing substituted dipeptides - Google Patents

Process for producing substituted dipeptides Download PDF

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Publication number
HU187090B
HU187090B HU832537A HU253783A HU187090B HU 187090 B HU187090 B HU 187090B HU 832537 A HU832537 A HU 832537A HU 253783 A HU253783 A HU 253783A HU 187090 B HU187090 B HU 187090B
Authority
HU
Hungary
Prior art keywords
phenyl
mmol
proline
ester
formula
Prior art date
Application number
HU832537A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT34040A (en
Inventor
Sesha I Natarajan
Eric M Gordon
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of HUT34040A publication Critical patent/HUT34040A/hu
Publication of HU187090B publication Critical patent/HU187090B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU832537A 1982-07-19 1983-07-18 Process for producing substituted dipeptides HU187090B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
HUT34040A HUT34040A (en) 1985-01-28
HU187090B true HU187090B (en) 1985-11-28

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
HU832537A HU187090B (en) 1982-07-19 1983-07-18 Process for producing substituted dipeptides

Country Status (21)

Country Link
JP (3) JPS5951246A (it)
KR (1) KR840005709A (it)
AU (1) AU1643283A (it)
BE (1) BE897327A (it)
CA (1) CA1244006A (it)
CH (1) CH659475A5 (it)
DE (1) DE3325850A1 (it)
DK (1) DK330683A (it)
ES (4) ES8504675A1 (it)
FI (1) FI832620A (it)
FR (3) FR2530238B1 (it)
GB (1) GB2123834B (it)
GR (1) GR79602B (it)
HU (1) HU187090B (it)
IE (1) IE55818B1 (it)
IL (1) IL69136A0 (it)
IT (1) IT1163800B (it)
NL (1) NL8302562A (it)
PT (1) PT77045B (it)
SE (1) SE8304031L (it)
ZA (1) ZA834980B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
NL8302562A (nl) 1984-02-16
FR2540867B1 (fr) 1987-07-31
ES524200A0 (es) 1985-04-16
GB2123834A (en) 1984-02-08
KR840005709A (ko) 1984-11-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
ES8707550A1 (es) 1986-04-01
SE8304031D0 (sv) 1983-07-18
JPH0532601A (ja) 1993-02-09
CA1244006A (en) 1988-11-01
ES8504675A1 (es) 1985-04-16
FI832620A0 (fi) 1983-07-19
PT77045B (en) 1986-02-12
FR2540867A1 (fr) 1984-08-17
FR2530238B1 (it) 1989-06-30
JPH0645582B2 (ja) 1994-06-15
IE55818B1 (en) 1991-01-30
HUT34040A (en) 1985-01-28
DK330683D0 (da) 1983-07-18
GB2123834B (en) 1986-10-22
JPH0517420A (ja) 1993-01-26
IE831655L (en) 1984-01-19
ES539082A0 (es) 1986-05-16
JPH0653713B2 (ja) 1994-07-20
ES539084A0 (es) 1986-04-01
SE8304031L (sv) 1984-03-30
DK330683A (da) 1984-01-20
IT8322114A0 (it) 1983-07-18
FI832620A (fi) 1984-01-20
ZA834980B (en) 1984-03-28
PT77045A (en) 1983-08-01
ES8707548A1 (es) 1986-05-16
GR79602B (it) 1984-10-31
IL69136A0 (en) 1983-10-31
FR2540866A1 (fr) 1984-08-17
JPS5951246A (ja) 1984-03-24
JPH0526775B2 (it) 1993-04-19
GB8318492D0 (en) 1983-08-10
CH659475A5 (fr) 1987-01-30
DE3325850A1 (de) 1984-01-19
ES539083A0 (es) 1986-04-01
FR2530238A1 (it) 1984-01-20
ES8707549A1 (es) 1986-04-01
IT1163800B (it) 1987-04-08

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